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The map label for this gene is msrAB [H]

Identifier: 89256425

GI number: 89256425

Start: 1041501

End: 1042355

Strand: Direct

Name: msrAB [H]

Synonym: FTL_1093

Alternate gene names: 89256425

Gene position: 1041501-1042355 (Clockwise)

Preceding gene: 89256420

Following gene: 89256429

Centisome position: 54.93

GC content: 32.98

Gene sequence:

>855_bases
ATGCTAAAAACTAAGAGCTTAACCCCACATGAGTACGATATTATCATTAATAAAGCTACAGAAAAACCTTTTACTGGTAG
ATATAATGATTTAGATCAAAAAAGCGTTTATATTTGTCGTAATTGCGGTACACCACTATTTAGAGCTGATAGTAAGTTTA
TCTCAGCTTGTGGTTGGCCAAGTTATGATATTCATATTGATAATAATGTAAAGCAACTTCCTGATGCTGATGGTATAAGA
ACTGAGATTTTATGTAGTAATTGTGATGGTCATCTTGGACATATATTTCATGGCGAAGGCTATACAAAACTAAATACTCG
CTATTGTGTCAACTCTGCTTGTGTAGATTTTATCCCAATAGAGGATTTTGGTACTACTGAAGAGATTATTGTTGCAGCAG
GGTGTTTTTGGGGCGTTGAATATTATATGAAAAAGCTTCCAGGAGTGCTATTTGCTGAGTCAGGCTACTGCGGAGGTGAT
CAGCCATATCCTGATTACAAAAAAGTTTGTCAAGGTGATACAGGTTATTTAGAAGTTGTTAGAGTTATATTTGATACTAG
TAAAGTTTCATTACAACAAGTTCTTAAGTATTTCTTTGAAATTCATGATTTTGAGCAAGTTGATGGCCAAGGTCCTGATA
TCGGTGAGCAATATAAATCTGCTATTTTTTACTATGATGATAAGCAAAAACAAATCGCAGAAGATCTAAAACATATATTA
GCTCAAAAGGGTTATAAAGTTGCTACAGAGATTAGAGCAATGAAACCATATTATGTAGCTGAGGATTATCATCTTGACTA
TTATATGAAAAAAGGTACTTTACCTTACTGTCATAGTCATAAGAAAATATTTTAA

Upstream 100 bases:

>100_bases
CCTTTCAATTTAGACTAGATATTGTAGATTAGAATATACTTTTTCTAAAGTTTATATCATAATTATTAACAATTATTTAA
CAAATTAATAAGGTAAGTAG

Downstream 100 bases:

>100_bases
TGATACTGATTTGGAAAAAGTCTATGTTTAATTAGTAAAAATAGACAGAAGCTACTATAAAGCCTAATTGTTGTGCCGGT
ATACCTATCATTAATTTTGA

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLKTKSLTPHEYDIIINKATEKPFTGRYNDLDQKSVYICRNCGTPLFRADSKFISACGWPSYDIHIDNNVKQLPDADGIR
TEILCSNCDGHLGHIFHGEGYTKLNTRYCVNSACVDFIPIEDFGTTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGD
QPYPDYKKVCQGDTGYLEVVRVIFDTSKVSLQQVLKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQIAEDLKHIL
AQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF

Sequences:

>Translated_284_residues
MLKTKSLTPHEYDIIINKATEKPFTGRYNDLDQKSVYICRNCGTPLFRADSKFISACGWPSYDIHIDNNVKQLPDADGIR
TEILCSNCDGHLGHIFHGEGYTKLNTRYCVNSACVDFIPIEDFGTTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGD
QPYPDYKKVCQGDTGYLEVVRVIFDTSKVSLQQVLKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQIAEDLKHIL
AQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF
>Mature_284_residues
MLKTKSLTPHEYDIIINKATEKPFTGRYNDLDQKSVYICRNCGTPLFRADSKFISACGWPSYDIHIDNNVKQLPDADGIR
TEILCSNCDGHLGHIFHGEGYTKLNTRYCVNSACVDFIPIEDFGTTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGD
QPYPDYKKVCQGDTGYLEVVRVIFDTSKVSLQQVLKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQIAEDLKHIL
AQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=38.8535031847134, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=38.8535031847134, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI37620216, Length=126, Percent_Identity=41.2698412698413, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI301336164, Length=126, Percent_Identity=41.2698412698413, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI301336162, Length=126, Percent_Identity=41.2698412698413, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI73089054, Length=126, Percent_Identity=41.2698412698413, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI117606353, Length=125, Percent_Identity=34.4, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI208609993, Length=184, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1790665, Length=174, Percent_Identity=38.5057471264368, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788077, Length=121, Percent_Identity=40.495867768595, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17553450, Length=118, Percent_Identity=40.6779661016949, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=118, Percent_Identity=40.6779661016949, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=30.9859154929577, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319816, Length=126, Percent_Identity=39.6825396825397, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24645799, Length=118, Percent_Identity=40.6779661016949, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45553335, Length=118, Percent_Identity=40.6779661016949, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356369, Length=118, Percent_Identity=40.6779661016949, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221378664, Length=123, Percent_Identity=37.3983739837398, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645801, Length=129, Percent_Identity=35.6589147286822, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645804, Length=129, Percent_Identity=35.6589147286822, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221378662, Length=125, Percent_Identity=36.8, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24664627, Length=161, Percent_Identity=31.6770186335404, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=34.0425531914894, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=161, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 32571; Mature: 32571

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTKSLTPHEYDIIINKATEKPFTGRYNDLDQKSVYICRNCGTPLFRADSKFISACGWP
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCEECCHHHHHHCCCC
SYDIHIDNNVKQLPDADGIRTEILCSNCDGHLGHIFHGEGYTKLNTRYCVNSACVDFIPI
CEEEEECCCHHHCCCCCCCEEEEEEECCCCCCCEEEECCCEEEECHHHECCCCCEEEEEC
EDFGTTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGDQPYPDYKKVCQGDTGYLEVV
CCCCCCHHHEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHH
RVIFDTSKVSLQQVLKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQIAEDLKHIL
HHHHCCCHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHCEEEEEECHHHHHHHHHHHHH
AQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF
HHCCCCHHHHHHHCCCEEEECCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MLKTKSLTPHEYDIIINKATEKPFTGRYNDLDQKSVYICRNCGTPLFRADSKFISACGWP
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCEECCHHHHHHCCCC
SYDIHIDNNVKQLPDADGIRTEILCSNCDGHLGHIFHGEGYTKLNTRYCVNSACVDFIPI
CEEEEECCCHHHCCCCCCCEEEEEEECCCCCCCEEEECCCEEEECHHHECCCCCEEEEEC
EDFGTTEEIIVAAGCFWGVEYYMKKLPGVLFAESGYCGGDQPYPDYKKVCQGDTGYLEVV
CCCCCCHHHEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHH
RVIFDTSKVSLQQVLKYFFEIHDFEQVDGQGPDIGEQYKSAIFYYDDKQKQIAEDLKHIL
HHHHCCCHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHCEEEEEECHHHHHHHHHHHHH
AQKGYKVATEIRAMKPYYVAEDYHLDYYMKKGTLPYCHSHKKIF
HHCCCCHHHHHHHCCCEEEECCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]