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The map label for this gene is exuR [H]

Identifier: 162138371

GI number: 162138371

Start: 3473182

End: 3473958

Strand: Direct

Name: exuR [H]

Synonym: UTI89_C3532

Alternate gene names: 162138371

Gene position: 3473182-3473958 (Clockwise)

Preceding gene: 91212522

Following gene: 91212524

Centisome position: 68.56

GC content: 50.97

Gene sequence:

>777_bases
ATGGAAATCACTGAACCACGCCGTTTGTATCAACAACTTGCCGCTGATCTGAAAGAGCGCATCGAACAGGGCGTCTATCT
GGTGGGTGATAAACTGCCTGCCGAACGCTTTATTGCCGATGAAAAAAACGTCAGCCGCACCGTGGTTCGTGAAGCCATCA
TCATGCTGGAAGTTGAAGGCTATGTCGAAGTGCGTAAAGGTTCAGGTATTCATGTGGTTTCCAACCAGCCTCGCCATCAG
CAGGCGGCTGACAATAATATGGAATTCGCCAATTACGGTCCGTTTGAGTTGCTCCAGGCTCGCCAGCTCATCGAAAGTAA
TATTGCCGAGTTCGCGGCAACTCAGGTAACGAAACAGGACATCATGAAATTGATGGCCATCCAGGAGCAGGCGCGCGGCG
AACAATGCTTCCGTGATTCCGAGTGGGATTTGCAGTTCCATATTCAGGTAGCCCTGGCGACGCAGAACTCCGCCCTGGCG
GCTATCGTTGAAAAAATGTGGACCCAGCGTAGTCATAACCCGTACTGGAAAAAACTGCACGAACACATTGATGCCCGTAC
CGTCGATAACTGGTGTGATGACCACGATCAAATCCTCAAGGCGCTGATTCGCAAAGATCCTCATGCTGCTAAGCTGGCAA
TGTGGCAGCACCTGGAAAACACCAAGATCATGTTATTTAACGAAACCAGCGACGATTTCGAGTTCAATGCCGACCGCTAT
CTGTTCGCCGAAAACCCGGTGGTGCATCTCGATACAGCCACCAGCGGCAGTAAATGA

Upstream 100 bases:

>100_bases
AAGCCGCCTTCTCAGGCGGCTTTTTCATCACTGCGAGTAGAGCTAAACTCGCAAAAGTGGTATAACAAATATAGTCTGCC
GTATCATGCCTGGAGCGCAT

Downstream 100 bases:

>100_bases
AATTCCTGTCCGACAGGCGCTACAGTGCGCCTGTTTGTCTCGTCGGTAAGCGAAAAGTATAAAGTGTCAGCCTGTGTAAA
TCCTCTCGCCTCCCTCCCCT

Product: DNA-binding transcriptional repressor ExuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ
QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALA
AIVEKMWTQRSHNPYWKKLHEHIDARTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
LFAENPVVHLDTATSGSK

Sequences:

>Translated_258_residues
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ
QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALA
AIVEKMWTQRSHNPYWKKLHEHIDARTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
LFAENPVVHLDTATSGSK
>Mature_258_residues
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ
QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALA
AIVEKMWTQRSHNPYWKKLHEHIDARTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
LFAENPVVHLDTATSGSK

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082208, Length=258, Percent_Identity=99.6124031007752, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1790780, Length=255, Percent_Identity=45.8823529411765, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1790032, Length=237, Percent_Identity=27.0042194092827, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789353, Length=244, Percent_Identity=24.1803278688525, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29820; Mature: 29820

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHH
EHIDARTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
HHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEECCCEE
LFAENPVVHLDTATSGSK
EEECCCEEEEECCCCCCC
>Mature Secondary Structure
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHH
EHIDARTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
HHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEECCCEE
LFAENPVVHLDTATSGSK
EEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]