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The map label for this gene is pyrG [H]

Identifier: 89256620

GI number: 89256620

Start: 1248370

End: 1250010

Strand: Reverse

Name: pyrG [H]

Synonym: FTL_1311

Alternate gene names: 89256620

Gene position: 1250010-1248370 (Counterclockwise)

Preceding gene: 89256623

Following gene: 89256619

Centisome position: 65.93

GC content: 37.42

Gene sequence:

>1641_bases
ATGAATTCTAACACTAAAATTATTTTCGTCACAGGTGGGGTAGTATCATCACTTGGTAAGGGTGTAACTGCGGCATCTTT
GGCTACTCTCTTAGAAAGTCGTGGTCTTAATGTAACAATGATGAAGCTTGATCCATACATCAATGTTGATCCAGGGACTA
TGAGTCCATTGCAACATGGTGAAGTTTTTGTAACCGAAGATGGCGCAGAGACTGATCTTGATTTGGGTCATTATGAGCGC
TTTATCCGCAATAAGATGACTCAAGCAAATAACTTCACAACCGGTAAAGTATACCAGAGTGTGTTAAGAAGAGAGCGTAA
GGGTGATTATCTAGGTGCTACTATCCAGGTGATTCCACATATCACTGATGAGATCAAAAGGCGTATTTGTAGTGGTATTG
CTGATGATGTTGATGTTGCGATTGTTGAGATTGGTGGTACTGTTGGTGATATCGAGTCACAACCATTTTTAGAAGCAATT
AGACAACTAAGAATAGAGTTAGGTAGAAATAGAACATTATTTGTGCATTTAACTCTTTTACCTTATATAAAAGTTGCTGG
TGAGATTAAGACAAAACCAACACAGCACTCTGTCAAGGAGTTAAGAGGTATCGGAATTCAAGCTGATGTACTAGTTTGTC
GTTGCGAGAAAAAATTTGATGATAGTGAAAAGCGTAAAATAGCACTTTTTACTAATGTTGATCAGGATTGTATATTTACA
GCAGAAGATGTTGATACGATTTATGAAGTGCCACTTAAGTACAACCAGCAAGGTTTTGATGCAAAGCTTGTTGAACTTTT
AAACCTAAATGCTAAAGAAGCTGATCTATCCGAATGGCAAAATGTTGTAAATACTATTAGAGATGTCAAAGGTGAAGTCA
TTATTGCGATGGTTGGTAAGTATGTTTCATTAACAGAAGCGTATAAGTCGCTAAATGAGGCATTGTATAATGCGGGTTAT
AAAAAAGGCGTTAAAGTAAAAATAAAATTTGTTGATTCAGAAGATGTTAACGAGAATAATGTTGAGTCGTACTTCAAAGA
TGTTGCTGCTATTTTAGTACCAGGGGGGTTTGGTAGTAGAGGTGTTGAAGGTAAGATAATCTCAATAAAATATGCTCGAG
AAAATCAGATTCCTTTCTTGGGGATATGTCTAGGAATGCAGTTGGCTGTTATCGAATACGCTAGAAATATTCTAGGTATA
AAGGACGCTCATTCTAGTGAACTAGAGCCAACGACAGCAAATCCAGTAATTGGATTAATAACAGAATGGCAAGCAGAAGA
TGGTACTGTTCATCAAAGAACACATAGTTCTGATCTCGGTGGGACAATGCGTCTAGGTGGATATAAGTGTGTCTTAAAAC
AAGGCTCGCGCGCTAGAGAAATATACCAAGCTGATGAAGTGGTTGAAAGACATCGTCACCGCTACGAGGTAAATAGTAAT
TATGTTGAGCGCCTTGAGGAAGCAGGTTTGATTTTCTCAGGAAGATCTGAAGATAATAAATTGATGGAGCTTATCGAAAT
TCCTCAGCATAAATGGTTTATAGCATGTCAGGCGCATCCAGAGTTTACTTCTACACCAAGATATGGACATAAATTGTTTG
AATCTTATATCCAAGCAGCTATCGAAAATTCTAATAATTAG

Upstream 100 bases:

>100_bases
TGAAAAATTAACTAAATAAATACTGTATTTTCAAATGGTAACATTTTTGTAAAAATGTTATTATTATGTTCCATGATTTT
TTATATTTTCATGTATCCAA

Downstream 100 bases:

>100_bases
TCACTACTTTTGATATTTCATGAATAAAAGTGCTATAATTTGACTTAATTAACTATTGGAGAATAATTTAAAATGACTAA
ACAAAGAACTTTATCTATAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MNSNTKIIFVTGGVVSSLGKGVTAASLATLLESRGLNVTMMKLDPYINVDPGTMSPLQHGEVFVTEDGAETDLDLGHYER
FIRNKMTQANNFTTGKVYQSVLRRERKGDYLGATIQVIPHITDEIKRRICSGIADDVDVAIVEIGGTVGDIESQPFLEAI
RQLRIELGRNRTLFVHLTLLPYIKVAGEIKTKPTQHSVKELRGIGIQADVLVCRCEKKFDDSEKRKIALFTNVDQDCIFT
AEDVDTIYEVPLKYNQQGFDAKLVELLNLNAKEADLSEWQNVVNTIRDVKGEVIIAMVGKYVSLTEAYKSLNEALYNAGY
KKGVKVKIKFVDSEDVNENNVESYFKDVAAILVPGGFGSRGVEGKIISIKYARENQIPFLGICLGMQLAVIEYARNILGI
KDAHSSELEPTTANPVIGLITEWQAEDGTVHQRTHSSDLGGTMRLGGYKCVLKQGSRAREIYQADEVVERHRHRYEVNSN
YVERLEEAGLIFSGRSEDNKLMELIEIPQHKWFIACQAHPEFTSTPRYGHKLFESYIQAAIENSNN

Sequences:

>Translated_546_residues
MNSNTKIIFVTGGVVSSLGKGVTAASLATLLESRGLNVTMMKLDPYINVDPGTMSPLQHGEVFVTEDGAETDLDLGHYER
FIRNKMTQANNFTTGKVYQSVLRRERKGDYLGATIQVIPHITDEIKRRICSGIADDVDVAIVEIGGTVGDIESQPFLEAI
RQLRIELGRNRTLFVHLTLLPYIKVAGEIKTKPTQHSVKELRGIGIQADVLVCRCEKKFDDSEKRKIALFTNVDQDCIFT
AEDVDTIYEVPLKYNQQGFDAKLVELLNLNAKEADLSEWQNVVNTIRDVKGEVIIAMVGKYVSLTEAYKSLNEALYNAGY
KKGVKVKIKFVDSEDVNENNVESYFKDVAAILVPGGFGSRGVEGKIISIKYARENQIPFLGICLGMQLAVIEYARNILGI
KDAHSSELEPTTANPVIGLITEWQAEDGTVHQRTHSSDLGGTMRLGGYKCVLKQGSRAREIYQADEVVERHRHRYEVNSN
YVERLEEAGLIFSGRSEDNKLMELIEIPQHKWFIACQAHPEFTSTPRYGHKLFESYIQAAIENSNN
>Mature_546_residues
MNSNTKIIFVTGGVVSSLGKGVTAASLATLLESRGLNVTMMKLDPYINVDPGTMSPLQHGEVFVTEDGAETDLDLGHYER
FIRNKMTQANNFTTGKVYQSVLRRERKGDYLGATIQVIPHITDEIKRRICSGIADDVDVAIVEIGGTVGDIESQPFLEAI
RQLRIELGRNRTLFVHLTLLPYIKVAGEIKTKPTQHSVKELRGIGIQADVLVCRCEKKFDDSEKRKIALFTNVDQDCIFT
AEDVDTIYEVPLKYNQQGFDAKLVELLNLNAKEADLSEWQNVVNTIRDVKGEVIIAMVGKYVSLTEAYKSLNEALYNAGY
KKGVKVKIKFVDSEDVNENNVESYFKDVAAILVPGGFGSRGVEGKIISIKYARENQIPFLGICLGMQLAVIEYARNILGI
KDAHSSELEPTTANPVIGLITEWQAEDGTVHQRTHSSDLGGTMRLGGYKCVLKQGSRAREIYQADEVVERHRHRYEVNSN
YVERLEEAGLIFSGRSEDNKLMELIEIPQHKWFIACQAHPEFTSTPRYGHKLFESYIQAAIENSNN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=543, Percent_Identity=44.7513812154696, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI28559085, Length=562, Percent_Identity=41.6370106761566, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI28559083, Length=562, Percent_Identity=41.6370106761566, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI221316689, Length=562, Percent_Identity=41.6370106761566, Blast_Score=441, Evalue=1e-123,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=60.2230483271376, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=613, Percent_Identity=36.8678629690049, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319432, Length=568, Percent_Identity=41.0211267605634, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=41.1247803163445, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24664469, Length=563, Percent_Identity=46.0035523978686, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI21357815, Length=507, Percent_Identity=44.1814595660749, Blast_Score=402, Evalue=1e-112,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61042; Mature: 61042

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNTKIIFVTGGVVSSLGKGVTAASLATLLESRGLNVTMMKLDPYINVDPGTMSPLQHG
CCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCC
EVFVTEDGAETDLDLGHYERFIRNKMTQANNFTTGKVYQSVLRRERKGDYLGATIQVIPH
CEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHH
ITDEIKRRICSGIADDVDVAIVEIGGTVGDIESQPFLEAIRQLRIELGRNRTLFVHLTLL
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHH
PYIKVAGEIKTKPTQHSVKELRGIGIQADVLVCRCEKKFDDSEKRKIALFTNVDQDCIFT
HHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEE
AEDVDTIYEVPLKYNQQGFDAKLVELLNLNAKEADLSEWQNVVNTIRDVKGEVIIAMVGK
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHH
YVSLTEAYKSLNEALYNAGYKKGVKVKIKFVDSEDVNENNVESYFKDVAAILVPGGFGSR
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCC
GVEGKIISIKYARENQIPFLGICLGMQLAVIEYARNILGIKDAHSSELEPTTANPVIGLI
CCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
TEWQAEDGTVHQRTHSSDLGGTMRLGGYKCVLKQGSRAREIYQADEVVERHRHRYEVNSN
EEECCCCCCEECCCCCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHEECCHH
YVERLEEAGLIFSGRSEDNKLMELIEIPQHKWFIACQAHPEFTSTPRYGHKLFESYIQAA
HHHHHHHCCCEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
IENSNN
HHCCCC
>Mature Secondary Structure
MNSNTKIIFVTGGVVSSLGKGVTAASLATLLESRGLNVTMMKLDPYINVDPGTMSPLQHG
CCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCC
EVFVTEDGAETDLDLGHYERFIRNKMTQANNFTTGKVYQSVLRRERKGDYLGATIQVIPH
CEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHH
ITDEIKRRICSGIADDVDVAIVEIGGTVGDIESQPFLEAIRQLRIELGRNRTLFVHLTLL
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHH
PYIKVAGEIKTKPTQHSVKELRGIGIQADVLVCRCEKKFDDSEKRKIALFTNVDQDCIFT
HHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEE
AEDVDTIYEVPLKYNQQGFDAKLVELLNLNAKEADLSEWQNVVNTIRDVKGEVIIAMVGK
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHH
YVSLTEAYKSLNEALYNAGYKKGVKVKIKFVDSEDVNENNVESYFKDVAAILVPGGFGSR
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCC
GVEGKIISIKYARENQIPFLGICLGMQLAVIEYARNILGIKDAHSSELEPTTANPVIGLI
CCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
TEWQAEDGTVHQRTHSSDLGGTMRLGGYKCVLKQGSRAREIYQADEVVERHRHRYEVNSN
EEECCCCCCEECCCCCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHEECCHH
YVERLEEAGLIFSGRSEDNKLMELIEIPQHKWFIACQAHPEFTSTPRYGHKLFESYIQAA
HHHHHHHCCCEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
IENSNN
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA