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The map label for this gene is dut [H]

Identifier: 88606839

GI number: 88606839

Start: 386447

End: 386887

Strand: Reverse

Name: dut [H]

Synonym: APH_0379

Alternate gene names: 88606839

Gene position: 386887-386447 (Counterclockwise)

Preceding gene: 88607179

Following gene: 88607365

Centisome position: 26.3

GC content: 48.07

Gene sequence:

>441_bases
ATGAAGGTAGGAATTATACGAATGAAGGGAGGAGAAGGGTTACCCTTGCCCTCTTACGCAACTCCGCAAAGTGCGGGGCT
GGATTTATATGCTGCACTTAGTGAAGAGGTGGTTATACGTTCTGGTGAGCGGTGTCTTATTCGCACAGGTGTGGCTATTG
AGCTTCCTGATGGCTATGAAGCACAAGTTCGATCGCGGTCTGGTTTGGCTGTAAAAGCTGGTGTTGTAGTTTTAAATTCT
CCTGGCACTATTGATGCAGATTACCGCGGTGAGATTGCCGTAATCCTAGCGAATTTTGGTGCTAGCGATTACGTTGTCAA
GCATGGTGACAGGATTGCCCAGCTCGTCATAGCGCCTGTTATGCGTATTTCTTGGGAAGAATCTTCCAATATTACTGAAA
CTCAGCGTGGCGCAGGGGGCTTTGGCTCTACTGGAGTCTAA

Upstream 100 bases:

>100_bases
TCCCAGCAAAAATACACCAACTTTTCGTTGCTTTGAATATGACTTGATTCTCTAGAGAAAGAACGTTATCATGCGGCACT
CGTGGCTGTTGCTGGCTTAT

Downstream 100 bases:

>100_bases
TCTTCCGAAAACAGGTTGTTTTTCCGTGAAGCGCTGTCTATTAGGGACGTGTGTTTGGTGGTGGTGTTGTGAACATTTGC
AAGGAAAAAACGCCTTGAGC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKVGIIRMKGGEGLPLPSYATPQSAGLDLYAALSEEVVIRSGERCLIRTGVAIELPDGYEAQVRSRSGLAVKAGVVVLNS
PGTIDADYRGEIAVILANFGASDYVVKHGDRIAQLVIAPVMRISWEESSNITETQRGAGGFGSTGV

Sequences:

>Translated_146_residues
MKVGIIRMKGGEGLPLPSYATPQSAGLDLYAALSEEVVIRSGERCLIRTGVAIELPDGYEAQVRSRSGLAVKAGVVVLNS
PGTIDADYRGEIAVILANFGASDYVVKHGDRIAQLVIAPVMRISWEESSNITETQRGAGGFGSTGV
>Mature_146_residues
MKVGIIRMKGGEGLPLPSYATPQSAGLDLYAALSEEVVIRSGERCLIRTGVAIELPDGYEAQVRSRSGLAVKAGVVVLNS
PGTIDADYRGEIAVILANFGASDYVVKHGDRIAQLVIAPVMRISWEESSNITETQRGAGGFGSTGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=129, Percent_Identity=42.6356589147287, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI4503423, Length=129, Percent_Identity=42.6356589147287, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI70906441, Length=129, Percent_Identity=42.6356589147287, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790071, Length=146, Percent_Identity=39.041095890411, Blast_Score=107, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71988561, Length=134, Percent_Identity=44.7761194029851, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319729, Length=133, Percent_Identity=36.8421052631579, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583610, Length=130, Percent_Identity=37.6923076923077, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19921126, Length=130, Percent_Identity=37.6923076923077, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15334; Mature: 15334

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGIIRMKGGEGLPLPSYATPQSAGLDLYAALSEEVVIRSGERCLIRTGVAIELPDGYE
CCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCEEEEEECCEEECCCCCC
AQVRSRSGLAVKAGVVVLNSPGTIDADYRGEIAVILANFGASDYVVKHGDRIAQLVIAPV
EEEECCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHHH
MRISWEESSNITETQRGAGGFGSTGV
HHEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVGIIRMKGGEGLPLPSYATPQSAGLDLYAALSEEVVIRSGERCLIRTGVAIELPDGYE
CCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCEEEEEECCEEECCCCCC
AQVRSRSGLAVKAGVVVLNSPGTIDADYRGEIAVILANFGASDYVVKHGDRIAQLVIAPV
EEEECCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHHH
MRISWEESSNITETQRGAGGFGSTGV
HHEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA