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The map label for this gene is thyA [H]

Identifier: 89256104

GI number: 89256104

Start: 705442

End: 706266

Strand: Reverse

Name: thyA [H]

Synonym: FTL_0715

Alternate gene names: 89256104

Gene position: 706266-705442 (Counterclockwise)

Preceding gene: 89256105

Following gene: 89256103

Centisome position: 37.25

GC content: 34.3

Gene sequence:

>825_bases
ATGCGAGAATATCTAAATTTCCTTAAGTATATCAAAGAAAATGGCGTTTTAAAGAATGATAGAACCGGTACTGGAACAAG
AAGTATCTTTGGCTATCAAATGCGTTTTGATCTTCAAAAAGGCTTCCCATTAGTAACTACAAAAAAAATTCATATTCCTA
GTGTTGTTCATGAATTATTATGGTTTTTAAGTGGTAGTACAAATATCAAATATCTTAATGATAACAATGTTAGAATTTGG
AATGAGTGGGCAACTGTAGATGGCGAACTTGGTCCTATTTATGGCAAGCAGTGGCGTGATTTTAATGGTCAAGGTATAGA
TCAAATTGCCGATGTAATTCAGATGCTAAAAACAAACCCAAACTCACGTAGGATTCTAGTTTTAGCGTGGAATCCATGTG
TTGTTCCATCAGAAAAAATCTCTCCACAAGAAAATGTTGTAAAAGGTAATTCAGCCCTACCACCATGCCATGCAATGTTT
CAGTTCTATGTAGCAAATAATAAACTATCATGCATGCTTACGCAAAGAAGTGCTGATGCTTTTCTTGGAGTACCATTTAA
CATTGCAAGTTATTCACTACTGACACATATGGTTGCACAACAATGTAATCTTGATGTTGGTGAGCTCATCTGGTCAGGTG
GTGATTGTCATATTTACAATAATCATATTGAGCAAGTCAATGAACAGCTTAGTCGTGAGCCTTTAGCTTTACCAACACTA
AAGATTTTAAGAAAATCAAACTCCATCTTTGATTATAAATACGAAGATTTTGAATTTGAAAACTATAACCATCACCCTGC
CATCAAAGCAAAAATATCTGTATAA

Upstream 100 bases:

>100_bases
TCTTTAATTGGATGACTATGGGGCAAATATTATCAATCCCAATGATATTACTAGGAGCGGTAATTTTAATCGCAGTATTT
ATTAAAACAAGGAAGAATAA

Downstream 100 bases:

>100_bases
GGATGCCCAAAATGAGCCAGCTATCTCTTAATAAAAAGAAAATCCCAATTCTTCTCTTAGAAGGTATACACTCAAATGCA
GTTGAATCATTCAAAGCTGC

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIW
NEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMF
QFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
KILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV

Sequences:

>Translated_274_residues
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIW
NEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMF
QFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
KILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV
>Mature_274_residues
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIW
NEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMF
QFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
KILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507751, Length=295, Percent_Identity=48.135593220339, Blast_Score=276, Evalue=1e-74,
Organism=Escherichia coli, GI1789191, Length=277, Percent_Identity=58.4837545126354, Blast_Score=346, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71993377, Length=296, Percent_Identity=43.2432432432432, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324648, Length=292, Percent_Identity=38.3561643835616, Blast_Score=188, Evalue=8e-49,
Organism=Drosophila melanogaster, GI17137556, Length=296, Percent_Identity=43.9189189189189, Blast_Score=259, Evalue=9e-70,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 31415; Mature: 31415

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELL
CHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEEEEEECCCCCCEEEEEEEECHHHHHHHH
WFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNP
HHHCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
NSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADA
CCCEEEEEEECCCCCCCCCCCCHHHEECCCCCCCHHHHHHEEEEECCCEEEEEEECCCCE
FLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
EECCCHHHHHHHHHHHHHHHHHCCCHHHHEECCCCEEEECHHHHHHHHHHCCCCCCCHHH
KILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV
HHHHCCCCEEEEECCCEECCCCCCCCCEEEEECC
>Mature Secondary Structure
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELL
CHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEEEEEECCCCCCEEEEEEEECHHHHHHHH
WFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNP
HHHCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
NSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADA
CCCEEEEEEECCCCCCCCCCCCHHHEECCCCCCCHHHHHHEEEEECCCEEEEEEECCCCE
FLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTL
EECCCHHHHHHHHHHHHHHHHHCCCHHHHEECCCCEEEECHHHHHHHHHHCCCCCCCHHH
KILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV
HHHHCCCCEEEEECCCEECCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA