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The map label for this gene is clpX

Identifier: 88607602

GI number: 88607602

Start: 1030173

End: 1031420

Strand: Reverse

Name: clpX

Synonym: APH_0969

Alternate gene names: 88607602

Gene position: 1031420-1030173 (Counterclockwise)

Preceding gene: 88607298

Following gene: 88606840

Centisome position: 70.1

GC content: 44.07

Gene sequence:

>1248_bases
ATGTCTGAGACGAAGAAAGGCGCTTATAGTTGTTCATTTTGCGGTAAGTTGCATAGTGAAGTAAAGAAGCTGATAGCCGG
TCCTGAGGCATACATTTGTAATGAGTGTGTTGAATTATGTGGTGGTATATTGCAGGAGGAGAATCTACCTGCTAAGCAGG
GTAGGTTTGATCTGAAGCCGCGGGAGATAAAAGAGGTTCTGGACGAGTATGTGATAGGTCAGGAGCATTCTAAGAAGGTT
TTGTCTGTTGCTGTATATAATCACTACAAACGTTTGAGGAACTCTGGGGTTATTAGTGAAGTTGAGATATCGAAATCGAA
TGTTTTGCTTATAGGTCCCACTGGGTCGGGGAAGACTCTACTTGCGCGGACTTTGGCGAGGGTATTGCAGGTGCCTTTCG
CTATGGCTGACGCTACTACACTTACAGAAGCTGGGTATGTTGGGGAAGATGTAGAGAACATCTTGCTTAAGCTATTGCAG
GCAGCAAATTTTAATGTTGAGGCTGCGCAGCGTGGTATAATTTACATAGATGAAGTTGATAAGATATCTAGGAAGTCTGA
GAATGCGTCGATTACCAGAGATGTATCGGGAGAGGGGGTACAGCAAGCTCTATTGAAGGTAATAGAGGGGACGGTATCGT
CTGTTCCTCCGCAGGGTGGTAGGAAGCATCCTCATCAGGAGTTTATACAAATCAGCACTGATAATATCTTGTTTATTTTT
GGTGGTGCGTTTGATGGGCTTGAGAAAATTATAGAGGCTCGTAATCGTGGAAGCTCCATGGGGTTTGAGGCGAACGTGCA
AAGCATGGTGAGTCCGACGAAAGATGTTTTATCCTATGCAGAGCCTGAAGATTTGGTTAAATTTGGACTTATTCCGGAGT
TTATAGGTAGGATTCCTGTTATTACTTCATTGGGTAAGTTGGATGAGAATACGCTTTTTCGGGTATTAGTGGAGCCGAAG
AATTCTTTGGTGAAGCAGTACGCTAAATTATTTGAGATGGATAATTTAGAGTTGAAGTTTGATGATGACGCGTTGATGGC
TATCGCGAGGAAGGCTGTTGACCGCAATACTGGGGCTCGTGGTCTCAGGGCAATAATGGAGTCATTGTTGCTTGACTTTA
TGTTTGATCCGCAGGGATGTGCGCATGAGGGGAAAGTCTCGATAAGTAAGGAGATGGTGGAGAACTTGGTTCTAGGCAAG
AACTGTTTTGAAGATGCTAGGAAGGGGAATCTTTATGGAAGAGGGTAA

Upstream 100 bases:

>100_bases
TGGAAAGGGATAATTTCATGATTGCCGAGAAGGCGCGGGATTTCGGTATTATAGATAAGGTGATAGAAAAGCGTATTGAG
GAAAAGTAGTAGGAAGGTAA

Downstream 100 bases:

>100_bases
AGTTGTGTTACTTCCCGTCTTGATGCTGAGAGACACGGTTGTATTCCCTAGGGTTGTTGTGCCTCTCTCGGTTGGGCGCG
GAAAGTCCGTTAATGCGCTC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSETKKGAYSCSFCGKLHSEVKKLIAGPEAYICNECVELCGGILQEENLPAKQGRFDLKPREIKEVLDEYVIGQEHSKKV
LSVAVYNHYKRLRNSGVISEVEISKSNVLLIGPTGSGKTLLARTLARVLQVPFAMADATTLTEAGYVGEDVENILLKLLQ
AANFNVEAAQRGIIYIDEVDKISRKSENASITRDVSGEGVQQALLKVIEGTVSSVPPQGGRKHPHQEFIQISTDNILFIF
GGAFDGLEKIIEARNRGSSMGFEANVQSMVSPTKDVLSYAEPEDLVKFGLIPEFIGRIPVITSLGKLDENTLFRVLVEPK
NSLVKQYAKLFEMDNLELKFDDDALMAIARKAVDRNTGARGLRAIMESLLLDFMFDPQGCAHEGKVSISKEMVENLVLGK
NCFEDARKGNLYGRG

Sequences:

>Translated_415_residues
MSETKKGAYSCSFCGKLHSEVKKLIAGPEAYICNECVELCGGILQEENLPAKQGRFDLKPREIKEVLDEYVIGQEHSKKV
LSVAVYNHYKRLRNSGVISEVEISKSNVLLIGPTGSGKTLLARTLARVLQVPFAMADATTLTEAGYVGEDVENILLKLLQ
AANFNVEAAQRGIIYIDEVDKISRKSENASITRDVSGEGVQQALLKVIEGTVSSVPPQGGRKHPHQEFIQISTDNILFIF
GGAFDGLEKIIEARNRGSSMGFEANVQSMVSPTKDVLSYAEPEDLVKFGLIPEFIGRIPVITSLGKLDENTLFRVLVEPK
NSLVKQYAKLFEMDNLELKFDDDALMAIARKAVDRNTGARGLRAIMESLLLDFMFDPQGCAHEGKVSISKEMVENLVLGK
NCFEDARKGNLYGRG
>Mature_414_residues
SETKKGAYSCSFCGKLHSEVKKLIAGPEAYICNECVELCGGILQEENLPAKQGRFDLKPREIKEVLDEYVIGQEHSKKVL
SVAVYNHYKRLRNSGVISEVEISKSNVLLIGPTGSGKTLLARTLARVLQVPFAMADATTLTEAGYVGEDVENILLKLLQA
ANFNVEAAQRGIIYIDEVDKISRKSENASITRDVSGEGVQQALLKVIEGTVSSVPPQGGRKHPHQEFIQISTDNILFIFG
GAFDGLEKIIEARNRGSSMGFEANVQSMVSPTKDVLSYAEPEDLVKFGLIPEFIGRIPVITSLGKLDENTLFRVLVEPKN
SLVKQYAKLFEMDNLELKFDDDALMAIARKAVDRNTGARGLRAIMESLLLDFMFDPQGCAHEGKVSISKEMVENLVLGKN
CFEDARKGNLYGRG

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=300, Percent_Identity=50, Blast_Score=295, Evalue=5e-80,
Organism=Escherichia coli, GI1786642, Length=401, Percent_Identity=60.5985037406484, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1790366, Length=106, Percent_Identity=40.5660377358491, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=322, Percent_Identity=46.8944099378882, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71982905, Length=322, Percent_Identity=46.8944099378882, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71988663, Length=393, Percent_Identity=37.4045801526718, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI71988660, Length=249, Percent_Identity=38.9558232931727, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319704, Length=409, Percent_Identity=39.6088019559902, Blast_Score=252, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24648291, Length=293, Percent_Identity=48.122866894198, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24648289, Length=293, Percent_Identity=48.122866894198, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_ANAPZ (Q2GJB5)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505536.1
- ProteinModelPortal:   Q2GJB5
- STRING:   Q2GJB5
- GeneID:   3930607
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0969
- NMPDR:   fig|212042.5.peg.915
- TIGR:   APH_0969
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   APHA212042:APH_0969-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45664; Mature: 45533

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKKGAYSCSFCGKLHSEVKKLIAGPEAYICNECVELCGGILQEENLPAKQGRFDLKP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCH
REIKEVLDEYVIGQEHSKKVLSVAVYNHYKRLRNSGVISEVEISKSNVLLIGPTGSGKTL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCHHH
LARTLARVLQVPFAMADATTLTEAGYVGEDVENILLKLLQAANFNVEAAQRGIIYIDEVD
HHHHHHHHHHCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEECHH
KISRKSENASITRDVSGEGVQQALLKVIEGTVSSVPPQGGRKHPHQEFIQISTDNILFIF
HHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCEEEEE
GGAFDGLEKIIEARNRGSSMGFEANVQSMVSPTKDVLSYAEPEDLVKFGLIPEFIGRIPV
CCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHCCCHHHHHHHCCCHHHHCCCHH
ITSLGKLDENTLFRVLVEPKNSLVKQYAKLFEMDNLELKFDDDALMAIARKAVDRNTGAR
HHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCHH
GLRAIMESLLLDFMFDPQGCAHEGKVSISKEMVENLVLGKNCFEDARKGNLYGRG
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SETKKGAYSCSFCGKLHSEVKKLIAGPEAYICNECVELCGGILQEENLPAKQGRFDLKP
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCH
REIKEVLDEYVIGQEHSKKVLSVAVYNHYKRLRNSGVISEVEISKSNVLLIGPTGSGKTL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCHHH
LARTLARVLQVPFAMADATTLTEAGYVGEDVENILLKLLQAANFNVEAAQRGIIYIDEVD
HHHHHHHHHHCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEECHH
KISRKSENASITRDVSGEGVQQALLKVIEGTVSSVPPQGGRKHPHQEFIQISTDNILFIF
HHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCEEEEE
GGAFDGLEKIIEARNRGSSMGFEANVQSMVSPTKDVLSYAEPEDLVKFGLIPEFIGRIPV
CCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHCCCHHHHHHHCCCHHHHCCCHH
ITSLGKLDENTLFRVLVEPKNSLVKQYAKLFEMDNLELKFDDDALMAIARKAVDRNTGAR
HHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCHH
GLRAIMESLLLDFMFDPQGCAHEGKVSISKEMVENLVLGKNCFEDARKGNLYGRG
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA