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The map label for this gene is rnr [H]

Identifier: 89255960

GI number: 89255960

Start: 537457

End: 539709

Strand: Direct

Name: rnr [H]

Synonym: FTL_0556

Alternate gene names: 89255960

Gene position: 537457-539709 (Clockwise)

Preceding gene: 89255959

Following gene: 89255967

Centisome position: 28.35

GC content: 34.18

Gene sequence:

>2253_bases
GTGAGTAAGTACAGCATACATAATGATCCGAATAAGGATATTGAAGCGCAAAAATATGAAAATCCAATTCCAAGTAGGGA
AGTGATTTTAAATTATATAAGAGATGTAAAACTTCCTGTAAGCATTGAAAATATAGCAAATGCTTTAGAGATTTTTAAAA
AAAATCTTTTCGAAGGTCTTGTAAATCGTTTGGGTGCAATGGTTAGAGATGGTCAGCTAGAGAAGGATAGATCATATTAT
AATTTGCCGGAAATGGCGCCAATATATATCACATCTAAAGTTACTGCAGATAGAGATTCTCGTTTAGAGCTATTTAGCCA
TACTCTAAATACAAAGGTAGGTATAGTATCTCATCAAGCAAAAATGGTAATGGTTGGTGATGAGGTAACTGCAAAAGTTC
TTGGGCTTAATAAGCGTGGTCGAATAGATGCTGAAATTAAAACCATAGTGACAAGAGCTCAGAAGACAGTCACGGGCTAT
TATTATAAGAGCTTTGATTGTGATTTTATTAAGCCGATAAGCAAAAGCATAATAAGTGACATAGTGCTATTACCACCAAA
GCAAAAAATAGAGCATAACTCTTTAATAGAAGCTGAGATTATTGTTTATCCTAGTATAAGTAGTGCAGCTGTTGCTAAAT
TTAAGCAAGAGGTCGAAGCAGTATCTCCAGTTAAAGAAGCGATGATGATGACAACACAGAAGTATGATTTAATTGAGCAG
TGGAGTAAAAAGGCTTTACGCTATTTAGATAATATTTCTGATGACGTGGTTGTTGGCAACAGGGTTGATCTACGTAATCA
ACACTTTGTAACAATTGATGGTGAAGATGCTAAGGATTTTGATGATGCAGTTTATGCACATAAGACTAAAAGTGGTAGTT
GGAAGTTATATGTAGCAATTGCAGATGTCTCAAACTATGTTGAGAAAGATTCAGCTTTGGATTTAGACGCTAAGCGTCGT
TCTACTTCAGTGTATTTCCCTGGTTATGTGATACCAATGCTACCAGAGAAATTATCAAATGGTTTATGTTCATTAAGACC
AAACGAAGATAGATATTCCTTAGTCTGTGAGATGAATATTAGTAAAGAAGGTAAACTTTCTAGGTATAAGTTTTATTCTG
CTGTAATAAACTCAAAGGCACGCTTAACTTATACAGAAGTTGCTAAACTTTTAGAAAAGAAACAAAACACTATAGTTGAG
AATACTCCTGAGCTAGTACCTAATATATTTGATTTATACGAGTTGTATAAAGTACTTCACCAAGCTAGGCAAGAACGAGG
TGCTATAGACTTTGATACAGTTGAAACACAGATAATTCTTGATGAGCATAATCATATTGAATCAATTGTGCCAAGACATC
GTAATGATGCACATAGGCTTATTGAAGAGTGTATGCTTGTTGCTAACGTTGCAGCAGCTAAGTTTACTATTAAGCATAAA
AAGACATCACCATTTAGAGTTCATAGTGAGCCTAAAGAAGATAGAATGGAAACTCTTAAGAAGTATCTTGCTAAGCATGG
TATACATCTTGCTCATGGTAAGAATGGTAAAGTGACTCCCAAAGCTTTAGCACAAATGCTAGATAGTATAAAAGATCGTC
CTGATTATGATGATATTCGGATGATGACTTTACGTAGTATGAATCAGGCCGTATATAGCATAAATAATGATGGACACTTT
GGACTAGCATATAGTGAATATACGCATTTTACCTCACCAATTCGTAGATATCCAGATTTAGTAGTACACAGAATAATAAA
ATCAATTATTGGTGAATATGAACATGGTGCTGCTGATTATAAACCTTCTGAATTGGCAAATATTTGTGAAAATGCCTCTG
ATCAAGAGCGAAATGCTGATGCAGCCTCTAAGCAAGTTGAGAATTGGTTGAAGTGCTACTTTATGCAAGACTACATTGGT
CATATACTTGAAGCTCAAATTAAGCATGTTAATGGTTTAGGTCTTTTTGCTGAACTAAAAGATATGTACATAGAAGGTCT
GATACATGTATCAGCTATTCCTGGTGATTACTATATTTATGATGAAGCCAAAGATATATTAATTGGTAAACGAACCCATA
AAGTCTATAAAATTGGTCAAGATATTACAGTAAGAGTTGTTCGAGCAGATCTCGAAAGAATTCATATAGATTTTGAGCTG
TATGATCCACGTAAGCCATTTGCTGAGAATAGCTCAGATAAGCCATTTGCAAAAAAACAAAAAAACTTAAAAAAGCTAAA
AAGAAGAAAGTAA

Upstream 100 bases:

>100_bases
ACGGTCAGGATATATGATGTTGAGAAGTTTGTTGCTATAGCAGAGTTTGATAAAGGTAAGTTGATTAATAAAAAATTTTT
TGATCAGGATATATTGATAA

Downstream 100 bases:

>100_bases
GAAGTAGAAAAAAGAATAAAACAAAAGCAAAATTAGCACACTAAATTTAATTTAAAAAGTTTTTGATCTAAATAGTTTTC
TTCGGTTGCTTAAAATCCCA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MSKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGLVNRLGAMVRDGQLEKDRSYY
NLPEMAPIYITSKVTADRDSRLELFSHTLNTKVGIVSHQAKMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGY
YYKSFDCDFIKPISKSIISDIVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHKTKSGSWKLYVAIADVSNYVEKDSALDLDAKRR
STSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNISKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVE
NTPELVPNIFDLYELYKVLHQARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIRMMTLRSMNQAVYSINNDGHF
GLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADYKPSELANICENASDQERNADAASKQVENWLKCYFMQDYIG
HILEAQIKHVNGLGLFAELKDMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKIGQDITVRVVRADLERIHIDFEL
YDPRKPFAENSSDKPFAKKQKNLKKLKRRK

Sequences:

>Translated_750_residues
MSKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGLVNRLGAMVRDGQLEKDRSYY
NLPEMAPIYITSKVTADRDSRLELFSHTLNTKVGIVSHQAKMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGY
YYKSFDCDFIKPISKSIISDIVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHKTKSGSWKLYVAIADVSNYVEKDSALDLDAKRR
STSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNISKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVE
NTPELVPNIFDLYELYKVLHQARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIRMMTLRSMNQAVYSINNDGHF
GLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADYKPSELANICENASDQERNADAASKQVENWLKCYFMQDYIG
HILEAQIKHVNGLGLFAELKDMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKIGQDITVRVVRADLERIHIDFEL
YDPRKPFAENSSDKPFAKKQKNLKKLKRRK
>Mature_749_residues
SKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGLVNRLGAMVRDGQLEKDRSYYN
LPEMAPIYITSKVTADRDSRLELFSHTLNTKVGIVSHQAKMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGYY
YKSFDCDFIKPISKSIISDIVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQW
SKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHKTKSGSWKLYVAIADVSNYVEKDSALDLDAKRRS
TSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNISKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVEN
TPELVPNIFDLYELYKVLHQARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHKK
TSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIRMMTLRSMNQAVYSINNDGHFG
LAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADYKPSELANICENASDQERNADAASKQVENWLKCYFMQDYIGH
ILEAQIKHVNGLGLFAELKDMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKIGQDITVRVVRADLERIHIDFELY
DPRKPFAENSSDKPFAKKQKNLKKLKRRK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=510, Percent_Identity=29.2156862745098, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI190014625, Length=510, Percent_Identity=29.2156862745098, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI19115966, Length=406, Percent_Identity=28.3251231527094, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI219521928, Length=406, Percent_Identity=28.3251231527094, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI134288890, Length=399, Percent_Identity=29.5739348370927, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI156105695, Length=566, Percent_Identity=23.1448763250883, Blast_Score=97, Evalue=8e-20,
Organism=Homo sapiens, GI156105693, Length=414, Percent_Identity=24.6376811594203, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI87082383, Length=729, Percent_Identity=40.0548696844993, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1787542, Length=471, Percent_Identity=30.7855626326964, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=375, Percent_Identity=31.2, Blast_Score=175, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=388, Percent_Identity=30.4123711340206, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324552, Length=448, Percent_Identity=30.3571428571429, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24649634, Length=492, Percent_Identity=28.6585365853659, Blast_Score=172, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24654592, Length=390, Percent_Identity=27.6923076923077, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19922976, Length=390, Percent_Identity=27.6923076923077, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24654597, Length=390, Percent_Identity=27.6923076923077, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85996; Mature: 85864

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGL
CCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
VNRLGAMVRDGQLEKDRSYYNLPEMAPIYITSKVTADRDSRLELFSHTLNTKVGIVSHQA
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCC
KMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGYYYKSFDCDFIKPISKSIISD
EEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
IVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
EEECCCHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHKTKSGSWKLYVAI
HHHHHHHHHHCCCCCEEECCEEECCCCEEEEECCCCCCCHHHHHHHEECCCCCEEEEEEE
ADVSNYVEKDSALDLDAKRRSTSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNI
ECHHHHHHCCCCCCCCHHHCCCEEECCCEEHHCCHHHHCCCCCCCCCCCCCEEEEEEECC
SKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVENTPELVPNIFDLYELYKVLH
CCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
HHHHHCCCCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIR
CCCCEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
MMTLRSMNQAVYSINNDGHFGLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADY
HHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPSELANICENASDQERNADAASKQVENWLKCYFMQDYIGHILEAQIKHVNGLGLFAELK
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKIGQDITVRVVRADLERIHIDFEL
HHHHHHHEEEEECCCCEEEEECCCHHHCCCHHHHHHCCCCCCEEHHEEECHHHEEEEEEE
YDPRKPFAENSSDKPFAKKQKNLKKLKRRK
ECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKYSIHNDPNKDIEAQKYENPIPSREVILNYIRDVKLPVSIENIANALEIFKKNLFEGL
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
VNRLGAMVRDGQLEKDRSYYNLPEMAPIYITSKVTADRDSRLELFSHTLNTKVGIVSHQA
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCEEEEEECCC
KMVMVGDEVTAKVLGLNKRGRIDAEIKTIVTRAQKTVTGYYYKSFDCDFIKPISKSIISD
EEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHH
IVLLPPKQKIEHNSLIEAEIIVYPSISSAAVAKFKQEVEAVSPVKEAMMMTTQKYDLIEQ
EEECCCHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSKKALRYLDNISDDVVVGNRVDLRNQHFVTIDGEDAKDFDDAVYAHKTKSGSWKLYVAI
HHHHHHHHHHCCCCCEEECCEEECCCCEEEEECCCCCCCHHHHHHHEECCCCCEEEEEEE
ADVSNYVEKDSALDLDAKRRSTSVYFPGYVIPMLPEKLSNGLCSLRPNEDRYSLVCEMNI
ECHHHHHHCCCCCCCCHHHCCCEEECCCEEHHCCHHHHCCCCCCCCCCCCCEEEEEEECC
SKEGKLSRYKFYSAVINSKARLTYTEVAKLLEKKQNTIVENTPELVPNIFDLYELYKVLH
CCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QARQERGAIDFDTVETQIILDEHNHIESIVPRHRNDAHRLIEECMLVANVAAAKFTIKHK
HHHHHCCCCCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEC
KTSPFRVHSEPKEDRMETLKKYLAKHGIHLAHGKNGKVTPKALAQMLDSIKDRPDYDDIR
CCCCEEECCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHH
MMTLRSMNQAVYSINNDGHFGLAYSEYTHFTSPIRRYPDLVVHRIIKSIIGEYEHGAADY
HHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KPSELANICENASDQERNADAASKQVENWLKCYFMQDYIGHILEAQIKHVNGLGLFAELK
CHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DMYIEGLIHVSAIPGDYYIYDEAKDILIGKRTHKVYKIGQDITVRVVRADLERIHIDFEL
HHHHHHHEEEEECCCCEEEEECCCHHHCCCHHHHHHCCCCCCEEHHEEECHHHEEEEEEE
YDPRKPFAENSSDKPFAKKQKNLKKLKRRK
ECCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]