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The map label for this gene is prlC [H]

Identifier: 89255830

GI number: 89255830

Start: 386267

End: 388273

Strand: Reverse

Name: prlC [H]

Synonym: FTL_0419

Alternate gene names: 89255830

Gene position: 388273-386267 (Counterclockwise)

Preceding gene: 89255836

Following gene: 89255829

Centisome position: 20.48

GC content: 33.88

Gene sequence:

>2007_bases
ATGAATTCGATAATTGAAGACTCTAAATTACCTAAACTTGCAGAATTTAAAGTAGACGAAGTAAAGCCTGCTATAGATAA
ACTCTTTAGCCTAGCTCAAAGCAACCTTGAAAATGCTCTACAAACTCAAAATCCCAATTGGCAGACGTTACTAAAACTAG
AGGAAGATGACGAGAAAATAAGTCAAGCTTTTTCAACAATCTCACATATGAATGCTGTTTGTAATTCTAAAGAACTGCGC
GAAAGTTATGAATATACGATAGCTAAACTTACTGACTACTATACCAAATTAGGACAAAATAAAGATTTATATGACCTCTA
CAAACAAATTCAAAAAGATAATTTAACTAATGAACAAGCTCAAGCAGTACGTAAAGCTATTATTGGCTTTGAGCAATCAG
GGGTAAATCTTGATGAAGCTAAGAGAAAGAGACTACAACAAATCTCTCAAGAACTTGCTCAACTAAGCACTAAATTTGAA
AATAATGTTCTAGATGCAACTATGGATTGGCTATATACTACCGATGATGAGAAAGAACTCAAAGGTTTATCACAACATAC
TATAGAATCAGCAAAAGCTAAAGCCAATCAAAAGAATATCGCTGAAAAATATGCTCTAGGTATAGACATCCCAACGTACT
TGGCAGTAATGCAGCAAGCAGACAATCGAAAACTTCGTGAAAAATTCTACAAAGCATATTGCACAAAAGCGTCAAAAGAA
GCTGATAATAAAAATTTTGATAATGATGAAAATATTGAAAAAATTCTAAAATTACGTATTGAAAAATCTCAAATACTTGG
CTTTGATAATTATGCTGAAAATTCTCTCTTTACAAAAATGGCTGAAACACCAGAACAAGTCTTAGAGCTATTAAATAAAC
TCCTAGAAAAATCTTTACTACAAGCTAAAAAAGAACTTAATGAATTACGTAGATTTGCAGAGGATGCTGGCCTTGTCGAT
GCGCTACAACCATGGGATAGCGCATACTACTATGAGAAACTCAAAAAAGCTAAATTCGACTTCACAGAAGAAGAACTTAG
AGAATACTTTCCATTAGAAAAAGTACAAGATGGATTATTTAAAATACTCAAGCAAATCTATAATTTAGATGTAAAAGAAA
ATACTCAATATACAAAATATGTACCCGAACAACAGACATTTGACTTTTTCAAAAATGATCAATATGTCGGTAGTATAATC
TGTGATTTTTTTGCTCGTGATAACAAACGCGGTGGTGCATGGATGGATGGTTCACGTACTGCTTTTACCACTTCTAGTGG
TTCAAAACAAAATCCAGTAGCTTATGTAAACTGCAATTTCCTACCACCCTCAAAAGATGGTGCAAATCTAACCCATAATG
ATGTTGTGACACTATTTCATGAGTTTGGTCATGCATTGCATCATATATTATCACAAGTAACTATTCCTTCTATCTCCGGT
ACAAATGGTGTTGAGTGGGATGCTATTGAGTTGCCGAGTCAATTTATGGAGAATTTCTGTTGGTGTCAGGAAGGTCTAGC
AGTTATATCTGGATCACGAGATGGTAAGGTACTCAGTAGCAAACAGATAGATAAGCTTGTAGGTACTAGACACTTTCATT
CAGCTCTAATGATGGTTAGACAACTTGAGTTTGGAATATTTGATATGAATATCCACTATAAAAAACTAACATCTGCAACA
GAAGTACAAAAAGAGCTAGACAGTATTAGAGAAAAAATTAATTTAATTAAAACGCCAAGTTATAATAAATTCCAAAATGG
CTTTTCACATATTTTTGCTGGTGGCTATGCTGCGGGTTACTATAGCTATAAATGGGCAGAAATCTTATCTTCAGATGTAT
TCTCACGCTTTGAGCAAGAAGGGATACTTAGTCATAAAGTTGGTAATGAGTTGTTAGAAAATATTATTTCTAAAGGGTCA
TCACGTGATGCTATGGATAACTTTGTCGCATTTATGGGACGCAAACCAAACGAAGATGCGCTACTTAGACATAGTGGCAT
TAACTAA

Upstream 100 bases:

>100_bases
AGTCATCATAGCAAAAAAACCTTGATTATAATAACATAGTTAACTATATATAAGATTATAACTTATTAACAACATATCTA
AACAATATTTTGAGGCGACT

Downstream 100 bases:

>100_bases
AGATTTACATTTAAGAAACTACCCTTCAAATTATTGAAACGGTGGCAACCAAAAACTGACAGGACAGCACAATAAAGAAA
ATGCAAACAATAGAAATAGG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKISQAFSTISHMNAVCNSKELR
ESYEYTIAKLTDYYTKLGQNKDLYDLYKQIQKDNLTNEQAQAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFE
NNVLDATMDWLYTTDDEKELKGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
ADNKNFDNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLLQAKKELNELRRFAEDAGLVD
ALQPWDSAYYYEKLKKAKFDFTEEELREYFPLEKVQDGLFKILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSII
CDFFARDNKRGGAWMDGSRTAFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVRQLEFGIFDMNIHYKKLTSAT
EVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGYYSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGS
SRDAMDNFVAFMGRKPNEDALLRHSGIN

Sequences:

>Translated_668_residues
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKISQAFSTISHMNAVCNSKELR
ESYEYTIAKLTDYYTKLGQNKDLYDLYKQIQKDNLTNEQAQAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFE
NNVLDATMDWLYTTDDEKELKGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
ADNKNFDNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLLQAKKELNELRRFAEDAGLVD
ALQPWDSAYYYEKLKKAKFDFTEEELREYFPLEKVQDGLFKILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSII
CDFFARDNKRGGAWMDGSRTAFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVRQLEFGIFDMNIHYKKLTSAT
EVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGYYSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGS
SRDAMDNFVAFMGRKPNEDALLRHSGIN
>Mature_668_residues
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKISQAFSTISHMNAVCNSKELR
ESYEYTIAKLTDYYTKLGQNKDLYDLYKQIQKDNLTNEQAQAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFE
NNVLDATMDWLYTTDDEKELKGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
ADNKNFDNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLLQAKKELNELRRFAEDAGLVD
ALQPWDSAYYYEKLKKAKFDFTEEELREYFPLEKVQDGLFKILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSII
CDFFARDNKRGGAWMDGSRTAFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVRQLEFGIFDMNIHYKKLTSAT
EVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGYYSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGS
SRDAMDNFVAFMGRKPNEDALLRHSGIN

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=611, Percent_Identity=28.8052373158756, Blast_Score=242, Evalue=1e-63,
Organism=Homo sapiens, GI14149738, Length=614, Percent_Identity=27.1986970684039, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI156105687, Length=640, Percent_Identity=23.4375, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1789913, Length=677, Percent_Identity=43.4268833087149, Blast_Score=576, Evalue=1e-165,
Organism=Escherichia coli, GI1787819, Length=689, Percent_Identity=28.1567489114659, Blast_Score=241, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI71999758, Length=587, Percent_Identity=24.3611584327087, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565901, Length=528, Percent_Identity=22.1590909090909, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319793, Length=644, Percent_Identity=28.5714285714286, Blast_Score=249, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6322715, Length=559, Percent_Identity=23.0769230769231, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356111, Length=577, Percent_Identity=24.7833622183709, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129717, Length=542, Percent_Identity=22.8782287822878, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76570; Mature: 76570

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKI
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCHHHHH
SQAFSTISHMNAVCNSKELRESYEYTIAKLTDYYTKLGQNKDLYDLYKQIQKDNLTNEQA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
QAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFENNVLDATMDWLYTTDDEKEL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
KGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADNKNFDNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QAKKELNELRRFAEDAGLVDALQPWDSAYYYEKLKKAKFDFTEEELREYFPLEKVQDGLF
HHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHH
KILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSIICDFFARDNKRGGAWMDGSRT
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
AFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVR
CCCCCCCHHHHHHHHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLEFGIFDMNIHYKKLTSATEVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGY
HHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
YSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGSSRDAMDNFVAFMGRKPNEDA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCH
LLRHSGIN
HHHCCCCC
>Mature Secondary Structure
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKI
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCHHHHH
SQAFSTISHMNAVCNSKELRESYEYTIAKLTDYYTKLGQNKDLYDLYKQIQKDNLTNEQA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
QAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFENNVLDATMDWLYTTDDEKEL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
KGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADNKNFDNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLL
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QAKKELNELRRFAEDAGLVDALQPWDSAYYYEKLKKAKFDFTEEELREYFPLEKVQDGLF
HHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHH
KILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSIICDFFARDNKRGGAWMDGSRT
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
AFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVR
CCCCCCCHHHHHHHHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLEFGIFDMNIHYKKLTSATEVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGY
HHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
YSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGSSRDAMDNFVAFMGRKPNEDA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCH
LLRHSGIN
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]