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The map label for this gene is yciC [H]

Identifier: 89256521

GI number: 89256521

Start: 1149226

End: 1150443

Strand: Direct

Name: yciC [H]

Synonym: FTL_1200

Alternate gene names: 89256521

Gene position: 1149226-1150443 (Clockwise)

Preceding gene: 89256519

Following gene: 89256522

Centisome position: 60.61

GC content: 32.51

Gene sequence:

>1218_bases
ATGAAAAAACTACCTGTTACTGTTTTATCGGGATTTTTAGGAGCTGGTAAAACTACTTTATTAAGTAATATTCTTAATAA
TGCTAATGGCCTTAGAATAGCTATGATTGTTAATGACATGAATGAAATTAATATTGATGCTGAGCTAATCAAAAATCATG
ATTCGCATATATCAAAAACTGAAGCAAAGATGGTTGAGCTTAGTAATGGCTGTATTTGCTGTACTCTGCGTGAAGATTTA
TTAGTAGAAGTAGAGCAGTTAGCAAAATCACAAAAATATGATTATTTAATTATTGAAAGTACTGGTATCTCAGAGCCTCT
ACCTGTGGCAACAACTTTTGAATTTAGAGATGAAGATGGTAAAAGCTTAGCGGATATTGCATACATTGATACAATGGTTA
CGGTAGTAGATAGTGTCAATTTTATGAATCATTATAGTTCTTCAGAATATCTAAAAAATACTAGCGAAAGCCTTGGAGAA
GATGATGATAGAGCAATAGTTGATCTTATGGTTGAGCAGATAGAGTTTGCTAATGTCATAATATTAAACAAAATTAATGA
GTGCTCGACAGCAGAAAAAGAGACTGTCAAATCTATAATCAAAGGACTAAATGTTGATGCAGAAATTATAGAAACAAATT
TTTCTAAAGTTGATATAAATAAAGTTATAAATACCAAGAAATTTAATTTAGAAGAAGCTGAAAATCATCCGTTATGGAAC
AAAGAGCTTTATAATTTCAAAGATCATGTGCCGGAAACTGAAGAATATGGTATTAGATCTTTTGTTTATCACTCAATAAA
TCCTTTTGATCCAGTTAAGATAATGAATTTTTTTGATAATGTTGACTGGCCAGGAGTAGTGCGAGCAAAAGGCTTTTTCT
GGTTAGCTACAAGACCTGATTATGTTGGCGAGGTTTCTCAAGCAGGTGCTTTGATAAGACATCAAGGTATGGGTATGTGG
TGGGCTAGCATGGACAAAGATCAGTGGCCAGACACTCCCGAATTTAAACAAATGTTAAAAGACAGATGGAATGATATAAG
TGGTGACAGAAGGCAAGAAATAGTATTTATTGGTTTAAAAGATGAGATGAAAGATGAGCAAATTAAAGCATCCTTGGATC
AATGCTTAATAAATGACTATTGGAATAATCCAGAAAAATATGCAAATTTAGTGGATCCATTTCCTGCTTGGTTTGAATCA
GATGATGAAGAGGTTTAA

Upstream 100 bases:

>100_bases
ATTTTTTATTATTTAATAAACTGTTATATTGTAACATTTATTATTTTTGTGTATTATTCTCTCGCAATAAATAATTTGAT
GATATGGAGTTCATAAATTT

Downstream 100 bases:

>100_bases
AAATGAGTAATTTTCAATTAACAATTTTGCTTGTAATTTTATTTGTAACGGCAATCTCTGGTATATTTCCTTTTGTAAAG
AAAGCAAATAATCCAAATGG

Product: cobalamin (vitamin B12) synthesis protein/P47K family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKKLPVTVLSGFLGAGKTTLLSNILNNANGLRIAMIVNDMNEINIDAELIKNHDSHISKTEAKMVELSNGCICCTLREDL
LVEVEQLAKSQKYDYLIIESTGISEPLPVATTFEFRDEDGKSLADIAYIDTMVTVVDSVNFMNHYSSSEYLKNTSESLGE
DDDRAIVDLMVEQIEFANVIILNKINECSTAEKETVKSIIKGLNVDAEIIETNFSKVDINKVINTKKFNLEEAENHPLWN
KELYNFKDHVPETEEYGIRSFVYHSINPFDPVKIMNFFDNVDWPGVVRAKGFFWLATRPDYVGEVSQAGALIRHQGMGMW
WASMDKDQWPDTPEFKQMLKDRWNDISGDRRQEIVFIGLKDEMKDEQIKASLDQCLINDYWNNPEKYANLVDPFPAWFES
DDEEV

Sequences:

>Translated_405_residues
MKKLPVTVLSGFLGAGKTTLLSNILNNANGLRIAMIVNDMNEINIDAELIKNHDSHISKTEAKMVELSNGCICCTLREDL
LVEVEQLAKSQKYDYLIIESTGISEPLPVATTFEFRDEDGKSLADIAYIDTMVTVVDSVNFMNHYSSSEYLKNTSESLGE
DDDRAIVDLMVEQIEFANVIILNKINECSTAEKETVKSIIKGLNVDAEIIETNFSKVDINKVINTKKFNLEEAENHPLWN
KELYNFKDHVPETEEYGIRSFVYHSINPFDPVKIMNFFDNVDWPGVVRAKGFFWLATRPDYVGEVSQAGALIRHQGMGMW
WASMDKDQWPDTPEFKQMLKDRWNDISGDRRQEIVFIGLKDEMKDEQIKASLDQCLINDYWNNPEKYANLVDPFPAWFES
DDEEV
>Mature_405_residues
MKKLPVTVLSGFLGAGKTTLLSNILNNANGLRIAMIVNDMNEINIDAELIKNHDSHISKTEAKMVELSNGCICCTLREDL
LVEVEQLAKSQKYDYLIIESTGISEPLPVATTFEFRDEDGKSLADIAYIDTMVTVVDSVNFMNHYSSSEYLKNTSESLGE
DDDRAIVDLMVEQIEFANVIILNKINECSTAEKETVKSIIKGLNVDAEIIETNFSKVDINKVINTKKFNLEEAENHPLWN
KELYNFKDHVPETEEYGIRSFVYHSINPFDPVKIMNFFDNVDWPGVVRAKGFFWLATRPDYVGEVSQAGALIRHQGMGMW
WASMDKDQWPDTPEFKQMLKDRWNDISGDRRQEIVFIGLKDEMKDEQIKASLDQCLINDYWNNPEKYANLVDPFPAWFES
DDEEV

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=293, Percent_Identity=29.3515358361775, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI126722884, Length=293, Percent_Identity=29.3515358361775, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI148727351, Length=293, Percent_Identity=29.0102389078498, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI146231952, Length=293, Percent_Identity=28.6689419795222, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI223941779, Length=217, Percent_Identity=30.8755760368664, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223941776, Length=282, Percent_Identity=28.3687943262411, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI119120938, Length=146, Percent_Identity=35.6164383561644, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082430, Length=311, Percent_Identity=27.6527331189711, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324356, Length=236, Percent_Identity=28.3898305084746, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 46328; Mature: 46328

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLPVTVLSGFLGAGKTTLLSNILNNANGLRIAMIVNDMNEINIDAELIKNHDSHISKT
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHCCCCHHHHH
EAKMVELSNGCICCTLREDLLVEVEQLAKSQKYDYLIIESTGISEPLPVATTFEFRDEDG
HHHHEEECCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCC
KSLADIAYIDTMVTVVDSVNFMNHYSSSEYLKNTSESLGEDDDRAIVDLMVEQIEFANVI
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEE
ILNKINECSTAEKETVKSIIKGLNVDAEIIETNFSKVDINKVINTKKFNLEEAENHPLWN
EEECCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEHHHHHCCCCCCCCCCCCCCCCC
KELYNFKDHVPETEEYGIRSFVYHSINPFDPVKIMNFFDNVDWPGVVRAKGFFWLATRPD
HHHHCHHHCCCCCHHHCHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCEEEEECCCC
YVGEVSQAGALIRHQGMGMWWASMDKDQWPDTPEFKQMLKDRWNDISGDRRQEIVFIGLK
HHHHHHHHCHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECC
DEMKDEQIKASLDQCLINDYWNNPEKYANLVDPFPAWFESDDEEV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKKLPVTVLSGFLGAGKTTLLSNILNNANGLRIAMIVNDMNEINIDAELIKNHDSHISKT
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHCCCCHHHHH
EAKMVELSNGCICCTLREDLLVEVEQLAKSQKYDYLIIESTGISEPLPVATTFEFRDEDG
HHHHEEECCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCC
KSLADIAYIDTMVTVVDSVNFMNHYSSSEYLKNTSESLGEDDDRAIVDLMVEQIEFANVI
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEE
ILNKINECSTAEKETVKSIIKGLNVDAEIIETNFSKVDINKVINTKKFNLEEAENHPLWN
EEECCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEHHHHHCCCCCCCCCCCCCCCCC
KELYNFKDHVPETEEYGIRSFVYHSINPFDPVKIMNFFDNVDWPGVVRAKGFFWLATRPD
HHHHCHHHCCCCCHHHCHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCEEEEECCCC
YVGEVSQAGALIRHQGMGMWWASMDKDQWPDTPEFKQMLKDRWNDISGDRRQEIVFIGLK
HHHHHHHHCHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECC
DEMKDEQIKASLDQCLINDYWNNPEKYANLVDPFPAWFESDDEEV
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]