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The map label for this gene is trxB [H]

Identifier: 88658008

GI number: 88658008

Start: 745536

End: 746492

Strand: Direct

Name: trxB [H]

Synonym: ECH_0735

Alternate gene names: 88658008

Gene position: 745536-746492 (Clockwise)

Preceding gene: 88658172

Following gene: 88658438

Centisome position: 63.38

GC content: 35.42

Gene sequence:

>957_bases
ATGACACAAACATATAATACAAAAGTTTTAATTATAGGATCTGGAGCAGCAGGTTGTACTGCTGCTATATATGCTGCTCG
TGCAAACTTAAAACCTATATTAATAACTGGAATGTGCCCCGGGGGACAGCTTACAATTACTACAGATGTTGAAAATTTTC
CAGGATTTGCACATGCAGTACAAGGTCCAGATTTAATGGAACAAATGAAACAACAAGCTCATAACTCCGGAGCTCAGATT
ATATCTGACGAAATAAAAGAAATACATTCAGATGTATACCCTTTTAAATGTATAGGAATATTTGGTGATCAGTACATTGC
AGATAGTATTATAATTGCAACAGGAGCTCAAGCAAAATGGCTCAACATAAAAAGCGAAGAAACCTTTAAAGGTAGAGGTG
TATCTGCATGTGCTACATGTGATGGAACGTTTTTCGCTGGTAGTGATATTGCCGTAATAGGAGGAGGTAATACAGCTGTA
GAAGAAGCATTATATCTAACAAGATATGCAACAAAAGTATTTTTAATTCATAGAAGAGATACTCTACGTGCTGAACCTAT
AATGCAAGAACGATTATTCAGTAATGATAAAATACAAGTTATATGGAACAGCGTTGTAGAAGAAATACTAGGAAATAAGG
AAAGTGGGAATGTAGAAGCTATAGCATTAAAGTCTGTAAAAACTGGAGACATCACTACTATTTCCGTAAAAGGAGTATTT
ATTGCTATAGGACATACTCCAAACACACAAATACTAACAACCAAAGATAATGGGAATATAGTAGATTTAGATAACGAAGG
ATATATCATTACTAAACCTGGTAGTACAGTAACTAGTCACCCTGGAATCTTTGCTGCAGGTGATGTACAAGATAAAATAT
ATAGACAAGCTGTTGTTGCAGCAGGATCTGGGTGTATGGCTGCATTGGAAGCTGCCAAATTTTTATCAGAGCAATAA

Upstream 100 bases:

>100_bases
GATGAAAGGAGATCCAGCAATGGAAGCATCACAACATGGTATTGAAGATTACTTAAAATCACACATAGATCACCTTGAAA
AAAGTATTATGGATGAATAA

Downstream 100 bases:

>100_bases
ACCCATAATCTACCGATACAATATTAAGAATTAATTACTTAGTTTAGCCTCTTCTAAAGATTCATTTTTTATTTCTTGAA
ATCCACTAGCATTGTAATCA

Product: thioredoxin-disulfide reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTQTYNTKVLIIGSGAAGCTAAIYAARANLKPILITGMCPGGQLTITTDVENFPGFAHAVQGPDLMEQMKQQAHNSGAQI
ISDEIKEIHSDVYPFKCIGIFGDQYIADSIIIATGAQAKWLNIKSEETFKGRGVSACATCDGTFFAGSDIAVIGGGNTAV
EEALYLTRYATKVFLIHRRDTLRAEPIMQERLFSNDKIQVIWNSVVEEILGNKESGNVEAIALKSVKTGDITTISVKGVF
IAIGHTPNTQILTTKDNGNIVDLDNEGYIITKPGSTVTSHPGIFAAGDVQDKIYRQAVVAAGSGCMAALEAAKFLSEQ

Sequences:

>Translated_318_residues
MTQTYNTKVLIIGSGAAGCTAAIYAARANLKPILITGMCPGGQLTITTDVENFPGFAHAVQGPDLMEQMKQQAHNSGAQI
ISDEIKEIHSDVYPFKCIGIFGDQYIADSIIIATGAQAKWLNIKSEETFKGRGVSACATCDGTFFAGSDIAVIGGGNTAV
EEALYLTRYATKVFLIHRRDTLRAEPIMQERLFSNDKIQVIWNSVVEEILGNKESGNVEAIALKSVKTGDITTISVKGVF
IAIGHTPNTQILTTKDNGNIVDLDNEGYIITKPGSTVTSHPGIFAAGDVQDKIYRQAVVAAGSGCMAALEAAKFLSEQ
>Mature_317_residues
TQTYNTKVLIIGSGAAGCTAAIYAARANLKPILITGMCPGGQLTITTDVENFPGFAHAVQGPDLMEQMKQQAHNSGAQII
SDEIKEIHSDVYPFKCIGIFGDQYIADSIIIATGAQAKWLNIKSEETFKGRGVSACATCDGTFFAGSDIAVIGGGNTAVE
EALYLTRYATKVFLIHRRDTLRAEPIMQERLFSNDKIQVIWNSVVEEILGNKESGNVEAIALKSVKTGDITTISVKGVFI
AIGHTPNTQILTTKDNGNIVDLDNEGYIITKPGSTVTSHPGIFAAGDVQDKIYRQAVVAAGSGCMAALEAAKFLSEQ

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=323, Percent_Identity=51.0835913312694, Blast_Score=303, Evalue=7e-84,
Organism=Escherichia coli, GI87081763, Length=314, Percent_Identity=32.8025477707006, Blast_Score=129, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320560, Length=321, Percent_Identity=47.9750778816199, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6321898, Length=328, Percent_Identity=45.7317073170732, Blast_Score=276, Evalue=3e-75,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 33910; Mature: 33779

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTYNTKVLIIGSGAAGCTAAIYAARANLKPILITGMCPGGQLTITTDVENFPGFAHAV
CCCEECEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHC
QGPDLMEQMKQQAHNSGAQIISDEIKEIHSDVYPFKCIGIFGDQYIADSIIIATGAQAKW
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCEEEEEECCCEEE
LNIKSEETFKGRGVSACATCDGTFFAGSDIAVIGGGNTAVEEALYLTRYATKVFLIHRRD
EECCCCCCCCCCCCEEEEECCCCEECCCCEEEEECCCHHHHHHHHHHHHEEEEEEEECCC
TLRAEPIMQERLFSNDKIQVIWNSVVEEILGNKESGNVEAIALKSVKTGDITTISVKGVF
CCCCCHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEEEEE
IAIGHTPNTQILTTKDNGNIVDLDNEGYIITKPGSTVTSHPGIFAAGDVQDKIYRQAVVA
EEEECCCCCEEEEECCCCCEEEECCCCEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHH
AGSGCMAALEAAKFLSEQ
CCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQTYNTKVLIIGSGAAGCTAAIYAARANLKPILITGMCPGGQLTITTDVENFPGFAHAV
CCEECEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHC
QGPDLMEQMKQQAHNSGAQIISDEIKEIHSDVYPFKCIGIFGDQYIADSIIIATGAQAKW
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCEEEEEECCCEEE
LNIKSEETFKGRGVSACATCDGTFFAGSDIAVIGGGNTAVEEALYLTRYATKVFLIHRRD
EECCCCCCCCCCCCEEEEECCCCEECCCCEEEEECCCHHHHHHHHHHHHEEEEEEEECCC
TLRAEPIMQERLFSNDKIQVIWNSVVEEILGNKESGNVEAIALKSVKTGDITTISVKGVF
CCCCCHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEEEEEE
IAIGHTPNTQILTTKDNGNIVDLDNEGYIITKPGSTVTSHPGIFAAGDVQDKIYRQAVVA
EEEECCCCCEEEEECCCCCEEEECCCCEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHH
AGSGCMAALEAAKFLSEQ
CCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]