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The map label for this gene is dut [H]

Identifier: 89053399

GI number: 89053399

Start: 863946

End: 864383

Strand: Direct

Name: dut [H]

Synonym: Jann_0908

Alternate gene names: 89053399

Gene position: 863946-864383 (Clockwise)

Preceding gene: 89053398

Following gene: 89053400

Centisome position: 20.01

GC content: 67.35

Gene sequence:

>438_bases
ATGCGAGAGGCATGGGCTGATCCATCGGTGCCGCTGCCGGCCTATGCCACTGCGGGGGCCGCGGGCGCGGATCTGCGCGC
GAATTTTGAGGGTGGGCAAGGGGTTGTGGTGCAACCCGGTGCGCGAGCGCTGATCTCGACAGGACTTCGCGTGGCCCTTG
CGGAGGGGTTTGAGATGCAGATCCGGCCCCGGTCCGGGCTGGCGCTGACGCATGGTGTGACCCTGGCCAATGCACCCGGT
ACGATTGATGCCGATTACCGCGGGCCGTTGGGGGTGATCCTGATCAATCTTGGGGCGGAGGCCTTTATGGTGGAGCACGG
CGCGCGGATTGCGCAGGCGGTGGTAGCACCCGTGGTGCAGGCCAGGTTTGAGCGTGTTGACGCCCTGGAAGAGACGGCGC
GCGGCGCGGGTGGGTTTGGGTCCACAGGGACGCGCTGA

Upstream 100 bases:

>100_bases
GGCGCGGCGCATCGCGGACGCGATTGGTGCGGTTTGAGGGGATGGAATTGAGTTGTATTTGCCCAGATGAAAGGAGCAGT
CGCGCGTGATCGTCCGTGTG

Downstream 100 bases:

>100_bases
TGGTGTTTGTGTTCTTTCTTGCCGGGATCTTGTGGGCGCTGGGTCATCTGATGAAGGTGCCCATGGCGGCGCGGCTGAAC
ATGCTGGCGCTGCTGTATGT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MREAWADPSVPLPAYATAGAAGADLRANFEGGQGVVVQPGARALISTGLRVALAEGFEMQIRPRSGLALTHGVTLANAPG
TIDADYRGPLGVILINLGAEAFMVEHGARIAQAVVAPVVQARFERVDALEETARGAGGFGSTGTR

Sequences:

>Translated_145_residues
MREAWADPSVPLPAYATAGAAGADLRANFEGGQGVVVQPGARALISTGLRVALAEGFEMQIRPRSGLALTHGVTLANAPG
TIDADYRGPLGVILINLGAEAFMVEHGARIAQAVVAPVVQARFERVDALEETARGAGGFGSTGTR
>Mature_145_residues
MREAWADPSVPLPAYATAGAAGADLRANFEGGQGVVVQPGARALISTGLRVALAEGFEMQIRPRSGLALTHGVTLANAPG
TIDADYRGPLGVILINLGAEAFMVEHGARIAQAVVAPVVQARFERVDALEETARGAGGFGSTGTR

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=131, Percent_Identity=41.2213740458015, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI4503423, Length=131, Percent_Identity=41.2213740458015, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI70906441, Length=132, Percent_Identity=40.9090909090909, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790071, Length=142, Percent_Identity=44.3661971830986, Blast_Score=113, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71988561, Length=138, Percent_Identity=41.304347826087, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319729, Length=136, Percent_Identity=37.5, Blast_Score=85, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19921126, Length=133, Percent_Identity=41.3533834586466, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24583610, Length=133, Percent_Identity=41.3533834586466, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 14849; Mature: 14849

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAWADPSVPLPAYATAGAAGADLRANFEGGQGVVVQPGARALISTGLRVALAEGFEMQ
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHCCHHEEEECCCEEE
IRPRSGLALTHGVTLANAPGTIDADYRGPLGVILINLGAEAFMVEHGARIAQAVVAPVVQ
EECCCCEEEECCEEEECCCCCCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHH
ARFERVDALEETARGAGGFGSTGTR
HHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MREAWADPSVPLPAYATAGAAGADLRANFEGGQGVVVQPGARALISTGLRVALAEGFEMQ
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCHHHHHCCHHEEEECCCEEE
IRPRSGLALTHGVTLANAPGTIDADYRGPLGVILINLGAEAFMVEHGARIAQAVVAPVVQ
EECCCCEEEECCEEEECCCCCCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHH
ARFERVDALEETARGAGGFGSTGTR
HHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA