BacMap

Definition	Jannaschia sp. CCS1 chromosome, complete genome.
Accession	NC_007802
Length	4,317,977

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The map label for this gene is kduD [H]

Identifier: 89053890

GI number: 89053890

Start: 1369457

End: 1370218

Strand: Direct

Name: kduD [H]

Synonym: Jann_1399

Alternate gene names: 89053890

Gene position: 1369457-1370218 (Clockwise)

Preceding gene: 89053889

Following gene: 89053891

Centisome position: 31.72

GC content: 67.98

Gene sequence:

>762_bases
ATGGTTGATGCCGGCGCGCTCTTTGATCTGCGCGGCCGGGTGGCTTGCGTCACCGGGGCCTCCGCGGGTCTGGGGCAGCG
CGCGGCTGAGGTCTTGGCGGATGCCGGGGCGCGCGTCGTGGGGGTGGCCCGCCGCGCCGACGCCCTGGCCGAGTGGGTGG
AGCGTATGGGCAAACCTGCGGCAGCCGTGGCTGCTGACCTCTCGGACAGGGGCGCGATTCCGCAGATCGCCGAAGACATC
TGCGGCCCGTTTGGCGCGCCTGACATTGTAGTCCATGCTGCGGGCATCAACACGCGCGAGACGGCGGATGATGTGACTGG
CGATGGTTGGGATGTCACACTGAACCTGAACCTCGCAGCGCCCTTCTTTCTGACCCAGGCGCTGGTGCCTGCGATGAAGG
CCCGGGGATGGGGCCGCGTGGTGAGCTTCGCATCGCTGCAGACGAGCCGTGCCTTTCCCGGCGGCGTTGCCTACGGCGCG
TCCAAGGCTGGCATCGCGCAGCTGACCCGCGCCATGGCCGAGGCCTGGTCGCGCGACGGGATCAACGCCAACGCAATCGG
TCCGGGTTTTTTCCCGACCGAGCTGACCGGCCCTGTCTTCGCCGACCCCGAGCGCGCAGCGCGCAACGCCGCGCAGACCT
GTGTGGGCCGCAATGGCGCGATGGAAGATATCGACGGGCCGCTTCTGTTCCTGTGCTCAGACGCCTCCTCATTTGTCACG
GGCCAAGTTCTGATGGTCGACGGGGGGTATACGGCGAAATGA

Upstream 100 bases:

>100_bases
GCGCGGATCTCTCGTCTGGAAGGGATGGAGGGGCACGCCCGGTCTGCGGATGTGCGGCTGGCCAAGTATTTCCCCGGCGA
GAACTTTGACCTCAGCGCCG

Downstream 100 bases:

>100_bases
AAGCGCTTGTGTACGACGGTCCTGAACAATTGGGTTTCCGCGATGTCGCCGATGCGGTCGCAGGCCCCGGCCAACACTTG
ATCAAGGTCCTGTCCGTGGG

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MVDAGALFDLRGRVACVTGASAGLGQRAAEVLADAGARVVGVARRADALAEWVERMGKPAAAVAADLSDRGAIPQIAEDI
CGPFGAPDIVVHAAGINTRETADDVTGDGWDVTLNLNLAAPFFLTQALVPAMKARGWGRVVSFASLQTSRAFPGGVAYGA
SKAGIAQLTRAMAEAWSRDGINANAIGPGFFPTELTGPVFADPERAARNAAQTCVGRNGAMEDIDGPLLFLCSDASSFVT
GQVLMVDGGYTAK

Sequences:

>Translated_253_residues
MVDAGALFDLRGRVACVTGASAGLGQRAAEVLADAGARVVGVARRADALAEWVERMGKPAAAVAADLSDRGAIPQIAEDI
CGPFGAPDIVVHAAGINTRETADDVTGDGWDVTLNLNLAAPFFLTQALVPAMKARGWGRVVSFASLQTSRAFPGGVAYGA
SKAGIAQLTRAMAEAWSRDGINANAIGPGFFPTELTGPVFADPERAARNAAQTCVGRNGAMEDIDGPLLFLCSDASSFVT
GQVLMVDGGYTAK
>Mature_253_residues
MVDAGALFDLRGRVACVTGASAGLGQRAAEVLADAGARVVGVARRADALAEWVERMGKPAAAVAADLSDRGAIPQIAEDI
CGPFGAPDIVVHAAGINTRETADDVTGDGWDVTLNLNLAAPFFLTQALVPAMKARGWGRVVSFASLQTSRAFPGGVAYGA
SKAGIAQLTRAMAEAWSRDGINANAIGPGFFPTELTGPVFADPERAARNAAQTCVGRNGAMEDIDGPLLFLCSDASSFVT
GQVLMVDGGYTAK

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=30.241935483871, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI20149619, Length=219, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=31.8897637795276, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7705925, Length=242, Percent_Identity=30.5785123966942, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=26.6932270916335, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=26.6932270916335, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66933014, Length=248, Percent_Identity=28.6290322580645, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=29.296875, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI109715829, Length=248, Percent_Identity=27.8225806451613, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4503301, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI157739938, Length=200, Percent_Identity=25.5, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4504505, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=28.7958115183246, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=24.8995983935743, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI31542939, Length=199, Percent_Identity=30.1507537688442, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI59889578, Length=224, Percent_Identity=27.2321428571429, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI126723191, Length=184, Percent_Identity=29.8913043478261, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=37.8486055776892, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=31.404958677686, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=31.3253012048193, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=31.7073170731707, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=31.4741035856574, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=32.0987654320988, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=29.1497975708502, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=26.5873015873016, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=28.4552845528455, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787820, Length=204, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=29.7619047619048, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=27.9835390946502, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=30.078125, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=30.0813008130081, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=28.2258064516129, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=26.530612244898, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=31.1284046692607, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=29.7520661157025, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=29.8387096774194, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=29.2682926829268, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=28.1124497991968, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=26.3565891472868, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=29.6577946768061, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=258, Percent_Identity=29.8449612403101, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=261, Percent_Identity=28.735632183908, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=28.6245353159851, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=28.957528957529, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=26.6932270916335, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=28.6792452830189, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=27.4131274131274, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=26.7175572519084, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=258, Percent_Identity=27.5193798449612, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=262, Percent_Identity=28.6259541984733, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=29.0697674418605, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=189, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=255, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=29.3193717277487, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=257, Percent_Identity=25.2918287937743, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=259, Percent_Identity=26.2548262548263, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=27.8947368421053, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=198, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=213, Percent_Identity=27.6995305164319, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=26.6129032258064, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=32.2709163346614, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=30.6122448979592, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=32.6530612244898, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.952380952381, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=30.0395256916996, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=32.6612903225806, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=31.1881188118812, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24644337, Length=250, Percent_Identity=31.6, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=32.2751322751323, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24647946, Length=268, Percent_Identity=23.134328358209, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553409, Length=257, Percent_Identity=22.9571984435798, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647948, Length=257, Percent_Identity=22.9571984435798, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357673, Length=200, Percent_Identity=26, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221331216, Length=199, Percent_Identity=31.1557788944724, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24665247, Length=201, Percent_Identity=30.8457711442786, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 25924; Mature: 25924

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDAGALFDLRGRVACVTGASAGLGQRAAEVLADAGARVVGVARRADALAEWVERMGKPA
CCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCH
AAVAADLSDRGAIPQIAEDICGPFGAPDIVVHAAGINTRETADDVTGDGWDVTLNLNLAA
HHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
PFFLTQALVPAMKARGWGRVVSFASLQTSRAFPGGVAYGASKAGIAQLTRAMAEAWSRDG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
INANAIGPGFFPTELTGPVFADPERAARNAAQTCVGRNGAMEDIDGPLLFLCSDASSFVT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHC
GQVLMVDGGYTAK
CEEEEECCCCCCC
>Mature Secondary Structure
MVDAGALFDLRGRVACVTGASAGLGQRAAEVLADAGARVVGVARRADALAEWVERMGKPA
CCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCH
AAVAADLSDRGAIPQIAEDICGPFGAPDIVVHAAGINTRETADDVTGDGWDVTLNLNLAA
HHHHHCCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEECCCC
PFFLTQALVPAMKARGWGRVVSFASLQTSRAFPGGVAYGASKAGIAQLTRAMAEAWSRDG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
INANAIGPGFFPTELTGPVFADPERAARNAAQTCVGRNGAMEDIDGPLLFLCSDASSFVT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHC
GQVLMVDGGYTAK
CEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 2836407; 1766386 [H]