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The map label for this gene is gyaR [H]

Identifier: 89053406

GI number: 89053406

Start: 870448

End: 871434

Strand: Direct

Name: gyaR [H]

Synonym: Jann_0915

Alternate gene names: 89053406

Gene position: 870448-871434 (Clockwise)

Preceding gene: 89053404

Following gene: 89053407

Centisome position: 20.16

GC content: 63.93

Gene sequence:

>987_bases
ATGCCATCTCAGCGATTAAGTGTTGTCGTTACGCGACGGTTGCCCGAGGCGGTCGAGACGCGAATGAGCGAATTGTTCGA
TGTGGAGCTGCGCGAAGACGACCGCCCGATGACCCGCGACGAGTTGGTGGATGCGATGAAACGCACGGACGTTCTGGTGC
CCTGTATCACCGATGTGATTGACGGCGGCATGTTGGGGCAGGCGGGCGATCGGCTGAAGCTGATCGCCAATTACGGCGCC
GGCGTGGACCATGTGGATGTGTCGACCGCCCGCCAACGCGGTGTGCTGGTCAGCAATACGCCGGGTGTGATGACCGATGA
CACGGCGGATATGGTGATGGCGCTGATCCTTGGCGTGCTGCGCCGGGTGCCTGAGGGCATGGCCGAGATGCAGGAGGGCA
ATTGGGCCGGTTGGGCCCCCACGGCGTTCATGGGCGGGCGCGTGGGCGGGAAACGCCTGGGCATTCTGGGCATGGGCCGG
ATCGGGCAGGCGGTGGCGCGGCGGGCGGCGGCGTTCGGGATGCAAGTGCATTACCACAACAGGCGACGCTTGCATGAGGA
TGTGGAGGGCGCGCTGGAGGCGACCTATTGGGACAGCCTCGACCAGATGATTGCGCGCATGGATGTCGTGTCCGTCAATT
GCCCCCACACGCCGAGCACGTTCCACCTGATGAATGCGCGGCGGCTGAAGCTGATGAAGCCCGAGGCGGTGATTGTGAAC
ACGTCGCGCGGTGAGGTGATTGACGAGAACGCCCTGACGCGGATGTTGCGTAGCGGGGAAATTGCGGGGGCAGGTTTGGA
CGTGTTCGAGAAGGGCCGCGAGGTGAACCCGAGGTTGCGGGAGCTGTCGAACGCGGTGCTGCTGCCCCATATGGGGAGTG
CGACGCGGGAAGGCCGGGCCGAGATGGGGGAGAAAGTTCTGATCAATATCAAGACCTTCGCCGACGGGCACCGGCCACCG
GATCTGGTTGTGCCGAGCATGTTGTGA

Upstream 100 bases:

>100_bases
GCCCTCGGGTGTCCTCAATCGTTCCCGCGATCTTGCGCCCCGGGTAACGATAAGAGAGTGTCATGGGCAGGTGCGAAAAT
CCACAAGGCGGAGCCATGCC

Downstream 100 bases:

>100_bases
GCCAACGGCCTGAGCCTCCGCTGCGCGCGCCCGCTGTGTCGGAGCGCCCGGTGTTGCAGGGGGAGCGGCGCCGTGGCGAC
ACGGTGCGGGGCGGACAGCG

Product: glycolate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MPSQRLSVVVTRRLPEAVETRMSELFDVELREDDRPMTRDELVDAMKRTDVLVPCITDVIDGGMLGQAGDRLKLIANYGA
GVDHVDVSTARQRGVLVSNTPGVMTDDTADMVMALILGVLRRVPEGMAEMQEGNWAGWAPTAFMGGRVGGKRLGILGMGR
IGQAVARRAAAFGMQVHYHNRRRLHEDVEGALEATYWDSLDQMIARMDVVSVNCPHTPSTFHLMNARRLKLMKPEAVIVN
TSRGEVIDENALTRMLRSGEIAGAGLDVFEKGREVNPRLRELSNAVLLPHMGSATREGRAEMGEKVLINIKTFADGHRPP
DLVVPSML

Sequences:

>Translated_328_residues
MPSQRLSVVVTRRLPEAVETRMSELFDVELREDDRPMTRDELVDAMKRTDVLVPCITDVIDGGMLGQAGDRLKLIANYGA
GVDHVDVSTARQRGVLVSNTPGVMTDDTADMVMALILGVLRRVPEGMAEMQEGNWAGWAPTAFMGGRVGGKRLGILGMGR
IGQAVARRAAAFGMQVHYHNRRRLHEDVEGALEATYWDSLDQMIARMDVVSVNCPHTPSTFHLMNARRLKLMKPEAVIVN
TSRGEVIDENALTRMLRSGEIAGAGLDVFEKGREVNPRLRELSNAVLLPHMGSATREGRAEMGEKVLINIKTFADGHRPP
DLVVPSML
>Mature_327_residues
PSQRLSVVVTRRLPEAVETRMSELFDVELREDDRPMTRDELVDAMKRTDVLVPCITDVIDGGMLGQAGDRLKLIANYGAG
VDHVDVSTARQRGVLVSNTPGVMTDDTADMVMALILGVLRRVPEGMAEMQEGNWAGWAPTAFMGGRVGGKRLGILGMGRI
GQAVARRAAAFGMQVHYHNRRRLHEDVEGALEATYWDSLDQMIARMDVVSVNCPHTPSTFHLMNARRLKLMKPEAVIVNT
SRGEVIDENALTRMLRSGEIAGAGLDVFEKGREVNPRLRELSNAVLLPHMGSATREGRAEMGEKVLINIKTFADGHRPPD
LVVPSML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=304, Percent_Identity=35.5263157894737, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=31.8493150684932, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=32.9457364341085, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=32.9457364341085, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=31.9066147859922, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=31.9066147859922, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=31.9066147859922, Blast_Score=121, Evalue=9e-28,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=35.202492211838, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789279, Length=257, Percent_Identity=34.6303501945525, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1787645, Length=339, Percent_Identity=26.8436578171091, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1788660, Length=301, Percent_Identity=25.5813953488372, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=282, Percent_Identity=32.9787234042553, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=262, Percent_Identity=32.0610687022901, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=41.49377593361, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320925, Length=295, Percent_Identity=28.8135593220339, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=314, Percent_Identity=27.0700636942675, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=215, Percent_Identity=31.6279069767442, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=179, Percent_Identity=32.4022346368715, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=150, Percent_Identity=34, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=203, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=38.0434782608696, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552429, Length=271, Percent_Identity=32.8413284132841, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=32.8413284132841, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24585514, Length=270, Percent_Identity=32.962962962963, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574282, Length=270, Percent_Identity=32.962962962963, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574284, Length=270, Percent_Identity=32.962962962963, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=29.757785467128, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585516, Length=283, Percent_Identity=30.0353356890459, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=32.2834645669291, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=32.2834645669291, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=32.2834645669291, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=32.2834645669291, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=32.156862745098, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921140, Length=270, Percent_Identity=30, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36086; Mature: 35955

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSQRLSVVVTRRLPEAVETRMSELFDVELREDDRPMTRDELVDAMKRTDVLVPCITDVI
CCCCCEEEHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
DGGMLGQAGDRLKLIANYGAGVDHVDVSTARQRGVLVSNTPGVMTDDTADMVMALILGVL
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHH
RRVPEGMAEMQEGNWAGWAPTAFMGGRVGGKRLGILGMGRIGQAVARRAAAFGMQVHYHN
HHCCHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHEEEECH
RRRLHEDVEGALEATYWDSLDQMIARMDVVSVNCPHTPSTFHLMNARRLKLMKPEAVIVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEECCHHHHEEECCCEEEEE
TSRGEVIDENALTRMLRSGEIAGAGLDVFEKGREVNPRLRELSNAVLLPHMGSATREGRA
CCCCCEECHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHCCEEECCCCCCCCCCCHH
EMGEKVLINIKTFADGHRPPDLVVPSML
HCCCEEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSQRLSVVVTRRLPEAVETRMSELFDVELREDDRPMTRDELVDAMKRTDVLVPCITDVI
CCCCEEEHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
DGGMLGQAGDRLKLIANYGAGVDHVDVSTARQRGVLVSNTPGVMTDDTADMVMALILGVL
CCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHH
RRVPEGMAEMQEGNWAGWAPTAFMGGRVGGKRLGILGMGRIGQAVARRAAAFGMQVHYHN
HHCCHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHEEEECH
RRRLHEDVEGALEATYWDSLDQMIARMDVVSVNCPHTPSTFHLMNARRLKLMKPEAVIVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEECCHHHHEEECCCEEEEE
TSRGEVIDENALTRMLRSGEIAGAGLDVFEKGREVNPRLRELSNAVLLPHMGSATREGRA
CCCCCEECHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHCCEEECCCCCCCCCCCHH
EMGEKVLINIKTFADGHRPPDLVVPSML
HCCCEEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA