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The map label for this gene is ribD [H]

Identifier: 88607630

GI number: 88607630

Start: 33356

End: 34450

Strand: Direct

Name: ribD [H]

Synonym: APH_0037

Alternate gene names: 88607630

Gene position: 33356-34450 (Clockwise)

Preceding gene: 88607481

Following gene: 88607245

Centisome position: 2.27

GC content: 43.93

Gene sequence:

>1095_bases
ATGGTGCCTGACGAGAGATTCATGGCTATGGCCTTGACCTTAGCGCGCAGAGGATTGGGTAATGTTTATCCAAACCCTGC
GGTAGGATGTGTTGTAATACGTGATGGTGTGGTTGTAGGCAGAGGGTGGACTGTTGCGGGAGGTAGACCTCATGCTGAGA
TCGTAGCACTACAAAATGCAGGGAATCGTGCTATAGGAGCTACGGTATATGTCACACTTGAGCCGTGTTGTCATGATGGT
GTAACAGGGCCATGTACTTCGGCATTAATCAATGCTGGGGTTAGTAGAGTTGTTATAGGAGTGCAGGATCCGGATTACAG
AGTATCTGGCAAGGGAATTAGTTCTCTAGAAGCTGCTGGTATAGAGGTTAAATACGGGGTTTTGCAGCAGCAAGCAGAGG
CCTTAAATGCTGGTTTTTTCTACAGCAAAGTACTACATAGACCATTAATTACGGCTAAGCTGGCAACGACTCTAGATGGG
AAAATATCGTTTGATGAAGGGTGTGATCGCTGGATAACAAACGATCTTACCAGAAAATGGGTGCATAAGCAGCGTGCAAT
GTATGACGCTATCTTGGTGGGTAGCAATACCGTTGTAGCCGATGATCCAATGCTAGACTGTAGGTTACCGGGGCTGGAAA
AGCATTCTCCAATACGGGTAGTCGTTGATAGGTCTGGTAAATTGTTGGCGCATCATAAAATAGTTTGTACAGCAGGTACC
ATTCCCACATACATTGTTACGGATAACGATCCTCAGTGCGTTTTCGAGAATGTAAAATATATTAAAGTTGATGGAGGAAC
AGAATTTTTGGAAAACATGGTACGTGCTCTCACCGCTCAGTTAGGCATTACTAGGCTGTTTGTTGAGGGAGGGGGTATCT
TGATCACGGAGCTGCTAAAAAAAAAGTTGATAGACCGTTTTATATGGACTAGGGCAAATAAAATAAGTGGCAGTAAAGGA
TTGAATTCCATTACCGACATTGATGCGCAGTTTGGCCAGTGCTGTAAGTTTGTAAAGACAGATACGCTATCTTTTTTTGA
CGATACAGTGGACCTTTTCGATGTTAAATACACTCAATTAGGAAGCAACCTCTAA

Upstream 100 bases:

>100_bases
TACGCGTTTCTCTTCTGTCATGGCACAAAAACTTCTACACAAGAACATTTAGGTATATAGTAGCTTTATAAGTAAATTTC
AAGAGCAAAAGCATTTACCG

Downstream 100 bases:

>100_bases
GAGACACTAAATGACAAAAATTAAGAATAGCCACAAGAACTCCTGTGTTCGTTGAGGAACTTCCTAACTCCGGGACGAAG
CCTTTTTCACCTGCAAAGTG

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MVPDERFMAMALTLARRGLGNVYPNPAVGCVVIRDGVVVGRGWTVAGGRPHAEIVALQNAGNRAIGATVYVTLEPCCHDG
VTGPCTSALINAGVSRVVIGVQDPDYRVSGKGISSLEAAGIEVKYGVLQQQAEALNAGFFYSKVLHRPLITAKLATTLDG
KISFDEGCDRWITNDLTRKWVHKQRAMYDAILVGSNTVVADDPMLDCRLPGLEKHSPIRVVVDRSGKLLAHHKIVCTAGT
IPTYIVTDNDPQCVFENVKYIKVDGGTEFLENMVRALTAQLGITRLFVEGGGILITELLKKKLIDRFIWTRANKISGSKG
LNSITDIDAQFGQCCKFVKTDTLSFFDDTVDLFDVKYTQLGSNL

Sequences:

>Translated_364_residues
MVPDERFMAMALTLARRGLGNVYPNPAVGCVVIRDGVVVGRGWTVAGGRPHAEIVALQNAGNRAIGATVYVTLEPCCHDG
VTGPCTSALINAGVSRVVIGVQDPDYRVSGKGISSLEAAGIEVKYGVLQQQAEALNAGFFYSKVLHRPLITAKLATTLDG
KISFDEGCDRWITNDLTRKWVHKQRAMYDAILVGSNTVVADDPMLDCRLPGLEKHSPIRVVVDRSGKLLAHHKIVCTAGT
IPTYIVTDNDPQCVFENVKYIKVDGGTEFLENMVRALTAQLGITRLFVEGGGILITELLKKKLIDRFIWTRANKISGSKG
LNSITDIDAQFGQCCKFVKTDTLSFFDDTVDLFDVKYTQLGSNL
>Mature_364_residues
MVPDERFMAMALTLARRGLGNVYPNPAVGCVVIRDGVVVGRGWTVAGGRPHAEIVALQNAGNRAIGATVYVTLEPCCHDG
VTGPCTSALINAGVSRVVIGVQDPDYRVSGKGISSLEAAGIEVKYGVLQQQAEALNAGFFYSKVLHRPLITAKLATTLDG
KISFDEGCDRWITNDLTRKWVHKQRAMYDAILVGSNTVVADDPMLDCRLPGLEKHSPIRVVVDRSGKLLAHHKIVCTAGT
IPTYIVTDNDPQCVFENVKYIKVDGGTEFLENMVRALTAQLGITRLFVEGGGILITELLKKKLIDRFIWTRANKISGSKG
LNSITDIDAQFGQCCKFVKTDTLSFFDDTVDLFDVKYTQLGSNL

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=341, Percent_Identity=40.1759530791789, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI145693172, Length=149, Percent_Identity=35.5704697986577, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319629, Length=196, Percent_Identity=27.5510204081633, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 39575; Mature: 39575

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPDERFMAMALTLARRGLGNVYPNPAVGCVVIRDGVVVGRGWTVAGGRPHAEIVALQNA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCEEECCCCCCEEEEEEECC
GNRAIGATVYVTLEPCCHDGVTGPCTSALINAGVSRVVIGVQDPDYRVSGKGISSLEAAG
CCCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCHHHCC
IEVKYGVLQQQAEALNAGFFYSKVLHRPLITAKLATTLDGKISFDEGCDRWITNDLTRKW
EEEEHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHH
VHKQRAMYDAILVGSNTVVADDPMLDCRLPGLEKHSPIRVVVDRSGKLLAHHKIVCTAGT
HHHHHHHHHEEEECCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEECC
IPTYIVTDNDPQCVFENVKYIKVDGGTEFLENMVRALTAQLGITRLFVEGGGILITELLK
CCEEEEECCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
KKLIDRFIWTRANKISGSKGLNSITDIDAQFGQCCKFVKTDTLSFFDDTVDLFDVKYTQL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHEEEHHHC
GSNL
CCCC
>Mature Secondary Structure
MVPDERFMAMALTLARRGLGNVYPNPAVGCVVIRDGVVVGRGWTVAGGRPHAEIVALQNA
CCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCEEECCCCCCEEEEEEECC
GNRAIGATVYVTLEPCCHDGVTGPCTSALINAGVSRVVIGVQDPDYRVSGKGISSLEAAG
CCCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCHHHCC
IEVKYGVLQQQAEALNAGFFYSKVLHRPLITAKLATTLDGKISFDEGCDRWITNDLTRKW
EEEEHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHH
VHKQRAMYDAILVGSNTVVADDPMLDCRLPGLEKHSPIRVVVDRSGKLLAHHKIVCTAGT
HHHHHHHHHEEEECCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEECC
IPTYIVTDNDPQCVFENVKYIKVDGGTEFLENMVRALTAQLGITRLFVEGGGILITELLK
CCEEEEECCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
KKLIDRFIWTRANKISGSKGLNSITDIDAQFGQCCKFVKTDTLSFFDDTVDLFDVKYTQL
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHEEEHHHC
GSNL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]