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The map label for this gene is serA [H]

Identifier: 89256103

GI number: 89256103

Start: 704195

End: 705430

Strand: Reverse

Name: serA [H]

Synonym: FTL_0714

Alternate gene names: 89256103

Gene position: 705430-704195 (Counterclockwise)

Preceding gene: 89256104

Following gene: 89256102

Centisome position: 37.21

GC content: 33.9

Gene sequence:

>1236_bases
ATGAGCCAGCTATCTCTTAATAAAAAGAAAATCCCAATTCTTCTCTTAGAAGGTATACACTCAAATGCAGTTGAATCATT
CAAAGCTGCAGGAGACGAAAATATCGAATTACTAAACACTGCGCTTGAAGGACAAGAACTAATAGATAAACTTAAAGATT
TTAAAATTGTCGGCTTACGCTCTCGTACTCAACTTACAAAAGAAGTCCTAGAGCAATCTGATCACCTTATAGCTATTGGT
TGCTTTTGTATTGATACTAATCAAGTAGATCTTAGAACTGCACAAAGCTTAGGTATACCTGTTTTTAATGCCCCATTTTC
AAATACTCGTAGTGTTGCTGAGCTTGTCTTAGAAGAAGCTATTTTACTGATACGTAATGTAATTGACAAAAATGCTAAAG
CCCACAGAGGTGAATGGCTTAAGTCAGCTGATAATGCTAATGAAGTAAGAGGTAAAACCTTAGGAATTGTTGGTTACGGT
CATATCGGTATGCAGCTTGGAGTTCTAGCAGAAAATATCGGTTTAAATGTGATATTTTATGATATCGAAGAGAAACTACC
TTTAGGTAATGCTTGTCAAGTTGATAGTTTAGCAACGCTACTACAACAATCTGATGTAGTTTCTCTACATGTACCACAAC
TGCCAACTACTGCAAATATGATATCAACCAAAGAATTCGCTCTTATGAAGCAAAATGCAGTGCTTATCAATGCTTCAAGA
GGTAATGTAATAGATATTGATGCTTTGGTTGATGCACTAACAAGCTCCAAGCTTAAAGGTGCGGCAATTGATGTTTTCCC
TAAAGATCCATCATCAAAAGGTGAAATTTTTGAAAGTCCTTTAAGAGGCCTTGATAATGTTTTTCTAACACTACACATAG
GTGGCAGTACTATAGAGGCACAAGAAAATATTGCTACAGAAGTAAGTGCAAAATTAATCAAATATTCAGACAATGGTTCA
ACATTAAATGCAGTAAACTTTTCTGAATTATCCTTACCTAGTCATAGAGAAACTCATCGAATCTTACATATTCATCAGAA
TATCCCAGGTATTATTAATGAGCTAAATAGAATTTTGGCGTCTAAAAATATCAATGTTGAAGGTCAATATTTAAGAACAT
TAGAAAATATTGGTTATGTTGTTATGGATATTAAATCAAGCTCAGATGAGGCTAAAGAACTTATTGATGAATTCAAAAAA
GTTAAAGCTACCATAAAAGCCCGTTATTTAGTATAA

Upstream 100 bases:

>100_bases
CAAACTCCATCTTTGATTATAAATACGAAGATTTTGAATTTGAAAACTATAACCATCACCCTGCCATCAAAGCAAAAATA
TCTGTATAAGGATGCCCAAA

Downstream 100 bases:

>100_bases
ATGTCTATAAGCAAATCTCTTGTTTTAAATGAAATAAAAAAATTCTCGCCTTCTCATATTATTATTGGTTATAGTGGTGG
CGTTGACTCAAGTGTTTTAC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSQLSLNKKKIPILLLEGIHSNAVESFKAAGDENIELLNTALEGQELIDKLKDFKIVGLRSRTQLTKEVLEQSDHLIAIG
CFCIDTNQVDLRTAQSLGIPVFNAPFSNTRSVAELVLEEAILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYG
HIGMQLGVLAENIGLNVIFYDIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
GNVIDIDALVDALTSSKLKGAAIDVFPKDPSSKGEIFESPLRGLDNVFLTLHIGGSTIEAQENIATEVSAKLIKYSDNGS
TLNAVNFSELSLPSHRETHRILHIHQNIPGIINELNRILASKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKK
VKATIKARYLV

Sequences:

>Translated_411_residues
MSQLSLNKKKIPILLLEGIHSNAVESFKAAGDENIELLNTALEGQELIDKLKDFKIVGLRSRTQLTKEVLEQSDHLIAIG
CFCIDTNQVDLRTAQSLGIPVFNAPFSNTRSVAELVLEEAILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYG
HIGMQLGVLAENIGLNVIFYDIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
GNVIDIDALVDALTSSKLKGAAIDVFPKDPSSKGEIFESPLRGLDNVFLTLHIGGSTIEAQENIATEVSAKLIKYSDNGS
TLNAVNFSELSLPSHRETHRILHIHQNIPGIINELNRILASKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKK
VKATIKARYLV
>Mature_410_residues
SQLSLNKKKIPILLLEGIHSNAVESFKAAGDENIELLNTALEGQELIDKLKDFKIVGLRSRTQLTKEVLEQSDHLIAIGC
FCIDTNQVDLRTAQSLGIPVFNAPFSNTRSVAELVLEEAILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYGH
IGMQLGVLAENIGLNVIFYDIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASRG
NVIDIDALVDALTSSKLKGAAIDVFPKDPSSKGEIFESPLRGLDNVFLTLHIGGSTIEAQENIATEVSAKLIKYSDNGST
LNAVNFSELSLPSHRETHRILHIHQNIPGIINELNRILASKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKKV
KATIKARYLV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=30.4794520547945, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI61743967, Length=324, Percent_Identity=29.320987654321, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=324, Percent_Identity=29.320987654321, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI145580578, Length=282, Percent_Identity=30.8510638297872, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4557499, Length=282, Percent_Identity=30.8510638297872, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI145580575, Length=286, Percent_Identity=31.4685314685315, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI6912396, Length=206, Percent_Identity=28.1553398058252, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1789279, Length=410, Percent_Identity=58.0487804878049, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI87082289, Length=279, Percent_Identity=32.258064516129, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1787645, Length=239, Percent_Identity=27.6150627615063, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=321, Percent_Identity=30.5295950155763, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=291, Percent_Identity=28.5223367697594, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322116, Length=411, Percent_Identity=46.4720194647202, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320925, Length=412, Percent_Identity=46.8446601941748, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324964, Length=259, Percent_Identity=30.5019305019305, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=202, Percent_Identity=29.7029702970297, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=330, Percent_Identity=29.3939393939394, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=31.6981132075472, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=31.6981132075472, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=31.6981132075472, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=31.6981132075472, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=31.6981132075472, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28574286, Length=281, Percent_Identity=28.1138790035587, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=27.2, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585514, Length=286, Percent_Identity=25.8741258741259, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574282, Length=286, Percent_Identity=25.8741258741259, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574284, Length=286, Percent_Identity=25.8741258741259, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45552429, Length=286, Percent_Identity=25.8741258741259, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551003, Length=286, Percent_Identity=25.8741258741259, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=22.9965156794425, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 45046; Mature: 44915

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLSLNKKKIPILLLEGIHSNAVESFKAAGDENIELLNTALEGQELIDKLKDFKIVGLR
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHCCEEEECC
SRTQLTKEVLEQSDHLIAIGCFCIDTNQVDLRTAQSLGIPVFNAPFSNTRSVAELVLEEA
HHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
ILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYGHIGMQLGVLAENIGLNVIFY
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCEEEEE
DIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
ECCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHEECCEEEEECCC
GNVIDIDALVDALTSSKLKGAAIDVFPKDPSSKGEIFESPLRGLDNVFLTLHIGGSTIEA
CCEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEH
QENIATEVSAKLIKYSDNGSTLNAVNFSELSLPSHRETHRILHIHQNIPGIINELNRILA
HHHHHHHHHHEEEEECCCCCEEEEECHHHCCCCCCCCCHHEEEEECCCCHHHHHHHHHHH
SKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKKVKATIKARYLV
HCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
SQLSLNKKKIPILLLEGIHSNAVESFKAAGDENIELLNTALEGQELIDKLKDFKIVGLR
CCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHCCEEEECC
SRTQLTKEVLEQSDHLIAIGCFCIDTNQVDLRTAQSLGIPVFNAPFSNTRSVAELVLEEA
HHHHHHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
ILLIRNVIDKNAKAHRGEWLKSADNANEVRGKTLGIVGYGHIGMQLGVLAENIGLNVIFY
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCEEEEE
DIEEKLPLGNACQVDSLATLLQQSDVVSLHVPQLPTTANMISTKEFALMKQNAVLINASR
ECCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHEECCEEEEECCC
GNVIDIDALVDALTSSKLKGAAIDVFPKDPSSKGEIFESPLRGLDNVFLTLHIGGSTIEA
CCEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEH
QENIATEVSAKLIKYSDNGSTLNAVNFSELSLPSHRETHRILHIHQNIPGIINELNRILA
HHHHHHHHHHEEEEECCCCCEEEEECHHHCCCCCCCCCHHEEEEECCCCHHHHHHHHHHH
SKNINVEGQYLRTLENIGYVVMDIKSSSDEAKELIDEFKKVKATIKARYLV
HCCCCCCHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]