Click here to switch to the map view.

The map label for this gene is nqo2 [H]

Identifier: 89053667

GI number: 89053667

Start: 1139598

End: 1140785

Strand: Direct

Name: nqo2 [H]

Synonym: Jann_1176

Alternate gene names: 89053667

Gene position: 1139598-1140785 (Clockwise)

Preceding gene: 89053666

Following gene: 89053668

Centisome position: 26.39

GC content: 66.67

Gene sequence:

>1188_bases
ATGCTGCGACGCCTCCACCCCGAGCAACCCGATAGCTTTGCCTTCACGTCTGACAATCAGGCCTGGGCGGAGGCTCAGAT
CACAAAATATCCCGAGGGGCGTGCGGCATCCGCGATCATTCCGCTGCTGTGGCGCGCGCAGGAGCAGGAGGGGTGGCTGA
CGCGCCCCGCCATCGAAGGCGTGGCCGACATGCTGGGTCTGGCGCATATTCGCGCGTTGGAAGTGGCGACGTTCTACTTC
ATGTTTCAACTGCAACCGGTGGGGGCGGTCGCCCATATCCAGATCTGCGGGACGCTGTCGTGCATGATCTGCGGGGCCGA
GGATCTGGTGGCTGTGGCACGCGAAAAGATCGCCGCGAACCCGCATCAGATCAGCGCCGACGGCAAATTTTCGTGGGAAG
AGGTCGAGTGTCTGGGGGCGTGTTCCAACGCGCCGATGGCCCAGATCGGCAAGGATTACTACGAGGATCTGACGGCGGAG
AGTTTCGCCGGGATCATCGACGCGATGGCGCGCGGCGAAGTGCCGACGCCCGGACCGCAGACTGAGCGCTACGCATCTGA
GCCTGCGGGCGGGCTGACCTCGTTGACAGAGCATGCGGCCGGGCGGGACGAGCTGAACATCTCGGCGCGGATGGCCACCG
ACATCGGCGATACGATCAAGCGGATTGACGGGACGGAAGTGCCGCTGCTGGCGCCTTGGGGTCGCCAATCGGGCGAAGGC
GTGCCGGACGAGCCTAAACGTCCGAAGCCCGCGAACCGGGCCGAGGGACGGCCCGCCGACGAGACCGGCGTGACCAAACA
GGCAGCCCCCGCCAAGGAAAAGGCCCGCCCGAAACCCAGCGCGCCACCGGCTAAGGGCAATCCGTCGCCCGCGCCCAAGG
GCGACCACGCCGCCGCAGGGTCCGCGCCCGAGACGACCGGCTCGCCAAAGGTGAGCGATGTGGCTGAGCAGGAACCGGAG
CTGTTGAATACTGCGCGGGACGGCGGGGCCGATGACCTCAAGCGCATCACCGGCGTGGGGCCGAAGCTGGAGGGCGTGCT
GAACGACCTCGGTTTCTACCACTTCGATCAGATCGCGGCCTGGGGCCCGGCAGAGATTGCCTGGGTTGACGCGCGCCTCA
AGTTCAAGGGCCGGATCGAGCGGGATGACTGGGTCGGCCAGGCCGCCGGTTTCGCCGCGGAAGACTAG

Upstream 100 bases:

>100_bases
AGGGGGTCACCGTCTCTGCGCCTGCGCCATAGCGCGCATGGACATCCGCCCGCGTTTGCGCGAAACCTCCCGCGACAGTT
GAACGCCAGGGACGACAAAG

Downstream 100 bases:

>100_bases
GCTCGCCCGCCCGGTGTGGTGCCGGGTCCACAGGCCCTGCGGCAAAATGTCAACTCGGTGGAAGACATGGGCGGCGTCGT
GCGCTAATGTCGCAGGCAAC

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLRRLHPEQPDSFAFTSDNQAWAEAQITKYPEGRAASAIIPLLWRAQEQEGWLTRPAIEGVADMLGLAHIRALEVATFYF
MFQLQPVGAVAHIQICGTLSCMICGAEDLVAVAREKIAANPHQISADGKFSWEEVECLGACSNAPMAQIGKDYYEDLTAE
SFAGIIDAMARGEVPTPGPQTERYASEPAGGLTSLTEHAAGRDELNISARMATDIGDTIKRIDGTEVPLLAPWGRQSGEG
VPDEPKRPKPANRAEGRPADETGVTKQAAPAKEKARPKPSAPPAKGNPSPAPKGDHAAAGSAPETTGSPKVSDVAEQEPE
LLNTARDGGADDLKRITGVGPKLEGVLNDLGFYHFDQIAAWGPAEIAWVDARLKFKGRIERDDWVGQAAGFAAED

Sequences:

>Translated_395_residues
MLRRLHPEQPDSFAFTSDNQAWAEAQITKYPEGRAASAIIPLLWRAQEQEGWLTRPAIEGVADMLGLAHIRALEVATFYF
MFQLQPVGAVAHIQICGTLSCMICGAEDLVAVAREKIAANPHQISADGKFSWEEVECLGACSNAPMAQIGKDYYEDLTAE
SFAGIIDAMARGEVPTPGPQTERYASEPAGGLTSLTEHAAGRDELNISARMATDIGDTIKRIDGTEVPLLAPWGRQSGEG
VPDEPKRPKPANRAEGRPADETGVTKQAAPAKEKARPKPSAPPAKGNPSPAPKGDHAAAGSAPETTGSPKVSDVAEQEPE
LLNTARDGGADDLKRITGVGPKLEGVLNDLGFYHFDQIAAWGPAEIAWVDARLKFKGRIERDDWVGQAAGFAAED
>Mature_395_residues
MLRRLHPEQPDSFAFTSDNQAWAEAQITKYPEGRAASAIIPLLWRAQEQEGWLTRPAIEGVADMLGLAHIRALEVATFYF
MFQLQPVGAVAHIQICGTLSCMICGAEDLVAVAREKIAANPHQISADGKFSWEEVECLGACSNAPMAQIGKDYYEDLTAE
SFAGIIDAMARGEVPTPGPQTERYASEPAGGLTSLTEHAAGRDELNISARMATDIGDTIKRIDGTEVPLLAPWGRQSGEG
VPDEPKRPKPANRAEGRPADETGVTKQAAPAKEKARPKPSAPPAKGNPSPAPKGDHAAAGSAPETTGSPKVSDVAEQEPE
LLNTARDGGADDLKRITGVGPKLEGVLNDLGFYHFDQIAAWGPAEIAWVDARLKFKGRIERDDWVGQAAGFAAED

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=203, Percent_Identity=45.320197044335, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1788621, Length=159, Percent_Identity=32.0754716981132, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561328, Length=185, Percent_Identity=48.1081081081081, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI18859877, Length=189, Percent_Identity=43.9153439153439, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21355353, Length=184, Percent_Identity=35.3260869565217, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 42191; Mature: 42191

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRLHPEQPDSFAFTSDNQAWAEAQITKYPEGRAASAIIPLLWRAQEQEGWLTRPAIEG
CCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
VADMLGLAHIRALEVATFYFMFQLQPVGAVAHIQICGTLSCMICGAEDLVAVAREKIAAN
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCHHHEEECHHHHHHHHHHHHCCC
PHQISADGKFSWEEVECLGACSNAPMAQIGKDYYEDLTAESFAGIIDAMARGEVPTPGPQ
CCEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TERYASEPAGGLTSLTEHAAGRDELNISARMATDIGDTIKRIDGTEVPLLAPWGRQSGEG
CHHHHCCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCEECCCCCCCCCC
VPDEPKRPKPANRAEGRPADETGVTKQAAPAKEKARPKPSAPPAKGNPSPAPKGDHAAAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
SAPETTGSPKVSDVAEQEPELLNTARDGGADDLKRITGVGPKLEGVLNDLGFYHFDQIAA
CCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHC
WGPAEIAWVDARLKFKGRIERDDWVGQAAGFAAED
CCCCEEEEEEEEEEECCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MLRRLHPEQPDSFAFTSDNQAWAEAQITKYPEGRAASAIIPLLWRAQEQEGWLTRPAIEG
CCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
VADMLGLAHIRALEVATFYFMFQLQPVGAVAHIQICGTLSCMICGAEDLVAVAREKIAAN
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCHHHEEECHHHHHHHHHHHHCCC
PHQISADGKFSWEEVECLGACSNAPMAQIGKDYYEDLTAESFAGIIDAMARGEVPTPGPQ
CCEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TERYASEPAGGLTSLTEHAAGRDELNISARMATDIGDTIKRIDGTEVPLLAPWGRQSGEG
CHHHHCCCCCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCEECCCCCCCCCC
VPDEPKRPKPANRAEGRPADETGVTKQAAPAKEKARPKPSAPPAKGNPSPAPKGDHAAAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
SAPETTGSPKVSDVAEQEPELLNTARDGGADDLKRITGVGPKLEGVLNDLGFYHFDQIAA
CCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHC
WGPAEIAWVDARLKFKGRIERDDWVGQAAGFAAED
CCCCEEEEEEEEEEECCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]