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The map label for this gene is upp [H]

Identifier: 89256805

GI number: 89256805

Start: 1448536

End: 1449165

Strand: Reverse

Name: upp [H]

Synonym: FTL_1520

Alternate gene names: 89256805

Gene position: 1449165-1448536 (Counterclockwise)

Preceding gene: 89256806

Following gene: 89256804

Centisome position: 76.43

GC content: 36.83

Gene sequence:

>630_bases
ATGAAAGTAGTAGAAATAAGCCACCCTATGGTCAAACATAAGCTCGGTCTTATGCGTGCGGCATCTATAAGTACACAAGA
ATTTAGAAGACTAACAAAAGAAATAACAAGCCTTTTAACTTATGAAGTAACAGCAGGCTTTGAGCTTGAGAAAACAGAAA
TTTTAGGATGGCAAGGCGAAAATATTGAAATTGATCAGATTAAGGGAAAAAAATTAACAGTTGTGCCTATTTTACGCGCA
GGTCTTGGAATGATGGATGGTGTTTTTGAGCATGTTCCAGCTGCTAAAGTGAGTATGGTTGGTATGTATCGTGATGAAAA
AACAGCAAAGCCCGTAGCTTATTTTGCTAAGCTTTGTGATAAGCTTGACGAGAGAGTTGCTTTGATTGTCGATCCAATGT
TGGCAACTGGTGGCTCAATGATTGCAACGGTTTCGTTACTTAAAAAAGCTGGCTCAAAAGATATCAAAATTATAACTTTA
GTTTCTGCACCTGAGGGAATAGATACGTTAGCAAAAGCACATCCGGATGTTGAGTTGTATACAGCCTCTATAGATAGTCA
TTTAAATGACAAAAAATATATAATTCCTGGTCTTGGAGATGCAGGAGATAAAATTTTCGGAACTAAATAA

Upstream 100 bases:

>100_bases
TTATCAAATCAGTATTTCAAATTTAGATAAGATTATTCAAAAGACTTAATTTGAATAAAGTTTTGCTATAATAAAATAAA
TTAGTTTGTTTTGGAGAGTT

Downstream 100 bases:

>100_bases
GTTCTATTAGTAATTAAATCCTAACTAAAAAAATATTTATGTATAATAGTTTATGATTTTAGATTAATTCAAGAAAACTA
ATAAATGCAAAAATATAGAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGENIEIDQIKGKKLTVVPILRA
GLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCDKLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITL
VSAPEGIDTLAKAHPDVELYTASIDSHLNDKKYIIPGLGDAGDKIFGTK

Sequences:

>Translated_209_residues
MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGENIEIDQIKGKKLTVVPILRA
GLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCDKLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITL
VSAPEGIDTLAKAHPDVELYTASIDSHLNDKKYIIPGLGDAGDKIFGTK
>Mature_209_residues
MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGENIEIDQIKGKKLTVVPILRA
GLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCDKLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITL
VSAPEGIDTLAKAHPDVELYTASIDSHLNDKKYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=26.9607843137255, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=26.9607843137255, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI87082118, Length=209, Percent_Identity=70.8133971291866, Blast_Score=304, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=24.2574257425743, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=203, Percent_Identity=33.0049261083744, Blast_Score=108, Evalue=9e-25,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.0935960591133, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.0935960591133, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.0935960591133, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.0935960591133, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22798; Mature: 22798

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGE
CEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHEEECCCCC
NIEIDQIKGKKLTVVPILRAGLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCD
CEEEEEECCCEEEEHHHHHHCCHHHHHHHHHCCCHHHHEEEEECCCCCCCHHHHHHHHHH
KLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITLVSAPEGIDTLAKAHPDVELY
HHHHHEEEEECHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEE
TASIDSHLNDKKYIIPGLGDAGDKIFGTK
EEEHHCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKVVEISHPMVKHKLGLMRAASISTQEFRRLTKEITSLLTYEVTAGFELEKTEILGWQGE
CEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHEEECCCCC
NIEIDQIKGKKLTVVPILRAGLGMMDGVFEHVPAAKVSMVGMYRDEKTAKPVAYFAKLCD
CEEEEEECCCEEEEHHHHHHCCHHHHHHHHHCCCHHHHEEEEECCCCCCCHHHHHHHHHH
KLDERVALIVDPMLATGGSMIATVSLLKKAGSKDIKIITLVSAPEGIDTLAKAHPDVELY
HHHHHEEEEECHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEE
TASIDSHLNDKKYIIPGLGDAGDKIFGTK
EEEHHCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA