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The map label for this gene is lplA [H]

Identifier: 89256316

GI number: 89256316

Start: 934654

End: 935556

Strand: Reverse

Name: lplA [H]

Synonym: FTL_0967

Alternate gene names: 89256316

Gene position: 935556-934654 (Counterclockwise)

Preceding gene: 89256328

Following gene: 89256314

Centisome position: 49.34

GC content: 29.13

Gene sequence:

>903_bases
ATGCATATATACATATCTCAAAGTAACGATATCTATTTTAATTTAGCTTTTGAAAATTGGTTATTCTTGGAGAAGCTGCA
TCAACAAAAAATTTTATTCTTGTGGCAGAATTCTCCTTGCGTTGTTATTGGTAGAGCCCAAAATCCTTGGCTTGAGTGCA
ATCTTGAAGCTATGGATAATGATAAAATACCAATGATTCGTCGTCAAAGTGGTGGCGGTACGGTTTATCATGATTATGGT
AATCTTAATTACACTATTATCAGCACTAAAAAAGATCATGATATCAAAGCAAATTTAGAACTAGTTTGTAATGCTATTAA
AAAACTAGGCATTGATGTATATCCCAACCGAAGAAATGATATTGTTCTTGATCATCACAACTATACATATAAAATATCAG
GTAGTGCCTTTAGAGAAAAAAAAGATCGAGCTTTTCATCATGGTACTCTATTGATTAATGCAAATACAAAAAAGCTTTAT
GATTATCTTCATCAGCCAATAGATAAATCTCTCGATACTAAAGGAGTTAAATCTCACCGTTCAAAAGTAATCAATCTATC
TGAAATAAAGCATGATATACAAACTCAGGATATAACTAGATCTTTCATTAAAAGCTTTAGAAGTATTGACCTAAGTTTAA
TCAATGAAGAAACTCCATTAGAAAATAAAGAGCTTATAGAAAAAGAAATTGAAATCTTAAAAGATTGGCAATGGCGTTTT
GGTAAAACTTTGCCTTTTACAAAAACTTATACAAAAGCAAGTGAACAAATTAAAATCAAAATTGAATCTGGAATTGTTAC
AGAAGTTAGGAATGTTTATAAAAATACAAATCTTGCTGATAAGAATATTCGCTTTGAAAATAGATATGATTTTGATTTCT
TTAAGAAAATTCTTACAGAATAA

Upstream 100 bases:

>100_bases
TTAAAAATTTCTCTCAATAAAGCAAAATTATAACACAAAACTCTTTTATAGAACCAATAAAACCTTATACTTATTAGAAA
GTAAAAATATCTAATATCCT

Downstream 100 bases:

>100_bases
GTTTATTTAGAACTTGTTGAAAAAAATGCTGCAACACTAATAGCAAAAATAAAAGGTAAAATAAAAGCATCAACTACTGT
CACAACAATGTTTTGAATAG

Product: lipoate-protein ligase A

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MHIYISQSNDIYFNLAFENWLFLEKLHQQKILFLWQNSPCVVIGRAQNPWLECNLEAMDNDKIPMIRRQSGGGTVYHDYG
NLNYTIISTKKDHDIKANLELVCNAIKKLGIDVYPNRRNDIVLDHHNYTYKISGSAFREKKDRAFHHGTLLINANTKKLY
DYLHQPIDKSLDTKGVKSHRSKVINLSEIKHDIQTQDITRSFIKSFRSIDLSLINEETPLENKELIEKEIEILKDWQWRF
GKTLPFTKTYTKASEQIKIKIESGIVTEVRNVYKNTNLADKNIRFENRYDFDFFKKILTE

Sequences:

>Translated_300_residues
MHIYISQSNDIYFNLAFENWLFLEKLHQQKILFLWQNSPCVVIGRAQNPWLECNLEAMDNDKIPMIRRQSGGGTVYHDYG
NLNYTIISTKKDHDIKANLELVCNAIKKLGIDVYPNRRNDIVLDHHNYTYKISGSAFREKKDRAFHHGTLLINANTKKLY
DYLHQPIDKSLDTKGVKSHRSKVINLSEIKHDIQTQDITRSFIKSFRSIDLSLINEETPLENKELIEKEIEILKDWQWRF
GKTLPFTKTYTKASEQIKIKIESGIVTEVRNVYKNTNLADKNIRFENRYDFDFFKKILTE
>Mature_300_residues
MHIYISQSNDIYFNLAFENWLFLEKLHQQKILFLWQNSPCVVIGRAQNPWLECNLEAMDNDKIPMIRRQSGGGTVYHDYG
NLNYTIISTKKDHDIKANLELVCNAIKKLGIDVYPNRRNDIVLDHHNYTYKISGSAFREKKDRAFHHGTLLINANTKKLY
DYLHQPIDKSLDTKGVKSHRSKVINLSEIKHDIQTQDITRSFIKSFRSIDLSLINEETPLENKELIEKEIEILKDWQWRF
GKTLPFTKTYTKASEQIKIKIESGIVTEVRNVYKNTNLADKNIRFENRYDFDFFKKILTE

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=255, Percent_Identity=38.8235294117647, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI21729884, Length=255, Percent_Identity=38.8235294117647, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI21729882, Length=255, Percent_Identity=38.8235294117647, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI21729880, Length=255, Percent_Identity=38.8235294117647, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI21729878, Length=255, Percent_Identity=38.8235294117647, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1790846, Length=291, Percent_Identity=37.8006872852234, Blast_Score=197, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71981909, Length=271, Percent_Identity=32.8413284132841, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322415, Length=277, Percent_Identity=28.158844765343, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI28573464, Length=295, Percent_Identity=30.8474576271186, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 35390; Mature: 35390

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIYISQSNDIYFNLAFENWLFLEKLHQQKILFLWQNSPCVVIGRAQNPWLECNLEAMDN
CEEEEECCCCEEEEEEEHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCEEEEEEECCC
DKIPMIRRQSGGGTVYHDYGNLNYTIISTKKDHDIKANLELVCNAIKKLGIDVYPNRRND
CCCCEEEEECCCCEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEECCCCCCC
IVLDHHNYTYKISGSAFREKKDRAFHHGTLLINANTKKLYDYLHQPIDKSLDTKGVKSHR
EEEECCCEEEEECCHHHHHHHHCCEECEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHH
SKVINLSEIKHDIQTQDITRSFIKSFRSIDLSLINEETPLENKELIEKEIEILKDWQWRF
HHEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GKTLPFTKTYTKASEQIKIKIESGIVTEVRNVYKNTNLADKNIRFENRYDFDFFKKILTE
CCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MHIYISQSNDIYFNLAFENWLFLEKLHQQKILFLWQNSPCVVIGRAQNPWLECNLEAMDN
CEEEEECCCCEEEEEEEHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCEEEEEEECCC
DKIPMIRRQSGGGTVYHDYGNLNYTIISTKKDHDIKANLELVCNAIKKLGIDVYPNRRND
CCCCEEEEECCCCEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCEECCCCCCC
IVLDHHNYTYKISGSAFREKKDRAFHHGTLLINANTKKLYDYLHQPIDKSLDTKGVKSHR
EEEECCCEEEEECCHHHHHHHHCCEECEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHH
SKVINLSEIKHDIQTQDITRSFIKSFRSIDLSLINEETPLENKELIEKEIEILKDWQWRF
HHEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GKTLPFTKTYTKASEQIKIKIESGIVTEVRNVYKNTNLADKNIRFENRYDFDFFKKILTE
CCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA