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The map label for this gene is tme [H]

Identifier: 88607511

GI number: 88607511

Start: 39100

End: 41355

Strand: Direct

Name: tme [H]

Synonym: APH_0042

Alternate gene names: 88607511

Gene position: 39100-41355 (Clockwise)

Preceding gene: 88607245

Following gene: 88606722

Centisome position: 2.66

GC content: 44.81

Gene sequence:

>2256_bases
ATGAGCGATTTTTCAGAAAAAGACATGGAGGCTCTTGAGTTTCATAGCAGGGGACGGCCGGGTAAAGTAGCCTTGTTGCC
AACGAAGCCTTTGTTGACTCAGGGAGATCTGTCTCTAGCATACTCTCCGGGGGTTGCTGTACCGTGTATCAAGATAGCGT
CGGACCCCGATCTGGTATACGAATATACGGCAAGAGGTAATTACGTTGCTGTGATATCAAATGGCACAGCAGTTTTGGGC
TTAGGAAATATAGGCACTTTGGCTGCTAAGCCGGTTATGGAGGGTAAAGCTGTTCTGTTTAAACGCTTCGCTGACATAGA
TGCAGTGGATATTGAAGTGAACACAGAAGACGTAGATGAGTTCATTAATGCTGTTAAATATCTGGGGCATAGTTGGGGGG
GTATCAATCTAGAAGATATACGTGCGCCCGAATGTTTTGTTATAGAGAGACGCCTGAGCGAACTTATGGATATACCGGTG
TTCCATGATGATCAGCATGGAACGGCGATTATTGTGCTTGCCGGTATAATAAATGCCCTTGATATTACGGGAAAGGTCCT
CAAGAACGTTAAGATAGTAGTAAATGGTGCAGGTGCTGCAGGCATTGCTTGTGTTGAGATGCTTAAGTTTGTTGGGATAC
CTAACGACAATATCATATTGTGCGACCAAAATGGTGTAATATACAAGGGGCGCCAACTTGGCGTTAATGAGTGGAAGTTG
AAGCATGCTGTTGAGACAGACGCAAGAGACTTGAAAGATGCGATAAAAGGTGCAGACATTTTCATAGGTTTGTCTGTGCG
GGATGTTCTCAGCAGGGAAATGCTCCTTTCTATGAATAAAGACCCTGTAATTTTCGCTCTTGCTAATCCGTATCCAGAGG
TTAATCCAGAGTTTGCGAGAGAAGTGAGGGGAGATGCGATCATAGCAACTGGAAGATCAGATTACAGCAACCAGATAAAC
AATGTGATGGGTTTCCCTTACATATTTAGGGGAGCGTTGGATGTGCGAGCTAAGAGAGTTAACAATGAGATGAAATTAGC
TGTTGCGCAGGCCATAGCGATGCTGGCAAGAGAAGTGGTGAGTGATGAAGTGTTGGAGGCTTATGGTGGCCGAGGCATGA
GGTATGGAAGGGATTATATAATACCTACACCGTTTGATCCACGTCTCATATCGGTAGTCTCCCCAGCGGTAGCAAGAGCT
GCGATAGAAACAGGGGTAGCGCAGAAGGGAATAGATGACTGGGACAAGTATGCGCGTGCATTAGGTTCTAGAATATCACC
TACTTCGAACGTGCTTAATCTTATTTATGGTTCCGTAAAGCAGACTCCTAAAAGGGTTATCTTTTCTGAAGGTGAGGAGA
TAAAGGTCATTAAGGCTGCCTTGCAGTGGAGGAGTCAGGGATATGGTGTGCCTATTTTGGTAGGGCGCGCTGATAAGATT
AAGGAGGGATTGGAGCGTATAGGAGTTGATAGCCTGGATGGTATAGAGATAGCCAATGCGGCGGTTTCTACTCGCAATGA
TGTATACATAGATTATCTGTACAGTAAGCTCCAGAGAAAAGGATACCTACATCGCAGGTGCGTTAGGGATGTGAAAACAG
ATAGAAATGTCTTTGCTGCGTGTATGTTAGCGTGTGGTGATGGGGATATTTTGGTTACAGGTGTAACTCGAGGATATAGA
GAATCGCTATCTGATGTAAGTAAGGTGATAGGAGCGCGTAGTGAGATTATGGGGCTATCTGTTATTGTTATGGAAGATAG
AACATTGTTTATTGCTGATACTGCGATTAATGAATTTCCAACATCTAAGCAGATGGCAGATATAGCTGTAACAGCAGCGG
CTGCTGCGAAAAAGATGGGGCATGAACCTAGGGTGGCGTTTGTATCGTGCTCTAATTTTGGTAGTCATGCGCAGGAGGGA
ACTGAAAGGATAAGAGAGAGCATAGAGATTCTCGATCGCCTTGGTGTAGGCTTTGAGTATGATGGAGAGATGTCCATAGA
TGTTGCACTGAGGAAGGAGTCTTTGGCATTATATCCCTTTAACCGCATAAAGGGTGGACCTGCTAATGTTTTGATAATGC
CTAGTCTGTACAGTGCCAGCATCTCTTCCAAGTTGCTACAGGAGGTAGGAGGTGTTGCAGTTGTAGGGCCTATTCTTATG
GGTATGGAAAAACCGGTGCAGATTGTACAAATGACAGCATCTGTCTCTGAGATATTGAATCTTGCGGTGCTCTCAACGCT
ATATAATGCATTGTAG

Upstream 100 bases:

>100_bases
GCTAGAGCACTGTAGCCGTCGTAGGGGAGGAAACAGTTGCGCAAAAAGACCAATGTGTATACCCTTCAGGATCATTTAAG
TTTGGGGGACTCTGAGTGCA

Downstream 100 bases:

>100_bases
GGTTAAGATATGGGGGTGTTAGTCTTTCCATAAGCGGAGGAAGGGCTTGACACTCCTACGCAGTTGTAGAGGATTGTTAG
GAATATCTCGTTTTGCATAA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MSDFSEKDMEALEFHSRGRPGKVALLPTKPLLTQGDLSLAYSPGVAVPCIKIASDPDLVYEYTARGNYVAVISNGTAVLG
LGNIGTLAAKPVMEGKAVLFKRFADIDAVDIEVNTEDVDEFINAVKYLGHSWGGINLEDIRAPECFVIERRLSELMDIPV
FHDDQHGTAIIVLAGIINALDITGKVLKNVKIVVNGAGAAGIACVEMLKFVGIPNDNIILCDQNGVIYKGRQLGVNEWKL
KHAVETDARDLKDAIKGADIFIGLSVRDVLSREMLLSMNKDPVIFALANPYPEVNPEFAREVRGDAIIATGRSDYSNQIN
NVMGFPYIFRGALDVRAKRVNNEMKLAVAQAIAMLAREVVSDEVLEAYGGRGMRYGRDYIIPTPFDPRLISVVSPAVARA
AIETGVAQKGIDDWDKYARALGSRISPTSNVLNLIYGSVKQTPKRVIFSEGEEIKVIKAALQWRSQGYGVPILVGRADKI
KEGLERIGVDSLDGIEIANAAVSTRNDVYIDYLYSKLQRKGYLHRRCVRDVKTDRNVFAACMLACGDGDILVTGVTRGYR
ESLSDVSKVIGARSEIMGLSVIVMEDRTLFIADTAINEFPTSKQMADIAVTAAAAAKKMGHEPRVAFVSCSNFGSHAQEG
TERIRESIEILDRLGVGFEYDGEMSIDVALRKESLALYPFNRIKGGPANVLIMPSLYSASISSKLLQEVGGVAVVGPILM
GMEKPVQIVQMTASVSEILNLAVLSTLYNAL

Sequences:

>Translated_751_residues
MSDFSEKDMEALEFHSRGRPGKVALLPTKPLLTQGDLSLAYSPGVAVPCIKIASDPDLVYEYTARGNYVAVISNGTAVLG
LGNIGTLAAKPVMEGKAVLFKRFADIDAVDIEVNTEDVDEFINAVKYLGHSWGGINLEDIRAPECFVIERRLSELMDIPV
FHDDQHGTAIIVLAGIINALDITGKVLKNVKIVVNGAGAAGIACVEMLKFVGIPNDNIILCDQNGVIYKGRQLGVNEWKL
KHAVETDARDLKDAIKGADIFIGLSVRDVLSREMLLSMNKDPVIFALANPYPEVNPEFAREVRGDAIIATGRSDYSNQIN
NVMGFPYIFRGALDVRAKRVNNEMKLAVAQAIAMLAREVVSDEVLEAYGGRGMRYGRDYIIPTPFDPRLISVVSPAVARA
AIETGVAQKGIDDWDKYARALGSRISPTSNVLNLIYGSVKQTPKRVIFSEGEEIKVIKAALQWRSQGYGVPILVGRADKI
KEGLERIGVDSLDGIEIANAAVSTRNDVYIDYLYSKLQRKGYLHRRCVRDVKTDRNVFAACMLACGDGDILVTGVTRGYR
ESLSDVSKVIGARSEIMGLSVIVMEDRTLFIADTAINEFPTSKQMADIAVTAAAAAKKMGHEPRVAFVSCSNFGSHAQEG
TERIRESIEILDRLGVGFEYDGEMSIDVALRKESLALYPFNRIKGGPANVLIMPSLYSASISSKLLQEVGGVAVVGPILM
GMEKPVQIVQMTASVSEILNLAVLSTLYNAL
>Mature_750_residues
SDFSEKDMEALEFHSRGRPGKVALLPTKPLLTQGDLSLAYSPGVAVPCIKIASDPDLVYEYTARGNYVAVISNGTAVLGL
GNIGTLAAKPVMEGKAVLFKRFADIDAVDIEVNTEDVDEFINAVKYLGHSWGGINLEDIRAPECFVIERRLSELMDIPVF
HDDQHGTAIIVLAGIINALDITGKVLKNVKIVVNGAGAAGIACVEMLKFVGIPNDNIILCDQNGVIYKGRQLGVNEWKLK
HAVETDARDLKDAIKGADIFIGLSVRDVLSREMLLSMNKDPVIFALANPYPEVNPEFAREVRGDAIIATGRSDYSNQINN
VMGFPYIFRGALDVRAKRVNNEMKLAVAQAIAMLAREVVSDEVLEAYGGRGMRYGRDYIIPTPFDPRLISVVSPAVARAA
IETGVAQKGIDDWDKYARALGSRISPTSNVLNLIYGSVKQTPKRVIFSEGEEIKVIKAALQWRSQGYGVPILVGRADKIK
EGLERIGVDSLDGIEIANAAVSTRNDVYIDYLYSKLQRKGYLHRRCVRDVKTDRNVFAACMLACGDGDILVTGVTRGYRE
SLSDVSKVIGARSEIMGLSVIVMEDRTLFIADTAINEFPTSKQMADIAVTAAAAAKKMGHEPRVAFVSCSNFGSHAQEGT
ERIRESIEILDRLGVGFEYDGEMSIDVALRKESLALYPFNRIKGGPANVLIMPSLYSASISSKLLQEVGGVAVVGPILMG
MEKPVQIVQMTASVSEILNLAVLSTLYNAL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=356, Percent_Identity=26.685393258427, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI62420882, Length=355, Percent_Identity=25.6338028169014, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI62420880, Length=355, Percent_Identity=25.6338028169014, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI239049447, Length=355, Percent_Identity=25.6338028169014, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788806, Length=748, Percent_Identity=46.524064171123, Blast_Score=650, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=330, Percent_Identity=28.7878787878788, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1788635, Length=310, Percent_Identity=27.4193548387097, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17537199, Length=361, Percent_Identity=27.7008310249307, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=275, Percent_Identity=27.6363636363636, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646388, Length=405, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646386, Length=405, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356279, Length=395, Percent_Identity=26.0759493670886, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281362674, Length=395, Percent_Identity=26.0759493670886, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281362672, Length=395, Percent_Identity=26.0759493670886, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI78707242, Length=429, Percent_Identity=24.9417249417249, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707238, Length=429, Percent_Identity=24.9417249417249, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81654; Mature: 81523

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFSEKDMEALEFHSRGRPGKVALLPTKPLLTQGDLSLAYSPGVAVPCIKIASDPDLVY
CCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEECCCCCEEE
EYTARGNYVAVISNGTAVLGLGNIGTLAAKPVMEGKAVLFKRFADIDAVDIEVNTEDVDE
EEECCCCEEEEEECCEEEEEECCCCHHHCCCHHCCHHHHHHHHCCCCEEEEEECHHHHHH
FINAVKYLGHSWGGINLEDIRAPECFVIERRLSELMDIPVFHDDQHGTAIIVLAGIINAL
HHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHHHH
DITGKVLKNVKIVVNGAGAAGIACVEMLKFVGIPNDNIILCDQNGVIYKGRQLGVNEWKL
HHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCHHHH
KHAVETDARDLKDAIKGADIFIGLSVRDVLSREMLLSMNKDPVIFALANPYPEVNPEFAR
HHHHHCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
EVRGDAIIATGRSDYSNQINNVMGFPYIFRGALDVRAKRVNNEMKLAVAQAIAMLAREVV
HCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SDEVLEAYGGRGMRYGRDYIIPTPFDPRLISVVSPAVARAAIETGVAQKGIDDWDKYARA
HHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGSRISPTSNVLNLIYGSVKQTPKRVIFSEGEEIKVIKAALQWRSQGYGVPILVGRADKI
HCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHH
KEGLERIGVDSLDGIEIANAAVSTRNDVYIDYLYSKLQRKGYLHRRCVRDVKTDRNVFAA
HHHHHHCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
CMLACGDGDILVTGVTRGYRESLSDVSKVIGARSEIMGLSVIVMEDRTLFIADTAINEFP
HHHEECCCCEEEEECCHHHHHHHHHHHHHHCCHHHHCCEEEEEEECCEEEEEECHHHCCC
TSKQMADIAVTAAAAAKKMGHEPRVAFVSCSNFGSHAQEGTERIRESIEILDRLGVGFEY
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
DGEMSIDVALRKESLALYPFNRIKGGPANVLIMPSLYSASISSKLLQEVGGVAVVGPILM
CCCEEEEEEEECCCEEEECHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCEEEEHHHHH
GMEKPVQIVQMTASVSEILNLAVLSTLYNAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDFSEKDMEALEFHSRGRPGKVALLPTKPLLTQGDLSLAYSPGVAVPCIKIASDPDLVY
CCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEECCCCCEEE
EYTARGNYVAVISNGTAVLGLGNIGTLAAKPVMEGKAVLFKRFADIDAVDIEVNTEDVDE
EEECCCCEEEEEECCEEEEEECCCCHHHCCCHHCCHHHHHHHHCCCCEEEEEECHHHHHH
FINAVKYLGHSWGGINLEDIRAPECFVIERRLSELMDIPVFHDDQHGTAIIVLAGIINAL
HHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHHHH
DITGKVLKNVKIVVNGAGAAGIACVEMLKFVGIPNDNIILCDQNGVIYKGRQLGVNEWKL
HHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCCHHHH
KHAVETDARDLKDAIKGADIFIGLSVRDVLSREMLLSMNKDPVIFALANPYPEVNPEFAR
HHHHHCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
EVRGDAIIATGRSDYSNQINNVMGFPYIFRGALDVRAKRVNNEMKLAVAQAIAMLAREVV
HCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SDEVLEAYGGRGMRYGRDYIIPTPFDPRLISVVSPAVARAAIETGVAQKGIDDWDKYARA
HHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGSRISPTSNVLNLIYGSVKQTPKRVIFSEGEEIKVIKAALQWRSQGYGVPILVGRADKI
HCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHH
KEGLERIGVDSLDGIEIANAAVSTRNDVYIDYLYSKLQRKGYLHRRCVRDVKTDRNVFAA
HHHHHHCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
CMLACGDGDILVTGVTRGYRESLSDVSKVIGARSEIMGLSVIVMEDRTLFIADTAINEFP
HHHEECCCCEEEEECCHHHHHHHHHHHHHHCCHHHHCCEEEEEEECCEEEEEECHHHCCC
TSKQMADIAVTAAAAAKKMGHEPRVAFVSCSNFGSHAQEGTERIRESIEILDRLGVGFEY
CCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEE
DGEMSIDVALRKESLALYPFNRIKGGPANVLIMPSLYSASISSKLLQEVGGVAVVGPILM
CCCEEEEEEEECCCEEEECHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCEEEEHHHHH
GMEKPVQIVQMTASVSEILNLAVLSTLYNAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]