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The map label for this gene is 89053605

Identifier: 89053605

GI number: 89053605

Start: 1073344

End: 1074471

Strand: Direct

Name: 89053605

Synonym: Jann_1114

Alternate gene names: NA

Gene position: 1073344-1074471 (Clockwise)

Preceding gene: 89053604

Following gene: 89053608

Centisome position: 24.86

GC content: 62.94

Gene sequence:

>1128_bases
ATGATCAAAACAACCCATGTGGGCAGCCTGCCGCGCACCCAGGACGTCGTGGACTTCATCTTTGCCCGGGAAAATGGCGA
GACCTATGACGCGGCCGCCTTCGACGCGGCGATGATGGCGGCGGTGGATGACACCGTGGCCAAACAGGTCGCAGCGGGCG
TTGATGTCGTGTCCGATGGGGAGACGTCGAAAATCTCCTACGCGACCTACGTCAAGGATCGATATACCGGGTTCTCCGGC
GACAGCCCGCGCAATGCGCCTGCGGACCTGAAGAAATTCCCGTCGTTCCTGAAGCGTCTGGCCGATGATGGTGGCACGCC
GCAATACGCGCGGCCCATGTGCACCGGAGAGGTGCGGAGCAAGGGGCAGGGGGAGTTGGGCAAGGACATCGCCAACCTCA
AGGCCGCGATGGCCAAACATGGCGCGGAGGAGGGGTTCATGAATGCGGCCTCTCCGGGTGTGATTTCGCTGTTCCTACAG
AACGATTTCTACCCGACGCGGGACGCCTATCTGGCCGCGCTGGCGGACGCGATGGCCGAGGAATATCGGACCATCGTCGA
CGCCGGCCTGCTGTTGCAACTGGATTGCCCCGACCTCGCGCTGTCGCGGCACATGTTGTTCAATGAACTGTCGGATGCGG
AGTTTCTGAAGATCGCCGCCTCCCATGTGGAAGCGTTGAACCATGCGCTGTCGGGGATCGACCCGTCCCGCGTGCGGGTC
CACATCTGCTGGGGTAATTACGAGGGGCCCCATGTCTGCGACGTGCCGATGGACACGGTGTTCACCACCTTCATGGGGGT
CGGCGCGAGCCAGCTGTTGTTCGAGACGTCCAACCCCCGCCATGCCCACGAATGGACCGTCTTCCGTGACCGCGCGGCAG
AGATCCCGGACGACAAGATCCTGGTGCCCGGCGTGGTCGATACCACCACCAATTTCGTGGAGCATCCCGAACTGGTCGCC
GAGCGGATCGCCAAGTTTACCGGCATTGTGGGGGCCGACCGGGTGATTGCGGGAAGCGATTGCGGCTTTGGCACTTTCGC
GGGGTTTGGCGCGGTGGATCCGACGATTGCCTATGCGAAACTGGAGGCGCTGTCCCAAGGCGTCGCTCTGGCGAATGGGC
GGGGATAG

Upstream 100 bases:

>100_bases
TCTGATGGCCAGCACGCTGTTTGGCTGTGCGGACGGCGCATGCGACACGCCATTTTATTGGGACGGAACCCAATTCACAC
AATAAAAACTGAGGGACACA

Downstream 100 bases:

>100_bases
TGCCAGATTTAGGCAAGTAAGCTGTGGATAACGCTGTGGAAGGATCGCAAAAGCGATAGGTCTATTGGCGCCCCGCATCC
CGTGGCAGCACCTGCGGCGA

Product: methionine synthase, vitamin-B12 independent

Products: tetrahydropteroyltri-L-glutamate; L-methionine

Alternate protein names: Methionine Synthase II; Methionine Synthase II- Like Protein; EpoxyalkaneCo M Transferase; Methyltransferase; Methionine Synthase Vitamin-B12 Independent Protein

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MIKTTHVGSLPRTQDVVDFIFARENGETYDAAAFDAAMMAAVDDTVAKQVAAGVDVVSDGETSKISYATYVKDRYTGFSG
DSPRNAPADLKKFPSFLKRLADDGGTPQYARPMCTGEVRSKGQGELGKDIANLKAAMAKHGAEEGFMNAASPGVISLFLQ
NDFYPTRDAYLAALADAMAEEYRTIVDAGLLLQLDCPDLALSRHMLFNELSDAEFLKIAASHVEALNHALSGIDPSRVRV
HICWGNYEGPHVCDVPMDTVFTTFMGVGASQLLFETSNPRHAHEWTVFRDRAAEIPDDKILVPGVVDTTTNFVEHPELVA
ERIAKFTGIVGADRVIAGSDCGFGTFAGFGAVDPTIAYAKLEALSQGVALANGRG

Sequences:

>Translated_375_residues
MIKTTHVGSLPRTQDVVDFIFARENGETYDAAAFDAAMMAAVDDTVAKQVAAGVDVVSDGETSKISYATYVKDRYTGFSG
DSPRNAPADLKKFPSFLKRLADDGGTPQYARPMCTGEVRSKGQGELGKDIANLKAAMAKHGAEEGFMNAASPGVISLFLQ
NDFYPTRDAYLAALADAMAEEYRTIVDAGLLLQLDCPDLALSRHMLFNELSDAEFLKIAASHVEALNHALSGIDPSRVRV
HICWGNYEGPHVCDVPMDTVFTTFMGVGASQLLFETSNPRHAHEWTVFRDRAAEIPDDKILVPGVVDTTTNFVEHPELVA
ERIAKFTGIVGADRVIAGSDCGFGTFAGFGAVDPTIAYAKLEALSQGVALANGRG
>Mature_375_residues
MIKTTHVGSLPRTQDVVDFIFARENGETYDAAAFDAAMMAAVDDTVAKQVAAGVDVVSDGETSKISYATYVKDRYTGFSG
DSPRNAPADLKKFPSFLKRLADDGGTPQYARPMCTGEVRSKGQGELGKDIANLKAAMAKHGAEEGFMNAASPGVISLFLQ
NDFYPTRDAYLAALADAMAEEYRTIVDAGLLLQLDCPDLALSRHMLFNELSDAEFLKIAASHVEALNHALSGIDPSRVRV
HICWGNYEGPHVCDVPMDTVFTTFMGVGASQLLFETSNPRHAHEWTVFRDRAAEIPDDKILVPGVVDTTTNFVEHPELVA
ERIAKFTGIVGADRVIAGSDCGFGTFAGFGAVDPTIAYAKLEALSQGVALANGRG

Specific function: Unknown

COG id: COG0620

COG function: function code E; Methionine synthase II (cobalamin-independent)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.14

Molecular weight: Translated: 40251; Mature: 40251

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTTHVGSLPRTQDVVDFIFARENGETYDAAAFDAAMMAAVDDTVAKQVAAGVDVVSDG
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
ETSKISYATYVKDRYTGFSGDSPRNAPADLKKFPSFLKRLADDGGTPQYARPMCTGEVRS
CCCEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHC
KGQGELGKDIANLKAAMAKHGAEEGFMNAASPGVISLFLQNDFYPTRDAYLAALADAMAE
CCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
EYRTIVDAGLLLQLDCPDLALSRHMLFNELSDAEFLKIAASHVEALNHALSGIDPSRVRV
HHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
HICWGNYEGPHVCDVPMDTVFTTFMGVGASQLLFETSNPRHAHEWTVFRDRAAEIPDDKI
EEEECCCCCCEEECCCHHHHHHHHHHCCHHHHEEECCCCCCCHHHHHHHHHHCCCCCCCE
LVPGVVDTTTNFVEHPELVAERIAKFTGIVGADRVIAGSDCGFGTFAGFGAVDPTIAYAK
EECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHCCCCCCCHHHHHHH
LEALSQGVALANGRG
HHHHHCCCCCCCCCC
>Mature Secondary Structure
MIKTTHVGSLPRTQDVVDFIFARENGETYDAAAFDAAMMAAVDDTVAKQVAAGVDVVSDG
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
ETSKISYATYVKDRYTGFSGDSPRNAPADLKKFPSFLKRLADDGGTPQYARPMCTGEVRS
CCCEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHC
KGQGELGKDIANLKAAMAKHGAEEGFMNAASPGVISLFLQNDFYPTRDAYLAALADAMAE
CCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
EYRTIVDAGLLLQLDCPDLALSRHMLFNELSDAEFLKIAASHVEALNHALSGIDPSRVRV
HHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
HICWGNYEGPHVCDVPMDTVFTTFMGVGASQLLFETSNPRHAHEWTVFRDRAAEIPDDKI
EEEECCCCCCEEECCCHHHHHHHHHHCCHHHHEEECCCCCCCHHHHHHHHHHCCCCCCCE
LVPGVVDTTTNFVEHPELVAERIAKFTGIVGADRVIAGSDCGFGTFAGFGAVDPTIAYAK
EECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHCCCCCCCHHHHHHH
LEALSQGVALANGRG
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-methyltetrahydropteroyltri-L-glutamate; L-homocysteine

Specific reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA