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The map label for this gene is metR [H]

Identifier: 89053518

GI number: 89053518

Start: 979757

End: 980665

Strand: Direct

Name: metR [H]

Synonym: Jann_1027

Alternate gene names: 89053518

Gene position: 979757-980665 (Clockwise)

Preceding gene: 89053512

Following gene: 89053519

Centisome position: 22.69

GC content: 62.93

Gene sequence:

>909_bases
ATGCATATCGAGTTTCGGCACCTGCGCACGATCAAGGCCATCCACGAGGAGGGGGGATTGGCGAAGGCAGCGGCAAGCCT
GCACATCACGCAGAGCGCGTTGAGCCACCAGATCAAAGGGTTGGAGGATCAGGCGGGATTGGAGCTGTTCATCCGACGCT
CCAAACCGATGCGGCTGTCACCGGCGGGGATGAAAATGCTGCGCCTGGCCGATGAGGTCCTTCCAAGGGTCGCTGCGCTG
GAGGAAGATTTCACCGGTCTGCGCGCGGGAAAATCCGGGCGGCTGCACATCGCCATTGAGTGCCACGCCTGTTTCGATTG
GCTGCTGCCGGTGCTGGAGGCGTTCCGGAAGACGTGGCCGGATGTAGATGTGGATATCCGCCCCGGCCTGCAATTCGAGG
CTTTGCCCGCGCTGAACCGTCAGGACGTGGATCTGGTGATCTCCAGCGATCCTGAGGATCTGCCGGGCGTCGATTTCACG
CCCCTGTTCGATTATGAGCCCGTGTTTGTCTGCGCCGCGGACCATCCGCTGGCGGCGAGACCCTATATCGAAGCCGGGGA
TTTTGCCGACCAGACCCTGATTACTTACCCGGTGGATCGCCCCCGGCTTGACGTGTTCAGCCAGCTTCTGTTCCCGGCGG
GCGTGGAGCCGAAGGCGATCCGACAGGTGGAACTATCTGCGGTGATCCTGCTGCTGGTGGCCTCGGGGCGGGGTGTGTCG
GTGTTGCCCGATTGGGTGGTGCGCGATGTGGGCGCAAGCCAGTCCATCGTGACGAAATCCCTGACGCAGGCGGGGCTGAC
GCGCAGGTTGTATGGGGCCAGCCGGTCCGAGGATACGGCGAAACCCTTCATGTCCCATGTCCTGAAACTGAGCCGGTCCG
AGCCCCTGAAACTGCAACGCCGGGCCTAG

Upstream 100 bases:

>100_bases
TGGGCATGGCGGAATCGATCCTTGATGTGTCGCTTACAGATGTCGCATAGACTCCGGCAATCAACAATTTCATAACTCTC
ATGATTAATATGAGGTTCGC

Downstream 100 bases:

>100_bases
ACGCAACCAGATCCTTGCAAGGATCTGGACAAACTCTTGCAAGAGTTTGGTGCGCCCCTTGGCATGGCGGAGCGCCCCGT
CTATAGGGTCGCGCCTGACC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MHIEFRHLRTIKAIHEEGGLAKAAASLHITQSALSHQIKGLEDQAGLELFIRRSKPMRLSPAGMKMLRLADEVLPRVAAL
EEDFTGLRAGKSGRLHIAIECHACFDWLLPVLEAFRKTWPDVDVDIRPGLQFEALPALNRQDVDLVISSDPEDLPGVDFT
PLFDYEPVFVCAADHPLAARPYIEAGDFADQTLITYPVDRPRLDVFSQLLFPAGVEPKAIRQVELSAVILLLVASGRGVS
VLPDWVVRDVGASQSIVTKSLTQAGLTRRLYGASRSEDTAKPFMSHVLKLSRSEPLKLQRRA

Sequences:

>Translated_302_residues
MHIEFRHLRTIKAIHEEGGLAKAAASLHITQSALSHQIKGLEDQAGLELFIRRSKPMRLSPAGMKMLRLADEVLPRVAAL
EEDFTGLRAGKSGRLHIAIECHACFDWLLPVLEAFRKTWPDVDVDIRPGLQFEALPALNRQDVDLVISSDPEDLPGVDFT
PLFDYEPVFVCAADHPLAARPYIEAGDFADQTLITYPVDRPRLDVFSQLLFPAGVEPKAIRQVELSAVILLLVASGRGVS
VLPDWVVRDVGASQSIVTKSLTQAGLTRRLYGASRSEDTAKPFMSHVLKLSRSEPLKLQRRA
>Mature_302_residues
MHIEFRHLRTIKAIHEEGGLAKAAASLHITQSALSHQIKGLEDQAGLELFIRRSKPMRLSPAGMKMLRLADEVLPRVAAL
EEDFTGLRAGKSGRLHIAIECHACFDWLLPVLEAFRKTWPDVDVDIRPGLQFEALPALNRQDVDLVISSDPEDLPGVDFT
PLFDYEPVFVCAADHPLAARPYIEAGDFADQTLITYPVDRPRLDVFSQLLFPAGVEPKAIRQVELSAVILLLVASGRGVS
VLPDWVVRDVGASQSIVTKSLTQAGLTRRLYGASRSEDTAKPFMSHVLKLSRSEPLKLQRRA

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=291, Percent_Identity=42.6116838487972, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=27.1604938271605, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787530, Length=308, Percent_Identity=26.6233766233766, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=25.3112033195021, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=27.2357723577236, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788887, Length=251, Percent_Identity=29.0836653386454, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI145693105, Length=283, Percent_Identity=25.7950530035336, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789204, Length=265, Percent_Identity=26.7924528301887, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789173, Length=243, Percent_Identity=27.1604938271605, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=248, Percent_Identity=27.4193548387097, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787806, Length=244, Percent_Identity=22.9508196721311, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082024, Length=173, Percent_Identity=29.4797687861272, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788748, Length=253, Percent_Identity=24.901185770751, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789506, Length=256, Percent_Identity=21.09375, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=305, Percent_Identity=22.2950819672131, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=25.296442687747, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33438; Mature: 33438

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50931 HTH_LYSR ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIEFRHLRTIKAIHEEGGLAKAAASLHITQSALSHQIKGLEDQAGLELFIRRSKPMRLS
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEC
PAGMKMLRLADEVLPRVAALEEDFTGLRAGKSGRLHIAIECHACFDWLLPVLEAFRKTWP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
DVDVDIRPGLQFEALPALNRQDVDLVISSDPEDLPGVDFTPLFDYEPVFVCAADHPLAAR
CCCEEECCCCCEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
PYIEAGDFADQTLITYPVDRPRLDVFSQLLFPAGVEPKAIRQVELSAVILLLVASGRGVS
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCE
VLPDWVVRDVGASQSIVTKSLTQAGLTRRLYGASRSEDTAKPFMSHVLKLSRSEPLKLQR
ECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
RA
CC
>Mature Secondary Structure
MHIEFRHLRTIKAIHEEGGLAKAAASLHITQSALSHQIKGLEDQAGLELFIRRSKPMRLS
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEC
PAGMKMLRLADEVLPRVAALEEDFTGLRAGKSGRLHIAIECHACFDWLLPVLEAFRKTWP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCC
DVDVDIRPGLQFEALPALNRQDVDLVISSDPEDLPGVDFTPLFDYEPVFVCAADHPLAAR
CCCEEECCCCCEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
PYIEAGDFADQTLITYPVDRPRLDVFSQLLFPAGVEPKAIRQVELSAVILLLVASGRGVS
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCE
VLPDWVVRDVGASQSIVTKSLTQAGLTRRLYGASRSEDTAKPFMSHVLKLSRSEPLKLQR
ECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
RA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]