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The map label for this gene is gpsA

Identifier: 88606741

GI number: 88606741

Start: 196345

End: 197319

Strand: Reverse

Name: gpsA

Synonym: APH_0198

Alternate gene names: 88606741

Gene position: 197319-196345 (Counterclockwise)

Preceding gene: 88607057

Following gene: 88606895

Centisome position: 13.41

GC content: 46.67

Gene sequence:

>975_bases
GTGCGGGTCACAGTTTTAGGAGCGGGCGCGTTTGGGACAGCCTTGTCTGTTGCGCTTTATAATTCATGCTGTAGCGTTGC
TCTTTGGAGCAGGAATAAACGTGTACTGGAAGAGTTGCGCAATACTGGCATGAACAGCCTATATTTACCAGGCTGTCTTG
TGCCAAAAGAAATAGAGCTTATACCCGATGTTGAGAGTGCGCTGAAGTGTGCTTCTGTGCTGTTGCTGTGTGTTCCAACA
CAGGAGTTACGCAACTTGTGTAATGACGTGAGAAATACTGCTGCACTGGATGCTTCTGTGCCGGTGCTCGTGTGTAGTAA
GGGCATTGAGAATAAGTCTTTGAAATTTGCTGGAGAAGTGATAGAGGAACTTTTACCTGATAATCCAGTGTTTGTTTTGT
CAGGTCCTGCACTTGCGAAAGAGATGGTTCGTGGGCTCCCCTGCGCAATGGTGCTTGCAGGACGGGATGAATCTCTTGCA
GCATCGCTCGCTGAAAAACTAAGCAGTGCTGTCATGTCCATAGCTCCTAGTACCGACTATGTAGGAGTGCAGATTGGTTC
AGTACTAAAAAATATTATTGCCATCGCATGTGGCATAGTCATAGGAAAAGGGCTAGGGTACAACGCTAGCGCCATGGTAG
TAGTGCGGGGCATTGCCGAAATACAGGCTGTAAGCACGGCGAAATCTGAGAGTGTCGACCTATCTACCATAATAGGTCTT
GCGTGTTTGGGAGATTTAGTTCTCACCTGCACATCTGCAAGTTCCCGCAACATGTCCTTTGGTCTTGCCATCGGAAAAGG
ACAGGATATTGCCTCACGTAATGATAGCCTGGTCGAAGGCGCAGAAAGCGCGCAATCTATAGATCGCTTGAGTAATACAC
TAGGTATTCATCTTCCAGTATGCTCTGCAATAGCAAAACTTCTAAGAGGTGAGTTGGATACTGATCAAGTAATTAACCAA
TTACTGTTCGCATAA

Upstream 100 bases:

>100_bases
AACATTTGTACTTTTAGCAAGATGGTACTAGAAAGTTTTTTCTATTGATAAACCATAGCCTACGCTATACCATGCTGACG
TGTATTTTTTGGCAGGCTAG

Downstream 100 bases:

>100_bases
TTTCAGAACCTGAACTTCATATGCTCTAAAAAGCTTTTTAATGGATGCTAGCACGAATACTGATGTGCCTTAAAGCTCAT
GCCATAGGCTGTAATATAAG

Product: glycerol-3-phosphate dehydrogenase (NAD(P)+)

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRVTVLGAGAFGTALSVALYNSCCSVALWSRNKRVLEELRNTGMNSLYLPGCLVPKEIELIPDVESALKCASVLLLCVPT
QELRNLCNDVRNTAALDASVPVLVCSKGIENKSLKFAGEVIEELLPDNPVFVLSGPALAKEMVRGLPCAMVLAGRDESLA
ASLAEKLSSAVMSIAPSTDYVGVQIGSVLKNIIAIACGIVIGKGLGYNASAMVVVRGIAEIQAVSTAKSESVDLSTIIGL
ACLGDLVLTCTSASSRNMSFGLAIGKGQDIASRNDSLVEGAESAQSIDRLSNTLGIHLPVCSAIAKLLRGELDTDQVINQ
LLFA

Sequences:

>Translated_324_residues
MRVTVLGAGAFGTALSVALYNSCCSVALWSRNKRVLEELRNTGMNSLYLPGCLVPKEIELIPDVESALKCASVLLLCVPT
QELRNLCNDVRNTAALDASVPVLVCSKGIENKSLKFAGEVIEELLPDNPVFVLSGPALAKEMVRGLPCAMVLAGRDESLA
ASLAEKLSSAVMSIAPSTDYVGVQIGSVLKNIIAIACGIVIGKGLGYNASAMVVVRGIAEIQAVSTAKSESVDLSTIIGL
ACLGDLVLTCTSASSRNMSFGLAIGKGQDIASRNDSLVEGAESAQSIDRLSNTLGIHLPVCSAIAKLLRGELDTDQVINQ
LLFA
>Mature_324_residues
MRVTVLGAGAFGTALSVALYNSCCSVALWSRNKRVLEELRNTGMNSLYLPGCLVPKEIELIPDVESALKCASVLLLCVPT
QELRNLCNDVRNTAALDASVPVLVCSKGIENKSLKFAGEVIEELLPDNPVFVLSGPALAKEMVRGLPCAMVLAGRDESLA
ASLAEKLSSAVMSIAPSTDYVGVQIGSVLKNIIAIACGIVIGKGLGYNASAMVVVRGIAEIQAVSTAKSESVDLSTIIGL
ACLGDLVLTCTSASSRNMSFGLAIGKGQDIASRNDSLVEGAESAQSIDRLSNTLGIHLPVCSAIAKLLRGELDTDQVINQ
LLFA

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=329, Percent_Identity=24.9240121580547, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI24307999, Length=328, Percent_Identity=22.5609756097561, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1790037, Length=311, Percent_Identity=33.1189710610932, Blast_Score=184, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17507425, Length=349, Percent_Identity=22.9226361031519, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32564399, Length=340, Percent_Identity=23.2352941176471, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564403, Length=349, Percent_Identity=22.6361031518625, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193210136, Length=349, Percent_Identity=22.6361031518625, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320181, Length=317, Percent_Identity=26.813880126183, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324513, Length=322, Percent_Identity=25.776397515528, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136200, Length=341, Percent_Identity=23.4604105571848, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136204, Length=341, Percent_Identity=23.4604105571848, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136202, Length=341, Percent_Identity=23.4604105571848, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI22026922, Length=302, Percent_Identity=20.8609271523179, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551945, Length=344, Percent_Identity=21.8023255813953, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281362270, Length=296, Percent_Identity=21.6216216216216, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_ANAPZ (Q2GLD0)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504821.1
- ProteinModelPortal:   Q2GLD0
- SMR:   Q2GLD0
- STRING:   Q2GLD0
- GeneID:   3930156
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0198
- NMPDR:   fig|212042.5.peg.189
- TIGR:   APH_0198
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   CLSK747383
- BioCyc:   APHA212042:APH_0198-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 33793; Mature: 33793

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 190-190 BINDING 107-107 BINDING 107-107 BINDING 139-139 BINDING 256-256 BINDING 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVTVLGAGAFGTALSVALYNSCCSVALWSRNKRVLEELRNTGMNSLYLPGCLVPKEIEL
CEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCCCCHHHC
IPDVESALKCASVLLLCVPTQELRNLCNDVRNTAALDASVPVLVCSKGIENKSLKFAGEV
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHH
IEELLPDNPVFVLSGPALAKEMVRGLPCAMVLAGRDESLAASLAEKLSSAVMSIAPSTDY
HHHHCCCCCEEEEECHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
VGVQIGSVLKNIIAIACGIVIGKGLGYNASAMVVVRGIAEIQAVSTAKSESVDLSTIIGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ACLGDLVLTCTSASSRNMSFGLAIGKGQDIASRNDSLVEGAESAQSIDRLSNTLGIHLPV
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEHHH
CSAIAKLLRGELDTDQVINQLLFA
HHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRVTVLGAGAFGTALSVALYNSCCSVALWSRNKRVLEELRNTGMNSLYLPGCLVPKEIEL
CEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCCCCHHHC
IPDVESALKCASVLLLCVPTQELRNLCNDVRNTAALDASVPVLVCSKGIENKSLKFAGEV
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHH
IEELLPDNPVFVLSGPALAKEMVRGLPCAMVLAGRDESLAASLAEKLSSAVMSIAPSTDY
HHHHCCCCCEEEEECHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
VGVQIGSVLKNIIAIACGIVIGKGLGYNASAMVVVRGIAEIQAVSTAKSESVDLSTIIGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ACLGDLVLTCTSASSRNMSFGLAIGKGQDIASRNDSLVEGAESAQSIDRLSNTLGIHLPV
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEHHH
CSAIAKLLRGELDTDQVINQLLFA
HHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA