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The map label for this gene is hisC

Identifier: 89053525

GI number: 89053525

Start: 987219

End: 988301

Strand: Direct

Name: hisC

Synonym: Jann_1034

Alternate gene names: 89053525

Gene position: 987219-988301 (Clockwise)

Preceding gene: 89053524

Following gene: 89053526

Centisome position: 22.86

GC content: 65.0

Gene sequence:

>1083_bases
ATGACCGCTCCCATCCGCCCGCAACCCGGCATTCTTGACATCGCCTTGTATCAGGGCGGGGCCTCCAAGATTGCGGGCCA
TGCGGATCCGTTGAAGCTGTCGTCGAACGAGAACCCATTCGGGCCGTCTCCGGCGGCTGTGCAGGCCATGGCAGACGCGG
TGGCCAGCAGTCACCGCTACCCCAACACCGATCACGCAGACCTGCGCGCGGCGATTTCGGAGATCCACGGGCTGGAGGCC
GACAATATCATCTGCGGTGTGGGCAGTGACGAGGTGATCCACTTCCTCTGCCAATGCTATGCCGGGCCGGGGGATGAGGT
GCTCTACACCCAGCACGGGTTCGGCATGTACCCGATTGCGGCGAAGGCTGCGGGGGCCACGCCGGTGCAGGTGGCGGAGG
ACGCGCGCCATGTGGATGTGGACGCACTGATTGCCGGGATCACGCCCGCCACCCGGCTCATTTTCATCGCCAACCCCTCC
AACCCCTGTGCGACGATGATCGACAACGGAGAGATCACGCGCCTGGCCGATGCGTTGCCGGATCAATGCCTGCTGATCCT
TGATGGGGCCTATGTGGAGTTCGCGGACGGCTACGATGGCGGCAAGAATCTGGTGGAGGCGCGCGACAACGTCGTGATGA
CGCGCACGTTTTCCAAGGTCTACGGGCTAGGTGGGCTGCGGGTGGGCTACGGGTATGGCCCGCGCCATGTGATCGACACG
CTCAACCGCATTCGCGGGCCGTTCAACCTGTCGGGAATGGCGCTGGCCGGGGCCGAGGCGGCGGTGCGCGACGTGGATTG
GGTGAACGAGTGCTTGCGGGTGAATGCCGATGAACGCGCCCGGCTGGTGGGCGGTTTGCGCCAATTGGGTCTGGCTTGCG
ACGACAGCCACGCCAATTTTGTGCTGGCCCGGTTCGCCAGTGAAGCCGCCGCAGATGCCGCTGATGCGCATCTGAAGCGC
GACGGCATCATTGTACGCGCGCCCAAATCATACGGCCTGCCCGACTGCCTGCGCATCACCGTGGGCCGGCCCGAAGATAA
CAGCCGTGTGCTTGCGTCCCTAACGGCACTGGTGGCGGCGTGA

Upstream 100 bases:

>100_bases
TTGCCATAGATATCGACCCGCAGAACTTCTTCTGAAAACGGTTCCCCCCCGCCGTCGCGCACGGTAGAAGTTTGCGAAAT
CGTAAACGGACGCTTTGCCC

Downstream 100 bases:

>100_bases
ACGTTCTGTACAACCGCGTTGCCCTGATTGGACTGGGTCTGATTGCGGGTTCCATGGCCCATGCCATGCGCCGCGCGGGC
CTTGCGGGGGAAATCGTGGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTAPIRPQPGILDIALYQGGASKIAGHADPLKLSSNENPFGPSPAAVQAMADAVASSHRYPNTDHADLRAAISEIHGLEA
DNIICGVGSDEVIHFLCQCYAGPGDEVLYTQHGFGMYPIAAKAAGATPVQVAEDARHVDVDALIAGITPATRLIFIANPS
NPCATMIDNGEITRLADALPDQCLLILDGAYVEFADGYDGGKNLVEARDNVVMTRTFSKVYGLGGLRVGYGYGPRHVIDT
LNRIRGPFNLSGMALAGAEAAVRDVDWVNECLRVNADERARLVGGLRQLGLACDDSHANFVLARFASEAAADAADAHLKR
DGIIVRAPKSYGLPDCLRITVGRPEDNSRVLASLTALVAA

Sequences:

>Translated_360_residues
MTAPIRPQPGILDIALYQGGASKIAGHADPLKLSSNENPFGPSPAAVQAMADAVASSHRYPNTDHADLRAAISEIHGLEA
DNIICGVGSDEVIHFLCQCYAGPGDEVLYTQHGFGMYPIAAKAAGATPVQVAEDARHVDVDALIAGITPATRLIFIANPS
NPCATMIDNGEITRLADALPDQCLLILDGAYVEFADGYDGGKNLVEARDNVVMTRTFSKVYGLGGLRVGYGYGPRHVIDT
LNRIRGPFNLSGMALAGAEAAVRDVDWVNECLRVNADERARLVGGLRQLGLACDDSHANFVLARFASEAAADAADAHLKR
DGIIVRAPKSYGLPDCLRITVGRPEDNSRVLASLTALVAA
>Mature_359_residues
TAPIRPQPGILDIALYQGGASKIAGHADPLKLSSNENPFGPSPAAVQAMADAVASSHRYPNTDHADLRAAISEIHGLEAD
NIICGVGSDEVIHFLCQCYAGPGDEVLYTQHGFGMYPIAAKAAGATPVQVAEDARHVDVDALIAGITPATRLIFIANPSN
PCATMIDNGEITRLADALPDQCLLILDGAYVEFADGYDGGKNLVEARDNVVMTRTFSKVYGLGGLRVGYGYGPRHVIDTL
NRIRGPFNLSGMALAGAEAAVRDVDWVNECLRVNADERARLVGGLRQLGLACDDSHANFVLARFASEAAADAADAHLKRD
GIIVRAPKSYGLPDCLRITVGRPEDNSRVLASLTALVAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=354, Percent_Identity=26.5536723163842, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17567369, Length=235, Percent_Identity=24.6808510638298, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=350, Percent_Identity=28.2857142857143, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_JANSC (Q28TL1)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508976.1
- ProteinModelPortal:   Q28TL1
- SMR:   Q28TL1
- STRING:   Q28TL1
- GeneID:   3933478
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1034
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   NPANILC
- PhylomeDB:   Q28TL1
- ProtClustDB:   PRK02731
- BioCyc:   JSP290400:JANN_1034-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 37979; Mature: 37848

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPIRPQPGILDIALYQGGASKIAGHADPLKLSSNENPFGPSPAAVQAMADAVASSHRY
CCCCCCCCCCEEEEEEECCCCHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
PNTDHADLRAAISEIHGLEADNIICGVGSDEVIHFLCQCYAGPGDEVLYTQHGFGMYPIA
CCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
AKAAGATPVQVAEDARHVDVDALIAGITPATRLIFIANPSNPCATMIDNGEITRLADALP
HHCCCCCCHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHCCC
DQCLLILDGAYVEFADGYDGGKNLVEARDNVVMTRTFSKVYGLGGLRVGYGYGPRHVIDT
CCEEEEEECCEEEECCCCCCCHHHHHHCCCEEEEEEHHHHHCCCCEEECCCCCHHHHHHH
LNRIRGPFNLSGMALAGAEAAVRDVDWVNECLRVNADERARLVGGLRQLGLACDDSHANF
HHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCCCCCC
VLARFASEAAADAADAHLKRDGIIVRAPKSYGLPDCLRITVGRPEDNSRVLASLTALVAA
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TAPIRPQPGILDIALYQGGASKIAGHADPLKLSSNENPFGPSPAAVQAMADAVASSHRY
CCCCCCCCCEEEEEEECCCCHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
PNTDHADLRAAISEIHGLEADNIICGVGSDEVIHFLCQCYAGPGDEVLYTQHGFGMYPIA
CCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHH
AKAAGATPVQVAEDARHVDVDALIAGITPATRLIFIANPSNPCATMIDNGEITRLADALP
HHCCCCCCHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHCCC
DQCLLILDGAYVEFADGYDGGKNLVEARDNVVMTRTFSKVYGLGGLRVGYGYGPRHVIDT
CCEEEEEECCEEEECCCCCCCHHHHHHCCCEEEEEEHHHHHCCCCEEECCCCCHHHHHHH
LNRIRGPFNLSGMALAGAEAAVRDVDWVNECLRVNADERARLVGGLRQLGLACDDSHANF
HHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCCCCCC
VLARFASEAAADAADAHLKRDGIIVRAPKSYGLPDCLRITVGRPEDNSRVLASLTALVAA
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA