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The map label for this gene is hflC [H]

Identifier: 88658164

GI number: 88658164

Start: 1079622

End: 1080491

Strand: Direct

Name: hflC [H]

Synonym: ECH_1051

Alternate gene names: 88658164

Gene position: 1079622-1080491 (Clockwise)

Preceding gene: 88657696

Following gene: 88658017

Centisome position: 91.79

GC content: 32.07

Gene sequence:

>870_bases
ATGAGTAAATCATTTAAGTTCATATTAGGGTTTTTAACTATCGCAACAGTTATCGTATCATTAAACTCCATGTTTATTGT
CGATGAAGCACATCAATCAATAGTCCTACAATTTGGACGCGTAGTAAAACAGATACACAATAGCGGATTATATTTTAAAG
TACCTTTTATACAGAAGGTTGTGTATGTTGACAAAAGAATTATCGATATTAGTTCTGACTCAAGAGAAGTTATCGCTGCT
GATCAAAAGAGATTTATCGTTGATTCTTATGCAAAATACAAGATTGTAGATGCCGTCAAATTTTATCAAACAGTCAGAAA
TGAAACAGGATTAAAGAATAGATTAAGTTCTATCATCGAATCAAACATCCGTGAAAAAATAGGAAATGTATCACTTATTA
ATTTTCTAAATGAAGCAAGATCAGAAGTTATGTCAGTGATACAAGAAGGCGTTAGCAAAGAGTCCCAAAAATTTGGCATA
GAAATGATAGACGTCAGAATTAAGCGTGCAGATCTACCAGAAGAAAATAGCATAGCTATATTTAGACGTATGCAAACAGA
TAGAGAAAAAGAAGCAAAAGAAATCAGAGCAGAAGGAGAAGCAGCGTCACAGCGCATTAAAGCTGATGCAGACCTTCAAA
CTCGTATTATCATCGCAAATGCGATCAAAGAAGCACAAATCATTCGAGGGAATGGAGATGCTAAAGCTTCAAAAATTTAC
AATGAAGCTTTAAAATCTGATCCAAATTTCTTTAGTTTTTATAGAACAATGCAAGCATATAAGCATGCTTTCAATGGGAA
AAATACAAGAATTATCTTATCACCTAATAATGATTTTATTAATTTGTTTAATAAAGAAAGAGGTAAATAA

Upstream 100 bases:

>100_bases
GAAATATTAAATAAAAATGATAAGGTAGTTGTCAGCGATGATCTGAAAGGTATGCTTTCTTACTTCCCGTTAGCAGATCC
TAGAAATAGTAGGTAAGTTT

Downstream 100 bases:

>100_bases
TTAATGAAAAGATTTCTATTACTAATATTAGTACTAATATTGGCAAATGTTCCTATAGGTAGTTTTGCTGATCAGAAAGC
AGAACAATATGATCCAAGGT

Product: hflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSKSFKFILGFLTIATVIVSLNSMFIVDEAHQSIVLQFGRVVKQIHNSGLYFKVPFIQKVVYVDKRIIDISSDSREVIAA
DQKRFIVDSYAKYKIVDAVKFYQTVRNETGLKNRLSSIIESNIREKIGNVSLINFLNEARSEVMSVIQEGVSKESQKFGI
EMIDVRIKRADLPEENSIAIFRRMQTDREKEAKEIRAEGEAASQRIKADADLQTRIIIANAIKEAQIIRGNGDAKASKIY
NEALKSDPNFFSFYRTMQAYKHAFNGKNTRIILSPNNDFINLFNKERGK

Sequences:

>Translated_289_residues
MSKSFKFILGFLTIATVIVSLNSMFIVDEAHQSIVLQFGRVVKQIHNSGLYFKVPFIQKVVYVDKRIIDISSDSREVIAA
DQKRFIVDSYAKYKIVDAVKFYQTVRNETGLKNRLSSIIESNIREKIGNVSLINFLNEARSEVMSVIQEGVSKESQKFGI
EMIDVRIKRADLPEENSIAIFRRMQTDREKEAKEIRAEGEAASQRIKADADLQTRIIIANAIKEAQIIRGNGDAKASKIY
NEALKSDPNFFSFYRTMQAYKHAFNGKNTRIILSPNNDFINLFNKERGK
>Mature_288_residues
SKSFKFILGFLTIATVIVSLNSMFIVDEAHQSIVLQFGRVVKQIHNSGLYFKVPFIQKVVYVDKRIIDISSDSREVIAAD
QKRFIVDSYAKYKIVDAVKFYQTVRNETGLKNRLSSIIESNIREKIGNVSLINFLNEARSEVMSVIQEGVSKESQKFGIE
MIDVRIKRADLPEENSIAIFRRMQTDREKEAKEIRAEGEAASQRIKADADLQTRIIIANAIKEAQIIRGNGDAKASKIYN
EALKSDPNFFSFYRTMQAYKHAFNGKNTRIILSPNNDFINLFNKERGK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=308, Percent_Identity=29.5454545454545, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1786697, Length=283, Percent_Identity=24.3816254416961, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17569493, Length=197, Percent_Identity=23.8578680203046, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193209764, Length=197, Percent_Identity=23.8578680203046, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 33017; Mature: 32886

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSFKFILGFLTIATVIVSLNSMFIVDEAHQSIVLQFGRVVKQIHNSGLYFKVPFIQKV
CCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHH
VYVDKRIIDISSDSREVIAADQKRFIVDSYAKYKIVDAVKFYQTVRNETGLKNRLSSIIE
HHHHHHEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SNIREKIGNVSLINFLNEARSEVMSVIQEGVSKESQKFGIEMIDVRIKRADLPEENSIAI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCEEEEEEEECCCCCCCCCHHH
FRRMQTDREKEAKEIRAEGEAASQRIKADADLQTRIIIANAIKEAQIIRGNGDAKASKIY
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEHHHHHHHHEEECCCCHHHHHHH
NEALKSDPNFFSFYRTMQAYKHAFNGKNTRIILSPNNDFINLFNKERGK
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCC
>Mature Secondary Structure 
SKSFKFILGFLTIATVIVSLNSMFIVDEAHQSIVLQFGRVVKQIHNSGLYFKVPFIQKV
CCHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHH
VYVDKRIIDISSDSREVIAADQKRFIVDSYAKYKIVDAVKFYQTVRNETGLKNRLSSIIE
HHHHHHEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SNIREKIGNVSLINFLNEARSEVMSVIQEGVSKESQKFGIEMIDVRIKRADLPEENSIAI
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCEEEEEEEECCCCCCCCCHHH
FRRMQTDREKEAKEIRAEGEAASQRIKADADLQTRIIIANAIKEAQIIRGNGDAKASKIY
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEHHHHHHHHEEECCCCHHHHHHH
NEALKSDPNFFSFYRTMQAYKHAFNGKNTRIILSPNNDFINLFNKERGK
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]