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The map label for this gene is mutL

Identifier: 88658331

GI number: 88658331

Start: 906936

End: 908957

Strand: Reverse

Name: mutL

Synonym: ECH_0884

Alternate gene names: 88658331

Gene position: 908957-906936 (Counterclockwise)

Preceding gene: 88658417

Following gene: 88657984

Centisome position: 77.28

GC content: 29.62

Gene sequence:

>2022_bases
ATGTCAATTATACTATTAGATCCTAGAACAATTAATAGAATTGCTGCAGGGGAAGTAATAGAATGTCCAGCTAGTGTGGT
TAAAGAATTAGTTGAAAATTCAATAGATGCTAAAGCTACTGCCATAAGTATTACAATAGAACGTGGAGGACGTAATTTAA
TAATTGTTAGTGATAATGGTATTGGAATAAAAAAAGAAGATATGGAAATTGCATTTGCTCGTCATGCAACGTCTAAGCTT
CCTGATGGTGATTTAACAAAAGTTAGATCCTTGGGGTTTCGAGGAGAAGGATTAACTTCTATTGCAGCTGTTGGAAAAGT
AAAAATGGTTTCAAAATATAGAGATTCTGATACTGCATGGTTAATGGTATTTGAAGGTGGAGAAAAAACACAAGAATTGA
CACCAGATGCACTTTCTTGTGGTACTTATATTGAAGTGAGAGATTTGTTTTTTGCTACACCTAATAGGTTAAAGTTTCTT
AGGACAGAAAAAGCAGAGGTTCAATCTATTATTGATATGATGAACAAACTAGCTATGGTAAATCATAATGTAATGTTTTC
ATTATTTGTTGATAATAAACAGGTATTTAAATATTTAACACAACAATCAAATATTGATAGATTATCTGAAATAAAAACTT
TGGGAATGGAATTTTGTAAAAATTCTTTACCAGTGAATGTAAAAGAAGAGCAGATTCAATTATCAGGTTATATTGGATCT
CCTACATTAAGTCGTGGTAAGTCAAGTCTTATATATACTTTTGTTAATAGTCGACCTGTTTATGATAATTTACTGATAGG
TGCAGTTAGATATGCTTATAGTGATTTTATAGAAAAGGATAAATATCCAGTTGTTGTATTATATCTTGATATTCCATGTG
ATCAAGTTGACGCTAATGTTCATCCGAATAAATCTGAGGTAAGATTTCAAGATAAAAAGTTAGTATATAGAACTGTAGTT
AATGCAATTAAAGAAGTGTTATCGATCAACCTAAATACTAAATTAAAGTCTATAAGTGAATTTGAAAATGATCATTTTGT
ACATGCTAGTATGGTAAATTCAAGAAACATAGGTAATAGCGTTTCTTCCGAGTTTTTTAAATGTTTTCAAAATAGAAAAC
CATTACTTAACAATGACGTGCAAAAATATAGTTCTAAAAATGTAGAAACAGATGACCAATCTTTGTTAGATACTAATGTC
TCCTTTTGTACAGATTCAAAAATGATAACGAATAAATTAAAAGAAGAGAGAGTTTATGAAAATTCTAGAGAGCATATTAA
TAAGGGAGATTCTAAAATAGAGGTTAGTAATTTTGATATATTAGGAGAGAAAAAAAATTTTGTTAATTTAGCTAATAATC
TTCTACAGGAGTCACCTAGTATAGATAGTGGTAAGTTTAATACTAGTAAAAAAGTACCAAGTGATTCATTAATTGATACT
TATCCATTAGGCTATGCTTTATGTCAAATACACAGTAGATATATCATCTCTCAAACACAGGATTCTATTGTTATTATTGA
TCAGCATGCAGCTCATGAGAGATTAACTTATGAATATATGAAACAAGTTATGGCAAAAGAGGGGATAAAGCGTCAGATAC
TATTGATACCTGAGATTATTGAAATGAATAACCATCTTGATTTGGAGTTACTTGTTGAATATAAGGAAAAGTTATTAAAA
CTTGGATTACTCATTGAACCACTTGGTAATTTATCGGTAATAGTAAGGGAAGTTCCAGCACTTTTTGGAAGTTTTGATGT
TAAATCGCTTATTATTAATATAGTTGATAGTATTATGGAAGTAGGTGATACTTTATTCTTAGATGATAAGATTAAGGATA
TATGTGGGACTATAGCATGTTATAGTTCTATTAGAAGTGGTAGAAAATTAAAGATTGAAGAAATGAATGCTATTTTAAGG
AATATGGAAAATACTGCACATTCTGGACAATGTAATCATGGTAGGCCAACTTATGTAGAGCTAAATTTAGTTGAGATAGA
TAGGCTTTTTTCAAGAAGATAG

Upstream 100 bases:

>100_bases
TTAAGGTAATTTATACTGGATGTTTAGTGGTTGTACTACTAAGAAATAGTTGTTATTTCTGTATGTCTATAAATGTTGTT
TCAATTATCAGTGTTAGCAT

Downstream 100 bases:

>100_bases
TGAAATAATTTGGATATGTTGACAATATAAAACTACATATTTAATGTCATCTAGTATATGTAGTTTTGTTGATTTTAAGT
GTGATTTTCAAAGTTTGTGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSIILLDPRTINRIAAGEVIECPASVVKELVENSIDAKATAISITIERGGRNLIIVSDNGIGIKKEDMEIAFARHATSKL
PDGDLTKVRSLGFRGEGLTSIAAVGKVKMVSKYRDSDTAWLMVFEGGEKTQELTPDALSCGTYIEVRDLFFATPNRLKFL
RTEKAEVQSIIDMMNKLAMVNHNVMFSLFVDNKQVFKYLTQQSNIDRLSEIKTLGMEFCKNSLPVNVKEEQIQLSGYIGS
PTLSRGKSSLIYTFVNSRPVYDNLLIGAVRYAYSDFIEKDKYPVVVLYLDIPCDQVDANVHPNKSEVRFQDKKLVYRTVV
NAIKEVLSINLNTKLKSISEFENDHFVHASMVNSRNIGNSVSSEFFKCFQNRKPLLNNDVQKYSSKNVETDDQSLLDTNV
SFCTDSKMITNKLKEERVYENSREHINKGDSKIEVSNFDILGEKKNFVNLANNLLQESPSIDSGKFNTSKKVPSDSLIDT
YPLGYALCQIHSRYIISQTQDSIVIIDQHAAHERLTYEYMKQVMAKEGIKRQILLIPEIIEMNNHLDLELLVEYKEKLLK
LGLLIEPLGNLSVIVREVPALFGSFDVKSLIINIVDSIMEVGDTLFLDDKIKDICGTIACYSSIRSGRKLKIEEMNAILR
NMENTAHSGQCNHGRPTYVELNLVEIDRLFSRR

Sequences:

>Translated_673_residues
MSIILLDPRTINRIAAGEVIECPASVVKELVENSIDAKATAISITIERGGRNLIIVSDNGIGIKKEDMEIAFARHATSKL
PDGDLTKVRSLGFRGEGLTSIAAVGKVKMVSKYRDSDTAWLMVFEGGEKTQELTPDALSCGTYIEVRDLFFATPNRLKFL
RTEKAEVQSIIDMMNKLAMVNHNVMFSLFVDNKQVFKYLTQQSNIDRLSEIKTLGMEFCKNSLPVNVKEEQIQLSGYIGS
PTLSRGKSSLIYTFVNSRPVYDNLLIGAVRYAYSDFIEKDKYPVVVLYLDIPCDQVDANVHPNKSEVRFQDKKLVYRTVV
NAIKEVLSINLNTKLKSISEFENDHFVHASMVNSRNIGNSVSSEFFKCFQNRKPLLNNDVQKYSSKNVETDDQSLLDTNV
SFCTDSKMITNKLKEERVYENSREHINKGDSKIEVSNFDILGEKKNFVNLANNLLQESPSIDSGKFNTSKKVPSDSLIDT
YPLGYALCQIHSRYIISQTQDSIVIIDQHAAHERLTYEYMKQVMAKEGIKRQILLIPEIIEMNNHLDLELLVEYKEKLLK
LGLLIEPLGNLSVIVREVPALFGSFDVKSLIINIVDSIMEVGDTLFLDDKIKDICGTIACYSSIRSGRKLKIEEMNAILR
NMENTAHSGQCNHGRPTYVELNLVEIDRLFSRR
>Mature_672_residues
SIILLDPRTINRIAAGEVIECPASVVKELVENSIDAKATAISITIERGGRNLIIVSDNGIGIKKEDMEIAFARHATSKLP
DGDLTKVRSLGFRGEGLTSIAAVGKVKMVSKYRDSDTAWLMVFEGGEKTQELTPDALSCGTYIEVRDLFFATPNRLKFLR
TEKAEVQSIIDMMNKLAMVNHNVMFSLFVDNKQVFKYLTQQSNIDRLSEIKTLGMEFCKNSLPVNVKEEQIQLSGYIGSP
TLSRGKSSLIYTFVNSRPVYDNLLIGAVRYAYSDFIEKDKYPVVVLYLDIPCDQVDANVHPNKSEVRFQDKKLVYRTVVN
AIKEVLSINLNTKLKSISEFENDHFVHASMVNSRNIGNSVSSEFFKCFQNRKPLLNNDVQKYSSKNVETDDQSLLDTNVS
FCTDSKMITNKLKEERVYENSREHINKGDSKIEVSNFDILGEKKNFVNLANNLLQESPSIDSGKFNTSKKVPSDSLIDTY
PLGYALCQIHSRYIISQTQDSIVIIDQHAAHERLTYEYMKQVMAKEGIKRQILLIPEIIEMNNHLDLELLVEYKEKLLKL
GLLIEPLGNLSVIVREVPALFGSFDVKSLIINIVDSIMEVGDTLFLDDKIKDICGTIACYSSIRSGRKLKIEEMNAILRN
MENTAHSGQCNHGRPTYVELNLVEIDRLFSRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=327, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=30.9815950920245, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=30.9815950920245, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=29.3604651162791, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=29.3604651162791, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI189458896, Length=322, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=28.0405405405405, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI263191589, Length=236, Percent_Identity=26.6949152542373, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI91992160, Length=254, Percent_Identity=27.5590551181102, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI91992162, Length=254, Percent_Identity=27.5590551181102, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790612, Length=338, Percent_Identity=41.1242603550296, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=329, Percent_Identity=33.434650455927, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562796, Length=446, Percent_Identity=24.4394618834081, Blast_Score=111, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323819, Length=336, Percent_Identity=33.9285714285714, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=348, Percent_Identity=28.735632183908, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=762, Percent_Identity=21.9160104986877, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=360, Percent_Identity=23.8888888888889, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136968, Length=331, Percent_Identity=31.7220543806647, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=24.2857142857143, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_EHRCR (Q2GFV4)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507679.1
- ProteinModelPortal:   Q2GFV4
- SMR:   Q2GFV4
- STRING:   Q2GFV4
- GeneID:   3927913
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0884
- TIGR:   ECH_0884
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q2GFV4
- ProtClustDB:   PRK00095
- BioCyc:   ECHA205920:ECH_0884-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 76056; Mature: 75925

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIILLDPRTINRIAAGEVIECPASVVKELVENSIDAKATAISITIERGGRNLIIVSDNG
CEEEEECCCHHHHHHCCCHHCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCC
IGIKKEDMEIAFARHATSKLPDGDLTKVRSLGFRGEGLTSIAAVGKVKMVSKYRDSDTAW
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
LMVFEGGEKTQELTPDALSCGTYIEVRDLFFATPNRLKFLRTEKAEVQSIIDMMNKLAMV
EEEEECCCCCCCCCCCHHCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NHNVMFSLFVDNKQVFKYLTQQSNIDRLSEIKTLGMEFCKNSLPVNVKEEQIQLSGYIGS
CCCEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEEEECC
PTLSRGKSSLIYTFVNSRPVYDNLLIGAVRYAYSDFIEKDKYPVVVLYLDIPCDQVDANV
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
HPNKSEVRFQDKKLVYRTVVNAIKEVLSINLNTKLKSISEFENDHFVHASMVNSRNIGNS
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCH
VSSEFFKCFQNRKPLLNNDVQKYSSKNVETDDQSLLDTNVSFCTDSKMITNKLKEERVYE
HHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHH
NSREHINKGDSKIEVSNFDILGEKKNFVNLANNLLQESPSIDSGKFNTSKKVPSDSLIDT
CCHHHHCCCCCEEEEECCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
YPLGYALCQIHSRYIISQTQDSIVIIDQHAAHERLTYEYMKQVMAKEGIKRQILLIPEII
CCHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHH
EMNNHLDLELLVEYKEKLLKLGLLIEPLGNLSVIVREVPALFGSFDVKSLIINIVDSIME
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VGDTLFLDDKIKDICGTIACYSSIRSGRKLKIEEMNAILRNMENTAHSGQCNHGRPTYVE
CCCEEEECHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LNLVEIDRLFSRR
EEHHHHHHHHCCC
>Mature Secondary Structure 
SIILLDPRTINRIAAGEVIECPASVVKELVENSIDAKATAISITIERGGRNLIIVSDNG
EEEEECCCHHHHHHCCCHHCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEECCCC
IGIKKEDMEIAFARHATSKLPDGDLTKVRSLGFRGEGLTSIAAVGKVKMVSKYRDSDTAW
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEE
LMVFEGGEKTQELTPDALSCGTYIEVRDLFFATPNRLKFLRTEKAEVQSIIDMMNKLAMV
EEEEECCCCCCCCCCCHHCCCCEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NHNVMFSLFVDNKQVFKYLTQQSNIDRLSEIKTLGMEFCKNSLPVNVKEEQIQLSGYIGS
CCCEEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEEEECC
PTLSRGKSSLIYTFVNSRPVYDNLLIGAVRYAYSDFIEKDKYPVVVLYLDIPCDQVDANV
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
HPNKSEVRFQDKKLVYRTVVNAIKEVLSINLNTKLKSISEFENDHFVHASMVNSRNIGNS
CCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCH
VSSEFFKCFQNRKPLLNNDVQKYSSKNVETDDQSLLDTNVSFCTDSKMITNKLKEERVYE
HHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHH
NSREHINKGDSKIEVSNFDILGEKKNFVNLANNLLQESPSIDSGKFNTSKKVPSDSLIDT
CCHHHHCCCCCEEEEECCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
YPLGYALCQIHSRYIISQTQDSIVIIDQHAAHERLTYEYMKQVMAKEGIKRQILLIPEII
CCHHHHHHHHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHH
EMNNHLDLELLVEYKEKLLKLGLLIEPLGNLSVIVREVPALFGSFDVKSLIINIVDSIME
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VGDTLFLDDKIKDICGTIACYSSIRSGRKLKIEEMNAILRNMENTAHSGQCNHGRPTYVE
CCCEEEECHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
LNLVEIDRLFSRR
EEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA