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The map label for this gene is dapA

Identifier: 88658264

GI number: 88658264

Start: 843296

End: 844189

Strand: Direct

Name: dapA

Synonym: ECH_0828

Alternate gene names: 88658264

Gene position: 843296-844189 (Clockwise)

Preceding gene: 88658042

Following gene: 88657903

Centisome position: 71.69

GC content: 32.77

Gene sequence:

>894_bases
ATGTACAGCCTTATGGGTGTTTTTACGGCATTAATTACACCATTTAAGGATGATTTTTCTATAGATGAAAACGCGTTTTG
TCATCTAATTGAAGAACAAATCAGTAATAATATTCATGGTTTAGTTCCATGCGGCACTACTGCAGAATGTCCTACTTTAA
GCTTTGAAGAGTACTGCAAAGTAATCGAATTATGTGTTAAAATCACAAATAAACGTGTCCCCATAATAGCTGGATCAAGC
TCAAATTCTACACAAGAAGCTATTAAACGCACGTTATATGTTCAGTCTCTAAATGTAGATGCAGCTTTAGTAGTTGTACC
ATATTACAATAGACCAAGTGATGAAGGAATATATCAACATTTTAAAGCAGTACATGATGCAACTAACCTTCCCATTATTG
CATATAATATACCTAATAGATCTGCTATTGATGCAAGCGATGCATTACTTGCACGAATTTTATCTTTGCCTAGAATAATA
GGGCTTAAAGATTCAACTGGAGATGTAAGTAGGCCTCTTAATTTAAAATTATTACTAAATAAAGAAGTAGTTTTATTCTC
AGGTGATGATTCTACATGCTTAGGGTTCTATGCTCAAAGTGGTAGTGGTGGTAGGACTGGATGCATTTCTGTTGTTTCAA
ATGTGATACCTAAAATACATGCTGATATGCACAATGCATTCCTTGCTAATAATATGAAAGAAGCTATGAATGCAAATTTA
TCAGTATTTAAATTAGCAAAAGCATTGTTTTGTCAGTCAAGCCCTGCACCAACAAAATATGCTATGAGCTTAATTAAAAA
TATCTCACCAGCAGTAAGGTTGCCATTAGTGGAATTAACTCAAGAAAACAAATTAAAAGTTGAAAAAACGCTAAAAGAAT
TAAAGTTAATTTAA

Upstream 100 bases:

>100_bases
ACAATAATCACTTAAAGTATCTTGTGTTTAATGTAATATTCATTTGACAACAAAATACCAATAGATATACTAACCTTGTT
TGAAATATGTGAGGTACAGT

Downstream 100 bases:

>100_bases
GACATATTCAATAACCTGGGGTTATGGTAATAAGCGTTGGTAGTTTGTATATTATGCTTTTTATTATCTAATATGCTTGA
CATGGTATATTGATGTGGAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MYSLMGVFTALITPFKDDFSIDENAFCHLIEEQISNNIHGLVPCGTTAECPTLSFEEYCKVIELCVKITNKRVPIIAGSS
SNSTQEAIKRTLYVQSLNVDAALVVVPYYNRPSDEGIYQHFKAVHDATNLPIIAYNIPNRSAIDASDALLARILSLPRII
GLKDSTGDVSRPLNLKLLLNKEVVLFSGDDSTCLGFYAQSGSGGRTGCISVVSNVIPKIHADMHNAFLANNMKEAMNANL
SVFKLAKALFCQSSPAPTKYAMSLIKNISPAVRLPLVELTQENKLKVEKTLKELKLI

Sequences:

>Translated_297_residues
MYSLMGVFTALITPFKDDFSIDENAFCHLIEEQISNNIHGLVPCGTTAECPTLSFEEYCKVIELCVKITNKRVPIIAGSS
SNSTQEAIKRTLYVQSLNVDAALVVVPYYNRPSDEGIYQHFKAVHDATNLPIIAYNIPNRSAIDASDALLARILSLPRII
GLKDSTGDVSRPLNLKLLLNKEVVLFSGDDSTCLGFYAQSGSGGRTGCISVVSNVIPKIHADMHNAFLANNMKEAMNANL
SVFKLAKALFCQSSPAPTKYAMSLIKNISPAVRLPLVELTQENKLKVEKTLKELKLI
>Mature_297_residues
MYSLMGVFTALITPFKDDFSIDENAFCHLIEEQISNNIHGLVPCGTTAECPTLSFEEYCKVIELCVKITNKRVPIIAGSS
SNSTQEAIKRTLYVQSLNVDAALVVVPYYNRPSDEGIYQHFKAVHDATNLPIIAYNIPNRSAIDASDALLARILSLPRII
GLKDSTGDVSRPLNLKLLLNKEVVLFSGDDSTCLGFYAQSGSGGRTGCISVVSNVIPKIHADMHNAFLANNMKEAMNANL
SVFKLAKALFCQSSPAPTKYAMSLIKNISPAVRLPLVELTQENKLKVEKTLKELKLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=295, Percent_Identity=23.0508474576271, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=33.1058020477816, Blast_Score=180, Evalue=9e-47,
Organism=Escherichia coli, GI87082415, Length=295, Percent_Identity=24.406779661017, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1786463, Length=252, Percent_Identity=23.4126984126984, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789620, Length=234, Percent_Identity=26.0683760683761, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_EHRCR (Q2GG09)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507624.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q2GG09
- SMR:   Q2GG09
- STRING:   Q2GG09
- GeneID:   3927943
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0828
- TIGR:   ECH_0828
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   YYNRPSD
- ProtClustDB:   PRK03170
- BioCyc:   ECHA205920:ECH_0828-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32523; Mature: 32523

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 163-163

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLMGVFTALITPFKDDFSIDENAFCHLIEEQISNNIHGLVPCGTTAECPTLSFEEYCK
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHH
VIELCVKITNKRVPIIAGSSSNSTQEAIKRTLYVQSLNVDAALVVVPYYNRPSDEGIYQH
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHEEECCCEEEEEEECCCCCCCCHHHHH
FKAVHDATNLPIIAYNIPNRSAIDASDALLARILSLPRIIGLKDSTGDVSRPLNLKLLLN
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEEEEEEC
KEVVLFSGDDSTCLGFYAQSGSGGRTGCISVVSNVIPKIHADMHNAFLANNMKEAMNANL
CEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SVFKLAKALFCQSSPAPTKYAMSLIKNISPAVRLPLVELTQENKLKVEKTLKELKLI
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHCCHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MYSLMGVFTALITPFKDDFSIDENAFCHLIEEQISNNIHGLVPCGTTAECPTLSFEEYCK
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHH
VIELCVKITNKRVPIIAGSSSNSTQEAIKRTLYVQSLNVDAALVVVPYYNRPSDEGIYQH
HHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHEEECCCEEEEEEECCCCCCCCHHHHH
FKAVHDATNLPIIAYNIPNRSAIDASDALLARILSLPRIIGLKDSTGDVSRPLNLKLLLN
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCCCCEEEEEEC
KEVVLFSGDDSTCLGFYAQSGSGGRTGCISVVSNVIPKIHADMHNAFLANNMKEAMNANL
CEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
SVFKLAKALFCQSSPAPTKYAMSLIKNISPAVRLPLVELTQENKLKVEKTLKELKLI
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHCCHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA