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The map label for this gene is hisD1 [H]

Identifier: 89053889

GI number: 89053889

Start: 1368157

End: 1369464

Strand: Direct

Name: hisD1 [H]

Synonym: Jann_1398

Alternate gene names: 89053889

Gene position: 1368157-1369464 (Clockwise)

Preceding gene: 89053887

Following gene: 89053890

Centisome position: 31.69

GC content: 63.07

Gene sequence:

>1308_bases
ATGACAAGAGAGTACCTCAAGAAAGCGCCACTGACCTCCGCCTCCGATGCGTCGGATGTGCAGGAAACCGTGCGCACGAT
CCTTGCCGATATCGAGGCGGGCGGTGACGACAAGGCCCGCGAATATGCGGCAAAGTTCGACAAGTATGAGGGCAACATCA
TCCTGACTGCCGAAGAGATCGAGGCCGCAAGCGCGCTGGTTCCCGATAAGCTGAAGGCCGACATCCAGTTCGCTCATGAC
AACGTCCGACGGTTCGCAGAGGCCCAGAAGGCCACCGTCAGTGACGTGGAGGTTGAGATCGTGCCGGGCCTGATCGCCGG
GCAGAAAGCCATCCCCGTCGATGCGGCGGGCTGCTACGTGCCCGGGGGTCGCTACAGCCACATCGCGTCCGCCATCATGA
CGGTGACAACAGCGAAGGTGGCGGGCTGCAACCACATCATCGCAACCTCGCCACCCCGCCCCGGCGTTGGCGTGGCGCCC
GCGATTGTCTACGCGGCCCATATTTGCGGCGCGGACACGATCATGGCGTTAGGTGGCGTGCAGGGCATCGCGGCGATGAC
CTTCGGCCTTTTCGGTCTGCCAAAGGCGAACATCCTCGTGGGCCCCGGCAACCAGTTCGTGGCGGAAGCCAAGCGCCATC
TCTTTGGCCGTGTGGGCATCGACATGATCGCAGGTCCGACGGATAGTCTGATCCTGGCCGACAAGACCGCTGATCCCCAT
GTCGTCGCGACAGACCTCGTGAGCCAGGCCGAGCATGGCTACAACTCGCCGGTCTGGCTGGTCACGGACAGCAAGGACCT
GGCTGAGGATGTGATGGCCCGCATTCCCGCGCTGATTGATGATCTGCCTGAGACCAACCGCGAAAACGCAGCTGCCGCGT
GGCGCGATTATGCCGAGGTCATCGTCTGTGCGGACCGCGAAGACATGGCGGCCTGCTCCGACGAGTACGCGCCCGAGCAC
CTGACGGTGCAGGCCGAGGATCTGGCGTGGTGGAAGGGGCGGCTCAGTTGCTATGGCTCGCTGTTTCTGGGCGAAGAGAC
GACCGTGTCTTATGGCGACAAGGCGGCGGGGACAAACCACGTTCTGCCAACATCGGGTGCGGCCAGCTACACAGGCGGGC
TTTCGGTCCATAAATACATGAAGATCGTCACCTGGCAGCAGGCGACGCGCGAAGGCTCCAAGGATGTGGCGATTGCCACG
GCGCGGATCTCTCGTCTGGAAGGGATGGAGGGGCACGCCCGGTCTGCGGATGTGCGGCTGGCCAAGTATTTCCCCGGCGA
GAACTTTGACCTCAGCGCCGATGGTTGA

Upstream 100 bases:

>100_bases
AGGGCTTACACACACGTTAACGGAATCGCGCATCGCGGGCTCAGGCCGCCGGGGTGTGTTGCTTCACCTGCCTTTTGAGC
CACCGATAGGACCGCCCCAG

Downstream 100 bases:

>100_bases
TGCCGGCGCGCTCTTTGATCTGCGCGGCCGGGTGGCTTGCGTCACCGGGGCCTCCGCGGGTCTGGGGCAGCGCGCGGCTG
AGGTCTTGGCGGATGCCGGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTREYLKKAPLTSASDASDVQETVRTILADIEAGGDDKAREYAAKFDKYEGNIILTAEEIEAASALVPDKLKADIQFAHD
NVRRFAEAQKATVSDVEVEIVPGLIAGQKAIPVDAAGCYVPGGRYSHIASAIMTVTTAKVAGCNHIIATSPPRPGVGVAP
AIVYAAHICGADTIMALGGVQGIAAMTFGLFGLPKANILVGPGNQFVAEAKRHLFGRVGIDMIAGPTDSLILADKTADPH
VVATDLVSQAEHGYNSPVWLVTDSKDLAEDVMARIPALIDDLPETNRENAAAAWRDYAEVIVCADREDMAACSDEYAPEH
LTVQAEDLAWWKGRLSCYGSLFLGEETTVSYGDKAAGTNHVLPTSGAASYTGGLSVHKYMKIVTWQQATREGSKDVAIAT
ARISRLEGMEGHARSADVRLAKYFPGENFDLSADG

Sequences:

>Translated_435_residues
MTREYLKKAPLTSASDASDVQETVRTILADIEAGGDDKAREYAAKFDKYEGNIILTAEEIEAASALVPDKLKADIQFAHD
NVRRFAEAQKATVSDVEVEIVPGLIAGQKAIPVDAAGCYVPGGRYSHIASAIMTVTTAKVAGCNHIIATSPPRPGVGVAP
AIVYAAHICGADTIMALGGVQGIAAMTFGLFGLPKANILVGPGNQFVAEAKRHLFGRVGIDMIAGPTDSLILADKTADPH
VVATDLVSQAEHGYNSPVWLVTDSKDLAEDVMARIPALIDDLPETNRENAAAAWRDYAEVIVCADREDMAACSDEYAPEH
LTVQAEDLAWWKGRLSCYGSLFLGEETTVSYGDKAAGTNHVLPTSGAASYTGGLSVHKYMKIVTWQQATREGSKDVAIAT
ARISRLEGMEGHARSADVRLAKYFPGENFDLSADG
>Mature_434_residues
TREYLKKAPLTSASDASDVQETVRTILADIEAGGDDKAREYAAKFDKYEGNIILTAEEIEAASALVPDKLKADIQFAHDN
VRRFAEAQKATVSDVEVEIVPGLIAGQKAIPVDAAGCYVPGGRYSHIASAIMTVTTAKVAGCNHIIATSPPRPGVGVAPA
IVYAAHICGADTIMALGGVQGIAAMTFGLFGLPKANILVGPGNQFVAEAKRHLFGRVGIDMIAGPTDSLILADKTADPHV
VATDLVSQAEHGYNSPVWLVTDSKDLAEDVMARIPALIDDLPETNRENAAAAWRDYAEVIVCADREDMAACSDEYAPEHL
TVQAEDLAWWKGRLSCYGSLFLGEETTVSYGDKAAGTNHVLPTSGAASYTGGLSVHKYMKIVTWQQATREGSKDVAIATA
RISRLEGMEGHARSADVRLAKYFPGENFDLSADG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=422, Percent_Identity=37.2037914691943, Blast_Score=261, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6319819, Length=424, Percent_Identity=33.7264150943396, Blast_Score=231, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46207; Mature: 46076

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREYLKKAPLTSASDASDVQETVRTILADIEAGGDDKAREYAAKFDKYEGNIILTAEEI
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEHHHH
EAASALVPDKLKADIQFAHDNVRRFAEAQKATVSDVEVEIVPGLIAGQKAIPVDAAGCYV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCC
PGGRYSHIASAIMTVTTAKVAGCNHIIATSPPRPGVGVAPAIVYAAHICGADTIMALGGV
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCH
QGIAAMTFGLFGLPKANILVGPGNQFVAEAKRHLFGRVGIDMIAGPTDSLILADKTADPH
HHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCCC
VVATDLVSQAEHGYNSPVWLVTDSKDLAEDVMARIPALIDDLPETNRENAAAAWRDYAEV
CHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEE
IVCADREDMAACSDEYAPEHLTVQAEDLAWWKGRLSCYGSLFLGEETTVSYGDKAAGTNH
EEECCCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHEEEEEEECCCCEECCCCCCCCCCC
VLPTSGAASYTGGLSVHKYMKIVTWQQATREGSKDVAIATARISRLEGMEGHARSADVRL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCCCCEEE
AKYFPGENFDLSADG
EEECCCCCCCCCCCC
>Mature Secondary Structure 
TREYLKKAPLTSASDASDVQETVRTILADIEAGGDDKAREYAAKFDKYEGNIILTAEEI
CHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEHHHH
EAASALVPDKLKADIQFAHDNVRRFAEAQKATVSDVEVEIVPGLIAGQKAIPVDAAGCYV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCC
PGGRYSHIASAIMTVTTAKVAGCNHIIATSPPRPGVGVAPAIVYAAHICGADTIMALGGV
CCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCH
QGIAAMTFGLFGLPKANILVGPGNQFVAEAKRHLFGRVGIDMIAGPTDSLILADKTADPH
HHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCCC
VVATDLVSQAEHGYNSPVWLVTDSKDLAEDVMARIPALIDDLPETNRENAAAAWRDYAEV
CHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEE
IVCADREDMAACSDEYAPEHLTVQAEDLAWWKGRLSCYGSLFLGEETTVSYGDKAAGTNH
EEECCCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHEEEEEEECCCCEECCCCCCCCCCC
VLPTSGAASYTGGLSVHKYMKIVTWQQATREGSKDVAIATARISRLEGMEGHARSADVRL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCCCCEEE
AKYFPGENFDLSADG
EEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA