Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 89256407

GI number: 89256407

Start: 1025111

End: 1026958

Strand: Direct

Name: dxs [H]

Synonym: FTL_1072

Alternate gene names: 89256407

Gene position: 1025111-1026958 (Clockwise)

Preceding gene: 89256406

Following gene: 89256408

Centisome position: 54.07

GC content: 34.69

Gene sequence:

>1848_bases
ATGTCAAAATATACTATTTTAGATAAAATAAATACCCCATCTGATCTTAAGCTAATTCCTGAGAGTCAGCTCAAAATCTT
ATCAGCAGAGTTAAGAGCTTTCTTAGTAGATACTTTAGATGTAAGCGGTGGGCATTTTGCAAGTAGTCTTGGAGCTACAG
AGTTAACAGTTGCTTTGCATTATGTTTATAATGCGCCATATGATAATATCGTGTGGGATGTAGGGCATCAGACATATATT
CATAAGATTCTTACTGGCAGAAAAGATAAACTTGTTACCATTAAAAAAGATGGCGGTATTTCAGGTTTTCCTAAACGCAG
TGAGAGTGAATATGACACCTTTGGAGTCGGCCACTCAAGTACTTCTATAAGCGCTGCTTTAGGTATGGCTATAGCAGACA
GGCTACAAGGCAAATCTTCTAATACTGTAGCTGTAATTGGAGATGGCGCTATAACTGGTGGTATGGCTTTTGAAGCCTTA
AATCATGCTGGCGGTATCAAAGAAGATATTCTTGTTATACTCAATGATAATGAAATGTCTATTTCTGATAATGTTGGCGG
ACTTTCAGCACATTTTAGTAAAATTATTTCCGGTGGTTTTTATAATTCTATACGTGAGAAAGGTAAGGAAGTATTGAAAA
ATATTCCACCAATATTTGAGTTTGTCAAAAAGATTGAAACTCAAACCAAGGGGATGTTTGTACCAGCAAATTTCTTTGAA
GATTTAGGCTTTTATTATGTTGGGCCTATCGATGGTCATGATGTTACAGAATTAGTTAAAACCCTAAGAATTCTAAAAGA
TCATAAGGGTCCAAAACTTTTACACGTGATTACTAAAAAAGGTAAAGGTTATACAAAAGCTGAATCAGATCCAATTAAAT
TTCATCATGTTGCACCAAGTTTTCATAGTGGCGAGAATATAACTACCAAGATTTCTAAACCAACTTATTCAAATATATTT
GGCGATTGGATTTGTCAAAAAGCTGCTAAAGATAAGCGTTTAGTTGGAATCACGCCAGCGATGAAAGAGGGTTCTGACTT
AATTAGGTTTTCACAACTATATCCGCATAGATATTTTGATGTAGCGATTGCTGAGCAACATGCAGTAACTTTTGCTGGTG
GCTTAGCTTGCCAAGGATTAAAGCCAGTCGTAGCAATATATTCAACATTCCTACAGCGAGCTTATGATCAAGTAATACAT
GATATAGCTTTACAAAATTTAGATGTACTATATGCTGTAGATAGAGCAGGTCTAGTTGGCGCTGATGGCGCAACTCATGA
TGGTAGCTTTGATTTAGCATTTATGCGATGTATTCCTAACCATGTGATTATGACTCCAAGTGATGAAAATGAAACTTATC
ATATGCTAGAGTTTGGCTATGAGTATAATGGTCCAGCAATGGTACGTTATCCACGTGGTGCTGGTATTGGCGCTGAAATT
ACTGGTAGTTTAGATCTAGAATTAGGTAAAGCAAAAATTGTTAAACAAGGATCAAAAATTGCAATTTTAAATTTTGGAAC
TTTATTGCCTCTAGCCAAACAGCTAGCTGAGAAGTATCATGCTACAGTTATAGATATGCGTTTTGTCAAACCACTTGATA
AAATTATGCTTGATAAAGTATCTCAAACTCACGAGATAATATTAACTTTAGAAGAGAATTGTATAGCTGGGGGCGCAGGT
TCTGCTGTTAATGAATATTTTGTAGCTAAAGATCTTAGCAATAAAATAATAGTTAGAAATTTTGGACTTCAAGATAAATT
TCTCAATCATGGTACAAAAGATTTATTATTAGCTCAAAGTAAGCTTTGTGTTGAAAATATATCTAAAGAGTTAGATAAAC
TAATTTAA

Upstream 100 bases:

>100_bases
AACAATTGAATGGGAATAACGCATCTCTGTGTTATAACATAAATGTTTAATTATAAAAGTATTTTTTATTTACTTTTAAG
TTAGATGAAGATTTTAAGCT

Downstream 100 bases:

>100_bases
TAGGAGGCTTATTTTATGGAATTATTATTTTCATATGGAACCTTACAGCAAGAAGAGGTACAACTTTCAGTCTTTGGCAG
AAAACTCGTAGGACAAAAAG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALHYVYNAPYDNIVWDVGHQTYI
HKILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSSTSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEAL
NHAGGIKEDILVILNDNEMSISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKIETQTKGMFVPANFFE
DLGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPSFHSGENITTKISKPTYSNIF
GDWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFDVAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIH
DIALQNLDVLYAVDRAGLVGADGATHDGSFDLAFMRCIPNHVIMTPSDENETYHMLEFGYEYNGPAMVRYPRGAGIGAEI
TGSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDKIMLDKVSQTHEIILTLEENCIAGGAG
SAVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQSKLCVENISKELDKLI

Sequences:

>Translated_615_residues
MSKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALHYVYNAPYDNIVWDVGHQTYI
HKILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSSTSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEAL
NHAGGIKEDILVILNDNEMSISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKIETQTKGMFVPANFFE
DLGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPSFHSGENITTKISKPTYSNIF
GDWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFDVAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIH
DIALQNLDVLYAVDRAGLVGADGATHDGSFDLAFMRCIPNHVIMTPSDENETYHMLEFGYEYNGPAMVRYPRGAGIGAEI
TGSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDKIMLDKVSQTHEIILTLEENCIAGGAG
SAVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQSKLCVENISKELDKLI
>Mature_614_residues
SKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALHYVYNAPYDNIVWDVGHQTYIH
KILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSSTSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEALN
HAGGIKEDILVILNDNEMSISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKIETQTKGMFVPANFFED
LGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPSFHSGENITTKISKPTYSNIFG
DWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFDVAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIHD
IALQNLDVLYAVDRAGLVGADGATHDGSFDLAFMRCIPNHVIMTPSDENETYHMLEFGYEYNGPAMVRYPRGAGIGAEIT
GSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDKIMLDKVSQTHEIILTLEENCIAGGAGS
AVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQSKLCVENISKELDKLI

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=631, Percent_Identity=23.2963549920761, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4507521, Length=631, Percent_Identity=23.2963549920761, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI225637463, Length=225, Percent_Identity=29.3333333333333, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI225637459, Length=225, Percent_Identity=29.3333333333333, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI225637461, Length=225, Percent_Identity=29.3333333333333, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI133778974, Length=225, Percent_Identity=27.5555555555556, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=602, Percent_Identity=57.3089700996678, Blast_Score=731, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=379, Percent_Identity=25.8575197889182, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645119, Length=496, Percent_Identity=26.8145161290323, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45551847, Length=496, Percent_Identity=26.8145161290323, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550715, Length=496, Percent_Identity=26.8145161290323, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24666278, Length=492, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67386; Mature: 67255

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALH
CCCEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHEECCCCCHHHHCCCHHHEEEEE
YVYNAPYDNIVWDVGHQTYIHKILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSS
EEECCCCCCCEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEALNHAGGIKEDILVILNDNEMS
CHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEE
ISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKIETQTKGMFVPANFFE
ECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEHHHHH
DLGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPS
HCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCC
FHSGENITTKISKPTYSNIFGDWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFD
CCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCEEE
VAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIHDIALQNLDVLYAVDRAGLVG
EEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEE
ADGATHDGSFDLAFMRCIPNHVIMTPSDENETYHMLEFGYEYNGPAMVRYPRGAGIGAEI
CCCCCCCCCCCCHHEECCCCCEEECCCCCCCEEEEEEECEEECCCEEEEECCCCCCCCEE
TGSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDKIMLDKV
ECCEEEEECHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQTHEIILTLEENCIAGGAGSAVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQS
CCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHHHHHHHH
KLCVENISKELDKLI
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKYTILDKINTPSDLKLIPESQLKILSAELRAFLVDTLDVSGGHFASSLGATELTVALH
CCEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHHHEECCCCCHHHHCCCHHHEEEEE
YVYNAPYDNIVWDVGHQTYIHKILTGRKDKLVTIKKDGGISGFPKRSESEYDTFGVGHSS
EEECCCCCCCEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TSISAALGMAIADRLQGKSSNTVAVIGDGAITGGMAFEALNHAGGIKEDILVILNDNEMS
CHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEE
ISDNVGGLSAHFSKIISGGFYNSIREKGKEVLKNIPPIFEFVKKIETQTKGMFVPANFFE
ECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEHHHHH
DLGFYYVGPIDGHDVTELVKTLRILKDHKGPKLLHVITKKGKGYTKAESDPIKFHHVAPS
HCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCC
FHSGENITTKISKPTYSNIFGDWICQKAAKDKRLVGITPAMKEGSDLIRFSQLYPHRYFD
CCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCEEE
VAIAEQHAVTFAGGLACQGLKPVVAIYSTFLQRAYDQVIHDIALQNLDVLYAVDRAGLVG
EEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEE
ADGATHDGSFDLAFMRCIPNHVIMTPSDENETYHMLEFGYEYNGPAMVRYPRGAGIGAEI
CCCCCCCCCCCCHHEECCCCCEEECCCCCCCEEEEEEECEEECCCEEEEECCCCCCCCEE
TGSLDLELGKAKIVKQGSKIAILNFGTLLPLAKQLAEKYHATVIDMRFVKPLDKIMLDKV
ECCEEEEECHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQTHEIILTLEENCIAGGAGSAVNEYFVAKDLSNKIIVRNFGLQDKFLNHGTKDLLLAQS
CCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCHHHHHHHH
KLCVENISKELDKLI
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA