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The map label for this gene is serA [H]

Identifier: 87200393

GI number: 87200393

Start: 2532877

End: 2533800

Strand: Reverse

Name: serA [H]

Synonym: Saro_2380

Alternate gene names: 87200393

Gene position: 2533800-2532877 (Counterclockwise)

Preceding gene: 87200394

Following gene: 87200392

Centisome position: 71.14

GC content: 65.26

Gene sequence:

>924_bases
ATGAATGCCGTCGCGGCGCCGCTGGTCGAAAGCCGCCTGCCGGATTGGATCGAACCCCGTTTCTTCCGGTCGGTCGAGGA
GCTGTTCCAACTGGCGCCCGAGGCAGAGATCGGCTGGTTCGATCTCAACGACAAGGAGCCGATGGCCAAGGCCATCCGCA
GCGCCACCAAGCTGAAGTGGCTCAACTCTATCTATGCGGGTGTCGACGCCATGCCGCTTGATCTCTTGCGCGAGCGCGGC
GTCGTTCTCACAAACGGCGTCGGCATCAACGCGATCACCATCGCCGAATATGTGGTCATGGGTATGCTTACGGTCGCGAA
GGGTTATCGCGAGGTGGTTCGCGCGCAGGAACGGCATGAGTGGCTGATGGATTCGCCCGGCAAGGTCGAGCTTCACGGCT
CGCGCGCGCTTGTTCTCGGTTACGGCGCGATCGGGCAGCGGGTCGAAAGGATGCTTCAGGCCTTCGACGTCGACGTGGCG
AAGGTCAGGCGCTCCGGAGGGGCCGGCGCTCTGGGCCCCGACGAATGGCGCTCACAGCTTGGCACATTCGACTGGGTCAT
CCTTGCCGTTCCGGCGACGGCCGAGACAGAAGGCATGATCGGCGCCGCCGAACTGGCGGCAATGAAGCCGACCGCGACCC
TCATCAACGTCGCCCGCGGCACCGTGGTCGATCAGGAGGCACTGGTCGTCGCGCTCTCGGCGGGGCGCCCGGGTCAAGCA
TTCCTCGATGTCACCTCGCCGGAGCCGCTGCCGGCGGATCATCCGCTGTGGTCCTTGCCGAACGCGCACGTGACGATGCA
TCTGTCGGGGCGGGCGCAGACGCGGATGTTCGAGCGGTCTGTAGCGCGGTTCCTCGAAAATCTCGCGCGGTTCCGGCGCG
GAGAGCCGCTCGAGCCGCAAGTCGACCTTGCGCTGGGATATTGA

Upstream 100 bases:

>100_bases
CTGGGAGTGGAAACTCGCGTAACCAGTTTCATTTCAGGACCGGCGCGCTAATCTCTCCGCCGACACAACCGGAGAGTGCC
GCAAAGTGACAGTTCTTGTG

Downstream 100 bases:

>100_bases
GCGGAACCCCGTGAGGGGGTGACTTGCTGCCCTCGGTTTGATAGCCCTTGCGCCAAGGGCACGTGCGGGGGCCATAACGA
CACGCACGAACGGCTTTTCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MNAVAAPLVESRLPDWIEPRFFRSVEELFQLAPEAEIGWFDLNDKEPMAKAIRSATKLKWLNSIYAGVDAMPLDLLRERG
VVLTNGVGINAITIAEYVVMGMLTVAKGYREVVRAQERHEWLMDSPGKVELHGSRALVLGYGAIGQRVERMLQAFDVDVA
KVRRSGGAGALGPDEWRSQLGTFDWVILAVPATAETEGMIGAAELAAMKPTATLINVARGTVVDQEALVVALSAGRPGQA
FLDVTSPEPLPADHPLWSLPNAHVTMHLSGRAQTRMFERSVARFLENLARFRRGEPLEPQVDLALGY

Sequences:

>Translated_307_residues
MNAVAAPLVESRLPDWIEPRFFRSVEELFQLAPEAEIGWFDLNDKEPMAKAIRSATKLKWLNSIYAGVDAMPLDLLRERG
VVLTNGVGINAITIAEYVVMGMLTVAKGYREVVRAQERHEWLMDSPGKVELHGSRALVLGYGAIGQRVERMLQAFDVDVA
KVRRSGGAGALGPDEWRSQLGTFDWVILAVPATAETEGMIGAAELAAMKPTATLINVARGTVVDQEALVVALSAGRPGQA
FLDVTSPEPLPADHPLWSLPNAHVTMHLSGRAQTRMFERSVARFLENLARFRRGEPLEPQVDLALGY
>Mature_307_residues
MNAVAAPLVESRLPDWIEPRFFRSVEELFQLAPEAEIGWFDLNDKEPMAKAIRSATKLKWLNSIYAGVDAMPLDLLRERG
VVLTNGVGINAITIAEYVVMGMLTVAKGYREVVRAQERHEWLMDSPGKVELHGSRALVLGYGAIGQRVERMLQAFDVDVA
KVRRSGGAGALGPDEWRSQLGTFDWVILAVPATAETEGMIGAAELAAMKPTATLINVARGTVVDQEALVVALSAGRPGQA
FLDVTSPEPLPADHPLWSLPNAHVTMHLSGRAQTRMFERSVARFLENLARFRRGEPLEPQVDLALGY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=264, Percent_Identity=29.9242424242424, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI23308577, Length=250, Percent_Identity=26.8, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1789279, Length=231, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082289, Length=230, Percent_Identity=30.8695652173913, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081824, Length=175, Percent_Identity=34.2857142857143, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=249, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=245, Percent_Identity=29.7959183673469, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=244, Percent_Identity=29.5081967213115, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=156, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=279, Percent_Identity=24.7311827956989, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=28.3464566929134, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585516, Length=272, Percent_Identity=27.2058823529412, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=272, Percent_Identity=27.9411764705882, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574282, Length=272, Percent_Identity=27.9411764705882, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45552429, Length=265, Percent_Identity=28.3018867924528, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574284, Length=269, Percent_Identity=28.2527881040892, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45551003, Length=269, Percent_Identity=28.2527881040892, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28571528, Length=152, Percent_Identity=38.1578947368421, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33648; Mature: 33648

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVAAPLVESRLPDWIEPRFFRSVEELFQLAPEAEIGWFDLNDKEPMAKAIRSATKLKW
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHH
LNSIYAGVDAMPLDLLRERGVVLTNGVGINAITIAEYVVMGMLTVAKGYREVVRAQERHE
HHHHHHCCCCCCHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLMDSPGKVELHGSRALVLGYGAIGQRVERMLQAFDVDVAKVRRSGGAGALGPDEWRSQL
HHCCCCCEEEEECCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHH
GTFDWVILAVPATAETEGMIGAAELAAMKPTATLINVARGTVVDQEALVVALSAGRPGQA
CCCEEEEEEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCEECCCEEEEEEECCCCCCE
FLDVTSPEPLPADHPLWSLPNAHVTMHLSGRAQTRMFERSVARFLENLARFRRGEPLEPQ
EEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VDLALGY
CCEEECC
>Mature Secondary Structure
MNAVAAPLVESRLPDWIEPRFFRSVEELFQLAPEAEIGWFDLNDKEPMAKAIRSATKLKW
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHH
LNSIYAGVDAMPLDLLRERGVVLTNGVGINAITIAEYVVMGMLTVAKGYREVVRAQERHE
HHHHHHCCCCCCHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLMDSPGKVELHGSRALVLGYGAIGQRVERMLQAFDVDVAKVRRSGGAGALGPDEWRSQL
HHCCCCCEEEEECCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHH
GTFDWVILAVPATAETEGMIGAAELAAMKPTATLINVARGTVVDQEALVVALSAGRPGQA
CCCEEEEEEECCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCEECCCEEEEEEECCCCCCE
FLDVTSPEPLPADHPLWSLPNAHVTMHLSGRAQTRMFERSVARFLENLARFRRGEPLEPQ
EEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VDLALGY
CCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]