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The map label for this gene is cls1 [H]

Identifier: 89256524

GI number: 89256524

Start: 1152371

End: 1153801

Strand: Reverse

Name: cls1 [H]

Synonym: FTL_1203

Alternate gene names: 89256524

Gene position: 1153801-1152371 (Counterclockwise)

Preceding gene: 89256525

Following gene: 89256523

Centisome position: 60.85

GC content: 29.14

Gene sequence:

>1431_bases
ATGGAAAATTTCTTACTTAGTTTACTTTATATTCTCGAGGCAAATATTGTTTTATTTGTCTGTCAAGCATTAACAATATT
TATCGTTTTAAAGCTAATAGTTGATAAAAAATCTGCTTCAAATATTTTAGCTTGGCTTTTAGCAATATTATTTATCCCAT
ATATTGCCATTCCATTTTTCTTTATCTTTCAACGCAAAGATAAACGTAGTTTTTGGCAAAAAGAAGCTATGAATATTAGT
CAACCATCATTAGATCTATTCTGCTTAGATAAAAGTGAAAGTTGTAAAAATCTGCCTAATGAAATTATCAATGTTTTTGC
TAACATGGATTTAAATACTCTTACGACTAAAAACTCTTTTGAAATGTATACAGATGGAGTTAAATCATTCCAAGCTTTTA
TGCAAGCAATTGAATCTGCTCAGCAAAATATTTATATCCAAACTTATGTATTTAAAAATGATACTACCTCTAAACTAGTA
ATAAATGCTTTAGAAAAAAAAGCTGCTGAAGGTGTAGAAATTAAAATGATGATAGACTCCCTTGGTTCTTTTTATGTCTA
TCGCCATAATAGAAAAATATTCAAGAAATTACGTGATTTAGGTGCTAAAGTAGTATTTTTTATGCCGGTGATATCTAATC
CTTTACGTAACTATATTAATTATAGGAATCATAGAAAAATATATATTTTTGATAATCATACTATATTTAGCGGCGGTATG
AATATCGGTGATGAATATATGTCGCCTATAGAACATCAAGGGATGTGGGATGATTTACTCTTTAAAATTCAGGGGGAATC
ATTAATCTATTTTCTAAAGGTTTTTTGTTCTGATTGGCACTTTGCGACAAATCAAGAAATCGATTTTAATATTGATAATA
CAATTATACAAGAAGGTTTTGTTCAAGTAATTCCATCAGGACCTGACCTAAAAGAAGATCAACTATATTCTGGATTAATC
ACAGCGATTAATTCAGCCAAAGAGAAATTATGGATTATAACTCCATATCTAATACCATCAGCAGAATTATATCATTCAAT
AGTTCTTGCTAAGAAAAAAGGTCTTGAAGTAAAAATTATCACGCCAAAAAAATCAAATCATAAGTTGGTTGATAAAGCTA
GAGCAAGTTATATAAGAGATTTTTTAGAAGCTAATATCGATATTCATTTCACTAAAAACATGATACACGCAAAAGCAGTA
TTAATTGACGATAATATCGCAATGCTAGGTTCAGTAAATTTAGATATTCGTAGCCTATTTCTAAATTATGAAATCGCTAC
ATTTTTATATAGTAAAAATGACGTTGCAAAAATCTATCGCTGGGCGGAAAAAATCTTAGCTGACTCAACGCAAAATACTC
AACATATGATTTCAAGTCGTGGTAGTCTGATTGCCGAAAGTATACTTAAAATACTTACTCCTTTAATGTAG

Upstream 100 bases:

>100_bases
CTAATGTAATAACTTAATTTAAGGCAAAATTTTATATAACTACCGAGAATATTATCTGTGTGTTACAATTTAGCATAATA
TAAGCTTAACGCTATTATAA

Downstream 100 bases:

>100_bases
TAAAGTAAGTTACAACAAAATACAAATTGTAACAATTATTTTTCTACTTTTAATATATTTTCAGCAATATTTTTTTATTT
GATAAAAGCTAATTAATATA

Product: cardiolipin synthetase

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MENFLLSLLYILEANIVLFVCQALTIFIVLKLIVDKKSASNILAWLLAILFIPYIAIPFFFIFQRKDKRSFWQKEAMNIS
QPSLDLFCLDKSESCKNLPNEIINVFANMDLNTLTTKNSFEMYTDGVKSFQAFMQAIESAQQNIYIQTYVFKNDTTSKLV
INALEKKAAEGVEIKMMIDSLGSFYVYRHNRKIFKKLRDLGAKVVFFMPVISNPLRNYINYRNHRKIYIFDNHTIFSGGM
NIGDEYMSPIEHQGMWDDLLFKIQGESLIYFLKVFCSDWHFATNQEIDFNIDNTIIQEGFVQVIPSGPDLKEDQLYSGLI
TAINSAKEKLWIITPYLIPSAELYHSIVLAKKKGLEVKIITPKKSNHKLVDKARASYIRDFLEANIDIHFTKNMIHAKAV
LIDDNIAMLGSVNLDIRSLFLNYEIATFLYSKNDVAKIYRWAEKILADSTQNTQHMISSRGSLIAESILKILTPLM

Sequences:

>Translated_476_residues
MENFLLSLLYILEANIVLFVCQALTIFIVLKLIVDKKSASNILAWLLAILFIPYIAIPFFFIFQRKDKRSFWQKEAMNIS
QPSLDLFCLDKSESCKNLPNEIINVFANMDLNTLTTKNSFEMYTDGVKSFQAFMQAIESAQQNIYIQTYVFKNDTTSKLV
INALEKKAAEGVEIKMMIDSLGSFYVYRHNRKIFKKLRDLGAKVVFFMPVISNPLRNYINYRNHRKIYIFDNHTIFSGGM
NIGDEYMSPIEHQGMWDDLLFKIQGESLIYFLKVFCSDWHFATNQEIDFNIDNTIIQEGFVQVIPSGPDLKEDQLYSGLI
TAINSAKEKLWIITPYLIPSAELYHSIVLAKKKGLEVKIITPKKSNHKLVDKARASYIRDFLEANIDIHFTKNMIHAKAV
LIDDNIAMLGSVNLDIRSLFLNYEIATFLYSKNDVAKIYRWAEKILADSTQNTQHMISSRGSLIAESILKILTPLM
>Mature_476_residues
MENFLLSLLYILEANIVLFVCQALTIFIVLKLIVDKKSASNILAWLLAILFIPYIAIPFFFIFQRKDKRSFWQKEAMNIS
QPSLDLFCLDKSESCKNLPNEIINVFANMDLNTLTTKNSFEMYTDGVKSFQAFMQAIESAQQNIYIQTYVFKNDTTSKLV
INALEKKAAEGVEIKMMIDSLGSFYVYRHNRKIFKKLRDLGAKVVFFMPVISNPLRNYINYRNHRKIYIFDNHTIFSGGM
NIGDEYMSPIEHQGMWDDLLFKIQGESLIYFLKVFCSDWHFATNQEIDFNIDNTIIQEGFVQVIPSGPDLKEDQLYSGLI
TAINSAKEKLWIITPYLIPSAELYHSIVLAKKKGLEVKIITPKKSNHKLVDKARASYIRDFLEANIDIHFTKNMIHAKAV
LIDDNIAMLGSVNLDIRSLFLNYEIATFLYSKNDVAKIYRWAEKILADSTQNTQHMISSRGSLIAESILKILTPLM

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=441, Percent_Identity=27.437641723356, Blast_Score=185, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 54864; Mature: 54864

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFLLSLLYILEANIVLFVCQALTIFIVLKLIVDKKSASNILAWLLAILFIPYIAIPFF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
FIFQRKDKRSFWQKEAMNISQPSLDLFCLDKSESCKNLPNEIINVFANMDLNTLTTKNSF
HHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHCHHHHHHHHHCCCCCEEECCCCH
EMYTDGVKSFQAFMQAIESAQQNIYIQTYVFKNDTTSKLVINALEKKAAEGVEIKMMIDS
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEHHC
LGSFYVYRHNRKIFKKLRDLGAKVVFFMPVISNPLRNYINYRNHRKIYIFDNHTIFSGGM
CCCEEEEECCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCC
NIGDEYMSPIEHQGMWDDLLFKIQGESLIYFLKVFCSDWHFATNQEIDFNIDNTIIQEGF
CCCHHHHCCHHHCCCHHHHEEEECCCHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHCCH
VQVIPSGPDLKEDQLYSGLITAINSAKEKLWIITPYLIPSAELYHSIVLAKKKGLEVKII
HEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEE
TPKKSNHKLVDKARASYIRDFLEANIDIHFTKNMIHAKAVLIDDNIAMLGSVNLDIRSLF
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEECCEEEEEECCCCHHHHH
LNYEIATFLYSKNDVAKIYRWAEKILADSTQNTQHMISSRGSLIAESILKILTPLM
HHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MENFLLSLLYILEANIVLFVCQALTIFIVLKLIVDKKSASNILAWLLAILFIPYIAIPFF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
FIFQRKDKRSFWQKEAMNISQPSLDLFCLDKSESCKNLPNEIINVFANMDLNTLTTKNSF
HHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHCHHHHHHHHHCCCCCEEECCCCH
EMYTDGVKSFQAFMQAIESAQQNIYIQTYVFKNDTTSKLVINALEKKAAEGVEIKMMIDS
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEHHC
LGSFYVYRHNRKIFKKLRDLGAKVVFFMPVISNPLRNYINYRNHRKIYIFDNHTIFSGGM
CCCEEEEECCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCC
NIGDEYMSPIEHQGMWDDLLFKIQGESLIYFLKVFCSDWHFATNQEIDFNIDNTIIQEGF
CCCHHHHCCHHHCCCHHHHEEEECCCHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHCCH
VQVIPSGPDLKEDQLYSGLITAINSAKEKLWIITPYLIPSAELYHSIVLAKKKGLEVKII
HEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEE
TPKKSNHKLVDKARASYIRDFLEANIDIHFTKNMIHAKAVLIDDNIAMLGSVNLDIRSLF
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEECCEEEEEECCCCHHHHH
LNYEIATFLYSKNDVAKIYRWAEKILADSTQNTQHMISSRGSLIAESILKILTPLM
HHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]