| Definition | Francisella tularensis subsp. holarctica LVS chromosome, complete genome. |
|---|---|
| Accession | NC_007880 |
| Length | 1,895,994 |
Click here to switch to the map view.
The map label for this gene is bacC [H]
Identifier: 89256411
GI number: 89256411
Start: 1028678
End: 1029403
Strand: Direct
Name: bacC [H]
Synonym: FTL_1076
Alternate gene names: 89256411
Gene position: 1028678-1029403 (Clockwise)
Preceding gene: 89256409
Following gene: 89256412
Centisome position: 54.26
GC content: 29.89
Gene sequence:
>726_bases ATGGCAAATTACCTAGTTACAGGTGGTTCAAAAGGGATTGGTAAAGCAGTTGTCGAGCTACTTTTACAAAATAAAAATCA TACTGTTATTAATATAGATATACAACAAAGTTTTAGTGCTGAAAACCTAAAATTTATCAAAGCTGATTTGACTAAACAAC AAGATATTACTAATGTTTTAGATATTATCAAAAATGTTAGCTTTGATGGAATTTTCTTGAATGCAGGAATTTTGATAAAA GGTTCAATTTTTGATATTGATATTGAAAGTATTAAAAAAGTATTAGATTTGAATGTTTGGTCAAGTATTTACTTTATCAA AGGTCTAGAAAATAACCTCAAAGTCGGAGCATCAATAGTATTTAATGGTTCTGATCAATGCTTTATCGCCAAGCCAAATA GTTTTGCTTATACTCTAAGTAAAGGAGCTATTGCACAAATGACTAAATCACTAGCGCTAGATCTAGCTAAATATCAAATT AGAGTCAATACAGTTTGTCCAGGTACTGTTGATACAGATTTATATCGAAATTTGATACAAAAATATGCAAATAATGTTGG AATATCATTTGATGAAGCACAAAAACAGGAAGAAAAAGAATTTCCGCTAAATAGAATCGCACAGCCTCAAGAAATTGCTG AATTAGTAATTTTTTTACTCAGTGATAAAAGTAAATTTATGACTGGTGGCTTAATTCCTATAGATGGTGGCTATACAGCG CAATAG
Upstream 100 bases:
>100_bases ATCAATCTAGATTTCATAATTAGATTTTAGACAAAATATTTGTCTTTTTCAAAGCTTATCATATATTATTTATTAGATGA TGAGAATTAGTTTATAAACT
Downstream 100 bases:
>100_bases TATTGTCAACATATAAGATAAAAATGTTATAATTATTAGCAAATTTTATTATAAAACTACAGTATGATCGAAACAGATAG AATAATCTCAGCTAATACAG
Product: short chain dehydrogenase family protein
Products: 2,3-Dihydroxybenzoate; H+; Nicotinamide adenine dinucleotide - reduced [C]
Alternate protein names: NA
Number of amino acids: Translated: 241; Mature: 240
Protein sequence:
>241_residues MANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVLDIIKNVSFDGIFLNAGILIK GSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIVFNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQI RVNTVCPGTVDTDLYRNLIQKYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA Q
Sequences:
>Translated_241_residues MANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVLDIIKNVSFDGIFLNAGILIK GSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIVFNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQI RVNTVCPGTVDTDLYRNLIQKYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA Q >Mature_240_residues ANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVLDIIKNVSFDGIFLNAGILIKG SIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIVFNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQIR VNTVCPGTVDTDLYRNLIQKYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTAQ
Specific function: Part of the bacABCDE operon responsible for the biosynthesis of bacilysin [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=28.4615384615385, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=31.5555555555556, Blast_Score=87, Evalue=9e-18, Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=28.8065843621399, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=27.4131274131274, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI4758504, Length=260, Percent_Identity=27.3076923076923, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=24.8091603053435, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=28.4263959390863, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=30.1587301587302, Blast_Score=92, Evalue=2e-20, Organism=Escherichia coli, GI2367175, Length=262, Percent_Identity=30.5343511450382, Blast_Score=92, Evalue=2e-20, Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=28.6290322580645, Blast_Score=91, Evalue=8e-20, Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=26.4227642276423, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=27.0491803278689, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1788459, Length=169, Percent_Identity=27.2189349112426, Blast_Score=74, Evalue=6e-15, Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=25.6, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=23.2931726907631, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=26.953125, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=24.4979919678715, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=25.2, Blast_Score=61, Evalue=8e-11, Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=30.952380952381, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=31.25, Blast_Score=100, Evalue=4e-22, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=30.4, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=29.5275590551181, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=29.0196078431373, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.5343511450382, Blast_Score=75, Evalue=2e-14, Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=29.3233082706767, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=27.8810408921933, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=29.811320754717, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=24.3027888446215, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=28.1368821292776, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=29.0697674418605, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17538480, Length=269, Percent_Identity=29.368029739777, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17560220, Length=258, Percent_Identity=28.2945736434109, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=25.5725190839695, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=24.904214559387, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17536025, Length=124, Percent_Identity=34.6774193548387, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=26.3565891472868, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322226, Length=203, Percent_Identity=28.0788177339901, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=33.8775510204082, Blast_Score=117, Evalue=9e-27, Organism=Drosophila melanogaster, GI24644337, Length=204, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=4e-20, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.3492063492063, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=32.6612903225806, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=31.496062992126, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=28.125, Blast_Score=72, Evalue=3e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.3.1.28 [C]
Molecular weight: Translated: 26563; Mature: 26432
Theoretical pI: Translated: 6.00; Mature: 6.00
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 1.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVL CCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEHHCCCHHHHHHHH DIIKNVSFDGIFLNAGILIKGSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIV HHHHCCCCCEEEEECCEEEECCEEECCHHHHHHHHHHHHHHHEEEEECCCCCCEECEEEE FNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQIRVNTVCPGTVDTDLYRNLIQ ECCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHHHH KYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA HHHHHCCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCC Q C >Mature Secondary Structure ANYLVTGGSKGIGKAVVELLLQNKNHTVINIDIQQSFSAENLKFIKADLTKQQDITNVL CCEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEHHCCCHHHHHHHH DIIKNVSFDGIFLNAGILIKGSIFDIDIESIKKVLDLNVWSSIYFIKGLENNLKVGASIV HHHHCCCCCEEEEECCEEEECCEEECCHHHHHHHHHHHHHHHEEEEECCCCCCEECEEEE FNGSDQCFIAKPNSFAYTLSKGAIAQMTKSLALDLAKYQIRVNTVCPGTVDTDLYRNLIQ ECCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHHHH KYANNVGISFDEAQKQEEKEFPLNRIAQPQEIAELVIFLLSDKSKFMTGGLIPIDGGYTA HHHHHCCCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCHHHCCCEEEECCCCCC Q C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+ [C]
Metal ions: NA
Kcat value (1/min): 5550 [C]
Specific activity: 66
Km value (mM): 0.26 {methyl-2,3-dehydro-3-hydroxybenzoate}} 0.2 {3-oxocyclohexane-1-carboxylic} 0.3 {2,3-dihydro-2,3-dihydroxybenzoate}} [C]
Substrates: 2,3-Dihydro-2,3-dihydroxybenzoate; Nicotinamide adenine dinucleotide [C]
Specific reaction: 2,3-Dihydro-2,3-dihydroxybenzoate + Nicotinamide adenine dinucleotide <==> 2,3-Dihydroxybenzoate + H+ + Nicotinamide adenine dinucleotide - reduced [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA