Click here to switch to the map view.

The map label for this gene is tdk

Identifier: 89256247

GI number: 89256247

Start: 867167

End: 867760

Strand: Direct

Name: tdk

Synonym: FTL_0890

Alternate gene names: 89256247

Gene position: 867167-867760 (Clockwise)

Preceding gene: 89256246

Following gene: 89256248

Centisome position: 45.74

GC content: 34.01

Gene sequence:

>594_bases
GTGGCGAAATTATATTTTAGATATTCGGCTATGGATGCTGGTAAGACACTAGATCTTTTAAAAGTTGCTTATAACTATGA
AGATAGAGGTAGGAAGCCCTTAGTATTAACATCAGCGATTGATAAAAGAGCGGGGTTAAATAAAGTTAAATCACGCATAG
GTATAGATCAGGATGCTTACTCACTGACTGATAGAGATAATATTTTTGAATTTGTCGAAAATTATAATAGTAGTAACAAG
ATAGATTGTGTATTGATAGATGAAATTCATTTTTTTACTCAAGAGCAAGTTTGGCAATTAGCAGAGATAGTTGATGAACT
AAATATTCCTGTGATTTGCTATGGGTTACGTACTAATTACTTAGGTCAGCCATTTGAGACAGCAGCATTACTTTTGGCTA
TTGCTGATACTCTTGAAGAAGTCAAAACAATTTGTCACTGCGGTAAAAAAGCAAGCTTTAATATGATGGTGCAGAATGGT
AAAGCAATAAAACAAGGTAATCCCATAGTGGTTGATGATGATTCGCTTAAAGAGATAGATACCAAATATGTCTCTGTATG
TCGTAAGCACTGGAAAGAAGGTGTGTATGAATAA

Upstream 100 bases:

>100_bases
GCGTAATGTTGATAATCACAAGTATACTATTTTTGGTGAAAAGTATTATATTTTTACAAATCCAATGTATGGCAGCTGGC
AATAATAGAGGGTTTTTGTA

Downstream 100 bases:

>100_bases
TATAGCAACTAAAGAAGGATAGTACTAATAAGTTAAATTTTACTAACAGATATTAATTTTCCTAGTTAATATCCTATACA
AAATATAAGCAATTAGAGCA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MAKLYFRYSAMDAGKTLDLLKVAYNYEDRGRKPLVLTSAIDKRAGLNKVKSRIGIDQDAYSLTDRDNIFEFVENYNSSNK
IDCVLIDEIHFFTQEQVWQLAEIVDELNIPVICYGLRTNYLGQPFETAALLLAIADTLEEVKTICHCGKKASFNMMVQNG
KAIKQGNPIVVDDDSLKEIDTKYVSVCRKHWKEGVYE

Sequences:

>Translated_197_residues
MAKLYFRYSAMDAGKTLDLLKVAYNYEDRGRKPLVLTSAIDKRAGLNKVKSRIGIDQDAYSLTDRDNIFEFVENYNSSNK
IDCVLIDEIHFFTQEQVWQLAEIVDELNIPVICYGLRTNYLGQPFETAALLLAIADTLEEVKTICHCGKKASFNMMVQNG
KAIKQGNPIVVDDDSLKEIDTKYVSVCRKHWKEGVYE
>Mature_196_residues
AKLYFRYSAMDAGKTLDLLKVAYNYEDRGRKPLVLTSAIDKRAGLNKVKSRIGIDQDAYSLTDRDNIFEFVENYNSSNKI
DCVLIDEIHFFTQEQVWQLAEIVDELNIPVICYGLRTNYLGQPFETAALLLAIADTLEEVKTICHCGKKASFNMMVQNGK
AIKQGNPIVVDDDSLKEIDTKYVSVCRKHWKEGVYE

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=196, Percent_Identity=44.8979591836735, Blast_Score=182, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_FRATH (Q2A3U3)

Other databases:

- EMBL:   AM233362
- RefSeq:   YP_513609.1
- ProteinModelPortal:   Q2A3U3
- GeneID:   3952364
- GenomeReviews:   AM233362_GR
- KEGG:   ftl:FTL_0890
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- ProtClustDB:   PRK04296
- BioCyc:   FTUL351581:FTL_0890-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 22474; Mature: 22343

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLYFRYSAMDAGKTLDLLKVAYNYEDRGRKPLVLTSAIDKRAGLNKVKSRIGIDQDAY
CCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHCCHHHHHHHHCCCCCHH
SLTDRDNIFEFVENYNSSNKIDCVLIDEIHFFTQEQVWQLAEIVDELNIPVICYGLRTNY
CCCCHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
LGQPFETAALLLAIADTLEEVKTICHCGKKASFNMMVQNGKAIKQGNPIVVDDDSLKEID
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCEEECCCCHHHHH
TKYVSVCRKHWKEGVYE
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKLYFRYSAMDAGKTLDLLKVAYNYEDRGRKPLVLTSAIDKRAGLNKVKSRIGIDQDAY
CEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHHCCHHHHHHHHCCCCCHH
SLTDRDNIFEFVENYNSSNKIDCVLIDEIHFFTQEQVWQLAEIVDELNIPVICYGLRTNY
CCCCHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
LGQPFETAALLLAIADTLEEVKTICHCGKKASFNMMVQNGKAIKQGNPIVVDDDSLKEID
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEECCCCEEECCCCHHHHH
TKYVSVCRKHWKEGVYE
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA