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The map label for this gene is tadA [H]

Identifier: 88607031

GI number: 88607031

Start: 304956

End: 305399

Strand: Reverse

Name: tadA [H]

Synonym: APH_0321

Alternate gene names: 88607031

Gene position: 305399-304956 (Counterclockwise)

Preceding gene: 88607744

Following gene: 88606822

Centisome position: 20.76

GC content: 44.82

Gene sequence:

>444_bases
ATGCGAGCTTCTGCCTACATGAAAATAGCGATGGAAGAAGCCAATTCATCCTCCGGAGAAATACCTGTGGGCGCGCTGGT
CGTGCGCAATGGAGTTATTATAGCCAAAGCACACAATCTCACCATTCAAAACACAGACCCAACAGCCCATGCTGAAATCG
TTGCTATTCGCATGGCATGCAAAGCTCTATCCACTCATATACTTGATGGTTGCGATATTTATGTAACCCTAGAACCCTGC
GCGATGTGTACACAGGCTATATCTCTAGCACGAATCAGAAGAATATACTTCGGTGCATGCAATGAAAAGCTAGGTGGCAT
AGAAAACGGAGCCCAAGTTCTCAAATATTGCTTGCACGTCCCTGAAGTATATGGCGGATTCCTGGAGCAAGAGAATGCCG
AACTACTAAAAGCTTTTTTCAAAAAAATGCGCCTTAAGAAGTAG

Upstream 100 bases:

>100_bases
CTTGTACCTGTATATTCAGTGCAGTATTACATGTTACAACCGTTTGCATTGGTCATGCCTGGCCCTACCTTCGAACACTT
TGCGCAGTATATTGTTTAAC

Downstream 100 bases:

>100_bases
CCACCATTACACAATGCAACCTTACCACTCTTGCAATAGTATCCACACGGGACACAACCGAAATTGACTTAAATATATAA
AGCGGCACTACAACATTGGG

Product: cytidine and deoxycytidylate deaminase family protein

Products: uracil; NH3

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MRASAYMKIAMEEANSSSGEIPVGALVVRNGVIIAKAHNLTIQNTDPTAHAEIVAIRMACKALSTHILDGCDIYVTLEPC
AMCTQAISLARIRRIYFGACNEKLGGIENGAQVLKYCLHVPEVYGGFLEQENAELLKAFFKKMRLKK

Sequences:

>Translated_147_residues
MRASAYMKIAMEEANSSSGEIPVGALVVRNGVIIAKAHNLTIQNTDPTAHAEIVAIRMACKALSTHILDGCDIYVTLEPC
AMCTQAISLARIRRIYFGACNEKLGGIENGAQVLKYCLHVPEVYGGFLEQENAELLKAFFKKMRLKK
>Mature_147_residues
MRASAYMKIAMEEANSSSGEIPVGALVVRNGVIIAKAHNLTIQNTDPTAHAEIVAIRMACKALSTHILDGCDIYVTLEPC
AMCTQAISLARIRRIYFGACNEKLGGIENGAQVLKYCLHVPEVYGGFLEQENAELLKAFFKKMRLKK

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=152, Percent_Identity=32.2368421052632, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI145693172, Length=127, Percent_Identity=40.9448818897638, Blast_Score=91, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554608, Length=120, Percent_Identity=37.5, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17541138, Length=146, Percent_Identity=32.1917808219178, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17555996, Length=79, Percent_Identity=48.1012658227848, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355527, Length=146, Percent_Identity=30.1369863013699, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.1

Molecular weight: Translated: 16102; Mature: 16102

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASAYMKIAMEEANSSSGEIPVGALVVRNGVIIAKAHNLTIQNTDPTAHAEIVAIRMAC
CCCCHHHHEEEECCCCCCCCCCCCEEEEECCEEEEEECCEEEECCCCCHHHHHHHHHHHH
KALSTHILDGCDIYVTLEPCAMCTQAISLARIRRIYFGACNEKLGGIENGAQVLKYCLHV
HHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHH
PEVYGGFLEQENAELLKAFFKKMRLKK
HHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRASAYMKIAMEEANSSSGEIPVGALVVRNGVIIAKAHNLTIQNTDPTAHAEIVAIRMAC
CCCCHHHHEEEECCCCCCCCCCCCEEEEECCEEEEEECCEEEECCCCCHHHHHHHHHHHH
KALSTHILDGCDIYVTLEPCAMCTQAISLARIRRIYFGACNEKLGGIENGAQVLKYCLHV
HHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHH
PEVYGGFLEQENAELLKAFFKKMRLKK
HHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytosine; H2O

Specific reaction: cytosine + H2O = uracil + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]