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The map label for this gene is coaBC [H]

Identifier: 89053398

GI number: 89053398

Start: 862680

End: 863882

Strand: Direct

Name: coaBC [H]

Synonym: Jann_0907

Alternate gene names: 89053398

Gene position: 862680-863882 (Clockwise)

Preceding gene: 89053397

Following gene: 89053399

Centisome position: 19.98

GC content: 64.26

Gene sequence:

>1203_bases
ATGCTAACGGGCAAGCGGATTTTGTTGATCATCGGCGGCGGAATTGCGGCGTTCAAGTCACTCGACCTGATCCGCCGCCT
GCGCGATCAGGGGGCCTTGGTCGTGCCGGTTCTGACCCGCTCGGCGGAAGAGTTTGTGACGCCCTTGTCGGTCTCGGCTT
TGGCGGCGCAGAAGGTTTACCGCGATCTGTTTGACCTGACCGACGAGGCGGAGATGGGGCATATCGAATTGTCACGCGCC
GCCGATCTTGTGGTCGTGGCGCCTGCAACGGCGGATCTGATGGCAAAGATGGCCGCGGGGCTGGCGAATGATCTGGCTTC
TACTCTTCTGATGGCGACCGATAAGCGCGTGTTGATCGCGCCGTCGATGAATGTGCGGATGTGGGAGCATCCGGCGACCC
GGCGCAATCTGGCGGTGTTGCAGGGGGACGGCGTTTTGGTCGTGGGTCCGGATGAGGGCAACATGGCGTGCGGAGAATAC
GGACCGGGCCGCATGGCTGACGTGCCGGAGATTATCGAGGCCGTGGGGGCTGCGCTTGGGGACGGGTCAATGAAAGACCG
CCACGTGATTGTGACGTCCGGTCCCACCCACGAGCCGATTGATCCGGTGCGCTATATTGCCAACCGGTCTTCGGGCGCGC
AGGGGGGCGCGATGGCCGCGGCGCTGCGCGATCTGGGCGCGAGGGTGACGTTTGTCACGGGCCCCGCAGATGTGCCGCCT
CCGGCGGGTGTCGATGTGGTGCGGGTAGAGACGGCGCGAGAGATGTTGTCGGCGGTTCAGGCCGCTCATCCAGCCGATGC
GGCTGTCTTCGCGGCTGCGGTGGCCGACTGGCGGGTTGAAAACGCCTCCGGCTCAAAGATGAAGAAAGATGGATCCGGCA
ACGCGCCAGCGCTGGAGTTCACGGAGAACCCGGACATCCTTGCGGGCGTGGCTCGGATGGAGGAGGGGCGGCCAAAGCTG
GTGGTGGGCTTTGCGGCTGAGACCGACAATGTGGTTGAGAATGCCACCGCCAAGCGCCTGCGCAAGGGCTGCGACTGGAT
CGTGGCCAATGATGTCTCCTCGGAGACGGGCATTATGGGCGGCGATGAGAATGCGATTGTCTTGATTGACGGGGACGGGG
CGGAGAGCTGGCCCAGATTGCCGAAGGCGGAGGTCGCCAAACGGTTGGCGCGGCGCATCGCGGACGCGATTGGTGCGGTT
TGA

Upstream 100 bases:

>100_bases
CTGTGACCCTCACGCCGCGCGACAGTGCGATCAACCTTTTGCGATTGAAGGAGGGGCACGGCGCGCTTACCGTGTCGCGG
CAGCAAGGCAAGAGGCAATC

Downstream 100 bases:

>100_bases
GGGGATGGAATTGAGTTGTATTTGCCCAGATGAAAGGAGCAGTCGCGCGTGATCGTCCGTGTGATGCGAGAGGCATGGGC
TGATCCATCGGTGCCGCTGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MLTGKRILLIIGGGIAAFKSLDLIRRLRDQGALVVPVLTRSAEEFVTPLSVSALAAQKVYRDLFDLTDEAEMGHIELSRA
ADLVVVAPATADLMAKMAAGLANDLASTLLMATDKRVLIAPSMNVRMWEHPATRRNLAVLQGDGVLVVGPDEGNMACGEY
GPGRMADVPEIIEAVGAALGDGSMKDRHVIVTSGPTHEPIDPVRYIANRSSGAQGGAMAAALRDLGARVTFVTGPADVPP
PAGVDVVRVETAREMLSAVQAAHPADAAVFAAAVADWRVENASGSKMKKDGSGNAPALEFTENPDILAGVARMEEGRPKL
VVGFAAETDNVVENATAKRLRKGCDWIVANDVSSETGIMGGDENAIVLIDGDGAESWPRLPKAEVAKRLARRIADAIGAV

Sequences:

>Translated_400_residues
MLTGKRILLIIGGGIAAFKSLDLIRRLRDQGALVVPVLTRSAEEFVTPLSVSALAAQKVYRDLFDLTDEAEMGHIELSRA
ADLVVVAPATADLMAKMAAGLANDLASTLLMATDKRVLIAPSMNVRMWEHPATRRNLAVLQGDGVLVVGPDEGNMACGEY
GPGRMADVPEIIEAVGAALGDGSMKDRHVIVTSGPTHEPIDPVRYIANRSSGAQGGAMAAALRDLGARVTFVTGPADVPP
PAGVDVVRVETAREMLSAVQAAHPADAAVFAAAVADWRVENASGSKMKKDGSGNAPALEFTENPDILAGVARMEEGRPKL
VVGFAAETDNVVENATAKRLRKGCDWIVANDVSSETGIMGGDENAIVLIDGDGAESWPRLPKAEVAKRLARRIADAIGAV
>Mature_400_residues
MLTGKRILLIIGGGIAAFKSLDLIRRLRDQGALVVPVLTRSAEEFVTPLSVSALAAQKVYRDLFDLTDEAEMGHIELSRA
ADLVVVAPATADLMAKMAAGLANDLASTLLMATDKRVLIAPSMNVRMWEHPATRRNLAVLQGDGVLVVGPDEGNMACGEY
GPGRMADVPEIIEAVGAALGDGSMKDRHVIVTSGPTHEPIDPVRYIANRSSGAQGGAMAAALRDLGARVTFVTGPADVPP
PAGVDVVRVETAREMLSAVQAAHPADAAVFAAAVADWRVENASGSKMKKDGSGNAPALEFTENPDILAGVARMEEGRPKL
VVGFAAETDNVVENATAKRLRKGCDWIVANDVSSETGIMGGDENAIVLIDGDGAESWPRLPKAEVAKRLARRIADAIGAV

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=32.2751322751323, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI87082301, Length=380, Percent_Identity=47.8947368421053, Blast_Score=311, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI17560194, Length=191, Percent_Identity=32.4607329842932, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24657262, Length=183, Percent_Identity=30.6010928961749, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41875; Mature: 41875

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGKRILLIIGGGIAAFKSLDLIRRLRDQGALVVPVLTRSAEEFVTPLSVSALAAQKVY
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHHCCHHHHHHHHHHHH
RDLFDLTDEAEMGHIELSRAADLVVVAPATADLMAKMAAGLANDLASTLLMATDKRVLIA
HHHHCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
PSMNVRMWEHPATRRNLAVLQGDGVLVVGPDEGNMACGEYGPGRMADVPEIIEAVGAALG
CCCCCEEECCCCCCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHCC
DGSMKDRHVIVTSGPTHEPIDPVRYIANRSSGAQGGAMAAALRDLGARVTFVTGPADVPP
CCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCC
PAGVDVVRVETAREMLSAVQAAHPADAAVFAAAVADWRVENASGSKMKKDGSGNAPALEF
CCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEE
TENPDILAGVARMEEGRPKLVVGFAAETDNVVENATAKRLRKGCDWIVANDVSSETGIMG
CCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
GDENAIVLIDGDGAESWPRLPKAEVAKRLARRIADAIGAV
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTGKRILLIIGGGIAAFKSLDLIRRLRDQGALVVPVLTRSAEEFVTPLSVSALAAQKVY
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEHHCCHHHHHCCHHHHHHHHHHHH
RDLFDLTDEAEMGHIELSRAADLVVVAPATADLMAKMAAGLANDLASTLLMATDKRVLIA
HHHHCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
PSMNVRMWEHPATRRNLAVLQGDGVLVVGPDEGNMACGEYGPGRMADVPEIIEAVGAALG
CCCCCEEECCCCCCCCEEEEECCCEEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHHCC
DGSMKDRHVIVTSGPTHEPIDPVRYIANRSSGAQGGAMAAALRDLGARVTFVTGPADVPP
CCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCC
PAGVDVVRVETAREMLSAVQAAHPADAAVFAAAVADWRVENASGSKMKKDGSGNAPALEF
CCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEE
TENPDILAGVARMEEGRPKLVVGFAAETDNVVENATAKRLRKGCDWIVANDVSSETGIMG
CCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
GDENAIVLIDGDGAESWPRLPKAEVAKRLARRIADAIGAV
CCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]