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The map label for this gene is gcvT [H]

Identifier: 89053410

GI number: 89053410

Start: 874618

End: 877131

Strand: Direct

Name: gcvT [H]

Synonym: Jann_0919

Alternate gene names: 89053410

Gene position: 874618-877131 (Clockwise)

Preceding gene: 89053408

Following gene: 89053412

Centisome position: 20.26

GC content: 63.01

Gene sequence:

>2514_bases
ATGAAGACGACTGTGAAAGCCCTTGTTGTTGGCGGTGGCGCCGTGGGCACCTCGATTGCCTATCATCTGGCGAAGGCCGG
GTGGGAGGATGTGGTGTTGTTGGAGCGCGACGAGCTGACGTCAGGCTCCACCTGGCATGCGGCGGGGCTTTTGCCGCTGT
TCAACATGTCTTTCGCCACGACGCACATCCACGATTATTCCGTGAAGTTCTACAAGGAGCTGGAGGCCGAGACGGGCCTG
AATGCGGGCTTTGCCGTAGTGGGCAACCTGCGGATGGCGCAAACGGACGAGCGCATGGACGAATACATGCTCTACGCGAG
TACCGCCGAGACCGTGGGCGTGCCGTTCGAGTTCCTGACGCCCGAGGAGATCAAGGATCGCTGGCCGCTGATCGAGACGT
CTGACCTGAAAGGCGCGATCTACCACGCCACCGACGGCTACATTAACCCCGCCGATGTCACGATGGCGATGGCCAAGGGC
GCGCGGCAGAGGGGCGTGGAGATTGTGCGCAAGTGGCAGGCCGATGGCTTTGTCTGGAATGGAGAGGCCTGGGAGGTCAC
CTGTACCAAGATGGTGGAGAAGGGCGGCAACCTCGTGCCCTCCGACGAGCAGGTGGTGATCACGGCGGAGCATGTGGTGA
CGGCCAGCGGCAACCACGCACAGCGCACGGCGCAGATGCTGGGGATCAAGATCCCCGCGATCCCGGTGGAGCATCAGTTT
ATCGTTATGGACCAGGACCCGGCGCTGGTGGCGTGGCGCGGGCAGGGCAACCCCGAGCATCCCGTCATCCGCGATGCCGA
TGCGCAAAGCTACGTGCGCGAGGAGCGGGGCGGTTGGATCCTGGGCGTCTACGAAAAGAACGCGCCGGCTCGGTTTGAAT
ACGGCGTGCCCGACAGCTTCCGGGCGGATCTGTTCCCGCTGGATCTGGAGCGCATTGAAGAGCAGTACATGGCGATGATC
CACCGCATCCCGTCCTGCGAGGAAAGCGGGTTGAAGGACGATTTCAACGGGCCGATTTGCTACACGCCGGACGGCAATCC
GCTGGTGGGGCCCGCGCCGGGCCTCGACAATATGTGGCTGGCCGAAGGGTTCTCGTTCGGGATCACGGCGGCGGGGGGCA
CGGGCTACTATCTGGCGCAGATGATGGTGGCGGGGGAGGCGGAGATCGACATGGCCTCGCTCGACCCGAAACGCTACGGC
AACGACTGGATGACCACGGAATATGCCGCGCGCAAGAATGAGGAGTGTTATGACCACGTCTACATTCTGCACCATCCCGA
TGAAGAACGGCCCGCGTGCCGCCCCCTGCGCACCGGCCCCGTCTATGACCGCCAGAAGGCATTGGGCGCGCAGTTTGGGT
GCGTAAACGGCTGGGAACGGCCGAATTATTACGGGCCTTTGGATGCACCGGAAAGTTTTGATCACGAGACGCGCAGTTTC
CGGCGCGGGGGATGGTGGGACTATGCCAAGGGCGAGGCGGAGGCCATTCGCAACGGTGTGGGTCTGGTGGACGCCAGTGC
CTTCGCCAAGCACCGCATCAGCGGGCCCGGGGCGGCGGATTTTCTGGATTGGTTCACCTCCAACAAGCTGCCCAAGGTCG
GGCGGATCAACCTGACCTATGCGCTGACCGGGGCGGGCACGACGCGCACAGAATATACGATTGTGCGGGTGGCCGAGGAT
GATTTCTATCTGGTGAGCGCGGGCGCTTGGCACGCCTATGACCAAGATTATCTGTTCAAGGCGATCATGGAGAATGAGGA
TCGGTTCGGGCGGATCAACGAGCAGGACGTGACGACCCAATGGGGGGTGTTTGCGCTGGCGGGGCCGAAGTCGCGCGATG
TTCTGGCCGAATTGGTGCGCGATGCCGACCCGGCCTCTGCATTGTCGAACAAGCGCTTCCCGTGGCTCTCGATGCGTAAC
ATCGAGTTGGGGATGTGCCCGGTGCGCGCGATCCGCGTGGCCTATACGGGCGAGTTGGGGTGGGAATTGCACCACCCGAT
CGAGATGCAAAGCTATCTTTGGGACCAACTGCTGATGGCGGGCGACAAGCACGGGCTGAAGCTTGTGGGGGGACGCGCGC
AGAACTGGTTGCGGCAGGAGAAGTCTTACCGCGCGTTCGGCACTGAATTGGGCCGGGACGCGACGCCGCTGGAAGCGGGG
CTGGACCGGTTCGTGGATCTGTCCAAGGACTTCCACGGGAAGGACGCGATGGTCGCGACGGGTATCCGGTCGAAATGTGT
GACGGTCCTGATTGATGGGCCGGATGATGCGGACCCGTGGGGGCGCGAGGCGTTGATTGTCGAGGGCGAGAAGGTCGGGC
GGTTGACGTCTGGCGGGTATTCGGTGGCCTTCGGCAAGCAGATTGGCATGGGTTATGTGCGCCCGGATCTGGCGGAGGTC
GGCACCAAATTACAGGTGCGGATGTTCCGGGAGTTGTGGGATGCTGAGGTCGTCGAGGACAGCCCCTATGACCCGACAAA
CGCGGCCATCCGGGTGAACGCGCCCGGGTTTTGA

Upstream 100 bases:

>100_bases
CGTCGGTTTTGGGTGCAATCGGGTCGGGTGGGCCATGCGCGCGGGTGGGTGTTGGGGCAGGTAGGGTTCAGGACTTTATC
TTTGCCGGAGAGCGCCCGCT

Downstream 100 bases:

>100_bases
TGTTTGAGGACCGGGGGAGACGCTGATCGACGATTTTTGCCAGGCAAAAACCGCCGACCTCGCCCCTCCCACCGTCCCGC
AGGTCTGGCGATTGGTCGCG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 837; Mature: 837

Protein sequence:

>837_residues
MKTTVKALVVGGGAVGTSIAYHLAKAGWEDVVLLERDELTSGSTWHAAGLLPLFNMSFATTHIHDYSVKFYKELEAETGL
NAGFAVVGNLRMAQTDERMDEYMLYASTAETVGVPFEFLTPEEIKDRWPLIETSDLKGAIYHATDGYINPADVTMAMAKG
ARQRGVEIVRKWQADGFVWNGEAWEVTCTKMVEKGGNLVPSDEQVVITAEHVVTASGNHAQRTAQMLGIKIPAIPVEHQF
IVMDQDPALVAWRGQGNPEHPVIRDADAQSYVREERGGWILGVYEKNAPARFEYGVPDSFRADLFPLDLERIEEQYMAMI
HRIPSCEESGLKDDFNGPICYTPDGNPLVGPAPGLDNMWLAEGFSFGITAAGGTGYYLAQMMVAGEAEIDMASLDPKRYG
NDWMTTEYAARKNEECYDHVYILHHPDEERPACRPLRTGPVYDRQKALGAQFGCVNGWERPNYYGPLDAPESFDHETRSF
RRGGWWDYAKGEAEAIRNGVGLVDASAFAKHRISGPGAADFLDWFTSNKLPKVGRINLTYALTGAGTTRTEYTIVRVAED
DFYLVSAGAWHAYDQDYLFKAIMENEDRFGRINEQDVTTQWGVFALAGPKSRDVLAELVRDADPASALSNKRFPWLSMRN
IELGMCPVRAIRVAYTGELGWELHHPIEMQSYLWDQLLMAGDKHGLKLVGGRAQNWLRQEKSYRAFGTELGRDATPLEAG
LDRFVDLSKDFHGKDAMVATGIRSKCVTVLIDGPDDADPWGREALIVEGEKVGRLTSGGYSVAFGKQIGMGYVRPDLAEV
GTKLQVRMFRELWDAEVVEDSPYDPTNAAIRVNAPGF

Sequences:

>Translated_837_residues
MKTTVKALVVGGGAVGTSIAYHLAKAGWEDVVLLERDELTSGSTWHAAGLLPLFNMSFATTHIHDYSVKFYKELEAETGL
NAGFAVVGNLRMAQTDERMDEYMLYASTAETVGVPFEFLTPEEIKDRWPLIETSDLKGAIYHATDGYINPADVTMAMAKG
ARQRGVEIVRKWQADGFVWNGEAWEVTCTKMVEKGGNLVPSDEQVVITAEHVVTASGNHAQRTAQMLGIKIPAIPVEHQF
IVMDQDPALVAWRGQGNPEHPVIRDADAQSYVREERGGWILGVYEKNAPARFEYGVPDSFRADLFPLDLERIEEQYMAMI
HRIPSCEESGLKDDFNGPICYTPDGNPLVGPAPGLDNMWLAEGFSFGITAAGGTGYYLAQMMVAGEAEIDMASLDPKRYG
NDWMTTEYAARKNEECYDHVYILHHPDEERPACRPLRTGPVYDRQKALGAQFGCVNGWERPNYYGPLDAPESFDHETRSF
RRGGWWDYAKGEAEAIRNGVGLVDASAFAKHRISGPGAADFLDWFTSNKLPKVGRINLTYALTGAGTTRTEYTIVRVAED
DFYLVSAGAWHAYDQDYLFKAIMENEDRFGRINEQDVTTQWGVFALAGPKSRDVLAELVRDADPASALSNKRFPWLSMRN
IELGMCPVRAIRVAYTGELGWELHHPIEMQSYLWDQLLMAGDKHGLKLVGGRAQNWLRQEKSYRAFGTELGRDATPLEAG
LDRFVDLSKDFHGKDAMVATGIRSKCVTVLIDGPDDADPWGREALIVEGEKVGRLTSGGYSVAFGKQIGMGYVRPDLAEV
GTKLQVRMFRELWDAEVVEDSPYDPTNAAIRVNAPGF
>Mature_837_residues
MKTTVKALVVGGGAVGTSIAYHLAKAGWEDVVLLERDELTSGSTWHAAGLLPLFNMSFATTHIHDYSVKFYKELEAETGL
NAGFAVVGNLRMAQTDERMDEYMLYASTAETVGVPFEFLTPEEIKDRWPLIETSDLKGAIYHATDGYINPADVTMAMAKG
ARQRGVEIVRKWQADGFVWNGEAWEVTCTKMVEKGGNLVPSDEQVVITAEHVVTASGNHAQRTAQMLGIKIPAIPVEHQF
IVMDQDPALVAWRGQGNPEHPVIRDADAQSYVREERGGWILGVYEKNAPARFEYGVPDSFRADLFPLDLERIEEQYMAMI
HRIPSCEESGLKDDFNGPICYTPDGNPLVGPAPGLDNMWLAEGFSFGITAAGGTGYYLAQMMVAGEAEIDMASLDPKRYG
NDWMTTEYAARKNEECYDHVYILHHPDEERPACRPLRTGPVYDRQKALGAQFGCVNGWERPNYYGPLDAPESFDHETRSF
RRGGWWDYAKGEAEAIRNGVGLVDASAFAKHRISGPGAADFLDWFTSNKLPKVGRINLTYALTGAGTTRTEYTIVRVAED
DFYLVSAGAWHAYDQDYLFKAIMENEDRFGRINEQDVTTQWGVFALAGPKSRDVLAELVRDADPASALSNKRFPWLSMRN
IELGMCPVRAIRVAYTGELGWELHHPIEMQSYLWDQLLMAGDKHGLKLVGGRAQNWLRQEKSYRAFGTELGRDATPLEAG
LDRFVDLSKDFHGKDAMVATGIRSKCVTVLIDGPDDADPWGREALIVEGEKVGRLTSGGYSVAFGKQIGMGYVRPDLAEV
GTKLQVRMFRELWDAEVVEDSPYDPTNAAIRVNAPGF

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=833, Percent_Identity=36.1344537815126, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI197927446, Length=883, Percent_Identity=30.5775764439411, Blast_Score=347, Evalue=3e-95,
Organism=Homo sapiens, GI21361378, Length=883, Percent_Identity=30.5775764439411, Blast_Score=347, Evalue=3e-95,
Organism=Homo sapiens, GI194306651, Length=811, Percent_Identity=28.7299630086313, Blast_Score=321, Evalue=2e-87,
Organism=Escherichia coli, GI1789272, Length=304, Percent_Identity=24.6710526315789, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994045, Length=823, Percent_Identity=28.7970838396112, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71994052, Length=830, Percent_Identity=28.5542168674699, Blast_Score=281, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI32563613, Length=819, Percent_Identity=26.984126984127, Blast_Score=242, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6320222, Length=358, Percent_Identity=27.0949720670391, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20130091, Length=876, Percent_Identity=29.2237442922374, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI28571104, Length=814, Percent_Identity=28.992628992629, Blast_Score=306, Evalue=4e-83,
Organism=Drosophila melanogaster, GI20129441, Length=333, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 92986; Mature: 92986

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTVKALVVGGGAVGTSIAYHLAKAGWEDVVLLERDELTSGSTWHAAGLLPLFNMSFAT
CCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHCCHHHHCCCEEE
THIHDYSVKFYKELEAETGLNAGFAVVGNLRMAQTDERMDEYMLYASTAETVGVPFEFLT
EEEECCHHHHHHHHHHHCCCCCCEEEEECEEEHHHHHHHHHEEEEECCCHHCCCCEEECC
PEEIKDRWPLIETSDLKGAIYHATDGYINPADVTMAMAKGARQRGVEIVRKWQADGFVWN
CHHHHHCCCEEECCCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEC
GEAWEVTCTKMVEKGGNLVPSDEQVVITAEHVVTASGNHAQRTAQMLGIKIPAIPVEHQF
CCEEEEEHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHCEECCCCCCCCEE
IVMDQDPALVAWRGQGNPEHPVIRDADAQSYVREERGGWILGVYEKNAPARFEYGVPDSF
EEEECCCCEEEEECCCCCCCCEEECCCHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCC
RADLFPLDLERIEEQYMAMIHRIPSCEESGLKDDFNGPICYTPDGNPLVGPAPGLDNMWL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHH
AEGFSFGITAAGGTGYYLAQMMVAGEAEIDMASLDPKRYGNDWMTTEYAARKNEECYDHV
HCCCCEEEEECCCCHHHHHHHHHCCCCCEEHCCCCHHHCCCCCCCHHHHHCCCCCCCCEE
YILHHPDEERPACRPLRTGPVYDRQKALGAQFGCVNGWERPNYYGPLDAPESFDHETRSF
EEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
RRGGWWDYAKGEAEAIRNGVGLVDASAFAKHRISGPGAADFLDWFTSNKLPKVGRINLTY
HCCCCCCCCCCHHHHHHCCCCEEEHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEE
ALTGAGTTRTEYTIVRVAEDDFYLVSAGAWHAYDQDYLFKAIMENEDRFGRINEQDVTTQ
EEECCCCCCCEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCEE
WGVFALAGPKSRDVLAELVRDADPASALSNKRFPWLSMRNIELGMCPVRAIRVAYTGELG
CCEEEECCCCCHHHHHHHHHCCCHHHHHCCCCCCEEEECCCEECCCCEEEEEEEEECCCC
WELHHPIEMQSYLWDQLLMAGDKHGLKLVGGRAQNWLRQEKSYRAFGTELGRDATPLEAG
CEECCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LDRFVDLSKDFHGKDAMVATGIRSKCVTVLIDGPDDADPWGREALIVEGEKVGRLTSGGY
HHHHHHHCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCEEEEEECHHHCCEECCCE
SVAFGKQIGMGYVRPDLAEVGTKLQVRMFRELWDAEVVEDSPYDPTNAAIRVNAPGF
EEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MKTTVKALVVGGGAVGTSIAYHLAKAGWEDVVLLERDELTSGSTWHAAGLLPLFNMSFAT
CCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHCCHHHHCCCEEE
THIHDYSVKFYKELEAETGLNAGFAVVGNLRMAQTDERMDEYMLYASTAETVGVPFEFLT
EEEECCHHHHHHHHHHHCCCCCCEEEEECEEEHHHHHHHHHEEEEECCCHHCCCCEEECC
PEEIKDRWPLIETSDLKGAIYHATDGYINPADVTMAMAKGARQRGVEIVRKWQADGFVWN
CHHHHHCCCEEECCCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEC
GEAWEVTCTKMVEKGGNLVPSDEQVVITAEHVVTASGNHAQRTAQMLGIKIPAIPVEHQF
CCEEEEEHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHCEECCCCCCCCEE
IVMDQDPALVAWRGQGNPEHPVIRDADAQSYVREERGGWILGVYEKNAPARFEYGVPDSF
EEEECCCCEEEEECCCCCCCCEEECCCHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCC
RADLFPLDLERIEEQYMAMIHRIPSCEESGLKDDFNGPICYTPDGNPLVGPAPGLDNMWL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHH
AEGFSFGITAAGGTGYYLAQMMVAGEAEIDMASLDPKRYGNDWMTTEYAARKNEECYDHV
HCCCCEEEEECCCCHHHHHHHHHCCCCCEEHCCCCHHHCCCCCCCHHHHHCCCCCCCCEE
YILHHPDEERPACRPLRTGPVYDRQKALGAQFGCVNGWERPNYYGPLDAPESFDHETRSF
EEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
RRGGWWDYAKGEAEAIRNGVGLVDASAFAKHRISGPGAADFLDWFTSNKLPKVGRINLTY
HCCCCCCCCCCHHHHHHCCCCEEEHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEE
ALTGAGTTRTEYTIVRVAEDDFYLVSAGAWHAYDQDYLFKAIMENEDRFGRINEQDVTTQ
EEECCCCCCCEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCEE
WGVFALAGPKSRDVLAELVRDADPASALSNKRFPWLSMRNIELGMCPVRAIRVAYTGELG
CCEEEECCCCCHHHHHHHHHCCCHHHHHCCCCCCEEEECCCEECCCCEEEEEEEEECCCC
WELHHPIEMQSYLWDQLLMAGDKHGLKLVGGRAQNWLRQEKSYRAFGTELGRDATPLEAG
CEECCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LDRFVDLSKDFHGKDAMVATGIRSKCVTVLIDGPDDADPWGREALIVEGEKVGRLTSGGY
HHHHHHHCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCEEEEEECHHHCCEECCCE
SVAFGKQIGMGYVRPDLAEVGTKLQVRMFRELWDAEVVEDSPYDPTNAAIRVNAPGF
EEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCHHCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA