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The map label for this gene is bioF [H]

Identifier: 89256582

GI number: 89256582

Start: 1213799

End: 1214926

Strand: Direct

Name: bioF [H]

Synonym: FTL_1273

Alternate gene names: 89256582

Gene position: 1213799-1214926 (Clockwise)

Preceding gene: 89256581

Following gene: 89256583

Centisome position: 64.02

GC content: 30.23

Gene sequence:

>1128_bases
ATGTTAAACCTACAAGATAAATATACTCAATATCAAAGAGATAATTTATTAAGAGAGTTAACTCTTTTTATAAAAGATGA
CTCTATTATAGATTTTACAACTAGTGACTATTTAAATCTATCATCAGCACACAACTTAAAACATGCCATAGTAAATGGTT
TTGATAAATATGGCTTTGGTAGTAAAGGATCTAATATAGTTTGTGGCTATACTGATGAGACACAACAGTTTGAACATGAG
TTTGCAAAGTTTATTAACTATCCTAGAGCAATATTTTTTAGTTCAGGTTTTATGGCAAATTTAGCAATTTATTCAACACT
GTTTAGTAAACATGATAGTATCTTTGCAGATAAGTATATCCATGCATCTATTATTGATGGAATCAAGCTTTCACAAGCTA
AGCTAAGAAGATATAAACATCAGCAATTAAGCCAACTTCAAGATATTTATGATGGTAAAAGTTTTATAACTACAGAAGGA
GTTTTTAGTACCTCAGGATCAATTACTCAACTTGATAAGCTTGCTAAAATCACACCAGAAAAGCTTATAGTTGATGAAGC
TCATAGTTTTGGAGTTTTGGGTAAAAATGGTCGCGGTGCGATCAACAGCTTTCGAATAAGCTATAAAAATTGTCCAATCT
GTGTTTTCCCTCTTGGTAAAGCATTTGGTGGAGTTGGTGCTGTGGTTTGTACTACAGAAGCAATTGCAGAATATCTAATA
CAATTTGCGCGTAACTATATCTATACAACAGCATTACCACCAATGATATTAAAAGCTGCTTTAATACAACTAAAAAACCT
TGAAAATGCTAATGATAATCGAGTAAGACTTCAGCAAAATATCACTTTTTTTAATGAGTTATGTGATGCTAAAGATCTTG
AGTTAGTCTCTAAAGATTTATCTCCTATTAGAAGTATTCAACTAAATAATGCTAATCTAGCAATTAGATTAAAAGATAAG
CTCTTTGAGAATAAAATAATAGTATCTTGTTTTAGATATCCTACTGTACCTAAAGACCAAGCTATACTAAGATTTTCGCT
ACATAGTAATAATACTTTTGATCAGATTCAACAAGCTTTAGAAATTATTTCCAAAGAGGTTAAGTATGAGTATATACGAT
CAAATTAG

Upstream 100 bases:

>100_bases
CAATATTTTATGGTAATAAGTTATTAACAGAAAATAATGCTACTGTTAATTCTGATAATTTTTTATTAGCTAAGCTTGGC
TTAAAATCAAATGCTGAATT

Downstream 100 bases:

>100_bases
AGGTAACTTTTCAAAAGCTACAGAATATTCTAAAAATTCGGCTATTCAAAATCAAGTTCGCCAACTACTTTTAGAACAAA
CGCTGAATTATTCAAGATTA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MLNLQDKYTQYQRDNLLRELTLFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHE
FAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEG
VFSTSGSITQLDKLAKITPEKLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
QFARNYIYTTALPPMILKAALIQLKNLENANDNRVRLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIRLKDK
LFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQALEIISKEVKYEYIRSN

Sequences:

>Translated_375_residues
MLNLQDKYTQYQRDNLLRELTLFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHE
FAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEG
VFSTSGSITQLDKLAKITPEKLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
QFARNYIYTTALPPMILKAALIQLKNLENANDNRVRLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIRLKDK
LFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQALEIISKEVKYEYIRSN
>Mature_375_residues
MLNLQDKYTQYQRDNLLRELTLFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHE
FAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEG
VFSTSGSITQLDKLAKITPEKLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
QFARNYIYTTALPPMILKAALIQLKNLENANDNRVRLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIRLKDK
LFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQALEIISKEVKYEYIRSN

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=344, Percent_Identity=29.3604651162791, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=29.3604651162791, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI83977442, Length=359, Percent_Identity=28.4122562674095, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI83977444, Length=359, Percent_Identity=28.4122562674095, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI83977440, Length=359, Percent_Identity=28.4122562674095, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4502025, Length=358, Percent_Identity=27.6536312849162, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI40316939, Length=358, Percent_Identity=27.6536312849162, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI119220554, Length=377, Percent_Identity=25.1989389920424, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=22.9281767955801, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI5454084, Length=322, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=33.7110481586402, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=31.638418079096, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=358, Percent_Identity=31.5642458100559, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI32566772, Length=393, Percent_Identity=23.1552162849873, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=23.6768802228412, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=23.6768802228412, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71982617, Length=303, Percent_Identity=24.0924092409241, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=303, Percent_Identity=24.0924092409241, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=382, Percent_Identity=26.7015706806283, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=24.5901639344262, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323954, Length=295, Percent_Identity=23.0508474576271, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=29.1428571428571, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17137420, Length=347, Percent_Identity=25.9365994236311, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136286, Length=387, Percent_Identity=25.5813953488372, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24653280, Length=298, Percent_Identity=24.496644295302, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653276, Length=298, Percent_Identity=24.496644295302, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24653278, Length=298, Percent_Identity=24.496644295302, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42596; Mature: 42596

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLQDKYTQYQRDNLLRELTLFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFG
CCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCCHHHHHHHHHHCCHHHCCCC
SKGSNIVCGYTDETQQFEHEFAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYI
CCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
HASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEGVFSTSGSITQLDKLAKITPE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHH
KLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
HHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHHHH
QFARNYIYTTALPPMILKAALIQLKNLENANDNRVRLQQNITFFNELCDAKDLELVSKDL
HHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHH
SPIRSIQLNNANLAIRLKDKLFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQAL
HHHHEEEECCCEEEEEEHHHHHCCHHEEHEECCCCCCCCCEEEEEEECCCCCHHHHHHHH
EIISKEVKYEYIRSN
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNLQDKYTQYQRDNLLRELTLFIKDDSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFG
CCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCCHHHHHHHHHHCCHHHCCCC
SKGSNIVCGYTDETQQFEHEFAKFINYPRAIFFSSGFMANLAIYSTLFSKHDSIFADKYI
CCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
HASIIDGIKLSQAKLRRYKHQQLSQLQDIYDGKSFITTEGVFSTSGSITQLDKLAKITPE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCHH
KLIVDEAHSFGVLGKNGRGAINSFRISYKNCPICVFPLGKAFGGVGAVVCTTEAIAEYLI
HHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCHHHCCCCHHHHHHHHHHHHHH
QFARNYIYTTALPPMILKAALIQLKNLENANDNRVRLQQNITFFNELCDAKDLELVSKDL
HHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCHHHHHHHHHH
SPIRSIQLNNANLAIRLKDKLFENKIIVSCFRYPTVPKDQAILRFSLHSNNTFDQIQQAL
HHHHEEEECCCEEEEEEHHHHHCCHHEEHEECCCCCCCCCEEEEEEECCCCCHHHHHHHH
EIISKEVKYEYIRSN
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA