Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 87199935

GI number: 87199935

Start: 2029039

End: 2031765

Strand: Reverse

Name: gyrA [H]

Synonym: Saro_1918

Alternate gene names: 87199935

Gene position: 2031765-2029039 (Counterclockwise)

Preceding gene: 87199937

Following gene: 87199934

Centisome position: 57.05

GC content: 65.2

Gene sequence:

>2727_bases
GTGAGCGACGACACCACGATCATCGACCCTCCCGCCCCCGCACCGGAAGGCGAGTTCCAGCGGATCGACATCGTCGATGA
GATGAAGACCAGTTATCTCGATTACGCGATGAGCGTGATCGTGAGCCGCGCGCTGCCCGACGTGCGCGACGGCCTGAAGC
CGGTCCATCGCCGTATCCTGTGGACCAGCCACGAGAACGGTTTCGTTTCGACCAAGGCCTATCGCAAGTCCGCCCGCATC
GTCGGCGACGCAATGGGCAAGTACCACCCGCACGGCGACGCCGCGATCTACGACGCGCTGGCGCGCATGACGCAGGACTG
GTCGATGCGCCTGCCGCTGATCGACGGTCAGGGCAACTTCGGCTCGATGGACCCCGATCCGCCGGCGTCGATGCGTTACA
CCGAAGCGCGCCTTGCCAAGGTGGCGGACTCGCTCCTTGCGGACATCGACAAGGACACGGTCGATTTCCAGCCCAACTAC
GACGGTGCGGAGCATGAGCCGCAGGTCCTTCCGGCGCGGTTTCCGAACCTCCTGGTCAACGGTGCCGGCGGTATCGCGGT
CGGCATGGCAACGAACATCCCGCCGCACAACCTCGGCGAGGTCATCGACGCCTGCCTTGCCTACATGGACAATCCGCTGG
TCACCATCGACGAGCTGATCCAGATCATCCCGGGCCCTGATTTCCCCACCGCCCCGCTGATCCTCGGCACTGCCGGCGCC
CGAAAGGCCTATCACGAAGGCCGGGGTTCGATCATCATGCGCGCGCGCCACCAGATCGAGGAAGGCCGGGGCGACCGTCG
TTCCATCGTCCTCACCTCGATCCCGTATCAGGTCGGCAAATCCGGGCTGGTCGAGAAGATCGCCGAGGCGGCCAAGGACA
AGCGGATCGAGGGCATCTCGGACATCCGCGACGAATCCAACCGTGAAGGCGTGCGCGTCGTCATCGACCTCAAGCGCGAC
GCAACGCCGGAGGTTGTGCTGAATCAACTCTGGCGCAACACGCCGGCGCAGTCGAGCTTCCCCGCCAACATGCTCGCCAT
CCGTGGCGGACGCCCGGAGGTCCTGAACCTCAAGGACATCATCGAGTCCTTTGTCCGCTTCCGCGAGGAGGTCATCACTC
GCCGCACCAAGTTCGAGCTGAACAAGGCGCGCGACCGGGCCCACATCCTTCTCGGTCTGGTCATTGCCGTCACCAACCTC
GATGAGGTCGTGCGGATCATCCGCGGGTCACCGAACCCCGCCGTCGCGCGCGAGACTCTGCTTGCCCGCGAATGGCCGAT
GGGCGAGATCGCGCCCTATATCCGCCTCGTCGAAGCGATCGAGGATGCGGGCGTCGCCGAAGCCGCGACCTATCGCCTGT
CCGAAATCCAGGTGCGCGCGATCCTCGACCTGCGCCTCCATCGCCTGACCGCGCTGGGCCGGGACGAGATCGGCGACGAA
CTGGAAGGCCTGGCCAAGGCCATCGCCGAGTACCTCTCCATCCTCGCTGACCGCGAGAAGCTCTTCGGCGTGATGCGCCA
GGAACTGCTCGAAGTGCAGCACGCCTTTGCCACGCCGCGCAAATCCGAGATCACCGCGCCCGCCGATGGCATCGAGGACG
AGGACCTGATCGAGCGCGAGGACATGGTCGTCACGATCACCCTCGACGGCTACATCAAGCGGACCCCGCTTTCGACCTTC
CGCGCGCAGAACCGTGGCGGCAAGGGCCGCTCGGGCATGGCAACGAAGGACGAGGATGCTGTGGCGACGATGTTCGTCAC
CAGCACCCACACGCCGGTTCTATTCTTCTCGACCGCAGGCAAGGTCTATCGCCTGAAGGTCTGGCGTCTGCCCGAAGGCG
GGCCCACCACGCGCGGTCGCCCGGTCGTCAACATGCTGCCCGCACTCGACAAGGACGAGACAATCGCAACCGTCCTTCCA
CTGCCCGAGGACGAGGCGGAATGGGGCAAGCTCTCGGTTGTATTCGCTACCGCCAAGGGCAATGTGCGCCGCAATTCGAT
GGACGCATTCGCGAACATCCCGTCCAACGGCAAGTTCGCGATGAAGTTCGAGGAAGACAGCGCGGATCGCCTGATCGGCG
TCGCCCTTCTCGAGGCGAGCGACGACGTCCTGCTCGCAACGCGTTCGGGCAAGGCCATCCGATTCGCCGGTGACGAGGTG
CGCGAATTCACGAGCCGCACCTCGACCGGCGTGCGCGGCATGACCCTGAAGGGCGACGACGAGGTTATCTCGCTTTCGAT
CCTCCATCGCGTCGGCACCACCCCGGACGAGCGCGAGGACTATGTGCGCTTTGCCCCGTGGAAGGGTGAGAAGGAGGGCG
AGCCGGCCCTTTCGGCGGAACGCTACGCCGAATTGCAGGCGCGCGAGCAGTTCATCCTGACCGTCTGTGCCAATGGCTAT
GGCAAGCTGTCGTCGGCCTACGAGTATCGCCGGACGGGCCGAGGCGGCCAGGGCATTACCAACATAGACAACATCGGCCG
CAATGGACCGGTGGTTGCAAGCTTCCCGGCGACCCAGGCCGACCAGCTCATGCTCGTGACCGACCAGGCCAAGCTCATCC
GCCTGCCGCTTGATTCGCTGCGCGTGATCGGGCGTGGTTCCGCGGGCGTCCGCCTGTTCAACGTCTCGGGCGGGGAACAC
GTCGTCAGCGCGGTGCGTTTGGCCGAGGAAGAGGGCGCCGAATCCGATGACGTCGGCGCCGTCCCGGACGAAGGAACGGC
AGAATGA

Upstream 100 bases:

>100_bases
CCGCCAATCCGGGGCATCGGGCCGCTCTTGCTGGCCTTCCCGGACCAATTGGCCTAGGGCCGTTCCCTATCCCTGAAACA
GAAGCGAAAAAGCCACCGAC

Downstream 100 bases:

>100_bases
GCGAACGCCCCCTCCTCGCCTACAAGGTGCTGACTGCCTCGCAGATGGCGGAGCTTGAGGCGGAGGGGACATTTGCAGGC
GCGCCGATCGATCTCACGGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 908; Mature: 907

Protein sequence:

>908_residues
MSDDTTIIDPPAPAPEGEFQRIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILWTSHENGFVSTKAYRKSARI
VGDAMGKYHPHGDAAIYDALARMTQDWSMRLPLIDGQGNFGSMDPDPPASMRYTEARLAKVADSLLADIDKDTVDFQPNY
DGAEHEPQVLPARFPNLLVNGAGGIAVGMATNIPPHNLGEVIDACLAYMDNPLVTIDELIQIIPGPDFPTAPLILGTAGA
RKAYHEGRGSIIMRARHQIEEGRGDRRSIVLTSIPYQVGKSGLVEKIAEAAKDKRIEGISDIRDESNREGVRVVIDLKRD
ATPEVVLNQLWRNTPAQSSFPANMLAIRGGRPEVLNLKDIIESFVRFREEVITRRTKFELNKARDRAHILLGLVIAVTNL
DEVVRIIRGSPNPAVARETLLAREWPMGEIAPYIRLVEAIEDAGVAEAATYRLSEIQVRAILDLRLHRLTALGRDEIGDE
LEGLAKAIAEYLSILADREKLFGVMRQELLEVQHAFATPRKSEITAPADGIEDEDLIEREDMVVTITLDGYIKRTPLSTF
RAQNRGGKGRSGMATKDEDAVATMFVTSTHTPVLFFSTAGKVYRLKVWRLPEGGPTTRGRPVVNMLPALDKDETIATVLP
LPEDEAEWGKLSVVFATAKGNVRRNSMDAFANIPSNGKFAMKFEEDSADRLIGVALLEASDDVLLATRSGKAIRFAGDEV
REFTSRTSTGVRGMTLKGDDEVISLSILHRVGTTPDEREDYVRFAPWKGEKEGEPALSAERYAELQAREQFILTVCANGY
GKLSSAYEYRRTGRGGQGITNIDNIGRNGPVVASFPATQADQLMLVTDQAKLIRLPLDSLRVIGRGSAGVRLFNVSGGEH
VVSAVRLAEEEGAESDDVGAVPDEGTAE

Sequences:

>Translated_908_residues
MSDDTTIIDPPAPAPEGEFQRIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILWTSHENGFVSTKAYRKSARI
VGDAMGKYHPHGDAAIYDALARMTQDWSMRLPLIDGQGNFGSMDPDPPASMRYTEARLAKVADSLLADIDKDTVDFQPNY
DGAEHEPQVLPARFPNLLVNGAGGIAVGMATNIPPHNLGEVIDACLAYMDNPLVTIDELIQIIPGPDFPTAPLILGTAGA
RKAYHEGRGSIIMRARHQIEEGRGDRRSIVLTSIPYQVGKSGLVEKIAEAAKDKRIEGISDIRDESNREGVRVVIDLKRD
ATPEVVLNQLWRNTPAQSSFPANMLAIRGGRPEVLNLKDIIESFVRFREEVITRRTKFELNKARDRAHILLGLVIAVTNL
DEVVRIIRGSPNPAVARETLLAREWPMGEIAPYIRLVEAIEDAGVAEAATYRLSEIQVRAILDLRLHRLTALGRDEIGDE
LEGLAKAIAEYLSILADREKLFGVMRQELLEVQHAFATPRKSEITAPADGIEDEDLIEREDMVVTITLDGYIKRTPLSTF
RAQNRGGKGRSGMATKDEDAVATMFVTSTHTPVLFFSTAGKVYRLKVWRLPEGGPTTRGRPVVNMLPALDKDETIATVLP
LPEDEAEWGKLSVVFATAKGNVRRNSMDAFANIPSNGKFAMKFEEDSADRLIGVALLEASDDVLLATRSGKAIRFAGDEV
REFTSRTSTGVRGMTLKGDDEVISLSILHRVGTTPDEREDYVRFAPWKGEKEGEPALSAERYAELQAREQFILTVCANGY
GKLSSAYEYRRTGRGGQGITNIDNIGRNGPVVASFPATQADQLMLVTDQAKLIRLPLDSLRVIGRGSAGVRLFNVSGGEH
VVSAVRLAEEEGAESDDVGAVPDEGTAE
>Mature_907_residues
SDDTTIIDPPAPAPEGEFQRIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILWTSHENGFVSTKAYRKSARIV
GDAMGKYHPHGDAAIYDALARMTQDWSMRLPLIDGQGNFGSMDPDPPASMRYTEARLAKVADSLLADIDKDTVDFQPNYD
GAEHEPQVLPARFPNLLVNGAGGIAVGMATNIPPHNLGEVIDACLAYMDNPLVTIDELIQIIPGPDFPTAPLILGTAGAR
KAYHEGRGSIIMRARHQIEEGRGDRRSIVLTSIPYQVGKSGLVEKIAEAAKDKRIEGISDIRDESNREGVRVVIDLKRDA
TPEVVLNQLWRNTPAQSSFPANMLAIRGGRPEVLNLKDIIESFVRFREEVITRRTKFELNKARDRAHILLGLVIAVTNLD
EVVRIIRGSPNPAVARETLLAREWPMGEIAPYIRLVEAIEDAGVAEAATYRLSEIQVRAILDLRLHRLTALGRDEIGDEL
EGLAKAIAEYLSILADREKLFGVMRQELLEVQHAFATPRKSEITAPADGIEDEDLIEREDMVVTITLDGYIKRTPLSTFR
AQNRGGKGRSGMATKDEDAVATMFVTSTHTPVLFFSTAGKVYRLKVWRLPEGGPTTRGRPVVNMLPALDKDETIATVLPL
PEDEAEWGKLSVVFATAKGNVRRNSMDAFANIPSNGKFAMKFEEDSADRLIGVALLEASDDVLLATRSGKAIRFAGDEVR
EFTSRTSTGVRGMTLKGDDEVISLSILHRVGTTPDEREDYVRFAPWKGEKEGEPALSAERYAELQAREQFILTVCANGYG
KLSSAYEYRRTGRGGQGITNIDNIGRNGPVVASFPATQADQLMLVTDQAKLIRLPLDSLRVIGRGSAGVRLFNVSGGEHV
VSAVRLAEEEGAESDDVGAVPDEGTAE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=343, Percent_Identity=23.3236151603499, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1788562, Length=882, Percent_Identity=46.8253968253968, Blast_Score=770, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=707, Percent_Identity=34.2291371994342, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI212645845, Length=180, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 99668; Mature: 99537

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDTTIIDPPAPAPEGEFQRIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRIL
CCCCCEEECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHE
WTSHENGFVSTKAYRKSARIVGDAMGKYHPHGDAAIYDALARMTQDWSMRLPLIDGQGNF
EECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
GSMDPDPPASMRYTEARLAKVADSLLADIDKDTVDFQPNYDGAEHEPQVLPARFPNLLVN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GAGGIAVGMATNIPPHNLGEVIDACLAYMDNPLVTIDELIQIIPGPDFPTAPLILGTAGA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCCCEEEECCCC
RKAYHEGRGSIIMRARHQIEEGRGDRRSIVLTSIPYQVGKSGLVEKIAEAAKDKRIEGIS
HHHHHCCCCCEEHHHHHHHHHCCCCCEEEEEEECCHHHCHHHHHHHHHHHHHHCCCCCHH
DIRDESNREGVRVVIDLKRDATPEVVLNQLWRNTPAQSSFPANMLAIRGGRPEVLNLKDI
HHHCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEECHHHH
IESFVRFREEVITRRTKFELNKARDRAHILLGLVIAVTNLDEVVRIIRGSPNPAVARETL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHH
LAREWPMGEIAPYIRLVEAIEDAGVAEAATYRLSEIQVRAILDLRLHRLTALGRDEIGDE
HHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LEGLAKAIAEYLSILADREKLFGVMRQELLEVQHAFATPRKSEITAPADGIEDEDLIERE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCC
DMVVTITLDGYIKRTPLSTFRAQNRGGKGRSGMATKDEDAVATMFVTSTHTPVLFFSTAG
CEEEEEEECCEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCC
KVYRLKVWRLPEGGPTTRGRPVVNMLPALDKDETIATVLPLPEDEAEWGKLSVVFATAKG
CEEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCC
NVRRNSMDAFANIPSNGKFAMKFEEDSADRLIGVALLEASDDVLLATRSGKAIRFAGDEV
CCCCCCHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCEEEEECCCCEEEECCHHH
REFTSRTSTGVRGMTLKGDDEVISLSILHRVGTTPDEREDYVRFAPWKGEKEGEPALSAE
HHHHHHHCCCCCEEEECCCCCEEEHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCHH
RYAELQAREQFILTVCANGYGKLSSAYEYRRTGRGGQGITNIDNIGRNGPVVASFPATQA
HHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEECCCCCC
DQLMLVTDQAKLIRLPLDSLRVIGRGSAGVRLFNVSGGEHVVSAVRLAEEEGAESDDVGA
CCEEEEECCCEEEECCHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCC
VPDEGTAE
CCCCCCCC
>Mature Secondary Structure 
SDDTTIIDPPAPAPEGEFQRIDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRIL
CCCCEEECCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHE
WTSHENGFVSTKAYRKSARIVGDAMGKYHPHGDAAIYDALARMTQDWSMRLPLIDGQGNF
EECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCC
GSMDPDPPASMRYTEARLAKVADSLLADIDKDTVDFQPNYDGAEHEPQVLPARFPNLLVN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
GAGGIAVGMATNIPPHNLGEVIDACLAYMDNPLVTIDELIQIIPGPDFPTAPLILGTAGA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCCCEEEECCCC
RKAYHEGRGSIIMRARHQIEEGRGDRRSIVLTSIPYQVGKSGLVEKIAEAAKDKRIEGIS
HHHHHCCCCCEEHHHHHHHHHCCCCCEEEEEEECCHHHCHHHHHHHHHHHHHHCCCCCHH
DIRDESNREGVRVVIDLKRDATPEVVLNQLWRNTPAQSSFPANMLAIRGGRPEVLNLKDI
HHHCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEECHHHH
IESFVRFREEVITRRTKFELNKARDRAHILLGLVIAVTNLDEVVRIIRGSPNPAVARETL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHH
LAREWPMGEIAPYIRLVEAIEDAGVAEAATYRLSEIQVRAILDLRLHRLTALGRDEIGDE
HHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LEGLAKAIAEYLSILADREKLFGVMRQELLEVQHAFATPRKSEITAPADGIEDEDLIERE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCC
DMVVTITLDGYIKRTPLSTFRAQNRGGKGRSGMATKDEDAVATMFVTSTHTPVLFFSTAG
CEEEEEEECCEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCC
KVYRLKVWRLPEGGPTTRGRPVVNMLPALDKDETIATVLPLPEDEAEWGKLSVVFATAKG
CEEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCC
NVRRNSMDAFANIPSNGKFAMKFEEDSADRLIGVALLEASDDVLLATRSGKAIRFAGDEV
CCCCCCHHHHHCCCCCCEEEEEECCCCCCCEEEEEEEECCCCEEEEECCCCEEEECCHHH
REFTSRTSTGVRGMTLKGDDEVISLSILHRVGTTPDEREDYVRFAPWKGEKEGEPALSAE
HHHHHHHCCCCCEEEECCCCCEEEHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCHH
RYAELQAREQFILTVCANGYGKLSSAYEYRRTGRGGQGITNIDNIGRNGPVVASFPATQA
HHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEECCCCCC
DQLMLVTDQAKLIRLPLDSLRVIGRGSAGVRLFNVSGGEHVVSAVRLAEEEGAESDDVGA
CCEEEEECCCEEEECCHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCC
VPDEGTAE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA