Click here to switch to the map view.

The map label for this gene is lspA

Identifier: 89255845

GI number: 89255845

Start: 400032

End: 400517

Strand: Reverse

Name: lspA

Synonym: FTL_0435

Alternate gene names: 89255845

Gene position: 400517-400032 (Counterclockwise)

Preceding gene: 89255846

Following gene: 89255843

Centisome position: 21.12

GC content: 29.84

Gene sequence:

>486_bases
GTGAATTTGCTTAGACCAAAATTGAAATATTTTATTTTAGCAATTTTAATTATTGCCGCTGACTTATACACTAAGTATTT
AGCAAATACATACCTAGAATTTGCTCAATCTCTTAAGATAACTAGTTTCTTTAATCTTACGTTGTTATACAATCATGGCG
CAGCATTTAGTCTTCTAAGCAATGATCAAACATCATGGCAAATGATAATGTTTTCTACAATCTCTCTAATTGCTGCTATT
GTACTTATTTATCTAATTATTAAACAACCAATTACTGAGAAAATTAATTTGTTCTCTTTTGCTCTTATTCTAGGTGGTGC
TTTAGGCAACTTTTACGATCGTGCTTTTCAAGGATATGTAATCGATTTTTTAGATTTTCACATAGGTAATTATCACTGGC
CGTCATTTAATATAGCTGATTCAGCTATCACATGTGGTGTTGTAATTTTGATAGCAGCTTCACTATTTACTAAAAAGAAA
TCATAA

Upstream 100 bases:

>100_bases
AGATGTTGGCACCGTAGCTCGACTGTTGGGGATAATCCTCAATACAAAGATATTTGTAGTCGCTGTGTTGAGAATATAAC
TACAGAAGCTGGAGAGTCGC

Downstream 100 bases:

>100_bases
TGTTTTTTTGTAATCAGTATAAAATTGACGTGCTTTAAATTCATTACCACCATAAGATATATTATAGATTGTCTGATCCA
TCCTCGAATCCTGTTGCATA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAI
VLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKK
S

Sequences:

>Translated_161_residues
MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAI
VLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKK
S
>Mature_161_residues
MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAI
VLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKK
S

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=152, Percent_Identity=32.8947368421053, Blast_Score=107, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_FRAT1 (Q14HT3)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667043.1
- STRING:   Q14HT3
- GeneID:   4199651
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0914c
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   LARRYVI
- PhylomeDB:   Q14HT3
- ProtClustDB:   PRK00376
- BioCyc:   FTUL393115:FTF0914C-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18182; Mature: 18182

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 113-113 ACT_SITE 140-140

Signals:

None

Transmembrane regions:

HASH(0x10454888)-; HASH(0xff5f85c)-; HASH(0x1005e624)-; HASH(0x104eea78)-; HASH(0x1068d308)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEC
NDQTSWQMIMFSTISLIAAIVLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKKS
HHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSLKITSFFNLTLLYNHGAAFSLLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEC
NDQTSWQMIMFSTISLIAAIVLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKKS
HHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA