Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 89256406

GI number: 89256406

Start: 1023479

End: 1025029

Strand: Direct

Name: guaA [H]

Synonym: FTL_1071

Alternate gene names: 89256406

Gene position: 1023479-1025029 (Clockwise)

Preceding gene: 89256405

Following gene: 89256407

Centisome position: 53.98

GC content: 34.56

Gene sequence:

>1551_bases
ATGACAGATATACATAATCATAAGATTTTGATTTTAGATTTTGGCTCGCAATATACACAACTTATTGCTCGTAGAGTAAG
AGAAGTAGGTGTTTTTTGTGAAATTTTCCCTCATGATGTAGCAGCTGATTTTATCAAAAATTATCAAGCAAAAGGAATAA
TTTTATCAGGTGGTCCTGAGTCAGTTTATGATTCTGATGTCAAAGCTCCTGAGATAGTTTTTGAGCTTGGAGTACCTGTT
TTGGGTATTTGTTATGGCATGCAAACAATGGTAATGCAGCATGGTGGCGAAGTAAAAGGAGCTGATCAAAGTGAATTTGG
TAAGGCAATTATAAATATCCTAAATTTAACAAATAACATATTTTCAAATATGGAGCATGAGCAGCTAGTTTGGATGAGTC
ATAGTGACAAAGTCACTCAAACTGGTGAGCATTTTGAGATAATTGCTTCTTCAACAAATGCTCCAGTTGCGGCAGTTGCA
CATAAAAATAAGCCTTTTTTTGGTGTGCAGTTTCACCCAGAAACTACTCATACAGAAAATGGTAAGCAAATTATTGAGAA
TTTTGTCGTTAATATCTGCGGATGTGATACTCTGTGGAATATCGAAAACATTATCGAAAATGATATAAAAGAAATTAAAC
AAAAAGTTGGTACTGATAAAGTAATTTTAGGGCTATCTGGAGGTGTTGATTCATCTGTTGTAGCTGCGATATTACATCAA
GCTATCGGCGATCAGCTAACTTGTATATTTGTAGATACTGGTTTACTGCGCCTTAATGAGGGTGATCAAGTTATGCAAGT
ATTTGCAGAGCATATGGATATTAATGTTATTCGTATCAATGCAAAAAATAGATTCTTAGATGCCCTAAGGGGTATCTGTG
ATCCAGAACAAAAACGTAAAATTATCGGTAAGCTATTTGTTGATATTTTTGATGAAGAGGCTGCTAAGATAGAGAATGCT
AAATGGCTTGCGCAGGGCACTATCTACAGTGATGTAATTGAATCAGCTAGCAATAATCAGTCTAAAGCACATGTAATTAA
ATCACATCATAATGTTGGTGGCTTACCAAAAGAAATGAAACTTAAGCTTTTAGAACCATTAAGAGAGCTTTTCAAAGATG
AGGTTCGTAAATTAGGCTTAGGTTTAGGATTACCTTATAATATGCTTTATAGACATCCATTTCCTGGTCCTGGTCTTGGA
GTACGTATATTAGGTGAAATAAAGAAAGAGTATGTAGAAACGTTACAAAAAGCTGATGCTATATTTACAGAAGAGCTTTA
TAAACATAATTTATACCATGATGTTTCTCAAGCTTTTGGGGTGTTTTTACCTATCAAATCGGTAGGTGTAGTTGGTGATC
AGCGTAGATATGAGTATGTAATAGCTCTAAGAGCTGTCGTTAGTATCGATTTTATGACTGCAACGTGGGCTAATTTACCT
TATGATTTTCTGTCACTAGTTTCAAATAGAATTGTAAATGAAGTAAAACAAGTATCAAGAGTTGTGTATGATGTGACAGG
AAAACCACCTGGAACAATTGAATGGGAATAA

Upstream 100 bases:

>100_bases
TAAAAGTATTTAAATATCATTTTTATTATTAAAAGCTAATTACAATCAACTTCATTTAGGATAAAATAACCTTTTAAGAA
AATGTTTATTTTTATAAAAA

Downstream 100 bases:

>100_bases
CGCATCTCTGTGTTATAACATAAATGTTTAATTATAAAAGTATTTTTTATTTACTTTTAAGTTAGATGAAGATTTTAAGC
TATGTCAAAATATACTATTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPV
LGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVA
HKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENA
KWLAQGTIYSDVIESASNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLG
VRILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE

Sequences:

>Translated_516_residues
MTDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPV
LGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVA
HKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENA
KWLAQGTIYSDVIESASNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLG
VRILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
>Mature_515_residues
TDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPVL
GICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAH
KNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQA
IGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENAK
WLAQGTIYSDVIESASNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGV
RILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLPY
DFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=569, Percent_Identity=37.609841827768, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=60.9195402298851, Blast_Score=680, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=569, Percent_Identity=35.676625659051, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=35.676625659051, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=569, Percent_Identity=35.676625659051, Blast_Score=288, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=517, Percent_Identity=48.936170212766, Blast_Score=519, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322638, Length=196, Percent_Identity=30.1020408163265, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281365319, Length=557, Percent_Identity=37.5224416517056, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57699; Mature: 57568

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCHHEEECCHHHHHHHHHCCCCCEEEEECCCC
SVYDSDVKAPEIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNI
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
FSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTEN
HCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCCC
GKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRK
HHCCCEEEEEEECCEEEECCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHHH
IIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESASNNQSKAHVIKSHHNVGGLPKEMK
HHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
LKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
HHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCHHEEECCHHHHHHHHHCCCCCEEEEECCCC
SVYDSDVKAPEIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNI
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
FSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTEN
HCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCCC
GKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRK
HHCCCEEEEEEECCEEEECCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHHH
IIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESASNNQSKAHVIKSHHNVGGLPKEMK
HHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
LKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
HHHHHHHHHHHHHHHHHHHHEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA