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The map label for this gene is fabF [H]

Identifier: 88658199

GI number: 88658199

Start: 903635

End: 904903

Strand: Direct

Name: fabF [H]

Synonym: ECH_0882

Alternate gene names: 88658199

Gene position: 903635-904903 (Clockwise)

Preceding gene: 88657574

Following gene: 88657722

Centisome position: 76.82

GC content: 36.33

Gene sequence:

>1269_bases
ATGGCAAAAAAGAGAGTTGTTATTACCGGGCTAGGGTTAGTCACTTCTCTAGGTAGCGATTTAAAAACAGTATGGGACTC
TTTATCTAAAGGAATTTCAGGTATAAGAAAAATTGATAGATTTGATACATCTGACCTTGACTGTAAAGTAGCTGGTCAGG
TAACAACAAAACCTGAATCTGAAGAATATATTTTTGATGCCGGAGATTATATACCAGAAAAAGATTTAAAAAAAATGGAT
ACTTTTATTCATTTTGGTATAGCATCTGCTACCCAAGCAATTAATGACTCTAATTTACTTGATTATAAAGATCTTGACTA
TAGTAGAGTAGGAGTAATAGTGGGATCAGGAATAGGTGGTCTCCAATTTATCGAAAAAACTGTTATATGTTTGAAAGAGC
GTGGTCCGAAGAGAATTAGTCCCTTTTTTATTCCTGCAAGTTTAATTAATTTAACATCTGGTCACATATCCATGAAGTAT
GGGTTCACAGGATTAAATGATGCAGTAGTAACCGCATGTTCAACAGGAGCACAAGCTATAGGTAATGCAGCAAGAGTCAT
TCAATCTGGTGAAGCAGATGTAATAATAGCTGGTGGAACAGAAAGTGCAATCTGCCGTATAGGAATTGCAGGATTTGCAG
CTATGAAAGCACTCTCAACAAAATTTAATGATACTCCAGAGTTAGCATCACGTCCCTGGGATAAGCAAAGAGACGGATTT
GTTATGGGAGAAGGTTCAGGAGTAGTTATATTAGAAGACTACGAACATGCTAAAAAACGTGGAGCAAGAATATACGGGGA
ACTGTTAGGGTATGGCATGACCTCAGATGCATATCATATGTCAGCACCTCATCCAGAAGGGAAAGGTGGAATAAAATCTA
TTGAGCTCGCACTATCTAACGCACAATTAAACCCAGAATCTATAAATTACATAAATGCACATGGTACTTCCACTCCTATA
GGAGATAGTATAGAAATCCAAGCAATAAAGAATGTATTTAAGGAAAGCGTATATAAAGTACCAATATCATCAACAAAATC
CTCCATAGGCCATTTACTTGGAGCAGCAGGAAGCGTTGAAGCTATATTCTGTATACTTGCTATGAATACAGGAATTGCCC
CTCCTACATTAAATTTACATGAGTCTTCTGAAGATCCAAAATTAAATCTTGTTCCACTTAATGCACAGGAACATAAGATC
AATTATTGTCTTTCTAACTCTTTTGGGTTTGGTGGAGTAAATGTATCTTTAGTATTTGGTAAGGTGTAG

Upstream 100 bases:

>100_bases
AAATTTCCGATGAAGAAGCACAAGAACTTGAAACTATAGATAAAATAGAAGAGTATATACGTAATAAGTTATCAAGTAAG
AATTGATTGGAGTAGCTTAT

Downstream 100 bases:

>100_bases
AGTTATTTTGGTTACATATCTTAGTATATAATCTTCACATATTTTGTTCTGTAATACTAGTTAAAACATTATCGTCTACT
TTTACTAATATGATAATTTA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MAKKRVVITGLGLVTSLGSDLKTVWDSLSKGISGIRKIDRFDTSDLDCKVAGQVTTKPESEEYIFDAGDYIPEKDLKKMD
TFIHFGIASATQAINDSNLLDYKDLDYSRVGVIVGSGIGGLQFIEKTVICLKERGPKRISPFFIPASLINLTSGHISMKY
GFTGLNDAVVTACSTGAQAIGNAARVIQSGEADVIIAGGTESAICRIGIAGFAAMKALSTKFNDTPELASRPWDKQRDGF
VMGEGSGVVILEDYEHAKKRGARIYGELLGYGMTSDAYHMSAPHPEGKGGIKSIELALSNAQLNPESINYINAHGTSTPI
GDSIEIQAIKNVFKESVYKVPISSTKSSIGHLLGAAGSVEAIFCILAMNTGIAPPTLNLHESSEDPKLNLVPLNAQEHKI
NYCLSNSFGFGGVNVSLVFGKV

Sequences:

>Translated_422_residues
MAKKRVVITGLGLVTSLGSDLKTVWDSLSKGISGIRKIDRFDTSDLDCKVAGQVTTKPESEEYIFDAGDYIPEKDLKKMD
TFIHFGIASATQAINDSNLLDYKDLDYSRVGVIVGSGIGGLQFIEKTVICLKERGPKRISPFFIPASLINLTSGHISMKY
GFTGLNDAVVTACSTGAQAIGNAARVIQSGEADVIIAGGTESAICRIGIAGFAAMKALSTKFNDTPELASRPWDKQRDGF
VMGEGSGVVILEDYEHAKKRGARIYGELLGYGMTSDAYHMSAPHPEGKGGIKSIELALSNAQLNPESINYINAHGTSTPI
GDSIEIQAIKNVFKESVYKVPISSTKSSIGHLLGAAGSVEAIFCILAMNTGIAPPTLNLHESSEDPKLNLVPLNAQEHKI
NYCLSNSFGFGGVNVSLVFGKV
>Mature_421_residues
AKKRVVITGLGLVTSLGSDLKTVWDSLSKGISGIRKIDRFDTSDLDCKVAGQVTTKPESEEYIFDAGDYIPEKDLKKMDT
FIHFGIASATQAINDSNLLDYKDLDYSRVGVIVGSGIGGLQFIEKTVICLKERGPKRISPFFIPASLINLTSGHISMKYG
FTGLNDAVVTACSTGAQAIGNAARVIQSGEADVIIAGGTESAICRIGIAGFAAMKALSTKFNDTPELASRPWDKQRDGFV
MGEGSGVVILEDYEHAKKRGARIYGELLGYGMTSDAYHMSAPHPEGKGGIKSIELALSNAQLNPESINYINAHGTSTPIG
DSIEIQAIKNVFKESVYKVPISSTKSSIGHLLGAAGSVEAIFCILAMNTGIAPPTLNLHESSEDPKLNLVPLNAQEHKIN
YCLSNSFGFGGVNVSLVFGKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=46.2829736211031, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=160, Percent_Identity=50, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI41872631, Length=427, Percent_Identity=26.2295081967213, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=48.4633569739953, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1788663, Length=422, Percent_Identity=39.0995260663507, Blast_Score=264, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=38.9150943396226, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=46.5384615384615, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17550940, Length=258, Percent_Identity=30.6201550387597, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=366, Percent_Identity=25.1366120218579, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.7713004484305, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6325025, Length=256, Percent_Identity=28.90625, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=41.4691943127962, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24581345, Length=360, Percent_Identity=26.9444444444444, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI221330659, Length=362, Percent_Identity=25.414364640884, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920632, Length=362, Percent_Identity=25.414364640884, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44960; Mature: 44829

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKRVVITGLGLVTSLGSDLKTVWDSLSKGISGIRKIDRFDTSDLDCKVAGQVTTKPES
CCCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEECCCCC
EEYIFDAGDYIPEKDLKKMDTFIHFGIASATQAINDSNLLDYKDLDYSRVGVIVGSGIGG
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCH
LQFIEKTVICLKERGPKRISPFFIPASLINLTSGHISMKYGFTGLNDAVVTACSTGAQAI
HHHHHHHHHHHHCCCCCCCCCEEECHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCHHHH
GNAARVIQSGEADVIIAGGTESAICRIGIAGFAAMKALSTKFNDTPELASRPWDKQRDGF
HHHHHHHCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCE
VMGEGSGVVILEDYEHAKKRGARIYGELLGYGMTSDAYHMSAPHPEGKGGIKSIELALSN
EEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCEEEEEEEEC
AQLNPESINYINAHGTSTPIGDSIEIQAIKNVFKESVYKVPISSTKSSIGHLLGAAGSVE
CCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHH
AIFCILAMNTGIAPPTLNLHESSEDPKLNLVPLNAQEHKINYCLSNSFGFGGVNVSLVFG
HEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEE
KV
CC
>Mature Secondary Structure 
AKKRVVITGLGLVTSLGSDLKTVWDSLSKGISGIRKIDRFDTSDLDCKVAGQVTTKPES
CCCEEEEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCEECCCCC
EEYIFDAGDYIPEKDLKKMDTFIHFGIASATQAINDSNLLDYKDLDYSRVGVIVGSGIGG
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCH
LQFIEKTVICLKERGPKRISPFFIPASLINLTSGHISMKYGFTGLNDAVVTACSTGAQAI
HHHHHHHHHHHHCCCCCCCCCEEECHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCHHHH
GNAARVIQSGEADVIIAGGTESAICRIGIAGFAAMKALSTKFNDTPELASRPWDKQRDGF
HHHHHHHCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCE
VMGEGSGVVILEDYEHAKKRGARIYGELLGYGMTSDAYHMSAPHPEGKGGIKSIELALSN
EEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCEEEEEEEEC
AQLNPESINYINAHGTSTPIGDSIEIQAIKNVFKESVYKVPISSTKSSIGHLLGAAGSVE
CCCCCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHH
AIFCILAMNTGIAPPTLNLHESSEDPKLNLVPLNAQEHKINYCLSNSFGFGGVNVSLVFG
HEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEE
KV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]