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The map label for this gene is purM-2 [H]

Identifier: 88607219

GI number: 88607219

Start: 205989

End: 207023

Strand: Reverse

Name: purM-2 [H]

Synonym: APH_0210

Alternate gene names: 88607219

Gene position: 207023-205989 (Counterclockwise)

Preceding gene: 88607777

Following gene: 88606809

Centisome position: 14.07

GC content: 44.83

Gene sequence:

>1035_bases
ATGAGTAAATACTTAGACTCGGGAGTAGATATTGCCTCTGCTGACAAGCTAGTAGGCGAAATAAAACAACTCTCGCAAGA
AACTAAAAGTGATAACGTAGTATCCGAAATTGGAGGTTTCGGCGCAGTGTTCGACTTATACGCTACCGGACACAAATATC
GCTCTCCTTTACTTGTATCCTCTACAGACGGTGTAGGCACTAAGTTGTTGATAGCGCAGGCTACAGTACAACACCAACAC
ATTGGCGTAGACCTAGTAGCAATGTGTGTAAATGACGTGCTTGCTCAAGGTGCAAAGCCCTTGTTCTTCCTCGATTACTT
TGCTACCGGAGCTCTTGATCCTTCTGTCGCACTGGAAGTGTTACGCGGGATATCTCATGGATGCAAACTTGCTGGGGCTT
CACTTGTAGGCGGTGAAACCGCTGAAATGCCCGGTATGTACTCCAGAGGACATTACGACCTCGCAGGATTTACCGTAGGT
ATAGTTGAAAGAGAAGACATCTTGCCAAAACTAGATCTCATACAAGCTGGGGACGTAATACTTGGTCTACCTTCTTCGGG
ACTGCATTCAAATGGGTTTTCTCTAGTACGGAAAATCCTCAAGGACCTAGATATAGATTATTCTAGCCCGTGCCCCTTTA
GCGAGAAAGAGCTTACCTGGGCAGATGTTCTTCTAGAACCCACTAGAATATACGTAAACTCGGTGCTACCTACCTGTCAT
CTCTTAAAAGCCATAGCACATATCACAGGAGGTGGGCTAGTACACAATGTTCCTCGAATATTACCAACTCATCTCGCTGC
TGAAATACGTCAAGACTCCTGGCCAAAGCAGAACATATTTACCTGGTTAGAAGGTGCCGGAAATATTCCTAAGGAAGATA
TGCTAGAAACCTTTAACTGTGGTATTGGTCTTGTATTAGTCACCGCAAGAGAAACTTCTGCAGAGTTAATGGCAATGTTG
GCGGAACTAGGGGAAACAGCATACGTCATAGGGGCAGTAATCCCTAGAGGCGAAAAACCTGTAGTTTTAAGATAA

Upstream 100 bases:

>100_bases
CCTCACAACGCATAGGGAGAATGAGGGGATACTTAAAATATTTTTGTACAAGTTTCACGCATCTAGTGTTACTCTCTCTC
CACCAGGTGTGGCTGATTCT

Downstream 100 bases:

>100_bases
CATGCTTGCAGCTCTTGACGCTGCTATACCTTCCAGGGGTTATATACTCTAAAAGTGATACGAGGCTGTAGCATATGGTA
TGCAGTATTGATATTGCTGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSKYLDSGVDIASADKLVGEIKQLSQETKSDNVVSEIGGFGAVFDLYATGHKYRSPLLVSSTDGVGTKLLIAQATVQHQH
IGVDLVAMCVNDVLAQGAKPLFFLDYFATGALDPSVALEVLRGISHGCKLAGASLVGGETAEMPGMYSRGHYDLAGFTVG
IVEREDILPKLDLIQAGDVILGLPSSGLHSNGFSLVRKILKDLDIDYSSPCPFSEKELTWADVLLEPTRIYVNSVLPTCH
LLKAIAHITGGGLVHNVPRILPTHLAAEIRQDSWPKQNIFTWLEGAGNIPKEDMLETFNCGIGLVLVTARETSAELMAML
AELGETAYVIGAVIPRGEKPVVLR

Sequences:

>Translated_344_residues
MSKYLDSGVDIASADKLVGEIKQLSQETKSDNVVSEIGGFGAVFDLYATGHKYRSPLLVSSTDGVGTKLLIAQATVQHQH
IGVDLVAMCVNDVLAQGAKPLFFLDYFATGALDPSVALEVLRGISHGCKLAGASLVGGETAEMPGMYSRGHYDLAGFTVG
IVEREDILPKLDLIQAGDVILGLPSSGLHSNGFSLVRKILKDLDIDYSSPCPFSEKELTWADVLLEPTRIYVNSVLPTCH
LLKAIAHITGGGLVHNVPRILPTHLAAEIRQDSWPKQNIFTWLEGAGNIPKEDMLETFNCGIGLVLVTARETSAELMAML
AELGETAYVIGAVIPRGEKPVVLR
>Mature_343_residues
SKYLDSGVDIASADKLVGEIKQLSQETKSDNVVSEIGGFGAVFDLYATGHKYRSPLLVSSTDGVGTKLLIAQATVQHQHI
GVDLVAMCVNDVLAQGAKPLFFLDYFATGALDPSVALEVLRGISHGCKLAGASLVGGETAEMPGMYSRGHYDLAGFTVGI
VEREDILPKLDLIQAGDVILGLPSSGLHSNGFSLVRKILKDLDIDYSSPCPFSEKELTWADVLLEPTRIYVNSVLPTCHL
LKAIAHITGGGLVHNVPRILPTHLAAEIRQDSWPKQNIFTWLEGAGNIPKEDMLETFNCGIGLVLVTARETSAELMAMLA
ELGETAYVIGAVIPRGEKPVVLR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=51.6320474777448, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=51.6320474777448, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=51.6320474777448, Blast_Score=348, Evalue=4e-96,
Organism=Escherichia coli, GI1788845, Length=335, Percent_Identity=49.5522388059701, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17567511, Length=337, Percent_Identity=45.9940652818991, Blast_Score=260, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=50.8928571428571, Blast_Score=344, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24582400, Length=290, Percent_Identity=45.5172413793103, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36862; Mature: 36731

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYLDSGVDIASADKLVGEIKQLSQETKSDNVVSEIGGFGAVFDLYATGHKYRSPLLVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHCCCEEEE
STDGVGTKLLIAQATVQHQHIGVDLVAMCVNDVLAQGAKPLFFLDYFATGALDPSVALEV
CCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCHHHHHHH
LRGISHGCKLAGASLVGGETAEMPGMYSRGHYDLAGFTVGIVEREDILPKLDLIQAGDVI
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEECCEEEEEEEHHHCCCCHHHEECCCEE
LGLPSSGLHSNGFSLVRKILKDLDIDYSSPCPFSEKELTWADVLLEPTRIYVNSVLPTCH
EECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHH
LLKAIAHITGGGLVHNVPRILPTHLAAEIRQDSWPKQNIFTWLEGAGNIPKEDMLETFNC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCC
GIGLVLVTARETSAELMAMLAELGETAYVIGAVIPRGEKPVVLR
CCEEEEEEECHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCEEC
>Mature Secondary Structure 
SKYLDSGVDIASADKLVGEIKQLSQETKSDNVVSEIGGFGAVFDLYATGHKYRSPLLVS
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHCCCEEEE
STDGVGTKLLIAQATVQHQHIGVDLVAMCVNDVLAQGAKPLFFLDYFATGALDPSVALEV
CCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCHHHHHHH
LRGISHGCKLAGASLVGGETAEMPGMYSRGHYDLAGFTVGIVEREDILPKLDLIQAGDVI
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEECCEEEEEEEHHHCCCCHHHEECCCEE
LGLPSSGLHSNGFSLVRKILKDLDIDYSSPCPFSEKELTWADVLLEPTRIYVNSVLPTCH
EECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHH
LLKAIAHITGGGLVHNVPRILPTHLAAEIRQDSWPKQNIFTWLEGAGNIPKEDMLETFNC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCC
GIGLVLVTARETSAELMAMLAELGETAYVIGAVIPRGEKPVVLR
CCEEEEEEECHHHHHHHHHHHHHCCCEEEEEHHCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]