Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 89054366

GI number: 89054366

Start: 1864305

End: 1865501

Strand: Reverse

Name: moeA [H]

Synonym: Jann_1875

Alternate gene names: 89054366

Gene position: 1865501-1864305 (Counterclockwise)

Preceding gene: 89054367

Following gene: 89054365

Centisome position: 43.2

GC content: 69.26

Gene sequence:

>1197_bases
ATGATCTCCGTCGAAGATGCCCTGCGCGCGTGCCTGGACCTTGCGGCCCCCGTGGGCTCCGAAACCGTGCCGTTGACCGA
TGCCGGAGGCCGCGTGTTGACTGCGCCCGTCACCGCGATGCGGGATCAGCCGCCGTTCAGCGCCTCGGCCATGGATGGCT
ATGCGGTGCGCGATATGGAAGCGATCCCGGGCCGCCGCCTGAAGATTGTGGGCGAGGCCCCCGCCGGGCATTACTGGCAC
GGGACTATCGGCCCTGGAGAGGCCTTGCGCATCTTCACCGGCGCCCCCCTGCCAGAAGGCACGGACCGCGTGGTGATCCA
GGAGGATGTCACCCGCGACGGCGACCGGATCACGCTGGGGCGCGATCTGGGGTCCGGGCACAATGTGCGGCCCTCCGGCG
CGGATTTCGTCGCGGGCGACGCGATGTTGGCCCCGCGCCGCCTGTCGCCCGCCGATGTGGCGCTGGCCGCCGCGATGAAC
GCGCCCGAATTGACCGTCTCGCGCAAACCTACGGTCGCGCTGATCGCCACGGGCGACGAATTGGTCACGCCGGGCGAAAA
CCCCCGCCCGGATCAGATCATCGCGTCGAACACCTATGGCTTGAAGGCCCGGATCGAAGCGGAGGGGGCCGAGGCCCGCC
TGCTGCCCATCGCCCGCGACCGCCGCGAAAGTCTGGAGCAGGTGCTGGATCTGGCCAAGGGCGCGGATCTGGTCGTCACT
GTGGGCGGCGCATCGGTGGGCGACCACGATCTGGTGGGCGATGTGGCCGCGTCCCGTGGGCTGGACCGCGCGTTTTACAA
AGTCGCCATGCGCCCCGGAAAACCCTTGATGGCCGGGCGTTTGGGGGATGCGGTTCTGCTGGGGCTGCCGGGCAATCCTG
TGTCAGCCATGGTTTGTGGAGAGCTGTTTCTGATCCCCATGCTGCACGCGATGATGGGCCTGCCTGCCGGGCCACGCCCC
CGTCTGCGGGCGCGCTTGGGCGTGGATCTGGACGCCAACGGCCCGCGCGAGCATTACATGCGCGCGGAGGTCACGCCGGA
CGACGACCTGCCGGTGATCACGCCCTATGGCAGCCAGGACAGCTCCCTGCTGACGGTCCTGTCCGGCGCGTCCGGCCTGC
TGGTGCGCCCCGTGGACGAACCGCGGAGCCGGGCGGGTGAGATCGTGGATTACGTGCCCCTCCACGCCATGTTTTGA

Upstream 100 bases:

>100_bases
TGAAAGCGGCGGAGAAGACCATGGAAATCGGCGGCTTGCGCGTGGTTCTGAAAGACGGTGGCAAGTCCGGGCGCTTTGAA
GCGCCGGAAGGATCTGCCCC

Downstream 100 bases:

>100_bases
TGATTCGTTGACAGACAGGCCGGAACAAGCGTAGAACATACCCTGAACGGGCACGGAATGTGTCACACCAATGGGCGCAA
ACCGCCCGGGACTATGTGAG

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MISVEDALRACLDLAAPVGSETVPLTDAGGRVLTAPVTAMRDQPPFSASAMDGYAVRDMEAIPGRRLKIVGEAPAGHYWH
GTIGPGEALRIFTGAPLPEGTDRVVIQEDVTRDGDRITLGRDLGSGHNVRPSGADFVAGDAMLAPRRLSPADVALAAAMN
APELTVSRKPTVALIATGDELVTPGENPRPDQIIASNTYGLKARIEAEGAEARLLPIARDRRESLEQVLDLAKGADLVVT
VGGASVGDHDLVGDVAASRGLDRAFYKVAMRPGKPLMAGRLGDAVLLGLPGNPVSAMVCGELFLIPMLHAMMGLPAGPRP
RLRARLGVDLDANGPREHYMRAEVTPDDDLPVITPYGSQDSSLLTVLSGASGLLVRPVDEPRSRAGEIVDYVPLHAMF

Sequences:

>Translated_398_residues
MISVEDALRACLDLAAPVGSETVPLTDAGGRVLTAPVTAMRDQPPFSASAMDGYAVRDMEAIPGRRLKIVGEAPAGHYWH
GTIGPGEALRIFTGAPLPEGTDRVVIQEDVTRDGDRITLGRDLGSGHNVRPSGADFVAGDAMLAPRRLSPADVALAAAMN
APELTVSRKPTVALIATGDELVTPGENPRPDQIIASNTYGLKARIEAEGAEARLLPIARDRRESLEQVLDLAKGADLVVT
VGGASVGDHDLVGDVAASRGLDRAFYKVAMRPGKPLMAGRLGDAVLLGLPGNPVSAMVCGELFLIPMLHAMMGLPAGPRP
RLRARLGVDLDANGPREHYMRAEVTPDDDLPVITPYGSQDSSLLTVLSGASGLLVRPVDEPRSRAGEIVDYVPLHAMF
>Mature_398_residues
MISVEDALRACLDLAAPVGSETVPLTDAGGRVLTAPVTAMRDQPPFSASAMDGYAVRDMEAIPGRRLKIVGEAPAGHYWH
GTIGPGEALRIFTGAPLPEGTDRVVIQEDVTRDGDRITLGRDLGSGHNVRPSGADFVAGDAMLAPRRLSPADVALAAAMN
APELTVSRKPTVALIATGDELVTPGENPRPDQIIASNTYGLKARIEAEGAEARLLPIARDRRESLEQVLDLAKGADLVVT
VGGASVGDHDLVGDVAASRGLDRAFYKVAMRPGKPLMAGRLGDAVLLGLPGNPVSAMVCGELFLIPMLHAMMGLPAGPRP
RLRARLGVDLDANGPREHYMRAEVTPDDDLPVITPYGSQDSSLLTVLSGASGLLVRPVDEPRSRAGEIVDYVPLHAMF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=413, Percent_Identity=34.3825665859564, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI10880983, Length=413, Percent_Identity=34.3825665859564, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1787049, Length=403, Percent_Identity=34.2431761786601, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25147659, Length=365, Percent_Identity=30.958904109589, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=400, Percent_Identity=24.75, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136978, Length=371, Percent_Identity=30.9973045822102, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24638841, Length=371, Percent_Identity=30.9973045822102, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41846; Mature: 41846

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVEDALRACLDLAAPVGSETVPLTDAGGRVLTAPVTAMRDQPPFSASAMDGYAVRDME
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHHCCCCCCCCCCCCCEEEECHH
AIPGRRLKIVGEAPAGHYWHGTIGPGEALRIFTGAPLPEGTDRVVIQEDVTRDGDRITLG
HCCCCEEEEEECCCCCCEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEE
RDLGSGHNVRPSGADFVAGDAMLAPRRLSPADVALAAAMNAPELTVSRKPTVALIATGDE
CCCCCCCCCCCCCCCEEECCCEECCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEECCCC
LVTPGENPRPDQIIASNTYGLKARIEAEGAEARLLPIARDRRESLEQVLDLAKGADLVVT
EECCCCCCCCCCEEECCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEE
VGGASVGDHDLVGDVAASRGLDRAFYKVAMRPGKPLMAGRLGDAVLLGLPGNPVSAMVCG
ECCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCCEEEEECCCCCHHHHHHH
ELFLIPMLHAMMGLPAGPRPRLRARLGVDLDANGPREHYMRAEVTPDDDLPVITPYGSQD
HHHHHHHHHHHHCCCCCCCCCEEEEECCEECCCCCHHHCEEEECCCCCCCCEECCCCCCC
SSLLTVLSGASGLLVRPVDEPRSRAGEIVDYVPLHAMF
CCEEEEECCCCCEEEECCCCHHHHHCCEEEECCCEECC
>Mature Secondary Structure
MISVEDALRACLDLAAPVGSETVPLTDAGGRVLTAPVTAMRDQPPFSASAMDGYAVRDME
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHHCCCCCCCCCCCCCEEEECHH
AIPGRRLKIVGEAPAGHYWHGTIGPGEALRIFTGAPLPEGTDRVVIQEDVTRDGDRITLG
HCCCCEEEEEECCCCCCEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEE
RDLGSGHNVRPSGADFVAGDAMLAPRRLSPADVALAAAMNAPELTVSRKPTVALIATGDE
CCCCCCCCCCCCCCCEEECCCEECCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEECCCC
LVTPGENPRPDQIIASNTYGLKARIEAEGAEARLLPIARDRRESLEQVLDLAKGADLVVT
EECCCCCCCCCCEEECCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEE
VGGASVGDHDLVGDVAASRGLDRAFYKVAMRPGKPLMAGRLGDAVLLGLPGNPVSAMVCG
ECCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCCEEEEECCCCCHHHHHHH
ELFLIPMLHAMMGLPAGPRPRLRARLGVDLDANGPREHYMRAEVTPDDDLPVITPYGSQD
HHHHHHHHHHHHCCCCCCCCCEEEEECCEECCCCCHHHCEEEECCCCCCCCEECCCCCCC
SSLLTVLSGASGLLVRPVDEPRSRAGEIVDYVPLHAMF
CCEEEEECCCCCEEEECCCCHHHHHCCEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]