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The map label for this gene is alaS [H]

Identifier: 89256431

GI number: 89256431

Start: 1049708

End: 1052305

Strand: Direct

Name: alaS [H]

Synonym: FTL_1106

Alternate gene names: 89256431

Gene position: 1049708-1052305 (Clockwise)

Preceding gene: 89256429

Following gene: 89256432

Centisome position: 55.36

GC content: 34.53

Gene sequence:

>2598_bases
ATGATTACTACTAAAGAGTTACGTAATAAATTTATAAATTATTTTGAGTCTAAAAATCACTCACATCAACCTAGCTCATC
TTTAATCCCATTTGGTGATGATACTTTATTATTTACAAATGCTGGGATGGTGCAGTTTAAAGATGTTTTTCTTGGAATTG
AAAAAAAGGATTTTTCGCGTGCGGTGACAGTACAAAAGTGTTTGCGTGCTGGTGGTAAGCATAATGACCTTGATAATGTA
GGCTATACAGCTCGACATCATACATTTTTCGAAATGTTAGGTAATTTCAGTTTTGGTGATTATTTTAAGAAGGAGGCTAT
TAGTTTTGCTTGGGAATTTTTGACTAAGGAAATTAAACTTCCTGTAGAGAAGCTATGGGTAACTATATATGCCAGTGATG
ATGAGGCTTTTGATGTCTGGCATAAGCATATTGGTTTAGCTAAAGAGAGAATCATCCGTATTGACTCAAGTGATAACTTT
TGGTCAATGGGTGATACTGGTCCATGTGGTCCATGTACAGAGATCTTCTATGATCATGGTGAAGATGTTGCTGGAGGATT
ACCTGGTACTCCGGAACAAGATGGTGATAGATATATCGAAATTTGGAATATTGTATTTATGCAATATAATCGCCATGCTG
ATGGTTCTACTACAGATCTCCCTAAACCATCTGTTGACACTGGAATGGGCCTAGAGAGAATCTCAGCAGTGTTACAAAAT
GTCCATAGTAACTATGAAATAGATTTGTTCCAAGCTTTAATCAAAAAAGCTCAACAAGTAACACATGCAAAAGATATAAA
CTCACCGTCACTAAAGGTTATTGCGGATCATATTCGCGCATGTGCTTTTTTAATTGCTGATGGGGTTTTACCTGCTAATG
AAGGGCGAGGCTATGTTCTAAGAAGAATTATTCGTAGAGCTATTCGACATGGCAATAAAGTTGGAGCGAAAGAGATATTT
TTCTATAAATTAGTCGCGGAGCTTGTAAGCCAGATGGGTGAAGCTTATTCGCAATTAATTGATAAAAGAGAGTTGATTGA
AAAAACACTTATAAAAGAAGAAGAACTTTTCTTGAAGACTATTGAAAATGGCATCAAAATATTTGATGCTGAAATAGAGA
ATCTAAAAGATAATACAATATCTGGGGAAGTAGCTTTTAAGTTATATGATACCTATGGTTTCCCTTTTGATTTAACTGCT
GATATGGCAAGAGAAAAAGGCTTGAAAGTTGACGAACAAGCATTTCTTGCACAAATGCAGATCCAAAAGCAAAGATCAAA
AGAAGCTGGTAAATTTAATGTTGATTATAATAGTTTGATTAATTCGCAAGTTAAATCAGAATTTAGAGGATATTCGACAC
TGATAGAAGACGCAAAAGTTTTGGAGATCTATCAAGATGGTCAATTAGTTGCTAGTACTTCTGAACAAGTATCAGCTGTT
GTTGTTTTGGATAAAACTCCTTTCTATGCAGAGTCAGGGGGACAGGTAGGTGACAAAGGTATACTTGAGGGCGTCGGCTT
TGAGTTTGTAGTTGAGGATGTCCAAAAGTCTGGTGAGGCGATTTTACATATCGGTAAGTTAGTAAAAGGTCGTTTAAATT
TAAATGATGAGCTAACTGCACGAGTAAGTGATAAACCTAGACTTGCTACAGCTGCTAATCATAGTGCTACACATTTATTG
TATAAAGCTTTAAAATTAGTTTTAGGTGGTCATGCTGAACAAAAAGGTTCACTTGTTGATGAAAATAGGCTAAGATTTGA
CTTTACTCATGACAAGGCTATTTCTCGTAGTGAAATAGAGCAAATAGAGCTTTTGGTAAATCAGCAAATACGTGCTAATT
ATCCAGTAACAACTATTGAAACATCGCAACAAAAAGCCAAGTCACTAGGAGCAGAGGCTTTATTTGGTGAAAAGTATGGT
GATATTGTACGTGTGATATCTATGGGTGATTTTTCTATAGAACTATGTGGTGGTACTCATGTTGCCTATACTGGAGATAT
AGGTTTATTTAAGGTAACTTCTGAAGGGAGTATTGCCTCAGGAGTTAGAAGGATAGAAGCAGTTACAGCAGATAAAGCTA
TAAGACATACTTTTACCAATGAAAATAAAATCATAGCGATTAAAGATAGTCTCAAAGCAAATGATACTAATTTGATAGAT
AAAATAAAGTCAATGCTTGAACAGATAAAAAATCAAGAAAAGCAAATAGCTAAACTAAAAAAAGAATTGTTATCAGGCTC
TAGTAATGATATCAAAGAGACAAGTATTGGTGATATAAAAATTGTTGTCGCTAATGTTGATGGCGTTGATGTCAAAACAT
TACGTAATAAAATTGATGATTATAAATCAAAAAATACTAAGGTAATTGCAGTTCTAACTACAACTAATGCAGATAAGGTA
CAGTTTGTAATTGGAGTTAGTAATGCTTTAACAACTTTAATTAAGGCTGGAGATATTGCTAAAGAGCTAAGTAGTCATAT
TGATGGTAAAGGCGGCGGTCGTGCTGATATGGCTCAAGGTGGTGGTAATAACTCTGCGAATATAGATCAAGCTTTATCTC
AAGTAGAAAAATTTATTTTAAATAATATAAAAGAGTAG

Upstream 100 bases:

>100_bases
AATGCGATTGGTAGAGTTTATTTTGTTTGTCAAAATGGTTTATAATGCTATCTGTTTTGAATTTAATAAATCTGTAGCAC
TATCTACTAAAAGGTAAATC

Downstream 100 bases:

>100_bases
TGGTGGCTTGAAAGTAGTGCGTAGATATTTATTAATATCCTTGGGTATATTTGCTTATTGTGCTAGTAGTATAGCTAATC
CTGTAGCTGACTATACTAGT

Product: alanyl-tRNA synthetase

Products: NA

Alternate protein names: Alanine--tRNA ligase; AlaRS [H]

Number of amino acids: Translated: 865; Mature: 865

Protein sequence:

>865_residues
MITTKELRNKFINYFESKNHSHQPSSSLIPFGDDTLLFTNAGMVQFKDVFLGIEKKDFSRAVTVQKCLRAGGKHNDLDNV
GYTARHHTFFEMLGNFSFGDYFKKEAISFAWEFLTKEIKLPVEKLWVTIYASDDEAFDVWHKHIGLAKERIIRIDSSDNF
WSMGDTGPCGPCTEIFYDHGEDVAGGLPGTPEQDGDRYIEIWNIVFMQYNRHADGSTTDLPKPSVDTGMGLERISAVLQN
VHSNYEIDLFQALIKKAQQVTHAKDINSPSLKVIADHIRACAFLIADGVLPANEGRGYVLRRIIRRAIRHGNKVGAKEIF
FYKLVAELVSQMGEAYSQLIDKRELIEKTLIKEEELFLKTIENGIKIFDAEIENLKDNTISGEVAFKLYDTYGFPFDLTA
DMAREKGLKVDEQAFLAQMQIQKQRSKEAGKFNVDYNSLINSQVKSEFRGYSTLIEDAKVLEIYQDGQLVASTSEQVSAV
VVLDKTPFYAESGGQVGDKGILEGVGFEFVVEDVQKSGEAILHIGKLVKGRLNLNDELTARVSDKPRLATAANHSATHLL
YKALKLVLGGHAEQKGSLVDENRLRFDFTHDKAISRSEIEQIELLVNQQIRANYPVTTIETSQQKAKSLGAEALFGEKYG
DIVRVISMGDFSIELCGGTHVAYTGDIGLFKVTSEGSIASGVRRIEAVTADKAIRHTFTNENKIIAIKDSLKANDTNLID
KIKSMLEQIKNQEKQIAKLKKELLSGSSNDIKETSIGDIKIVVANVDGVDVKTLRNKIDDYKSKNTKVIAVLTTTNADKV
QFVIGVSNALTTLIKAGDIAKELSSHIDGKGGGRADMAQGGGNNSANIDQALSQVEKFILNNIKE

Sequences:

>Translated_865_residues
MITTKELRNKFINYFESKNHSHQPSSSLIPFGDDTLLFTNAGMVQFKDVFLGIEKKDFSRAVTVQKCLRAGGKHNDLDNV
GYTARHHTFFEMLGNFSFGDYFKKEAISFAWEFLTKEIKLPVEKLWVTIYASDDEAFDVWHKHIGLAKERIIRIDSSDNF
WSMGDTGPCGPCTEIFYDHGEDVAGGLPGTPEQDGDRYIEIWNIVFMQYNRHADGSTTDLPKPSVDTGMGLERISAVLQN
VHSNYEIDLFQALIKKAQQVTHAKDINSPSLKVIADHIRACAFLIADGVLPANEGRGYVLRRIIRRAIRHGNKVGAKEIF
FYKLVAELVSQMGEAYSQLIDKRELIEKTLIKEEELFLKTIENGIKIFDAEIENLKDNTISGEVAFKLYDTYGFPFDLTA
DMAREKGLKVDEQAFLAQMQIQKQRSKEAGKFNVDYNSLINSQVKSEFRGYSTLIEDAKVLEIYQDGQLVASTSEQVSAV
VVLDKTPFYAESGGQVGDKGILEGVGFEFVVEDVQKSGEAILHIGKLVKGRLNLNDELTARVSDKPRLATAANHSATHLL
YKALKLVLGGHAEQKGSLVDENRLRFDFTHDKAISRSEIEQIELLVNQQIRANYPVTTIETSQQKAKSLGAEALFGEKYG
DIVRVISMGDFSIELCGGTHVAYTGDIGLFKVTSEGSIASGVRRIEAVTADKAIRHTFTNENKIIAIKDSLKANDTNLID
KIKSMLEQIKNQEKQIAKLKKELLSGSSNDIKETSIGDIKIVVANVDGVDVKTLRNKIDDYKSKNTKVIAVLTTTNADKV
QFVIGVSNALTTLIKAGDIAKELSSHIDGKGGGRADMAQGGGNNSANIDQALSQVEKFILNNIKE
>Mature_865_residues
MITTKELRNKFINYFESKNHSHQPSSSLIPFGDDTLLFTNAGMVQFKDVFLGIEKKDFSRAVTVQKCLRAGGKHNDLDNV
GYTARHHTFFEMLGNFSFGDYFKKEAISFAWEFLTKEIKLPVEKLWVTIYASDDEAFDVWHKHIGLAKERIIRIDSSDNF
WSMGDTGPCGPCTEIFYDHGEDVAGGLPGTPEQDGDRYIEIWNIVFMQYNRHADGSTTDLPKPSVDTGMGLERISAVLQN
VHSNYEIDLFQALIKKAQQVTHAKDINSPSLKVIADHIRACAFLIADGVLPANEGRGYVLRRIIRRAIRHGNKVGAKEIF
FYKLVAELVSQMGEAYSQLIDKRELIEKTLIKEEELFLKTIENGIKIFDAEIENLKDNTISGEVAFKLYDTYGFPFDLTA
DMAREKGLKVDEQAFLAQMQIQKQRSKEAGKFNVDYNSLINSQVKSEFRGYSTLIEDAKVLEIYQDGQLVASTSEQVSAV
VVLDKTPFYAESGGQVGDKGILEGVGFEFVVEDVQKSGEAILHIGKLVKGRLNLNDELTARVSDKPRLATAANHSATHLL
YKALKLVLGGHAEQKGSLVDENRLRFDFTHDKAISRSEIEQIELLVNQQIRANYPVTTIETSQQKAKSLGAEALFGEKYG
DIVRVISMGDFSIELCGGTHVAYTGDIGLFKVTSEGSIASGVRRIEAVTADKAIRHTFTNENKIIAIKDSLKANDTNLID
KIKSMLEQIKNQEKQIAKLKKELLSGSSNDIKETSIGDIKIVVANVDGVDVKTLRNKIDDYKSKNTKVIAVLTTTNADKV
QFVIGVSNALTTLIKAGDIAKELSSHIDGKGGGRADMAQGGGNNSANIDQALSQVEKFILNNIKE

Specific function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editin

COG id: COG0013

COG function: function code J; Alanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI109148542, Length=964, Percent_Identity=36.9294605809129, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI38569417, Length=958, Percent_Identity=33.2985386221294, Blast_Score=451, Evalue=1e-126,
Organism=Escherichia coli, GI1789048, Length=853, Percent_Identity=55.8030480656506, Blast_Score=994, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506981, Length=978, Percent_Identity=35.6850715746421, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17536681, Length=754, Percent_Identity=35.5437665782493, Blast_Score=393, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324911, Length=753, Percent_Identity=41.6998671978752, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24582809, Length=968, Percent_Identity=37.396694214876, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45552267, Length=968, Percent_Identity=37.396694214876, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24658214, Length=789, Percent_Identity=31.6856780735108, Blast_Score=353, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002318
- InterPro:   IPR018162
- InterPro:   IPR018165
- InterPro:   IPR018164
- InterPro:   IPR023033
- InterPro:   IPR003156
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF02272 DHHA1; PF01411 tRNA-synt_2c; PF07973 tRNA_SAD [H]

EC number: =6.1.1.7 [H]

Molecular weight: Translated: 96052; Mature: 96052

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50860 AA_TRNA_LIGASE_II_ALA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTKELRNKFINYFESKNHSHQPSSSLIPFGDDTLLFTNAGMVQFKDVFLGIEKKDFSR
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHCCCHHHHHH
AVTVQKCLRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKKEAISFAWEFLTKEIKL
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
PVEKLWVTIYASDDEAFDVWHKHIGLAKERIIRIDSSDNFWSMGDTGPCGPCTEIFYDHG
CHHHEEEEEEECCCHHHHHHHHHHCCCHHHEEEECCCCCCEECCCCCCCCHHHHHHHCCC
EDVAGGLPGTPEQDGDRYIEIWNIVFMQYNRHADGSTTDLPKPSVDTGMGLERISAVLQN
CCCCCCCCCCCCCCCCHHEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VHSNYEIDLFQALIKKAQQVTHAKDINSPSLKVIADHIRACAFLIADGVLPANEGRGYVL
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RRIIRRAIRHGNKVGAKEIFFYKLVAELVSQMGEAYSQLIDKRELIEKTLIKEEELFLKT
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IENGIKIFDAEIENLKDNTISGEVAFKLYDTYGFPFDLTADMAREKGLKVDEQAFLAQMQ
HHCCCEEEEHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHH
IQKQRSKEAGKFNVDYNSLINSQVKSEFRGYSTLIEDAKVLEIYQDGQLVASTSEQVSAV
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCEEECCCCCCEEE
VVLDKTPFYAESGGQVGDKGILEGVGFEFVVEDVQKSGEAILHIGKLVKGRLNLNDELTA
EEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEE
RVSDKPRLATAANHSATHLLYKALKLVLGGHAEQKGSLVDENRLRFDFTHDKAISRSEIE
EECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHH
QIELLVNQQIRANYPVTTIETSQQKAKSLGAEALFGEKYGDIVRVISMGDFSIELCGGTH
HHHHHHHHHHHCCCCEEEEECHHHHHHHCCCHHHHCHHHHHHEEEEECCCEEEEEECCCE
VAYTGDIGLFKVTSEGSIASGVRRIEAVTADKAIRHTFTNENKIIAIKDSLKANDTNLID
EEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
KIKSMLEQIKNQEKQIAKLKKELLSGSSNDIKETSIGDIKIVVANVDGVDVKTLRNKIDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
YKSKNTKVIAVLTTTNADKVQFVIGVSNALTTLIKAGDIAKELSSHIDGKGGGRADMAQG
HCCCCCEEEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GGNNSANIDQALSQVEKFILNNIKE
CCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITTKELRNKFINYFESKNHSHQPSSSLIPFGDDTLLFTNAGMVQFKDVFLGIEKKDFSR
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHCCCHHHHHH
AVTVQKCLRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKKEAISFAWEFLTKEIKL
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
PVEKLWVTIYASDDEAFDVWHKHIGLAKERIIRIDSSDNFWSMGDTGPCGPCTEIFYDHG
CHHHEEEEEEECCCHHHHHHHHHHCCCHHHEEEECCCCCCEECCCCCCCCHHHHHHHCCC
EDVAGGLPGTPEQDGDRYIEIWNIVFMQYNRHADGSTTDLPKPSVDTGMGLERISAVLQN
CCCCCCCCCCCCCCCCHHEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VHSNYEIDLFQALIKKAQQVTHAKDINSPSLKVIADHIRACAFLIADGVLPANEGRGYVL
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
RRIIRRAIRHGNKVGAKEIFFYKLVAELVSQMGEAYSQLIDKRELIEKTLIKEEELFLKT
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IENGIKIFDAEIENLKDNTISGEVAFKLYDTYGFPFDLTADMAREKGLKVDEQAFLAQMQ
HHCCCEEEEHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHH
IQKQRSKEAGKFNVDYNSLINSQVKSEFRGYSTLIEDAKVLEIYQDGQLVASTSEQVSAV
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCEEECCCCCCEEE
VVLDKTPFYAESGGQVGDKGILEGVGFEFVVEDVQKSGEAILHIGKLVKGRLNLNDELTA
EEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEE
RVSDKPRLATAANHSATHLLYKALKLVLGGHAEQKGSLVDENRLRFDFTHDKAISRSEIE
EECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHH
QIELLVNQQIRANYPVTTIETSQQKAKSLGAEALFGEKYGDIVRVISMGDFSIELCGGTH
HHHHHHHHHHHCCCCEEEEECHHHHHHHCCCHHHHCHHHHHHEEEEECCCEEEEEECCCE
VAYTGDIGLFKVTSEGSIASGVRRIEAVTADKAIRHTFTNENKIIAIKDSLKANDTNLID
EEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
KIKSMLEQIKNQEKQIAKLKKELLSGSSNDIKETSIGDIKIVVANVDGVDVKTLRNKIDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
YKSKNTKVIAVLTTTNADKVQFVIGVSNALTTLIKAGDIAKELSSHIDGKGGGRADMAQG
HCCCCCEEEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GGNNSANIDQALSQVEKFILNNIKE
CCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA