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The map label for this gene is guaB [H]

Identifier: 88607628

GI number: 88607628

Start: 94542

End: 96002

Strand: Reverse

Name: guaB [H]

Synonym: APH_0088

Alternate gene names: 88607628

Gene position: 96002-94542 (Counterclockwise)

Preceding gene: 88607693

Following gene: 88606915

Centisome position: 6.53

GC content: 46.0

Gene sequence:

>1461_bases
GTGGAGATTGCTTACTCATTTGACGATATCTTGATTATCCCCTCGTTTTCTGATGTCCTTCCCGCTGATACAGAGGTAAG
TACATATGTTACGAAGAGCCTTCAGCTCAATATACCAATCATGTCAGCTGCTATGGATACGGTAACCGAGTCTAGGTTAG
CCATATCTGTTGCACAACACGGTGGGATTGGGTGTATACACAAAAATATGTCCATAGAACGACAGGTAGCTGAGGTTCAG
AAGGTAAAGAAATTTGAGAGCTGGATAGTTAGCAATCCAGTAACAGTGTCCCCGGATGCCACATTAAAGACTGCTCTTTC
AATAATGCAGCAGCATAGTTACTCTGGAATCCCAGTAGTTGAGGAAAATAAGAAGCTTGTAGGTATCATTACAAACCGGG
ATGTGCGCTTCGTTGAAGACATGAACTGTCGCGTGTGCGACATAATGACAAAAGAGAATCTAGTCACCGTACGCGAGGGC
GTCAGTCAATCTGAGGCAACCCGCCTCCTCCACAAACATAAGATTGAGAGACTGATCGTGACTGATGAGTATGGTTGTTG
CATCGGGCTAATAACAGTCAAAGACATAGAAAAGTTCAATAAGTTTCCAAATTCATGCAAGGATAAGAAAGCTCGCCTTA
GAGTAGCCGCGGCAGTGGGAGCAGGGCCACGGGAAGGTATAAAACGAGCAGAGGCATTGATCCACGCAGAAGCTGATGTA
ATAGTAGTTGATACTGCCCACGGTCACTCTGAAAGAGTAATAAATACTGTAAGAGAAATAAAAACTCTATACCCTGAGGC
ACAAGTCATCGGAGGCAACGTTGCCACTGCAGCAGGTGCATTAGCGCTTATAGAAGCAGGTGTTGATGCTGTAAAAGTTG
GGATTGGACCGGGCTCGATATGCACAACTCGCATAGTAACCGGGGTCGGAGTGCCGCAATTTACTGCTATACGCAATGTT
GCTGCTGTCTGTAAAGATGCCGGAGTCGGAGTAATAGCAGATGGTGGCATTAAACACTCTGGCGACATAGCAAAGTCCAT
TGCTGCCGGCGCGGATGTTGTGATGATAGGTTCCATTTTCGCTGGAACTGATGAAAGTCCTGGAAATACCGTCATATACA
ACGGAAGAGCATATAAATGCTATAGAGGCATGGGATCGGTAATGGCCATGAAGGAAGGTGCTAGTGATCGCTATTTCCAA
GACACTAGTAGTAAATTCATTCCTGAAGGCGTTGAAGGCAGGGTACCGTTTAAAGGAGCTGCTTCAGAAGTAATTTATCA
GCTTGTAGGCGGCCTGCGCTCCTCTATGGGTTATACTGGCAATCGTACTATCGCTGAGATGAAACAAAACTGTCAATTCA
CGGTGATTACTTCCGCGGGCCTGCAGGAAAGTCACGTACATGGCGTGACGATAACTCAGGAGACTCCTAACTATCACCCC
CCATTTCAGCAATCACAGTAG

Upstream 100 bases:

>100_bases
CATTGCTGAACAATTCTTAGCATAGGGTCATGTTTACACTATTGCGCATTACTGCTAAAGAACCTATACTCTCCGCAGTG
TGAAATCGGCGTAGACGGTT

Downstream 100 bases:

>100_bases
CTAGAGTATCTGTTAGTACTGAACATGGTTTTTAGGAGAGCTTATAGAATCTCACGCAGATCTCTTGACCTTTGTTGTTA
GGCGGAAACCGCTGGATATA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MEIAYSFDDILIIPSFSDVLPADTEVSTYVTKSLQLNIPIMSAAMDTVTESRLAISVAQHGGIGCIHKNMSIERQVAEVQ
KVKKFESWIVSNPVTVSPDATLKTALSIMQQHSYSGIPVVEENKKLVGIITNRDVRFVEDMNCRVCDIMTKENLVTVREG
VSQSEATRLLHKHKIERLIVTDEYGCCIGLITVKDIEKFNKFPNSCKDKKARLRVAAAVGAGPREGIKRAEALIHAEADV
IVVDTAHGHSERVINTVREIKTLYPEAQVIGGNVATAAGALALIEAGVDAVKVGIGPGSICTTRIVTGVGVPQFTAIRNV
AAVCKDAGVGVIADGGIKHSGDIAKSIAAGADVVMIGSIFAGTDESPGNTVIYNGRAYKCYRGMGSVMAMKEGASDRYFQ
DTSSKFIPEGVEGRVPFKGAASEVIYQLVGGLRSSMGYTGNRTIAEMKQNCQFTVITSAGLQESHVHGVTITQETPNYHP
PFQQSQ

Sequences:

>Translated_486_residues
MEIAYSFDDILIIPSFSDVLPADTEVSTYVTKSLQLNIPIMSAAMDTVTESRLAISVAQHGGIGCIHKNMSIERQVAEVQ
KVKKFESWIVSNPVTVSPDATLKTALSIMQQHSYSGIPVVEENKKLVGIITNRDVRFVEDMNCRVCDIMTKENLVTVREG
VSQSEATRLLHKHKIERLIVTDEYGCCIGLITVKDIEKFNKFPNSCKDKKARLRVAAAVGAGPREGIKRAEALIHAEADV
IVVDTAHGHSERVINTVREIKTLYPEAQVIGGNVATAAGALALIEAGVDAVKVGIGPGSICTTRIVTGVGVPQFTAIRNV
AAVCKDAGVGVIADGGIKHSGDIAKSIAAGADVVMIGSIFAGTDESPGNTVIYNGRAYKCYRGMGSVMAMKEGASDRYFQ
DTSSKFIPEGVEGRVPFKGAASEVIYQLVGGLRSSMGYTGNRTIAEMKQNCQFTVITSAGLQESHVHGVTITQETPNYHP
PFQQSQ
>Mature_486_residues
MEIAYSFDDILIIPSFSDVLPADTEVSTYVTKSLQLNIPIMSAAMDTVTESRLAISVAQHGGIGCIHKNMSIERQVAEVQ
KVKKFESWIVSNPVTVSPDATLKTALSIMQQHSYSGIPVVEENKKLVGIITNRDVRFVEDMNCRVCDIMTKENLVTVREG
VSQSEATRLLHKHKIERLIVTDEYGCCIGLITVKDIEKFNKFPNSCKDKKARLRVAAAVGAGPREGIKRAEALIHAEADV
IVVDTAHGHSERVINTVREIKTLYPEAQVIGGNVATAAGALALIEAGVDAVKVGIGPGSICTTRIVTGVGVPQFTAIRNV
AAVCKDAGVGVIADGGIKHSGDIAKSIAAGADVVMIGSIFAGTDESPGNTVIYNGRAYKCYRGMGSVMAMKEGASDRYFQ
DTSSKFIPEGVEGRVPFKGAASEVIYQLVGGLRSSMGYTGNRTIAEMKQNCQFTVITSAGLQESHVHGVTITQETPNYHP
PFQQSQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=477, Percent_Identity=37.9454926624738, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI34328930, Length=478, Percent_Identity=38.4937238493724, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI34328928, Length=478, Percent_Identity=38.4937238493724, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI217035146, Length=478, Percent_Identity=38.4937238493724, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI156616279, Length=478, Percent_Identity=38.4937238493724, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=38.7368421052632, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI217035148, Length=478, Percent_Identity=37.6569037656904, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI217035150, Length=478, Percent_Identity=35.5648535564854, Blast_Score=273, Evalue=4e-73,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=37.3493975903614, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI156104880, Length=353, Percent_Identity=29.7450424929178, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1788855, Length=479, Percent_Identity=56.7849686847599, Blast_Score=500, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=215, Percent_Identity=36.2790697674419, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=470, Percent_Identity=34.2553191489362, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=36.0381861575179, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17560440, Length=247, Percent_Identity=36.0323886639676, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=479, Percent_Identity=37.160751565762, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=479, Percent_Identity=36.5344467640919, Blast_Score=305, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6323585, Length=479, Percent_Identity=35.2818371607516, Blast_Score=302, Evalue=8e-83,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=38.3480825958702, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=37.9310344827586, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=38.8308977035491, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=38.8308977035491, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.3181818181818, Blast_Score=282, Evalue=4e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52144; Mature: 52144

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIAYSFDDILIIPSFSDVLPADTEVSTYVTKSLQLNIPIMSAAMDTVTESRLAISVAQH
CCEEEECCCEEEECCCHHCCCCCCCHHHEEEEEEEECCCHHHHHHHHHHHHHEEEEEECC
GGIGCIHKNMSIERQVAEVQKVKKFESWIVSNPVTVSPDATLKTALSIMQQHSYSGIPVV
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCEE
EENKKLVGIITNRDVRFVEDMNCRVCDIMTKENLVTVREGVSQSEATRLLHKHKIERLIV
ECCCEEEEEEECCCEEEEECCCCEEEEEECCCCEEHHHHCCCHHHHHHHHHHHHHCEEEE
TDEYGCCIGLITVKDIEKFNKFPNSCKDKKARLRVAAAVGAGPREGIKRAEALIHAEADV
ECCCCCEEEEEEHHHHHHHHCCCCCHHCHHHHEEEEEECCCCCHHHHHHHHHHHCCCCCE
IVVDTAHGHSERVINTVREIKTLYPEAQVIGGNVATAAGALALIEAGVDAVKVGIGPGSI
EEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCH
CTTRIVTGVGVPQFTAIRNVAAVCKDAGVGVIADGGIKHSGDIAKSIAAGADVVMIGSIF
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEEEE
AGTDESPGNTVIYNGRAYKCYRGMGSVMAMKEGASDRYFQDTSSKFIPEGVEGRVPFKGA
ECCCCCCCCEEEECCEEEEEHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ASEVIYQLVGGLRSSMGYTGNRTIAEMKQNCQFTVITSAGLQESHVHGVTITQETPNYHP
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCC
PFQQSQ
CCCCCC
>Mature Secondary Structure
MEIAYSFDDILIIPSFSDVLPADTEVSTYVTKSLQLNIPIMSAAMDTVTESRLAISVAQH
CCEEEECCCEEEECCCHHCCCCCCCHHHEEEEEEEECCCHHHHHHHHHHHHHEEEEEECC
GGIGCIHKNMSIERQVAEVQKVKKFESWIVSNPVTVSPDATLKTALSIMQQHSYSGIPVV
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCEE
EENKKLVGIITNRDVRFVEDMNCRVCDIMTKENLVTVREGVSQSEATRLLHKHKIERLIV
ECCCEEEEEEECCCEEEEECCCCEEEEEECCCCEEHHHHCCCHHHHHHHHHHHHHCEEEE
TDEYGCCIGLITVKDIEKFNKFPNSCKDKKARLRVAAAVGAGPREGIKRAEALIHAEADV
ECCCCCEEEEEEHHHHHHHHCCCCCHHCHHHHEEEEEECCCCCHHHHHHHHHHHCCCCCE
IVVDTAHGHSERVINTVREIKTLYPEAQVIGGNVATAAGALALIEAGVDAVKVGIGPGSI
EEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCH
CTTRIVTGVGVPQFTAIRNVAAVCKDAGVGVIADGGIKHSGDIAKSIAAGADVVMIGSIF
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEEEE
AGTDESPGNTVIYNGRAYKCYRGMGSVMAMKEGASDRYFQDTSSKFIPEGVEGRVPFKGA
ECCCCCCCCEEEECCEEEEEHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ASEVIYQLVGGLRSSMGYTGNRTIAEMKQNCQFTVITSAGLQESHVHGVTITQETPNYHP
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCC
PFQQSQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]