Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 88658017

GI number: 88658017

Start: 1080495

End: 1081910

Strand: Direct

Name: degP [H]

Synonym: ECH_1052

Alternate gene names: 88658017

Gene position: 1080495-1081910 (Clockwise)

Preceding gene: 88658164

Following gene: 88658500

Centisome position: 91.86

GC content: 33.97

Gene sequence:

>1416_bases
ATGAAAAGATTTCTATTACTAATATTAGTACTAATATTGGCAAATGTTCCTATAGGTAGTTTTGCTGATCAGAAAGCAGA
ACAATATGATCCAAGGTCAGGCTTTTCTAAATTAATCAAAGAATCTACACCAGCAGTAGTTAATATCAGTATAGTACATG
ATTTAATACAGGAACAATTTCCTTTAATAACTCTCGAAGAACTTTTAAGGAATATATTAGAAGGCAAGCCAGTAAAAAAA
GACATACCACAAGAAGTATTAAGCGCAGGGTCGGGATTTGTTGTAGATGAATCAGGTATTATCGTCACCAACTATCATGT
TGTACACAATGCAAAAGAAGTTTATGTCACATTTAGTGACAACAAGTCAATTCCTGCTAAGATTTTAGGAGTTGACCCAC
AAACAGACCTAGCAGTGTTAAAAGTTGAAGTTAATGAAAAACTTCCTTATCTAGAATTTGGAGATTCTGACAAGACTATG
GTTGGAGACTGGGTAGTTGCCATAGGTAACCCATTTGGTCTTGGTGGTTCTGCAAGTATTGGTATTATATCTGCACGCGC
AAGAGATCTTAACATTGGCACAGCAACAGAATTTTTACAAACTGATGCTGCAATTAATAAGGGTAACTCTGGTGGTCCTC
TATTTAATATAGATGGTAAAGTAATTGGTATTAACACAGCAATATTATCTACACAAAAAGGTGGTGGTAACATAGGAGTT
GGATTTGCTATCCCATCAAATAATGCTGTTTCTATAATAAAAGTTTTATCCCAAGGGAAAAAAGTAGAACATGGTTGGCT
CGGTGTAGTGATGCAACCGATAACTGAAGAACTAGTAGAACCATTACAACTAAAAGAAGTGGGTGGAGCTTTAATTACTA
ATGTAGTCAAAGGTAGTCCAGCAAGTAAAGCAAACTTGCTTCCAGGGGATATTATACTTGAGTTTAATGGTACTAAGATT
AATTCAATATCACAACTACATCAATTAGTACTAAGATCAGAAGCAGACAATGAAGTAAAATTACTTGTGTCACGTAATGG
TAGTATTATAAGTATACTAGTCAAAATAGGGAAATTTGAGAATCCTGATATTTCAGAAAACGGAATGCCTAAGGATGCTA
TCCAATCCCCGGAGTTAGGGTTAACAGTAGGTAGTGTACAACGCAATAACATATATAATAATATTGAGGAAGAAGAAGCA
AAAGGAGTGGTGATATTAGATATAGATAGTACAAGTAATGCTTCAACCAGAAATATAAGAAAAGGCGATATAATATTACA
AATCAATCAATCACCAGTAAATAATCTCGAAGATTTTAAAAATGTTATGAAAAAAGTACGTAAAAATAAATCTGTAGCAT
TGTTAATCAGTAGGGATAATATATCAGCTTTTGTGACTGTCAAGCTGAAGCAGTAG

Upstream 100 bases:

>100_bases
AGCATATAAGCATGCTTTCAATGGGAAAAATACAAGAATTATCTTATCACCTAATAATGATTTTATTAATTTGTTTAATA
AAGAAAGAGGTAAATAATTA

Downstream 100 bases:

>100_bases
GATGAAAACTAAAATAGCATATATATATTTTTTTATAGTGTATTTTGTCAGTATACATGCGTATTCAACTGAAACAATAA
AAGAAGAATTACTATCTTAT

Product: serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKRFLLLILVLILANVPIGSFADQKAEQYDPRSGFSKLIKESTPAVVNISIVHDLIQEQFPLITLEELLRNILEGKPVKK
DIPQEVLSAGSGFVVDESGIIVTNYHVVHNAKEVYVTFSDNKSIPAKILGVDPQTDLAVLKVEVNEKLPYLEFGDSDKTM
VGDWVVAIGNPFGLGGSASIGIISARARDLNIGTATEFLQTDAAINKGNSGGPLFNIDGKVIGINTAILSTQKGGGNIGV
GFAIPSNNAVSIIKVLSQGKKVEHGWLGVVMQPITEELVEPLQLKEVGGALITNVVKGSPASKANLLPGDIILEFNGTKI
NSISQLHQLVLRSEADNEVKLLVSRNGSIISILVKIGKFENPDISENGMPKDAIQSPELGLTVGSVQRNNIYNNIEEEEA
KGVVILDIDSTSNASTRNIRKGDIILQINQSPVNNLEDFKNVMKKVRKNKSVALLISRDNISAFVTVKLKQ

Sequences:

>Translated_471_residues
MKRFLLLILVLILANVPIGSFADQKAEQYDPRSGFSKLIKESTPAVVNISIVHDLIQEQFPLITLEELLRNILEGKPVKK
DIPQEVLSAGSGFVVDESGIIVTNYHVVHNAKEVYVTFSDNKSIPAKILGVDPQTDLAVLKVEVNEKLPYLEFGDSDKTM
VGDWVVAIGNPFGLGGSASIGIISARARDLNIGTATEFLQTDAAINKGNSGGPLFNIDGKVIGINTAILSTQKGGGNIGV
GFAIPSNNAVSIIKVLSQGKKVEHGWLGVVMQPITEELVEPLQLKEVGGALITNVVKGSPASKANLLPGDIILEFNGTKI
NSISQLHQLVLRSEADNEVKLLVSRNGSIISILVKIGKFENPDISENGMPKDAIQSPELGLTVGSVQRNNIYNNIEEEEA
KGVVILDIDSTSNASTRNIRKGDIILQINQSPVNNLEDFKNVMKKVRKNKSVALLISRDNISAFVTVKLKQ
>Mature_471_residues
MKRFLLLILVLILANVPIGSFADQKAEQYDPRSGFSKLIKESTPAVVNISIVHDLIQEQFPLITLEELLRNILEGKPVKK
DIPQEVLSAGSGFVVDESGIIVTNYHVVHNAKEVYVTFSDNKSIPAKILGVDPQTDLAVLKVEVNEKLPYLEFGDSDKTM
VGDWVVAIGNPFGLGGSASIGIISARARDLNIGTATEFLQTDAAINKGNSGGPLFNIDGKVIGINTAILSTQKGGGNIGV
GFAIPSNNAVSIIKVLSQGKKVEHGWLGVVMQPITEELVEPLQLKEVGGALITNVVKGSPASKANLLPGDIILEFNGTKI
NSISQLHQLVLRSEADNEVKLLVSRNGSIISILVKIGKFENPDISENGMPKDAIQSPELGLTVGSVQRNNIYNNIEEEEA
KGVVILDIDSTSNASTRNIRKGDIILQINQSPVNNLEDFKNVMKKVRKNKSVALLISRDNISAFVTVKLKQ

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=336, Percent_Identity=33.0357142857143, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4506141, Length=323, Percent_Identity=33.4365325077399, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI22129776, Length=302, Percent_Identity=34.1059602649007, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI24308541, Length=302, Percent_Identity=31.4569536423841, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789629, Length=459, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1786356, Length=392, Percent_Identity=34.4387755102041, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=33.4532374100719, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646839, Length=303, Percent_Identity=33.003300330033, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50772; Mature: 50772

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFLLLILVLILANVPIGSFADQKAEQYDPRSGFSKLIKESTPAVVNISIVHDLIQEQF
CHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHC
PLITLEELLRNILEGKPVKKDIPQEVLSAGSGFVVDESGIIVTNYHVVHNAKEVYVTFSD
CEEHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCEEEEEEEEEECCEEEEEEECC
NKSIPAKILGVDPQTDLAVLKVEVNEKLPYLEFGDSDKTMVGDWVVAIGNPFGLGGSASI
CCCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCCCEEECEEEEEECCCCCCCCCCCE
GIISARARDLNIGTATEFLQTDAAINKGNSGGPLFNIDGKVIGINTAILSTQKGGGNIGV
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCEEEEEEEEEEEECCCCCCEEE
GFAIPSNNAVSIIKVLSQGKKVEHGWLGVVMQPITEELVEPLQLKEVGGALITNVVKGSP
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHCCCC
ASKANLLPGDIILEFNGTKINSISQLHQLVLRSEADNEVKLLVSRNGSIISILVKIGKFE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCC
NPDISENGMPKDAIQSPELGLTVGSVQRNNIYNNIEEEEAKGVVILDIDSTSNASTRNIR
CCCCCCCCCCHHHHCCCCCCEEECCEECCCCCCCCCHHHCCEEEEEEECCCCCCCCCCEE
KGDIILQINQSPVNNLEDFKNVMKKVRKNKSVALLISRDNISAFVTVKLKQ
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECC
>Mature Secondary Structure
MKRFLLLILVLILANVPIGSFADQKAEQYDPRSGFSKLIKESTPAVVNISIVHDLIQEQF
CHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHC
PLITLEELLRNILEGKPVKKDIPQEVLSAGSGFVVDESGIIVTNYHVVHNAKEVYVTFSD
CEEHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCEEEEEEEEEECCEEEEEEECC
NKSIPAKILGVDPQTDLAVLKVEVNEKLPYLEFGDSDKTMVGDWVVAIGNPFGLGGSASI
CCCCCEEEEECCCCCCEEEEEEEECCCCCEEEECCCCCEEECEEEEEECCCCCCCCCCCE
GIISARARDLNIGTATEFLQTDAAINKGNSGGPLFNIDGKVIGINTAILSTQKGGGNIGV
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCEEEEEEEEEEEECCCCCCEEE
GFAIPSNNAVSIIKVLSQGKKVEHGWLGVVMQPITEELVEPLQLKEVGGALITNVVKGSP
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHCCCC
ASKANLLPGDIILEFNGTKINSISQLHQLVLRSEADNEVKLLVSRNGSIISILVKIGKFE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCC
NPDISENGMPKDAIQSPELGLTVGSVQRNNIYNNIEEEEAKGVVILDIDSTSNASTRNIR
CCCCCCCCCCHHHHCCCCCCEEECCEECCCCCCCCCHHHCCEEEEEEECCCCCCCCCCEE
KGDIILQINQSPVNNLEDFKNVMKKVRKNKSVALLISRDNISAFVTVKLKQ
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]