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The map label for this gene is pcoA [H]

Identifier: 87200941

GI number: 87200941

Start: 3143931

End: 3145715

Strand: Direct

Name: pcoA [H]

Synonym: Saro_2929

Alternate gene names: 87200941

Gene position: 3143931-3145715 (Clockwise)

Preceding gene: 87200940

Following gene: 87200942

Centisome position: 88.27

GC content: 67.11

Gene sequence:

>1785_bases
ATGGACAAGAACCTCCTGCTCGACCGCCGCCGCCTGCTTGTCGGCTCCGGCGCCCTGGCCCTCGCGCCGCTGTTTCCGGC
CTGGGCGCAATCCGGGAATCTGGCCGGCCATGGCGGCCATTCCCGTGGCTCCGGCCCGATGGCCGGGCGCAACAGCGGGG
GGACGCTCTCGGGCGACACCATCGCGCTGAACATCGGCGAGGCGCGCTATTCGGTGGGGCGGCGCTCTGCCTCGGCGGTT
GCGGTAAACGGCACGATCCCCGCCCCCCTCATCCGCCTGCGCGAAGGCCAGACGGTTCGCATCGCGGTTACCAACCATCT
GAAGGAACAGTCTTCCATCCACTGGCACGGGCTGCTCGTGCCCTTCCAGATGGACGGCGTGCCCGGCCTGTCGTTCCCGG
GCATCGACCCGGGCGAGACCTTTACCTACCAGTTTCCGATCCTCCACTCCGGCACGTTCTGGTACCACTCCCACTCCGGA
ATGCAGGAAGCGGTCGGCCTTTACGGCCCGATCGTGATCGACCCCGCCCTGCCCGATGCCGCCGCACCGTTCGACCGCGA
ATACGTGCTGATGCTGGCCGACTGGAGCCCCGTCGATCCGCATGCCCAGCTCAGGAAGCTGAAGACCATGGGCGGCTACT
ACAACTGGCAGCGCCAGACCGTGGGCGGCCTGATTGCCGGCAAGGACCAGAGCCTGAAGGACCGGCTCGAATGGGCGAAG
ATGCGCATGGACGCGACCGACATCTCGGACGTGACCGGCGCCACCTACAGCTTCCTCGTCAACGGCCACGACACCGAAGC
CAACTGGACCGCCCTGTTCCGTCCCGGCGAGCGGGTGAAGCTGCGGATCATCAATGCCTCGGCCATGACCAACTTCAACT
TCCGCATCCCCGGCCTGCCGATGACGGTGGTTGCCGCCGACGGCTGCAACGTCGCGCCGGTCGAGACCGACGAGATCCAG
ATCGCCATCGCCGAAACCTATGACGTGATCGTCCAGCCCGGCGAGGCGGCACCGTTCGGCATCATTGCCGAAGCCATCGA
CCGGTCCGGCCTGGTCCGCGCGACGCTGGCCCCGCAGGCCGGCATGGTCGGCCCGGTGCCGAAGCTGCGCCAGCGCCCGA
TCCTGACCATGCGCGACATGGGCATGGACATGTCGGGCATGGACATGGGCGCGGGCGGCGAGATCGACCTGTCGAAGCCC
GCAAACGAGAGCATGGACGGCCATTCGATGTCGATGCGCGACTTCTCTGCCGCGCCAGGCGTAAAGAAAGGCCCGGGCGT
GGCGACGATATCGCCGATGCCGGCCGACCGGCTTGCCGACCGGGGAACGGGCCTCGAGAACGAAGACCACCGCGTCCTGA
CCTATGCCGACCTGCGCTCGCGCGATCCGAACCCCGATCCGCGCAAACCGACCCGGCAGATCGACGTGAACCTGACCGCG
AACATGGAACGCTACATGTGGTCCATCGACGGCGAGACCATTTCCGACGGCGCCGCTCCGATCCCCTTCCGCAAGGGCGA
ACGCGTGCGGGTGAACCTTATCAACCACACGATGATGCCGCACCCGATCCATCTCCACGGCCACTTCTTCGAACTGGTGA
CCGGCGAGGCGGGCAACCGGCCGCGCAAGCACACCGTCAACGTGCTGCCCGGCGGCAAGGCCAGCTTCGACCTTACGGCC
GATGCCGAGGGAGACTGGGCGTTTCACTGCCACATGCTGCTGCACATGCATTCGGGGATGATGCGCGTCGTCACCGTCCG
CGCCGACAAGGGAGACGCGGCATGA

Upstream 100 bases:

>100_bases
GCCTTTCGGAAAAGGCCGTGGAAACGCGCATTTACCGGGCAAGGCAGAAATTGTCGGAAATTCTTGAGGGATAGTTCCCG
CGCGTGCGTATTCGCAATCG

Downstream 100 bases:

>100_bases
GCCCGCTTCGCACAGTCCTTTTCGCCGGAGCGGCGTTGATCTCCATCCCCGTGGCGGCGCAGGAAGCGCAGGACCCGCAC
GCCGGGCACGACATGAGCCA

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MDKNLLLDRRRLLVGSGALALAPLFPAWAQSGNLAGHGGHSRGSGPMAGRNSGGTLSGDTIALNIGEARYSVGRRSASAV
AVNGTIPAPLIRLREGQTVRIAVTNHLKEQSSIHWHGLLVPFQMDGVPGLSFPGIDPGETFTYQFPILHSGTFWYHSHSG
MQEAVGLYGPIVIDPALPDAAAPFDREYVLMLADWSPVDPHAQLRKLKTMGGYYNWQRQTVGGLIAGKDQSLKDRLEWAK
MRMDATDISDVTGATYSFLVNGHDTEANWTALFRPGERVKLRIINASAMTNFNFRIPGLPMTVVAADGCNVAPVETDEIQ
IAIAETYDVIVQPGEAAPFGIIAEAIDRSGLVRATLAPQAGMVGPVPKLRQRPILTMRDMGMDMSGMDMGAGGEIDLSKP
ANESMDGHSMSMRDFSAAPGVKKGPGVATISPMPADRLADRGTGLENEDHRVLTYADLRSRDPNPDPRKPTRQIDVNLTA
NMERYMWSIDGETISDGAAPIPFRKGERVRVNLINHTMMPHPIHLHGHFFELVTGEAGNRPRKHTVNVLPGGKASFDLTA
DAEGDWAFHCHMLLHMHSGMMRVVTVRADKGDAA

Sequences:

>Translated_594_residues
MDKNLLLDRRRLLVGSGALALAPLFPAWAQSGNLAGHGGHSRGSGPMAGRNSGGTLSGDTIALNIGEARYSVGRRSASAV
AVNGTIPAPLIRLREGQTVRIAVTNHLKEQSSIHWHGLLVPFQMDGVPGLSFPGIDPGETFTYQFPILHSGTFWYHSHSG
MQEAVGLYGPIVIDPALPDAAAPFDREYVLMLADWSPVDPHAQLRKLKTMGGYYNWQRQTVGGLIAGKDQSLKDRLEWAK
MRMDATDISDVTGATYSFLVNGHDTEANWTALFRPGERVKLRIINASAMTNFNFRIPGLPMTVVAADGCNVAPVETDEIQ
IAIAETYDVIVQPGEAAPFGIIAEAIDRSGLVRATLAPQAGMVGPVPKLRQRPILTMRDMGMDMSGMDMGAGGEIDLSKP
ANESMDGHSMSMRDFSAAPGVKKGPGVATISPMPADRLADRGTGLENEDHRVLTYADLRSRDPNPDPRKPTRQIDVNLTA
NMERYMWSIDGETISDGAAPIPFRKGERVRVNLINHTMMPHPIHLHGHFFELVTGEAGNRPRKHTVNVLPGGKASFDLTA
DAEGDWAFHCHMLLHMHSGMMRVVTVRADKGDAA
>Mature_594_residues
MDKNLLLDRRRLLVGSGALALAPLFPAWAQSGNLAGHGGHSRGSGPMAGRNSGGTLSGDTIALNIGEARYSVGRRSASAV
AVNGTIPAPLIRLREGQTVRIAVTNHLKEQSSIHWHGLLVPFQMDGVPGLSFPGIDPGETFTYQFPILHSGTFWYHSHSG
MQEAVGLYGPIVIDPALPDAAAPFDREYVLMLADWSPVDPHAQLRKLKTMGGYYNWQRQTVGGLIAGKDQSLKDRLEWAK
MRMDATDISDVTGATYSFLVNGHDTEANWTALFRPGERVKLRIINASAMTNFNFRIPGLPMTVVAADGCNVAPVETDEIQ
IAIAETYDVIVQPGEAAPFGIIAEAIDRSGLVRATLAPQAGMVGPVPKLRQRPILTMRDMGMDMSGMDMGAGGEIDLSKP
ANESMDGHSMSMRDFSAAPGVKKGPGVATISPMPADRLADRGTGLENEDHRVLTYADLRSRDPNPDPRKPTRQIDVNLTA
NMERYMWSIDGETISDGAAPIPFRKGERVRVNLINHTMMPHPIHLHGHFFELVTGEAGNRPRKHTVNVLPGGKASFDLTA
DAEGDWAFHCHMLLHMHSGMMRVVTVRADKGDAA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=375, Percent_Identity=25.6, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539950, Length=282, Percent_Identity=27.3049645390071, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320714, Length=602, Percent_Identity=21.7607973421927, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321067, Length=551, Percent_Identity=23.2304900181488, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323703, Length=544, Percent_Identity=24.8161764705882, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859919, Length=567, Percent_Identity=25.7495590828924, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28574104, Length=636, Percent_Identity=24.5283018867925, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24650186, Length=577, Percent_Identity=22.7036395147314, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221329998, Length=557, Percent_Identity=25.3141831238779, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281360167, Length=285, Percent_Identity=27.719298245614, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24585842, Length=285, Percent_Identity=27.719298245614, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221330000, Length=285, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 64384; Mature: 64384

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNLLLDRRRLLVGSGALALAPLFPAWAQSGNLAGHGGHSRGSGPMAGRNSGGTLSGDT
CCCCCEECCCCEEEECCCCEEHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEECCCE
IALNIGEARYSVGRRSASAVAVNGTIPAPLIRLREGQTVRIAVTNHLKEQSSIHWHGLLV
EEEEECHHHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCHHCCCCEEEEEEE
PFQMDGVPGLSFPGIDPGETFTYQFPILHSGTFWYHSHSGMQEAVGLYGPIVIDPALPDA
EEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEEEECCCCHHHHHHCCCCEEECCCCCCC
AAPFDREYVLMLADWSPVDPHAQLRKLKTMGGYYNWQRQTVGGLIAGKDQSLKDRLEWAK
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHCCCCEEECCCHHHHHHHHHHH
MRMDATDISDVTGATYSFLVNGHDTEANWTALFRPGERVKLRIINASAMTNFNFRIPGLP
HHCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCEEEEEEEEHHHEEECEEECCCCC
MTVVAADGCNVAPVETDEIQIAIAETYDVIVQPGEAAPFGIIAEAIDRSGLVRATLAPQA
EEEEEECCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCC
GMVGPVPKLRQRPILTMRDMGMDMSGMDMGAGGEIDLSKPANESMDGHSMSMRDFSAAPG
CCCCCCHHHHCCCCEEHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCC
VKKGPGVATISPMPADRLADRGTGLENEDHRVLTYADLRSRDPNPDPRKPTRQIDVNLTA
CCCCCCEEEECCCCHHHHHHCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEEEE
NMERYMWSIDGETISDGAAPIPFRKGERVRVNLINHTMMPHPIHLHGHFFELVTGEAGNR
CCEEEEEEECCCEECCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCEEEEEEECCCCCC
PRKHTVNVLPGGKASFDLTADAEGDWAFHCHMLLHMHSGMMRVVTVRADKGDAA
CCCEEEEEECCCCCEEEEEECCCCCEEEEEEEEEHHHCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MDKNLLLDRRRLLVGSGALALAPLFPAWAQSGNLAGHGGHSRGSGPMAGRNSGGTLSGDT
CCCCCEECCCCEEEECCCCEEHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEECCCE
IALNIGEARYSVGRRSASAVAVNGTIPAPLIRLREGQTVRIAVTNHLKEQSSIHWHGLLV
EEEEECHHHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCHHCCCCEEEEEEE
PFQMDGVPGLSFPGIDPGETFTYQFPILHSGTFWYHSHSGMQEAVGLYGPIVIDPALPDA
EEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEEEECCCCHHHHHHCCCCEEECCCCCCC
AAPFDREYVLMLADWSPVDPHAQLRKLKTMGGYYNWQRQTVGGLIAGKDQSLKDRLEWAK
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHCCCCEEECCCHHHHHHHHHHH
MRMDATDISDVTGATYSFLVNGHDTEANWTALFRPGERVKLRIINASAMTNFNFRIPGLP
HHCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCEEEEEEEEHHHEEECEEECCCCC
MTVVAADGCNVAPVETDEIQIAIAETYDVIVQPGEAAPFGIIAEAIDRSGLVRATLAPQA
EEEEEECCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCC
GMVGPVPKLRQRPILTMRDMGMDMSGMDMGAGGEIDLSKPANESMDGHSMSMRDFSAAPG
CCCCCCHHHHCCCCEEHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCC
VKKGPGVATISPMPADRLADRGTGLENEDHRVLTYADLRSRDPNPDPRKPTRQIDVNLTA
CCCCCCEEEECCCCHHHHHHCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEEEE
NMERYMWSIDGETISDGAAPIPFRKGERVRVNLINHTMMPHPIHLHGHFFELVTGEAGNR
CCEEEEEEECCCEECCCCCCCCCCCCCEEEEEEEECCCCCCEEEECCEEEEEEECCCCCC
PRKHTVNVLPGGKASFDLTADAEGDWAFHCHMLLHMHSGMMRVVTVRADKGDAA
CCCEEEEEECCCCCEEEEEECCCCCEEEEEEEEEHHHCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]