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The map label for this gene is nuoH

Identifier: 88607453

GI number: 88607453

Start: 743252

End: 744274

Strand: Reverse

Name: nuoH

Synonym: APH_0711

Alternate gene names: 88607453

Gene position: 744274-743252 (Counterclockwise)

Preceding gene: 88607242

Following gene: 88606803

Centisome position: 50.59

GC content: 42.42

Gene sequence:

>1023_bases
ATGCAGCTAGTAGGTATGGTCGCCTTGATGGTGGGTGTACTTGTGAGTGTTGCGTATCTTGTATATATGGAACGGAAGGT
GATGGCTTTCATGCAGCTGAGGCATGGTCCTAGTGTTGTGGGGCCTTGGGGTTTATTGCAGCCGTTTTCTGATGCGCTGA
AGTTGCTTGCTAAAGAGTGTATTATTCCGTTTAAATCAAGAGGGTGGGCGTTTTTTGCGGCGCCGGTTATTACCTTTGCG
CTTGCGCTTGCGGGATGGGCTGTGATTCCTTTGGGTGCTACTGAGGTAATCAGGGATGGTGTTGTTGTAGTAATGCCCTA
TGTTGTAGCTGACCTTAATTTAGGAGTGCTTTATGTTTTAGCTATATCATCTTTGGAGGTGTATGGCATTATTATGGCGG
GTTGGGCTAGTGGCTCAAATTATGCATTTTTAGGTGCTATAAGATCGGTTTCCCAGATGATTTCGTATGAGATGTCTATG
GGGCTGGTTATGTTGTCTGTCTCGTTGTGTGCTGGTTCTTTGAGGTTGACTGATATTGTGGTAGCAAGGCACGCAATGCC
ATATTGGATGGATTTGCTTCTCTTGCCAATGGCGGGTGTATTTTTTGTTTCTATGTTAGCGGAGACAAATCGCCATCCGT
TTGATCTTCCTGAAGCTGAATCTGAGCTTGTCTCAGGATATAATGTTGAATATTCCTCGATGTCATTTGCTATGTTCTTT
TTAGGGGAATATGCCAACATGATATTAGTTAGTGCAATGATGGTTGTTCTATTTCTAGGTGGTTGGTATCCTCCGCTAAA
TATTCATATTTTGTATTACATTCCTGGATTTGTTTGGTTCTGTTCTAAAGTATTTCTTTTACTATTCTGCTTTATTTGGG
TCAGATCTACCGTTCCTAGGTATAGATATGATCAGCTCATGCGTTTGGGATGGAAGGTGTTTTTGCCATTTTCTTTTGTT
TGGGTAATGGTGATATCAGGTGTTCTTTTATGGGTCAAGGCTCTACCTGGTATGCAGAACTAA

Upstream 100 bases:

>100_bases
GCTTCGCCTACTATGGCTAAGTGTACTAAGTTTTTTATGAGGCAAGTCTGCTGATATGGATACTTTGTATGCTTTATATG
GGTGGTTAGTTGCTTCGGGA

Downstream 100 bases:

>100_bases
ACTTCGGGTATATGTTTCTGCTCGTTGCGCAATCTCTGACATGGGGATGTTTCACTCGCGTAGCATGTCTTCAGTCTTCT
AAAATGTGTGTTTGATCTAT

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQLVGMVALMVGVLVSVAYLVYMERKVMAFMQLRHGPSVVGPWGLLQPFSDALKLLAKECIIPFKSRGWAFFAAPVITFA
LALAGWAVIPLGATEVIRDGVVVVMPYVVADLNLGVLYVLAISSLEVYGIIMAGWASGSNYAFLGAIRSVSQMISYEMSM
GLVMLSVSLCAGSLRLTDIVVARHAMPYWMDLLLLPMAGVFFVSMLAETNRHPFDLPEAESELVSGYNVEYSSMSFAMFF
LGEYANMILVSAMMVVLFLGGWYPPLNIHILYYIPGFVWFCSKVFLLLFCFIWVRSTVPRYRYDQLMRLGWKVFLPFSFV
WVMVISGVLLWVKALPGMQN

Sequences:

>Translated_340_residues
MQLVGMVALMVGVLVSVAYLVYMERKVMAFMQLRHGPSVVGPWGLLQPFSDALKLLAKECIIPFKSRGWAFFAAPVITFA
LALAGWAVIPLGATEVIRDGVVVVMPYVVADLNLGVLYVLAISSLEVYGIIMAGWASGSNYAFLGAIRSVSQMISYEMSM
GLVMLSVSLCAGSLRLTDIVVARHAMPYWMDLLLLPMAGVFFVSMLAETNRHPFDLPEAESELVSGYNVEYSSMSFAMFF
LGEYANMILVSAMMVVLFLGGWYPPLNIHILYYIPGFVWFCSKVFLLLFCFIWVRSTVPRYRYDQLMRLGWKVFLPFSFV
WVMVISGVLLWVKALPGMQN
>Mature_340_residues
MQLVGMVALMVGVLVSVAYLVYMERKVMAFMQLRHGPSVVGPWGLLQPFSDALKLLAKECIIPFKSRGWAFFAAPVITFA
LALAGWAVIPLGATEVIRDGVVVVMPYVVADLNLGVLYVLAISSLEVYGIIMAGWASGSNYAFLGAIRSVSQMISYEMSM
GLVMLSVSLCAGSLRLTDIVVARHAMPYWMDLLLLPMAGVFFVSMLAETNRHPFDLPEAESELVSGYNVEYSSMSFAMFF
LGEYANMILVSAMMVVLFLGGWYPPLNIHILYYIPGFVWFCSKVFLLLFCFIWVRSTVPRYRYDQLMRLGWKVFLPFSFV
WVMVISGVLLWVKALPGMQN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=308, Percent_Identity=43.1818181818182, Blast_Score=258, Evalue=5e-69,
Organism=Escherichia coli, GI1788618, Length=335, Percent_Identity=37.910447761194, Blast_Score=234, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_ANAPZ (Q2GK09)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505292.1
- STRING:   Q2GK09
- GeneID:   3930347
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0711
- NMPDR:   fig|212042.5.peg.693
- TIGR:   APH_0711
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q2GK09
- ProtClustDB:   PRK06076
- BioCyc:   APHA212042:APH_0711-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37989; Mature: 37989

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18ad4308)-; HASH(0x1932edb0)-; HASH(0x1932edd4)-; HASH(0x969ee10)-; HASH(0x19319a64)-; HASH(0x193199ec)-; HASH(0x183b8ab8)-; HASH(0x192ab7d0)-; HASH(0x192b4308)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
7.1 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
7.1 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLVGMVALMVGVLVSVAYLVYMERKVMAFMQLRHGPSVVGPWGLLQPFSDALKLLAKEC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
IIPFKSRGWAFFAAPVITFALALAGWAVIPLGATEVIRDGVVVVMPYVVADLNLGVLYVL
CCCCCCCCCHHHHHHHHHHHHHHHCHHEECCCHHHHHHCCHHEEHHHHHHHCCHHHHHHH
AISSLEVYGIIMAGWASGSNYAFLGAIRSVSQMISYEMSMGLVMLSVSLCAGSLRLTDIV
HHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VARHAMPYWMDLLLLPMAGVFFVSMLAETNRHPFDLPEAESELVSGYNVEYSSMSFAMFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHH
LGEYANMILVSAMMVVLFLGGWYPPLNIHILYYIPGFVWFCSKVFLLLFCFIWVRSTVPR
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YRYDQLMRLGWKVFLPFSFVWVMVISGVLLWVKALPGMQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MQLVGMVALMVGVLVSVAYLVYMERKVMAFMQLRHGPSVVGPWGLLQPFSDALKLLAKEC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
IIPFKSRGWAFFAAPVITFALALAGWAVIPLGATEVIRDGVVVVMPYVVADLNLGVLYVL
CCCCCCCCCHHHHHHHHHHHHHHHCHHEECCCHHHHHHCCHHEEHHHHHHHCCHHHHHHH
AISSLEVYGIIMAGWASGSNYAFLGAIRSVSQMISYEMSMGLVMLSVSLCAGSLRLTDIV
HHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VARHAMPYWMDLLLLPMAGVFFVSMLAETNRHPFDLPEAESELVSGYNVEYSSMSFAMFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHH
LGEYANMILVSAMMVVLFLGGWYPPLNIHILYYIPGFVWFCSKVFLLLFCFIWVRSTVPR
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YRYDQLMRLGWKVFLPFSFVWVMVISGVLLWVKALPGMQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA