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The map label for this gene is lon [H]

Identifier: 88606840

GI number: 88606840

Start: 1027778

End: 1030186

Strand: Reverse

Name: lon [H]

Synonym: APH_0968

Alternate gene names: 88606840

Gene position: 1030186-1027778 (Counterclockwise)

Preceding gene: 88607602

Following gene: 88606917

Centisome position: 70.02

GC content: 44.67

Gene sequence:

>2409_bases
ATGGAAGAGGGTAAAGTTGTGTTACTTCCCGTCTTGATGCTGAGAGACACGGTTGTATTCCCTAGGGTTGTTGTGCCTCT
CTCGGTTGGGCGCGGAAAGTCCGTTAATGCGCTCGAGTATACTGCGAAGACGGAGGGATGTAAGATTCTGCTGTTGACGC
AGATTGATGGTTCTGTTGATAACCCGGGCAATGATGATTTGTATACTGTGGGTGTAGTAGCTGATGTTGTGCAATTGTTA
CGGTTGCCTGATGGTGTATTGAAAGTTTTAATAAAGGGTGAGAGTAGGGCTAAGGTTCTAAATCTAGTAGATGAGGGAGA
TTTTTTAAGCGCAAGCGTTGAAATTATTGAGGATGATGAAGACGTTGAGATAGATAGTAGGGTGGAAGCGCTAAGGAGAT
CGGTTCTGCGTGAATTTGATGTATGGAACAAGCTTAGCAAGAAGATGCAGCCGGAGGTTGTTGCCTCTACGTACGAGATC
AAGAAATTAGGGCATCTATCTGATGTTGTGGCTTCTCATCTTGCGGTTAGTATAGAAGATAAGCAGAAGGTTATTGAGGA
GTTTTGTGTAGTCAAGCGTCTCGACCTGGTCTTCGGCATGATAAAGCTGGAGATAGGGGTTTTGAATGCTCAGAAAAAGA
TAGATGATAGGGTGCGGTCTCAGGTAGAGGCTACTCATAAAGTGTATTACTTGAATGAGCAATTAAAGGCTATTCAGCGT
GAATTGGAAGAGAGTGATGGTTCGTGCTGTGATAGTGATTCTGCTAGTGAATTTGAGAAAAGGATAAATGCCACTCCGCT
ATCGGAGGAGGCTAGGGAACGTGCTTTGAGTGATTTGAAGCGCTACAGGAAAATGAATTTGATGTCTCCCGAGGCTAATA
TCATTTCTGGTTATATGCAATGGTTGCTTGATTTGCCATGGGGGAAGTTTAAGAGCGGCAAGATAGATATGACCAGCTCT
GCGAAAATCCTTAACAACAACCACTTTGGCATGGATAAGGTTAAGGAGAGGGTGCTGGAATTTTTAGCTGTTTTGAAGAG
GGTGAAGAAGCCTAAGGGTTCAGTTTTATGTTTCGTTGGTCCTCCTGGTGTGGGAAAAACTTCACTGGCTAAGTCTATAG
CAGAGGCTACGGGGCGCGAGTTTGTGCGCGTATCATTAGGTGGTGTGCATGATGAGTCTGAGATACGTGGGCACCGGCGC
ACTTATGTAGGTGCAATGCCTGGGAAGATAATAAAGCAGATGAAGCGTGCTAAGACTTGTAATCCGTTATTCTTGTTGGA
TGAAATAGATAAGGTGGGGTCGGATTATAGGGGTGATCCGGTTGCGGCTCTATTAGAAGTGTTGGACCCTGAGCACAACA
AGCATTTCGTCGATAATTACCTCGAGGTGGAGTTTGACCTTTCGAATGTTATGTTTGTTGCGACTGCAAACAATCTCAAT
TTTCAGAAGCCTTTGCTAGATAGGATGGAGATAATTCAGCTTTCTGGGTACACGGAGGAGGAGAAGCTGCAGATTGCCAA
GGTTCATCTTATTCCTGGTTTGCGTAAGGAGCATGGTTTACGTGAGAAGGAGTGGGATATTTCTGCTGAAGCGATTTGTG
ATTTAATTAGGTTTTACACTAGGGAGAGTGGTGTTAGAGGCTTAAGGAGAGAATTGTCTTCGTTGATGCGGGGGGCTGTG
AAGGAAATTCTCACTAATAAAGATGTAAAAAGCGTATTTGTAACGCCTGAGAATGTGGATAAGTATGTAGGTGTGCGCAA
GTACGACTATGGTATTAAAGAGAAAAGCAGCATGGTGGGAGTTGTTACTGGGCTTGCGTATACGGAGACTGGTGGTGATC
TCTTAACCATAGAATCGGTGATGATGCCTGGTAGGGGTGGTATAAAATGCACTGGTAAGCTTGGGGAGGTTATGCAAGAG
TCTGTGAAGGCTGCATATAGCTATGTGCGTTCTCGGTGTTTTGAGTTTGGGATTAAATCTAAGGATTTTCAGAGCAAGGA
TATACACGTGCATGTTCCCGAGGGAGCGATACCGAAAGATGGTCCATCGGCGGGTATAGCTATGTGCATTTCTATTGTGT
CGCTGATGACTGGTATTCCTGTGAAAAACTCGGTGGCAATGACTGGGGAGGTTACTCTTCGGGGTAGAGTGCTGCCTATA
GGTGGATTGAAGGAGAAGTTGTTGGCTGCAATGCGTGGTGGTGTGACGACTGTTATTCTTCCTATTAAGAATAAAAAGGA
TTTTGCAGAACTTCCTGAGAGTGTTAAGCAATCCCTGGAGCTGGTGCTGGTTTCTAGTGTAGATGAAGTTATAGCTTGCG
CGCTAGAGTCACCAGTTGTACCTTTGAGCGAGGATGAGGTATTTGTCAATCAGATGTCAGGTGTTGGTGATTGTTCTTTT
CTGAATTAA

Upstream 100 bases:

>100_bases
GGATGTGCGCATGAGGGGAAAGTCTCGATAAGTAAGGAGATGGTGGAGAACTTGGTTCTAGGCAAGAACTGTTTTGAAGA
TGCTAGGAAGGGGAATCTTT

Downstream 100 bases:

>100_bases
GTTGAGTAGTTGCTTGGGTTCTGATTGTGTTTCCCTTTTCGTTTTGGGGCGAGGGGGTAGTTAGGATGTGGTACTTTTAC
CGCTAGGTGTGGTGGGTGTT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 802; Mature: 802

Protein sequence:

>802_residues
MEEGKVVLLPVLMLRDTVVFPRVVVPLSVGRGKSVNALEYTAKTEGCKILLLTQIDGSVDNPGNDDLYTVGVVADVVQLL
RLPDGVLKVLIKGESRAKVLNLVDEGDFLSASVEIIEDDEDVEIDSRVEALRRSVLREFDVWNKLSKKMQPEVVASTYEI
KKLGHLSDVVASHLAVSIEDKQKVIEEFCVVKRLDLVFGMIKLEIGVLNAQKKIDDRVRSQVEATHKVYYLNEQLKAIQR
ELEESDGSCCDSDSASEFEKRINATPLSEEARERALSDLKRYRKMNLMSPEANIISGYMQWLLDLPWGKFKSGKIDMTSS
AKILNNNHFGMDKVKERVLEFLAVLKRVKKPKGSVLCFVGPPGVGKTSLAKSIAEATGREFVRVSLGGVHDESEIRGHRR
TYVGAMPGKIIKQMKRAKTCNPLFLLDEIDKVGSDYRGDPVAALLEVLDPEHNKHFVDNYLEVEFDLSNVMFVATANNLN
FQKPLLDRMEIIQLSGYTEEEKLQIAKVHLIPGLRKEHGLREKEWDISAEAICDLIRFYTRESGVRGLRRELSSLMRGAV
KEILTNKDVKSVFVTPENVDKYVGVRKYDYGIKEKSSMVGVVTGLAYTETGGDLLTIESVMMPGRGGIKCTGKLGEVMQE
SVKAAYSYVRSRCFEFGIKSKDFQSKDIHVHVPEGAIPKDGPSAGIAMCISIVSLMTGIPVKNSVAMTGEVTLRGRVLPI
GGLKEKLLAAMRGGVTTVILPIKNKKDFAELPESVKQSLELVLVSSVDEVIACALESPVVPLSEDEVFVNQMSGVGDCSF
LN

Sequences:

>Translated_802_residues
MEEGKVVLLPVLMLRDTVVFPRVVVPLSVGRGKSVNALEYTAKTEGCKILLLTQIDGSVDNPGNDDLYTVGVVADVVQLL
RLPDGVLKVLIKGESRAKVLNLVDEGDFLSASVEIIEDDEDVEIDSRVEALRRSVLREFDVWNKLSKKMQPEVVASTYEI
KKLGHLSDVVASHLAVSIEDKQKVIEEFCVVKRLDLVFGMIKLEIGVLNAQKKIDDRVRSQVEATHKVYYLNEQLKAIQR
ELEESDGSCCDSDSASEFEKRINATPLSEEARERALSDLKRYRKMNLMSPEANIISGYMQWLLDLPWGKFKSGKIDMTSS
AKILNNNHFGMDKVKERVLEFLAVLKRVKKPKGSVLCFVGPPGVGKTSLAKSIAEATGREFVRVSLGGVHDESEIRGHRR
TYVGAMPGKIIKQMKRAKTCNPLFLLDEIDKVGSDYRGDPVAALLEVLDPEHNKHFVDNYLEVEFDLSNVMFVATANNLN
FQKPLLDRMEIIQLSGYTEEEKLQIAKVHLIPGLRKEHGLREKEWDISAEAICDLIRFYTRESGVRGLRRELSSLMRGAV
KEILTNKDVKSVFVTPENVDKYVGVRKYDYGIKEKSSMVGVVTGLAYTETGGDLLTIESVMMPGRGGIKCTGKLGEVMQE
SVKAAYSYVRSRCFEFGIKSKDFQSKDIHVHVPEGAIPKDGPSAGIAMCISIVSLMTGIPVKNSVAMTGEVTLRGRVLPI
GGLKEKLLAAMRGGVTTVILPIKNKKDFAELPESVKQSLELVLVSSVDEVIACALESPVVPLSEDEVFVNQMSGVGDCSF
LN
>Mature_802_residues
MEEGKVVLLPVLMLRDTVVFPRVVVPLSVGRGKSVNALEYTAKTEGCKILLLTQIDGSVDNPGNDDLYTVGVVADVVQLL
RLPDGVLKVLIKGESRAKVLNLVDEGDFLSASVEIIEDDEDVEIDSRVEALRRSVLREFDVWNKLSKKMQPEVVASTYEI
KKLGHLSDVVASHLAVSIEDKQKVIEEFCVVKRLDLVFGMIKLEIGVLNAQKKIDDRVRSQVEATHKVYYLNEQLKAIQR
ELEESDGSCCDSDSASEFEKRINATPLSEEARERALSDLKRYRKMNLMSPEANIISGYMQWLLDLPWGKFKSGKIDMTSS
AKILNNNHFGMDKVKERVLEFLAVLKRVKKPKGSVLCFVGPPGVGKTSLAKSIAEATGREFVRVSLGGVHDESEIRGHRR
TYVGAMPGKIIKQMKRAKTCNPLFLLDEIDKVGSDYRGDPVAALLEVLDPEHNKHFVDNYLEVEFDLSNVMFVATANNLN
FQKPLLDRMEIIQLSGYTEEEKLQIAKVHLIPGLRKEHGLREKEWDISAEAICDLIRFYTRESGVRGLRRELSSLMRGAV
KEILTNKDVKSVFVTPENVDKYVGVRKYDYGIKEKSSMVGVVTGLAYTETGGDLLTIESVMMPGRGGIKCTGKLGEVMQE
SVKAAYSYVRSRCFEFGIKSKDFQSKDIHVHVPEGAIPKDGPSAGIAMCISIVSLMTGIPVKNSVAMTGEVTLRGRVLPI
GGLKEKLLAAMRGGVTTVILPIKNKKDFAELPESVKQSLELVLVSSVDEVIACALESPVVPLSEDEVFVNQMSGVGDCSF
LN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=41.5730337078652, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI31377667, Length=833, Percent_Identity=34.093637454982, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1786643, Length=777, Percent_Identity=50.8365508365508, Blast_Score=797, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=652, Percent_Identity=39.8773006134969, Blast_Score=452, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=41.9117647058824, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=701, Percent_Identity=37.0898716119829, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI221513036, Length=625, Percent_Identity=42.08, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24666867, Length=625, Percent_Identity=42.08, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88841; Mature: 88841

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEGKVVLLPVLMLRDTVVFPRVVVPLSVGRGKSVNALEYTAKTEGCKILLLTQIDGSVD
CCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEEEECCCCCC
NPGNDDLYTVGVVADVVQLLRLPDGVLKVLIKGESRAKVLNLVDEGDFLSASVEIIEDDE
CCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEECCC
DVEIDSRVEALRRSVLREFDVWNKLSKKMQPEVVASTYEIKKLGHLSDVVASHLAVSIED
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEHH
KQKVIEEFCVVKRLDLVFGMIKLEIGVLNAQKKIDDRVRSQVEATHKVYYLNEQLKAIQR
HHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
ELEESDGSCCDSDSASEFEKRINATPLSEEARERALSDLKRYRKMNLMSPEANIISGYMQ
HHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
WLLDLPWGKFKSGKIDMTSSAKILNNNHFGMDKVKERVLEFLAVLKRVKKPKGSVLCFVG
HHHHCCCCCCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PPGVGKTSLAKSIAEATGREFVRVSLGGVHDESEIRGHRRTYVGAMPGKIIKQMKRAKTC
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCC
NPLFLLDEIDKVGSDYRGDPVAALLEVLDPEHNKHFVDNYLEVEFDLSNVMFVATANNLN
CCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHCCEEEEEEECCCEEEEEEECCCC
FQKPLLDRMEIIQLSGYTEEEKLQIAKVHLIPGLRKEHGLREKEWDISAEAICDLIRFYT
CCHHHHHHHHHHHHCCCCCHHHHEEEEEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHH
RESGVRGLRRELSSLMRGAVKEILTNKDVKSVFVTPENVDKYVGVRKYDYGIKEKSSMVG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCEE
VVTGLAYTETGGDLLTIESVMMPGRGGIKCTGKLGEVMQESVKAAYSYVRSRCFEFGIKS
HHCCCEEECCCCCEEEEHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KDFQSKDIHVHVPEGAIPKDGPSAGIAMCISIVSLMTGIPVKNSVAMTGEVTLRGRVLPI
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEC
GGLKEKLLAAMRGGVTTVILPIKNKKDFAELPESVKQSLELVLVSSVDEVIACALESPVV
CCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLSEDEVFVNQMSGVGDCSFLN
CCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEEGKVVLLPVLMLRDTVVFPRVVVPLSVGRGKSVNALEYTAKTEGCKILLLTQIDGSVD
CCCCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEEEECCCCCC
NPGNDDLYTVGVVADVVQLLRLPDGVLKVLIKGESRAKVLNLVDEGDFLSASVEIIEDDE
CCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEECCC
DVEIDSRVEALRRSVLREFDVWNKLSKKMQPEVVASTYEIKKLGHLSDVVASHLAVSIED
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEHH
KQKVIEEFCVVKRLDLVFGMIKLEIGVLNAQKKIDDRVRSQVEATHKVYYLNEQLKAIQR
HHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
ELEESDGSCCDSDSASEFEKRINATPLSEEARERALSDLKRYRKMNLMSPEANIISGYMQ
HHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
WLLDLPWGKFKSGKIDMTSSAKILNNNHFGMDKVKERVLEFLAVLKRVKKPKGSVLCFVG
HHHHCCCCCCCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PPGVGKTSLAKSIAEATGREFVRVSLGGVHDESEIRGHRRTYVGAMPGKIIKQMKRAKTC
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCC
NPLFLLDEIDKVGSDYRGDPVAALLEVLDPEHNKHFVDNYLEVEFDLSNVMFVATANNLN
CCEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHCCEEEEEEECCCEEEEEEECCCC
FQKPLLDRMEIIQLSGYTEEEKLQIAKVHLIPGLRKEHGLREKEWDISAEAICDLIRFYT
CCHHHHHHHHHHHHCCCCCHHHHEEEEEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHH
RESGVRGLRRELSSLMRGAVKEILTNKDVKSVFVTPENVDKYVGVRKYDYGIKEKSSMVG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCEE
VVTGLAYTETGGDLLTIESVMMPGRGGIKCTGKLGEVMQESVKAAYSYVRSRCFEFGIKS
HHCCCEEECCCCCEEEEHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KDFQSKDIHVHVPEGAIPKDGPSAGIAMCISIVSLMTGIPVKNSVAMTGEVTLRGRVLPI
CCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEC
GGLKEKLLAAMRGGVTTVILPIKNKKDFAELPESVKQSLELVLVSSVDEVIACALESPVV
CCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLSEDEVFVNQMSGVGDCSFLN
CCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA