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The map label for this gene is argD [H]

Identifier: 88658406

GI number: 88658406

Start: 910768

End: 911946

Strand: Direct

Name: argD [H]

Synonym: ECH_0886

Alternate gene names: 88658406

Gene position: 910768-911946 (Clockwise)

Preceding gene: 88657722

Following gene: 88657658

Centisome position: 77.43

GC content: 33.33

Gene sequence:

>1179_bases
ATGAATAGTTCGCCAATTTTACCTGTTTATGCACCATCTAAGGTTACTTTCTCACATGGGAAAGGAGTCTATTTATACGA
CTATAATAATAAAAAATATGTAGATTTTCATGCAGGCATTGCAACTAGTTCGTTAGGACACGCTCATCCAGCATTAGTAA
ATGCATTAAAAACACAAGGTGAAAAGTTATGGCACATATCAAATGTACATACAATACCTGAAGCTATCAAGTTAGCACAA
AAATTAGTAGATATTAGCTTCGCTGATAAAGTGTTTTTTAATAATTCAGGTGCAGAATCTGTAGAATGTTGCTTAAAGAT
AGCAAGGTCATACCAATGTGGTAAAGGTAATACTCAACGTTATAGATTCATTACAATGAAGCAGTCTTATCATGGAAGAA
CATGTGCTGCATGTTCAGCAAATGATCCAAGTAAATTCTCTCCATTTCTTAAACCATACGTTGAATGGTTTGACTGTGTA
AATCCTGATATCACATCCATAAAAAATGCAATTAATGAAACTATAGGTGCTATACTATTAGAACCTATACAAGGAGAAGG
AGGAATCAACGTACTTGATGATTCTTTCTTGAAAGAATTACGTACAATTTGTGATCAAAACGATATACTGCTAATTTTCG
ATTGTGTACAATGTGGAAGTGGAAGAACAGGAAAATTCTTTGCTCATGAGCATACTGGAGTAACTCCTGACATATGTTGT
CTTGCAAAAGGATTAGGTGGTGGTTTCCCTATATCAGCAACTTTAGCAACCAATAATGCTTCTCAGTTTATGGGTGTTGG
CATGCATGGTTCTACTTTTGGAGGAAATCCTTTAGCAACTACTATTGGAATGACTGTAGTTGAAGAAATTTTAAAAGATG
GGTTTTTAGACAATGTAACTAAAAATGGCCATTATCTGTACAAAAGGTTGGAAGATTTAGCTAAAAAATTTCCAGTAATT
GAAGAAGTAAAAGGTAAAGGGCTCATGATAGGACTAAAAATCAATACTAATATTAATAATAGAGAATTAATGCATGATTT
AATAAGTTGTGGGTTACTAACCAACACTGCAAGCAATAATACTTTAAGGATAGTACCTCCTTTAATCATAACTCAACAAG
AAATTGATGAAGGTCTTGCTATACTAGAAAGTTATCTGCAAAGCAAATATCATCAGTAA

Upstream 100 bases:

>100_bases
TTTATAAACTTTTTCTTAGTTGACATATAACAATATCGTGTTACAGTTACACACTATTATATTCTATTTACTTAGTTCTT
TAATTTTGAGGAAATGTTAA

Downstream 100 bases:

>100_bases
ATAACAAGCTTTACTAATATCAAATATATAAGGTTTACTTACAGGTATTATTGCATTATTTTATCAATATTCAGTAGTAT
CGGCTACATAATATAAAGCT

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNSSPILPVYAPSKVTFSHGKGVYLYDYNNKKYVDFHAGIATSSLGHAHPALVNALKTQGEKLWHISNVHTIPEAIKLAQ
KLVDISFADKVFFNNSGAESVECCLKIARSYQCGKGNTQRYRFITMKQSYHGRTCAACSANDPSKFSPFLKPYVEWFDCV
NPDITSIKNAINETIGAILLEPIQGEGGINVLDDSFLKELRTICDQNDILLIFDCVQCGSGRTGKFFAHEHTGVTPDICC
LAKGLGGGFPISATLATNNASQFMGVGMHGSTFGGNPLATTIGMTVVEEILKDGFLDNVTKNGHYLYKRLEDLAKKFPVI
EEVKGKGLMIGLKINTNINNRELMHDLISCGLLTNTASNNTLRIVPPLIITQQEIDEGLAILESYLQSKYHQ

Sequences:

>Translated_392_residues
MNSSPILPVYAPSKVTFSHGKGVYLYDYNNKKYVDFHAGIATSSLGHAHPALVNALKTQGEKLWHISNVHTIPEAIKLAQ
KLVDISFADKVFFNNSGAESVECCLKIARSYQCGKGNTQRYRFITMKQSYHGRTCAACSANDPSKFSPFLKPYVEWFDCV
NPDITSIKNAINETIGAILLEPIQGEGGINVLDDSFLKELRTICDQNDILLIFDCVQCGSGRTGKFFAHEHTGVTPDICC
LAKGLGGGFPISATLATNNASQFMGVGMHGSTFGGNPLATTIGMTVVEEILKDGFLDNVTKNGHYLYKRLEDLAKKFPVI
EEVKGKGLMIGLKINTNINNRELMHDLISCGLLTNTASNNTLRIVPPLIITQQEIDEGLAILESYLQSKYHQ
>Mature_392_residues
MNSSPILPVYAPSKVTFSHGKGVYLYDYNNKKYVDFHAGIATSSLGHAHPALVNALKTQGEKLWHISNVHTIPEAIKLAQ
KLVDISFADKVFFNNSGAESVECCLKIARSYQCGKGNTQRYRFITMKQSYHGRTCAACSANDPSKFSPFLKPYVEWFDCV
NPDITSIKNAINETIGAILLEPIQGEGGINVLDDSFLKELRTICDQNDILLIFDCVQCGSGRTGKFFAHEHTGVTPDICC
LAKGLGGGFPISATLATNNASQFMGVGMHGSTFGGNPLATTIGMTVVEEILKDGFLDNVTKNGHYLYKRLEDLAKKFPVI
EEVKGKGLMIGLKINTNINNRELMHDLISCGLLTNTASNNTLRIVPPLIITQQEIDEGLAILESYLQSKYHQ

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=32.3076923076923, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=27.6887871853547, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI284507298, Length=302, Percent_Identity=31.4569536423841, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=24.9417249417249, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=24.8192771084337, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=25.3807106598985, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226442705, Length=429, Percent_Identity=24.4755244755245, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI188536080, Length=412, Percent_Identity=24.5145631067961, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI38679950, Length=412, Percent_Identity=24.5145631067961, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI38679946, Length=412, Percent_Identity=24.5145631067961, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1789759, Length=377, Percent_Identity=40.053050397878, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1788044, Length=377, Percent_Identity=38.7267904509284, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=33.6842105263158, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789016, Length=389, Percent_Identity=32.133676092545, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1787560, Length=396, Percent_Identity=32.8282828282828, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786991, Length=414, Percent_Identity=30.4347826086957, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=27.3775216138329, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=382, Percent_Identity=32.9842931937173, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=29.8165137614679, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=263, Percent_Identity=34.6007604562738, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=27.2727272727273, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=232, Percent_Identity=28.0172413793103, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71981843, Length=157, Percent_Identity=31.2101910828025, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=37.1212121212121, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6323470, Length=393, Percent_Identity=31.5521628498728, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=391, Percent_Identity=27.8772378516624, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=419, Percent_Identity=25.5369928400955, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357415, Length=385, Percent_Identity=32.7272727272727, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=28.2805429864253, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28574759, Length=422, Percent_Identity=28.9099526066351, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=25.6038647342995, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281366494, Length=429, Percent_Identity=23.3100233100233, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667139, Length=429, Percent_Identity=23.3100233100233, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667143, Length=429, Percent_Identity=23.3100233100233, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42989; Mature: 42989

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSPILPVYAPSKVTFSHGKGVYLYDYNNKKYVDFHAGIATSSLGHAHPALVNALKTQG
CCCCCEEEEECCCEEEEECCCEEEEEECCCCEEEEEECCCHHCCCCCCCHHHHHHHHHCC
EKLWHISNVHTIPEAIKLAQKLVDISFADKVFFNNSGAESVECCLKIARSYQCGKGNTQR
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCE
YRFITMKQSYHGRTCAACSANDPSKFSPFLKPYVEWFDCVNPDITSIKNAINETIGAILL
EEEEEEECCCCCCEEEECCCCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEE
EPIQGEGGINVLDDSFLKELRTICDQNDILLIFDCVQCGSGRTGKFFAHEHTGVTPDICC
ECCCCCCCCEECCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCCCCHHHHH
LAKGLGGGFPISATLATNNASQFMGVGMHGSTFGGNPLATTIGMTVVEEILKDGFLDNVT
HHHHCCCCCCEEEEEECCCHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCC
KNGHYLYKRLEDLAKKFPVIEEVKGKGLMIGLKINTNINNRELMHDLISCGLLTNTASNN
CCCHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCHHCCCCCCC
TLRIVPPLIITQQEIDEGLAILESYLQSKYHQ
EEEEECCEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSSPILPVYAPSKVTFSHGKGVYLYDYNNKKYVDFHAGIATSSLGHAHPALVNALKTQG
CCCCCEEEEECCCEEEEECCCEEEEEECCCCEEEEEECCCHHCCCCCCCHHHHHHHHHCC
EKLWHISNVHTIPEAIKLAQKLVDISFADKVFFNNSGAESVECCLKIARSYQCGKGNTQR
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCE
YRFITMKQSYHGRTCAACSANDPSKFSPFLKPYVEWFDCVNPDITSIKNAINETIGAILL
EEEEEEECCCCCCEEEECCCCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEE
EPIQGEGGINVLDDSFLKELRTICDQNDILLIFDCVQCGSGRTGKFFAHEHTGVTPDICC
ECCCCCCCCEECCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCCCCHHHHH
LAKGLGGGFPISATLATNNASQFMGVGMHGSTFGGNPLATTIGMTVVEEILKDGFLDNVT
HHHHCCCCCCEEEEEECCCHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCC
KNGHYLYKRLEDLAKKFPVIEEVKGKGLMIGLKINTNINNRELMHDLISCGLLTNTASNN
CCCHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCHHCCCCCCC
TLRIVPPLIITQQEIDEGLAILESYLQSKYHQ
EEEEECCEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]