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The map label for this gene is mutS [H]

Identifier: 88607281

GI number: 88607281

Start: 600532

End: 600936

Strand: Reverse

Name: mutS [H]

Synonym: APH_0572

Alternate gene names: 88607281

Gene position: 600936-600532 (Counterclockwise)

Preceding gene: 88607234

Following gene: 88607611

Centisome position: 40.84

GC content: 41.48

Gene sequence:

>405_bases
ATGTCTCTCATTACCGGGCCAAATATGGCAGGTAAGAGCACGTTTTTGAGGCAAAATGCTTTAATAGCAGTTTTGGCTCA
TATAGGGTCATTTGTTCCTGCTGAGCATGCGCATATAGGGGTGATAGATAAAATATTTAGTAGGGTAGGTGCATCGGATA
ACATAGCGCTTGGGCACTCTACTTTTATGGTGGAGATGGTAGAGACTGCAGCGATTTTGAATCAAGCAACTTCGAAGTCA
CTGGTTATTTTAGATGAAATTGGCCGTGGAACCGCTATTAATGATGGCCTTTCCATAGCTTTAGCCGCTATTGAACACAT
ACATGATGTTACAAAGAGTAGGGCGATATGTGCAACGCACTATCATGAGCTACCAAAACTTAGTTCGCATTTTGTGTATA
TGTAA

Upstream 100 bases:

>100_bases
GTATAGTAAGCAGTTTAAAATAGTACGAGGTCGTCATCCAGTAGTAGAAGTAGGAACGGATTTTATTGCGAATGACTGTG
ATCTTTCAGAGGGGAACAGT

Downstream 100 bases:

>100_bases
GTTGTCTATGTAGTTCTTACTGCATGAAGATGTAATTCCTTATATTGGGCATATTTTTCAACCTCAGGAGTATAGAACAA
GACGTGCTGTAACGACACTT

Product: DNA mismatch repair protein MutS, truncation

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 133

Protein sequence:

>134_residues
MSLITGPNMAGKSTFLRQNALIAVLAHIGSFVPAEHAHIGVIDKIFSRVGASDNIALGHSTFMVEMVETAAILNQATSKS
LVILDEIGRGTAINDGLSIALAAIEHIHDVTKSRAICATHYHELPKLSSHFVYM

Sequences:

>Translated_134_residues
MSLITGPNMAGKSTFLRQNALIAVLAHIGSFVPAEHAHIGVIDKIFSRVGASDNIALGHSTFMVEMVETAAILNQATSKS
LVILDEIGRGTAINDGLSIALAAIEHIHDVTKSRAICATHYHELPKLSSHFVYM
>Mature_133_residues
SLITGPNMAGKSTFLRQNALIAVLAHIGSFVPAEHAHIGVIDKIFSRVGASDNIALGHSTFMVEMVETAAILNQATSKSL
VILDEIGRGTAINDGLSIALAAIEHIHDVTKSRAICATHYHELPKLSSHFVYM

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=133, Percent_Identity=54.8872180451128, Blast_Score=145, Evalue=1e-35,
Organism=Homo sapiens, GI4504191, Length=122, Percent_Identity=53.2786885245902, Blast_Score=140, Evalue=3e-34,
Organism=Homo sapiens, GI4557761, Length=130, Percent_Identity=52.3076923076923, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI36949366, Length=122, Percent_Identity=46.7213114754098, Blast_Score=117, Evalue=2e-27,
Organism=Homo sapiens, GI26638666, Length=106, Percent_Identity=48.1132075471698, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI4505253, Length=106, Percent_Identity=48.1132075471698, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI262231786, Length=107, Percent_Identity=47.6635514018692, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI26638664, Length=107, Percent_Identity=47.6635514018692, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1789089, Length=127, Percent_Identity=59.8425196850394, Blast_Score=157, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508447, Length=122, Percent_Identity=50.8196721311475, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17508445, Length=128, Percent_Identity=51.5625, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17534743, Length=128, Percent_Identity=41.40625, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539736, Length=127, Percent_Identity=40.1574803149606, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321912, Length=119, Percent_Identity=56.3025210084034, Blast_Score=145, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324482, Length=126, Percent_Identity=53.1746031746032, Blast_Score=139, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320302, Length=130, Percent_Identity=43.8461538461538, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319935, Length=133, Percent_Identity=41.3533834586466, Blast_Score=118, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320047, Length=123, Percent_Identity=43.0894308943089, Blast_Score=103, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321109, Length=129, Percent_Identity=39.5348837209302, Blast_Score=101, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24584320, Length=128, Percent_Identity=53.90625, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24664545, Length=124, Percent_Identity=49.1935483870968, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62471629, Length=73, Percent_Identity=57.5342465753425, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 14331; Mature: 14200

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLITGPNMAGKSTFLRQNALIAVLAHIGSFVPAEHAHIGVIDKIFSRVGASDNIALGHS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECHH
TFMVEMVETAAILNQATSKSLVILDEIGRGTAINDGLSIALAAIEHIHDVTKSRAICATH
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
YHELPKLSSHFVYM
HHHCCCCCCCEECC
>Mature Secondary Structure 
SLITGPNMAGKSTFLRQNALIAVLAHIGSFVPAEHAHIGVIDKIFSRVGASDNIALGHS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECHH
TFMVEMVETAAILNQATSKSLVILDEIGRGTAINDGLSIALAAIEHIHDVTKSRAICATH
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
YHELPKLSSHFVYM
HHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA